Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice by Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang

“…In USP21fl/flFOXP3Cre mice, levels of IFN-gamma, IL-4, anti-soluble egg antigen (SEA) IgG and anti-soluble worm antigen preparation (SWAP) IgG increased in blood, as determined using ELISAs and multiplex fluorescent microsphere immunoassays, while the levels of IL-10, lL-17A, IL-23, IL-9, and anti-SEA IgM decreased. …”
Get full text

Shock Breakouts from Compact Circumstellar Medium Surrounding Core-collapse Supernova Progenitors May Contribute Significantly to the Observed ≳10 TeV Neutrino Background by Eli Waxman, Tal Wasserman, Eran O. Ofek, Avishay Gal-Yam

“…The compact size and large UV luminosity imply a pair production optical depth of  ~10 ^4 for  > 100 GeV photons, naturally accounting for the lack of a high-energy gamma-ray background accompanying the neutrino background. …”
Get full text

Estimation of radiation doses of population residing nearby area of uranium ore mining and processing in Kazakhstan by tooth enamel EPR spectroscopy by Kassym Zhumadilov, Alexander Ivannikov, Murat Kassymzhanov, Assel Bagramova, Issa Zhantore, Sarsenova Samal, Valeriy Stepanenko, Artem Khailov, Masaharu Hoshi

“…These data were compared with ambient dose equivalent rate (ADER) of gamma radiation measured by the conventional instrumental dosimetry. …”
Get full text

Experimental study of mortar incorporating nano-magnetite on engineering performance and radiation shielding by Kunchariyakun Kittipong, Sinyoung Suthatip, MacKenzie Kenneth J. D., Pungkun Vithit, Raknarong Pakkamai, Teh Musofpar, Jekabaso Afham, Sittichan Narumol

“…These results indicate that the addition of nano-Fe3O4 to radiation-shielding mortar can potentially attenuate gamma rays rather than neutrons and lead to the development of materials for shielding radiation from radioactive storage facilities, thereby reducing the impact of this hazardous waste on humans and the environment.…”
Get full text

Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review by Rahul G. Matnani, Rachel L. Stewart, Joseph Pulliam, Chester D. Jennings, Melissa Kesler

“…Gene rearrangement studies performed on paraffin blocks demonstrated monoclonal T-cell receptor gamma chain rearrangement with no evidence of clonal heavy chain rearrangement. …”
Get full text

Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension by Christos Papageorgiou, Efstathios Manios, Eleftheria Tsaltas, Eleni Koroboki, Maria Alevizaki, Elias Angelopoulos, Meletios-Athanasios Dimopoulos, Charalabos Papageorgiou, Nikolaos Zakopoulos

“…Negative correlations were found between ABPM variables and Beta2 oscillations (16.5–20 Hz) during the posttest phase and Gamma (28.5–45 Hz) oscillations during the CPT phases overall. …”
Get full text

Drug-Induced Myoclonus: A Systematic Review by Jamir Pitton Rissardo, Ana Letícia Fornari Caprara, Nidhi Bhal, Rishikulya Repudi, Lea Zlatin, Ian M. Walker

“…The neurotransmitters likely involved in DIM are serotonin, dopamine, gamma-aminobutyric acid (GABA), and glutamate. <i>Conclusions</i>: DIM may be reversible with management that can include drug discontinuation, dose adjustment, and the prescription of a medication used to treat idiopathic myoclonus. …”
Get full text

IRF3 Promotes Production of IL-6 and Nitric Oxide but Represses CCL22 in RAW264.7 Macrophage Cells Exposed to Lipopolysaccharides in Culture by Moore TC, Pinkerton TS, Petro TM

“…For comparison, responses to poly I:C and IFN-gamma and responses from RAW264.7 cells deficient in IRF3 were also assessed.Results: Herein, LPS of P. gingivalis, significantly enhanced production of IL-6 and NO that was induced by E. coli LPS but significantly decreased poly I:C-induced ISRE promoter activity. …”
Get full text

Metabolic Activity in Human Intermuscular Adipose Tissue Directs the Response of Resident PPARγ⁺ Macrophages to Fatty Acids by Xiaoying Chen, Sebastian Ludger Schubert, Aline Müller, Miguel Pishnamaz, Frank Hildebrand, Mahtab Nourbakhsh

“…<b>Background/Objectives</b>: Peroxisome proliferator-activated receptor gamma (PPARγ) is a fatty acid-binding transcription activator of the adipokine chemerin. …”
Get full text

Identification of mitophagy-related biomarkers and immune infiltration in polycystic ovarian syndrome by bioinformatic study by Hongjuan Ye, Xicheng Wang, Zhiying He

“…Specifically, the hub gene GRN showed a positive correlation with monocytes and plasmacytoid dendritic cells, while hub gene NAPA was negatively correlated with gamma delta T cell. Conclusions: The current study identified immune-mitophagy-related hub genes for prognostic biomarkers of PCOS, which provided an innovative insight for the prevention and treatment of PCOS.…”
Get full text

Evaluation of the Acute Hepatoprotective Potential of Hydroethanolic Extract of Duranta erecta L. Parts by Shadrack Donkor, Christopher Larbie, Gustav Komlaga, Benjamin Obukowho Emikpe

“…Hepatoprotective efficacy was assessed by assaying serum biochemical markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (γGT), bilirubin (Bil), antioxidative biomarkers including reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione transferase (GST), superoxide dismutase (SOD), malondialdehyde (MDA), hydrogen peroxidase (H202), and nitric oxide (NO), as well as histological observations. …”
Get full text

Benchmarking of snow water equivalent (SWE) products based on outcomes of the SnowPEx+ Intercomparison Project by L. Mudryk, C. Mortimer, C. Derksen, A. Elias Chereque, P. Kushner

“…The new reference data combine in situ measurements from both snow courses and airborne gamma measurements. Compared to previous evaluations of gridded products, we have substantially increased the spatial coverage and sample size across North America, and we are able to evaluate product performance across both mountainous and nonmountainous regions. …”
Get full text

A 19-year-old Patient with Recurrent Pruritus and Jaundice by K. S. Nezhdanov, E. N. Shirokova, Yu. O. Shulpekova, A. S. Ostrovskaya, M. S. Zharkova, V. T. Ivashkin

“…Blood chemistry results revealed an elevation of total bilirubin (up to 634 μmol/L), direct bilirubin (up to 354 μmol/L), bile acids (up to 510 μmol/L) and normal gamma glutamyl transferase level. Workup was negative for viral hepatitis, autoimmune liver diseases, obstructive choledochal lesions, storage diseases, although mutation in gene ABCB11 was found. …”
Get full text

PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression by Caroline N. Rivera, Jason S. Hinkle, Rachel M. Watne, Trent C. Macgowan, Andrew J. Wommack, Roger A. Vaughan

“…Type 2 diabetes is characterized by reduced insulin sensitivity, elevated blood metabolites, and reduced mitochondrial metabolism with reduced expression of genes governing metabolism such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). PGC-1α regulates the expression of branched-chain amino acid (BCAA) metabolism, and thus, increased circulating BCAA in diabetics may be partially explained by reduced PGC-1α expression. …”
Get full text

Distribution and frequency of genetic mutations in three insecticide targets in field populations of Culex tritaeniorhynchus in Mianyang City, Sichuan Province, China by Hongwei Xie, Meilin Tang, Hongying Sun, Zhengzheng Huang, Mengmeng Dong, Xianying Wen

“…In the study, a total of 314 adults of Cx. tritaeniorhynchus, collected from 6 sites across Mianyang City, were inspected for resistance-conferring mutations in three genes encoding voltage-gated sodium channel (VGSC), Gamma-aminobutyric acid (GABA) receptor Rdl subunit (Rdl), and acetylcholinesterase (AChE) by DNA Sanger sequencing. …”
Get full text

PPARγ activation attenuates neonatal CRD-induced visceral pain sensitization and anxiety in male rats by alleviating oxidative stress by Minjie Li, Xiyu Zhuo, Yongxiao Liu, Jinchao You, Jianqing Lin

“…Previous studies have demonstrated that activation of peroxisome proliferator-activated receptor gamma (PPARγ) has analgesic effects. Therefore, we aimed to determine whether PPARγ activation ameliorates oxidative stress and affects thus nociceptive sensitization and emotional responses in IBS. …”
Get full text

Association of oxidative balance score with all-cause and cardiovascular mortality in overweight and obese by Shuxin Ying, Hongyan Ding, Yanjin Chen, Su Zheng

“…Mediation analysis indicates that white blood cell count (WBC) and gamma-glutamyl transferase (GGT) serve as significant mediators in the association between OBS and mortality risk.ConclusionElevated levels of OBS were strongly linked to reduced potential for both cardiovascular and all-cause mortality among individuals who are overweight or obese.…”
Get full text

Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanoma by Chun Wai Wong, Rotem Leshem, Kieran Neil Sefton, I-Hsuan Lin, Dervla Tamara Isaac, Mario Niepel, Adam Hurlstone

“…However, chronic interferon-gamma (IFNγ)-induced immune homeostatic responses in melanoma cells contribute to immune evasion and acquired resistance to ICI. …”
Get full text

Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2pos Breast Cancer by Nirmala Ghimirey, Chase Steele, Brian J. Czerniecki, Gary K. Koski, Loral E. Showalter

“…Nonetheless, this suppression was circumvented in a mouse model of HER-2pos breast disease by supplying recombinant interferon-gamma to achieve a combination therapy significantly more potent than either agent.…”
Get full text

Effects of a Multispecies Probiotic Mixture on Glycemic Control and Inflammatory Status in Women with Gestational Diabetes: A Randomized Controlled Clinical Trial by Sadegh Jafarnejad, Sadaf Saremi, Farzan Jafarnejad, Arman Arab

“…Fasting plasma glucose, homeostatic model assessment of insulin resistance, glycosylated hemoglobin, high-sensitivity C-reactive protein, tumor necrosis factor-α, interleukin-6, Interferon gamma, and interleukin-10 were measured before and after the intervention. …”
Get full text