CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma by Dan Zhu, Haralambos Hadjivassiliou, Catherine Jennings, David Mikolon, Massimo Ammirante, Sharmistha Acharya, Jon Lloyd, Mahan Abbasian, Rama Krishna Narla, Joseph R. Piccotti, Katie Stamp, Ho Cho, Kandasamy Hariharan

“…This increased selectivity of CC-96673 over monospecific anti-CD47 approaches allows for the use of wild-type IgG1 Fc, which engages activating crystallizable fragment gamma receptors (FcγRs) to fully potentiate macrophages to engulf and destroy CD20+ cells, while sparing CD47+CD20− normal cells. …”
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An intelligent lithology identification method for sandstone and mudstone strata and its applications: A case study of the Jurassic strata in the Lunnan area, Xinjiang, China by Ming CAI, Qingwen ZHOU, Cong YANG, Feng CHEN, Dong WU, Wang LIN, Chengguang ZHANG, Yuanjun ZHANG, Yuxin MIAO

“…Using five logging parameters determined through sensitivity analysis, i.e., natural gamma-ray value, spontaneous potential, deep and shallow resistivity ratio, sonic interval transit time, and density, this study developed an intelligent lithology identification model based on the CatBoost algorithm. …”
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MOLECULAR SCREENING OF POTATO VARIETIES BRED IN THE NORTHWESTERN ZONE OF THE RUSSIAN FEDERАTION by Т. A. Gavrilenko, N. S. Klimenko, O. Yu. Antonova, V. A. Lebedeva, Z. Z. Evdokimova, N. M. Gadjiyev, O. V. Apalikova, N. V. Alpatyeva, L. I. Kostina, N. M. Zoteyeva, F. T. Mamadbokirova, K. V. Egorova

“…Among them, genotypes with sterile D-, T-, W/gamma cytoplasmic types were selected. Analysis of their pollen fertility, crossability and pedigree data showed that breeders succeed in obtaining fertile forms with the D- and T-types of cytoplasm carrying genetic material of Mexican polyploid species Solanum stoloniferum and S. demissum. …”
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Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment: a randomized controlled trail by Jing Li, Xian Mo, Dan Jiang, Xinyu Huang, Xiao Wang, Tingting Xia, Wei Zhang, Wei Zhang, Wei Zhang

“…Regarding functional connectivity, the small-world properties Sigma and Gamma were enhanced.ConclusioniTBS on bilateral DMPFC can effectively alleviate negative symptoms and enhance prefrontal cortex activation and the small-world properties in patients of schizophrenia.…”
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Overexpression of Tear Inflammatory Cytokines as Additional Finding in Keratoconus Patients and Their First Degree Family Members by Ioana Catalina Ionescu, Catalina Gabriela Corbu, Cristiana Tanase, Gabriela Ionita, Cristina Nicula, Valeria Coviltir, Vasile Potop, Mihaela Constantin, Elena Codrici, Simona Mihai, Ionela Daniela Popescu, Ana-Maria Enciu, Dana Dascalescu, Miruna Burcel, Radu Ciuluvica, Liliana-Mary Voinea

“…Our aim was to determine the concentration of IL-4, IL-6, IL-10, RANTES, IFN gamma, and TNF alpha in the tear film of patients with keratoconus and their first degree family members. …”
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Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes by Ana Cecilia Fernández-Gaxiola, Roxana Valdés-Ramos, Kimberly Fulda, Ana Laura Guadarrama López, Beatriz E. Martínez-Carrillo, Susan F. Franks, Shane Fernando

“…Liver enzymes alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) are markers for type 2 diabetes mellitus (T2DM); alkaline phosphatase is a marker of liver disease. …”
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Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis by Salvatore Dimonte, Paywast Jamal Jalal, Hiwa Abdulrahman Ahmad, Safa Bakr Karim, Taib Ahmed Hama Soor, Salar Ibrahim Ali, Muhammed Babakir-Mina, Francesco Greco

“…Moreover, the 2019-nCoV is not closely related to other alpha, beta and gamma human Coronavirus, including MERS-CoV. The current study concluded that 2019-nCoV is more likely believed to originated from SARS-CoV. …”
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Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma by Deana Haralampieva, Souzan Salemi, Thomas Betzel, Ivana Dinulovic, Stefanie D. Krämer, Roger Schibli, Tullio Sulser, Christoph Handschin, Simon M. Ametamey, Daniel Eberli

“…Therefore, the first goal of our project was to optimize the functional regenerative potential of hMPC by genetic modification to overexpress human peroxisome proliferator-activated receptor gamma coactivator 1-alpha (hPGC-1α), key regulator of exercise-mediated adaptation. …”
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Cytotoxic Function and Cytokine Production of Natural Killer Cells and Natural Killer T-Like Cells in Systemic Lupus Erythematosis Regulation with Interleukin-15 by Syh-Jae Lin, Ming-Ling Kuo, Hsiu-Shan Hsiao, Pei-Tzu Lee, Wen-I Lee, Ji-Yih Chen, Jing-Long Huang

“…We sought to examine the perforin and granzyme B expression, interferon-gamma (IFN-γ), and tumor-necrosis factor-alpha (TNF-α) production and CD107a degranulation of NK and NKT-like cells from SLE patients and their regulation by IL-15. …”
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A Resource-Efficient Multi-Entropy Fusion Method and Its Application for EEG-Based Emotion Recognition by Jiawen Li, Guanyuan Feng, Chen Ling, Ximing Ren, Xin Liu, Shuang Zhang, Leijun Wang, Yanmei Chen, Xianxian Zeng, Rongjun Chen

“…., delta, theta, alpha, beta, and gamma, from EEG signals, followed by the acquisition of multi-entropy features, including Spectral Entropy (PSDE), Singular Spectrum Entropy (SSE), Sample Entropy (SE), Fuzzy Entropy (FE), Approximation Entropy (AE), and Permutation Entropy (PE). …”
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Unveiling the prognostic value of ARID3A in breast cancer through bioinformatic analysis by Wen-Run Cai, Xu-Gang Sun, Yue Yu, Xin Wang, Xu-Chen Cao, Xiao-Feng Liu

“…A positive correlation with REXO1 was identified, and enrichment analysis emphasized ARID3A's involvement in immune-related pathways, such as “interferon gamma production” and “primary immunodeficiency.” …”
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Ginger protects against vein graft remodeling by precisely modulating ferroptotic stress in vascular smooth muscle cell dedifferentiation by Xiaoyu Yu, Weiwei Wu, Jingjun Hao, Yuxin Zhou, Deyang Yu, Wei Ding, Xuejuan Zhang, Gaoli Liu, Jianxun Wang

“…Furthermore, both ingredients co-target peroxisome proliferator-activated receptor gamma (PPARγ), decreasing PPARγ-mediated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (Nox1) expression. …”
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Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

“…These compounds activate or inhibit toll-like receptor 4 (TLR4) and peroxisome proliferator-activated receptor-gamma (PPAR-γ), which are associated with pathways having the potential to cause pulmonary fibrosis. …”
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Association of aerobic capacity and muscular strength with health-related quality of life in adolescents: A school-based cross-sectional study by Bianca Lins dos Santos, João Paulo Rodrigues dos Santos, José Damião Saraiva Gomes-Júnior, Eriston de Souza Bezerra, Samuel Lira da Silva Barbosa, Bárbara Gicélia da Silva Araújo, Fabio Thiago Maciel da Silva, João Pedro Magalhães, Vera Lúcia Zymbal, Eduardo Caldas Costa, Rodrigo Alberto Vieira Browne

“…HRQoL was measured using the validated KIDSCREEN-27 questionnaire. A generalized gamma regression model was used to estimate coefficients (β) and 95% confidence intervals for HRQoL domains, adjusting mutually for aerobic capacity and muscle strength as predictors. …”
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Dosimetry of automatic non-coplanar volumetric-modulated arc therapy for nasopharyngeal carcinoma by Kaiqiang Chen, Jihong Chen, Yanming Cheng, Danni Hong, Cairong Hu, Penggang Bai, Jinyong Lin, Yang Yang, Xiuchun Zhang

“…Additionally, the average beam-on time for the HA plans (252 ​s) was shorter than that of the TOMO plans (326 ​s, P ​< ​0.05). The mean gamma passing rate at 3%/2 ​mm for all plans exceeded 98%. …”
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Parameters Suggesting Spontaneous Passage of Stones from Common Bile Duct: A Retrospective Study by Tawfik Khoury, Mohamed Adileh, Ashraf Imam, Yosef Azraq, Avital Bilitzky-Kopit, Muhamad Massarwa, Ari Benson, Zaher Bahouth, Samir Abu-Gazaleh, Wisam Sbeit, Rifaat Safadi, Abed Khalaileh

“…Comparing groups A versus B, only gamma-glutamyl transferase predicted spontaneous passage of stones from CBD, as the level was significantly higher in group A (677±12.1) versus group B (362.4±216.2) (P=0.023). …”
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Marker-assisted breeding of hybrid lines of <i>Triticum dicoccon</i> (Schrank) Schuebl. × <i>Triticum aethiopicum</i> Jakubz. with purple grain by P. I. Stepochkin, E. I. Gordeeva, Е. K. Khlestkina

“…The parent forms of the hybrids were a naked-grain emmer cultivar ‘Gremme’, an awnless emmer accession (k-25516) from the VIR collection, and an accession from the collection of IPK Gatersleben (Ethiopian wheat line TRI 15744), the donor of the purple color. …”
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Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer by Mitchell S. von Itzstein, MD, Jialiang Liu, PhD, Hong Mu-Mosley, PhD, Farjana Fattah, PhD, Jason Y. Park, MD, PhD, Jeffrey A. SoRelle, MD, J. David Farrar, PhD, Mary E. Gwin, MD, David Hsiehchen, MD, Yvonne Gloria-McCutchen, Edward K. Wakeland, PhD, Suzanne Cole, MD, Sheena Bhalla, MD, Radhika Kainthla, MD, Igor Puzanov, MD, MSCI, Benjamin Switzer, DO, MHSA, MS, Gregory A. Daniels, MD, PhD, Yousef Zakharia, MD, Montaser Shaheen, MD, Jianjun Zhang, MD, PhD, Yang Xie, PhD, David E. Gerber, MD

“…Black patients also exhibited greater populations of nonclassical CD16+ monocytes, NKT-like cells, CD4+ cells, CD38+ monocytes, and CD57+ gamma delta T cells (all p < 0.05). Conclusions: Black and White patients with lung cancer exhibit several differences in immune parameters, with Black patients exhibiting greater levels of numerous proinflammatory cytokines and cell populations. …”
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Analysis of thyroid function and structure and serum metabolomics in pregnant rats exposed to airborne contaminants: Combined perchlorate, thiocyanate, and nitrate exposure by Chenchen Wang, Xiaohui Xu, Jiangling Yuan, Ran An, Aierken Taxitiemuer, Yan Zhang, Tao Luo, Jing Zhou, Chang Wang, Ling Zhang, Shunhua Wu

“…The involved pathways included lipid, glucose, bile acid, choline, and gamma-aminobutyric acid metabolism and peroxisome proliferation-activated receptors. …”
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ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

“…Results Tumor cells treated with ferroptosis inducers showed increased sensitivity to Interferon gamma (IFN-γ) secreted by ROR1 CAR-T cells. Furthermore, ROR1 CAR-T cells enhanced the production of phosphatidylcholine with diacyl-polyunsaturated fatty acid tails (PC-PUFA2) by working in tandem with IFN-γ. …”
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