The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator? by Daniel S. Smyk, Athanasios Mavropoulos, Giorgina Mieli-Vergani, Diego Vergani, Marco Lenzi, Dimitrios P. Bogdanos

“…CD1d-restricted iNKT cells are regulators of immune responses and produce cytokines that may be proinflammatory (such as interferon-gamma (IFN-γ)) or anti-inflammatory (such as IL-4). iNKT cells also appear to play a role in B cell regulation and antibody production. …”
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Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder by Marina Ivanova, Ksenia Germanova, Dmitry S. Petelin, Aynur Ragimova, Grigory Kopytin, Beatrice A. Volel, Vadim V. Nikulin, Maria Herrojo Ruiz

“…On a neural level, while healthy individuals exhibited an alpha-beta suppression and gamma increase during belief updating, BD participants showed dampened effects, extending across the PFC, OFC, and ACC regions. …”
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Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3. by Chrissy H Roberts, Sandra Molina, Pateh Makalo, Hassan Joof, Emma M Harding-Esch, Sarah E Burr, David C W Mabey, Robin L Bailey, Matthew J Burton, Martin J Holland

“…<h4>Conclusions</h4>To explain the observations in the context of chlamydial infection and trachoma we propose a two-stage model of response and disease that balances the cytolytic response of KIR expressing NK cells with the ability to secrete interferon gamma, a combination that may cause pathology. The data presented indicate that HLA-C genotypes are important determinants of conjunctival scarring in trachoma and that KIR2DL2/KIR2DL3 heterozygosity further increases risk of conjunctival scarring in individuals carrying HLA-C2.…”
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Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein–Bar virus in host by Muhammad Naveed, Muzamal Hussain, Tariq Aziz, Nimra Hanif, Nazia Kanwal, Arooj Arshad, Ayaz Ali Khan, Abdulrahman Alshammari, Metab Alharbi

“…The current study performed computer-assisted techniques to analyses the potential drug candidates against Epstein–Barr virus toxin Zta [Human gamma-herpesvirus 4 (Epstein–Barr virus)] from phytochemicals derived natural inhibitors. …”
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Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients by Rahul Saxena, Baskar Chakrapani, M. P. Sarath Krishnan, Amit Gupta, Sweety Gupta, Jayanta Das, Subash C. Gupta, Anissa A. Mirza, Shalinee Rao, Bela Goyal

“…Kirsten rat sarcoma virus (KRAS), AR, and interferon gamma (IFN-γ) pathways were identified among the key pathways potentially amenable to targeted therapy. …”
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Soybean biochar as highly efficient adsorbent for ofloxacin from aqueous and CO2 from gaseous phase: Mathematical modelling and regeneration studies by Vaishnavi Gomase, Tejaswini Rathi, Aparna Muley, D. Saravanan, Ravin Jugade

“…The study investigated the regeneration of PTSB and the degradation of OFX using reagents, UV, and gamma radiation.…”
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The elderly population’s social networks and HIV perceptions: Evidence from China by Jie Shen, Junfang Xu

“…Based on the Goodman–Kruskal Gamma test, it was found that there was a positive correlation between social support and HIV knowledge perceptions in the elderly population, and there was a negative correlation between social support and HIV attitudinal perceptions in the elderly population. …”
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Crotonylation-Related Prognostic Model of Esophageal Squamous Cell Carcinoma Based on Transcriptome Analysis and Single-Cell Sequencing Analysis by Lin RY, Chen RP, Lin FQ

“…MICB and FABP3 showed strong positive correlations with natural killer T (NKT) cells, while FAM189A2 negatively correlated with gamma delta T (γδT) cells. Single-cell analysis identified mast cells and neutrophils as key cells, differentiating into seven and three states, respectively.Conclusion: Four genes (OSM, FABP3, MICB, and FAM189A2) were identified as prognostic crotonylation-related genes in ESCC, potentially involved in its pathogenesis. …”
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Ameliorative Effect of Hovenia dulcis Fruit Pedicel Polysaccharides on Alcohol-Induced Intestinal Injury in Mice Investigated Using 16S rRNA Sequencing and Metabolomics by ZHANG Yuchao, ZHU Sijie, LIU Liangyu, WANG Jianyun, ZHANG Jiaxin, SU Zexiong, CHEN Jiangyan, LIU Xudong

“…The results indicated that HDPs significantly reduced the levels of pro-inflammatory factors such as interleukin-4 (IL-4), interferon-gamma (IFN-γ), and tumor necrosis factor-α (TNF-α) in mice with intestinal injury induced by alcohol, decreased the levels of lipopolysaccharide (LPS) and lipopolysaccharide binding protein (LBP), increased the level of α-amylase (AMS), and upregulated the tight junction protein Claudin 1, thereby improving intestinal barrier function. 16S rRNA sequencing revealed that compared to mice gavaged with alcohol at 114 µL/20 g mb, HDPs increased the abundance of the Lactobacillus genus and reduced alcohol exposure-induced disorders in gut microbiota diversity and structure. …”
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Cytokine and Chemokine Responses of Peripheral Blood Mononuclear Cells from Dogs Infected with <i>Mycobacterium bovis</i> by Tyler Morrison, Danielle A. Gunn-Moore, Jayne C. Hope, Conor O’Halloran

“…We sought to further define the cellular response of peripheral blood mononuclear cells (PBMCs) from dogs infected with <i>Mycobacterium bovis</i>, as determined using a commercial interferon-gamma response assay (IGRA). To this end, PBMCs from healthy or infected dogs were collected. …”
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Hypolipidemic effect of coffee silver skin in rats fed a high-fat diet by Ayman Mohammed El-Anany, Rehab Farouk M. Ali

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RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling by Megan A. Palmer, Rebecca Kirchhoff, Claudia Buerger, Yvonne Benatzy, Nils Helge Schebb, Bernhard Brüne

“…Using a cytokine cocktail containing IL-17A, interferon-gamma and tumour necrosis factor-alpha to produce a psoriasis-like phenotype, a role for ALOX15B in human epidermal keratinocyte inflammation was investigated. siRNA-mediated silencing of ALOX15B increased CCL2 expression and secretion. …”
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Association of Pathology Markers with Somatostatin Analogue Responsiveness in Acromegaly by George Kontogeorgos, Vyron Markussis, Eleni Thodou, Efi Kyrodimou, Theodossia Choreftaki, Panagiotis Nomikos, Kostas I. Lampropoulos, Stylianos Tsagarakis

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The impact of the ursodeoxycholic acid as monotherapy and in the combination with the lactulose on the biochemical blood tests values of the nonalcoholic steatohepatitis patients by I. V. Mayev, Yu. A. Kucheryavyy, S. V. Morozov, M. G. Saidullayeva, M. L. Akhtayeva, N. Yu. Stukova, E. A. Krasnyakova

“…The credible dynamic of the biochemical tests values of the cytolysis as compared with the baseline (the reducing of the activity of the alanine transaminase and the aspartate transaminase) and of the cholestasis (gamma-glutamyl transpeptidase) was observed; the positive changes in the lipid profile (the increase in the concentration of the high density lipoproteins and the reduction in the total cholesterol, the low density lipoproteins, the very low density lipoproteins and triglycerides ) were seen during the treatmet in both groups. …”
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RNAseq of peripheral blood mononucleated cells exposed to platelet-rich fibrin and enamel matrix derivatives by Layla Panahipour, Zahra Kargarpour, Michael Mildner, Hannes Kühtreiber, Reinhard Gruber

“…Representative is a characteristic IFN response indicated by various human leukocyte antigens (HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DRA, HLA-DRB1, HLA-DRB5), gamma Fc receptors (FCGR1A, FCGR1B, FCGR3B), chemokines (CXCL9-11), and calprotectin (S100A8/9 and S100A12), complement (C1QA/B, C2) and interferon-induced guanylate-binding proteins (GBP1, GBP5). …”
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Hubungan Pertambahan Berat Badan Ibu Hamil terhadap Berat Bayi Lahir di Kota Pariaman by Akbar Shiddiq, Nur Indrawaty Lipoeto, Yusrawati .

“…Bayi dengan berat badan lahir rendah (≤ 2,5 kg) sebanyak 2 bayi (2,1%) dengan berat rerata 2,350 gram (± 0,2121 SD) sedangkan berat badan normal (&gt;2,5 – 4 kg) adalah 92 bayi atau 96,8% dengan berat rerata 3,176 gram (± 0,3339 SD). …”
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Brain Reward System and Its Volumetric Investigations in Alcohol Addiction by Muhammed Fatih Tabara, Murad Atmaca, Hanefi Yıldırım, Onur Solmaz, Muhammed Amir Essibayi, Mehmet Gürkan Gurok

“…Structural magnetic resonance imaging was employed to compare the volumes of total white matter and gray matter, as well as those of the nucleus accumbens, ventral tegmental area, amygdala, and hippocampus between 15 individuals diag- nosed with alcohol use disorder and 17 healthy controls. …”
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Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study by Chengqing Zhong, Rong Liu, Cheng Luo, Sisi Jiang, Li Dong, Rui Peng, Fuqiang Guo, Pu Wang

“…A FC analysis was subsequently performed, with seeding at the regions that demonstrated between-group differences in gray matter volume (GMV). Then, the observed structural and FCs were associated with the clinical manifestations. …”
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Synthesis and Use of Environmentally Friendly Superabsorbent Smart Polymer to Improve the Properties of the Gypsum Soil by Foud Nihad Abed, Mustafa Mahdi Abdulridha, A. A. Hamad Mohamad, Zelalem Meraf, Mohamed Abdelhedi

“…The results showed that the absorption value of polymer is at the equivalent acid function, where the absorption capacity was 467.32 grams. At room temperature, the water retention rate was 71%, and at 50°C, it was 52%, and the gel content was 90%. …”
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Ti(C, N)-Based Cermets with Two Kinds of Core-Rim Structures Constructed by β-Co Microspheres by Hui Yan, Ying Deng, Yong Yao Su, Shan Jiang, Qiao Wang Chen, Shi Xiu Cao, Bing Liu

“…In our process, first we mix the cobalt and (Ti, W, Mo, Ta) (C, N) powders; then we press the powder mixtures into rectangular samples and sinter them in a pressure sintering furnace to obtain Ti(C, N)-based cermets with two kinds of core-rim structure, that is, black core/white rim and white core/gray rim. The results show that the new cermets demonstrate excellent toughness and performance.…”
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