The role of artificial intelligence and machine learning in predicting and combating antimicrobial resistance by Hazrat Bilal, Muhammad Nadeem Khan, Sabir Khan, Muhammad Shafiq, Wenjie Fang, Rahat Ullah Khan, Mujeeb Ur Rahman, Xiaohui Li, Qiao-Li Lv, Bin Xu

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Prevention and Treatment of Esophageal Stenosis after Endoscopic Submucosal Dissection for Early Esophageal Cancer by Jing Wen, Zhongsheng Lu, Qingsen Liu

“…This short review will focus on direct prevention and treatment, which may help guide the way forward.…”
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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters

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Qualitative and Quantitative Evaluation of Chemical Constituents from Shuanghuanglian Injection Using Nuclear Magnetic Resonance Spectroscopy by Ziyan Wang, Zuoyuan Wang, Miaomiao Jiang, Jing Yang, Qingfen Meng, Jianli Guan, Maoling Xu, Xin Chai

“…By employing nuclear magnetic resonance (NMR), we implemented a chemical research on Shuanghuanglian injection (SHLI) and identified 17 components, including eight primary metabolites and nine secondary metabolites. Guided by the approach of network pharmacology, the potential activities were briefly predicted for seven primary metabolites except for formic acid, such as anti-inflammation, antioxidation, and cardiovascular protection. …”
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Progress on neuromodulation for treatment of central pain by GAN Yu, WAN Jun⁃ge, LI Zhong⁃hua, LI Shuai, HAN Shuai

“…Central pain often arises as a sequela of lesions in the central somatosensory nervous system, and the intensity of pain is generally severe, significantly impacting patients' quality of life. Conventional pharmacological therapies usually have limited efficacy. …”
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Economic evaluation of a strategy to shorten the time to surgery with neuraxial anaesthesia compared with usual clinical practice in patients on chronic antiplatelet therapy with a... by Claudia Erika Delgado-Espinoza, Rosa Maria Antonijoan, Ignasi Gich, Ignasi Gich, Rafael Anaya, Mireia Rodriguez, Angélica Millan, Jordi Llorca, Gemma Usua, Ana Ruiz, Angela Merchán-Galvis, Angela Merchán-Galvis, Maria Jose Martinez-Zapata, Maria Jose Martinez-Zapata

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Treatment of Anxiety Disorders and Comorbid Alcohol Abuse with Buspirone in a Patient with Antidepressant-Induced Platelet Dysfunction: A Case Report by Mir Mazhar, Tariq Hassan, Tariq Munshi

“…The risk of abnormal bleeding with serotonin reuptake inhibitors has been known, but there is insufficient evidence base to guide pharmacological treatment of anxiety in patients with underlying haematological conditions. …”
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Improving Communication with Patients Discharged from the Emergency Department with Noncardiac Chest Pain: A Scoping Review with Narrative Synthesis by Ramzi Shawahna, Aya Ghoul, Najlaa Zaid, Wassan Damrah, Mohammad Jaber

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Psychological interventions for patients with delirium in intensive care: A scoping review protocol. by Madiha Shaikh, Dorothy M Wade, Lara King, Liam Mackay, Isabelle Symes, Anam Syeda, Anna Greenburgh

“…However, current non-pharmacological interventions often fail to consider this issue. …”
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An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) by Aly M. Waseem, Ranya Mohammed Elmagzoub, Mervat Mohammed Mazhar Abdelgadir, Areej Al Bahir, N.S. Abd EL-Gawaad, Ahmed S. Abdel-Samea, Devendra Pratap Rao, Konstantinos Kossenas, Stefan Bräse, Hamada Hashem

“…Structural modifications guided by structure–activity relationship (SAR) studies have enabled the development of targeted quinoxaline-based compounds with enhanced efficacy. …”
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Controversies in the Anesthetic Management of Intraoperative Rupture of Intracranial Aneurysm by Tumul Chowdhury, Andrea Petropolis, Marshall Wilkinson, Bernhard Schaller, Nora Sandu, Ronald B. Cappellani

“…In addition, little data exists to guide the anesthetic management of intraoperative aneurysm rupture (IAR), though intraoperative management may have a significant effect on overall neurological outcomes. …”
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Types of discomfort and pre-hospital interventions administered to trauma victims: scoping review protocol by Filipe Melo, Mauro Mota, Margarida Reis Santos, Miguel Castelo Branco

“…Objective: To identify the types of discomforts reported by trauma victims and map pharmacological and non-pharmacological interventions for relief in pre-hospital settings. …”
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The Potential Use of the CRISPR-Cas System for HIV-1 Gene Therapy by Gabriela De Nardi Sanches-da-Silva, Luiza Fonseca Sales Medeiros, Fabio Mitsuo Lima

“…Despite advances in pharmacological treatment, it is still difficult to eliminate latent reservoirs, becoming one of the main obstacles for viral eradication. …”
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A new method of distracting attention: Is it effective for pain and fear during phlebotomy in children? by Mine Aydemir Sahin, Yeliz Cigerci, Hamide Nur Cevik Ozdemir

“…The musical blood collection tube can be used by health professionals as a non-pharmacological method to reduce the pain and fear of children during blood collection. …”
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AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volun... by Kapedanovska Nestorovska Aleksandra, Jakjovski Krume, Naumovska Zorica, Sterjev Zoran, Geskovska Nadica Matevska, Mladenovska Kristina, Suturkova Ljubica, Dimovski Aleksandar

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Knowledge, Attitudes, Motivations, Expectations, and Systemic Factors Regarding Antimicrobial Use Amongst Community Members Seeking Care at the Primary Healthcare Level: A Scoping... by Nishana Ramdas, Johanna C. Meyer, Natalie Schellack, Brian Godman, Eunice Turawa, Stephen M. Campbell

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Optimum Conditions and LC-ESI-MS Analysis of Phenolic Rich Extract from Eucalyptus marginata L. under Maceration and Ultrasound-Assisted Extraction Methods Using Response Surface M... by Soumaya Hasni, Ghayth Rigane, Hanene Ghazghazi, Hajer Riguene, Amir Bouallegue, Olfa Khedher, Moufida A. Oueslati, Ridha Ben Salem

“…These green and efficient procedures should be a promising option to guide industrial design for the production of phenolic-rich plant extracts.…”
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Resource constraints, patient emotions, and therapy: experiences of healthcare providers in the screening and management of gestational diabetes mellitus in northern Ghana by Mohammed Bukari, Abdulai Abubakari, Hawa Malechi, Thomas Hinneh, Humphrey Garti, Faith Agbozo

“…Face-to-face interviews were conducted with the aid of an interview guide, and the data were analysed via thematic analysis. …”
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From guideline to practice: three years of ICH S11 insights and recommendations by Diana Tavares, Hsiao-Tzu Chien, Hsiao-Tzu Chien, Maria Elzbieta Sheean, Peter Theunissen, Peter Theunissen, Peter van Meer, Peter van Meer, Peter van Meer, Karen Van Malderen

“…The ICH S11 guideline was developed to guide the need for and design of JAS, and proposes a weight-of-evidence (WoE) approach. …”
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Development, validation, and clinical application of a machine learning model for risk stratification and management of cervical cancer screening based on full-genotyping hrHPV tes... by Binhua Dong, Zhen Lu, Tianjie Yang, Junfeng Wang, Yan Zhang, Xunyuan Tuo, Juntao Wang, Shaomei Lin, Hongning Cai, Huan Cheng, Xiaoli Cao, Xinxin Huang, Zheng Zheng, Chong Miao, Yue Wang, Huifeng Xue, Shuxia Xu, Xianhua Liu, Huachun Zou, Pengming Sun

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