Co‐Translational Deposition of N6‐Acetyl‐L‐Lysine in Nascent Proteins Contributes to the Acetylome in Mammalian Cells by Dingyuan Guo, Nan Li, Xiaoyan Zhang, Runxin Zhou, Jie He, Xiao‐Ping Ding, Weixing Yu, Fuqiang Tong, Sibi Yin, Yu Wang, Xin Xu, Long Wang, Mingzhu Fan, Shan Feng, Ke Liu, Ke Tang, Zhuqing Ouyang, Yusong R Guo, Yugang Wang

“…This undocumented protein modification mechanism is inherently different from PTM and termed as co‐translational modification (coTM). It is expected to extend the repertoire of acetylome and improve the understanding of protein modification mechanisms in cells.…”
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Construction of a prognostic model for gastric cancer based on immune infiltration and microenvironment, and exploration of MEF2C gene function by Si-yu Wang, Yu-xin Wang, Lu-shun Guan, Ao Shen, Run-jie Huang, Shu-qiang Yuan, Yu-long Xiao, Li-shuai Wang, Dan Lei, Yin Zhao, Chuan Lin, Chang-ping Wang, Zhi-ping Yuan

“…And our Nomogram showed good agreement between predicted and actual probabilities. …”
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Association between traffic-related air pollution and risk of outpatient visits for dry eye disease in a megacity along the subtropical coast in South China by Fan Cao, Yue Chen, Yan-Chao Gui, Zi-Yue Fu, Zheng Lyu, Kou Liu, Li-Ming Tao, Zhi-Fan Chen, Hai-Feng Pan, Zheng-Xuan Jiang, Qian-Li Meng

“…The associations of PM2.5 (first visit, RR = 1.006, 95% CI: 1.001–1.011, lag0 day; re-visit, RR = 1.002, 95% CI: 1.000–1.005, lag6 day), NO2 (first visit, RR = 1.006, 95% CI: 1.001–1.012, lag0 day; re-visit, RR = 1.007, 95% CI: 1.002–1.012, lag0 day), and SO2 (first visit, RR = 1.023, 95% CI: 1.002–1.044, lag0 day; re-visit, RR = 1.023, 95% CI: 1.000–1.045, lag0 day) exposure with risk of DED outpatient visits were significant for both first- and re-visits. Conclusions Our study revealed that short-term exposure to PM2.5, NO2 and SO2 were positively associated with risk of DED outpatient visits, especially for the youngers, females and during warm seasons, providing evidence for making public health policy to improve life quality in developed megacity.…”
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Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived ModelSummary by Jun Tsuchiya, Masato Miyoshi, Sei Kakinuma, Fukiko Kawai-Kitahata, Akihide Kamiya, Taro Shimizu, Ayako Sato, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Rion Kamimae, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto

“…Conclusions: Our disease model using genetically engineered iPSCs provides the first insight into both the KMT2B function in HCC development and the oncogenic processes by HBV-KMT2B integration. …”
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Evaluation of Urban Composite Carbon Sink Value: A Case Study of Shenyang by Tiemao SHI, Di WANG, Yu TANG, Peiying LI

“…ObjectiveIn view of the urgent necessity to achieve the carbon peaking and carbon neutrality goals and establish an effective ecological compensation system, it is of crucial significance to evaluate the carbon sink value. …”
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Computed tomography-guided microwave ablation for right middle lobe pulmonary nodules: a retrospective, single-center, case-control study by Yanting Hu, Guoliang Xue, Xinyu Liang, Zhichao Li, Nan Wang, Pikun Cao, Gang Wang, Haitao Zhang, Xiaohuan Zheng, Aiguang Wang, Wenhua Zhao, Cuiping Han, Zhigang Wei, Xin Ye

“…There were no significant differences in technique efficacy rates between the RML and non-RML groups (97.2% vs. 95.1%, p = 0.721). However, both major (47.9% vs. 19.7%, p < 0.001) and minor (26.8% vs. 11.3%, p = 0.004) pneumothorax were more common in the RML group than non-RML group. …”
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Network analysis of suicide ideation and depression–anxiety symptoms among Chinese adolescents by Yan Zhang, Jin Liu, Mei Huang, Liang Li, Yumeng Ju, Bangshan Liu, Shuyin Xu, Xiyu Wei, Wenwen Ou, Mohan Ma, Guanyi Lv, Xiaotian Zhao, Yaqi Qin, Yunjing Li, Siqi Yang, Yimei Lu, Yafei Chen, Junwu Liu

“…Background The co-occurrence of depression and anxiety among adolescents is typically associated with suicide ideation.Aims The study aimed to investigate the symptom-level relationship between suicide ideation and the comorbidity of depression and anxiety.Methods 1501 adolescents aged 12–19 years were assessed using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder Scale, and 716 adolescents who scored ≥5 on both scales were selected as participants. Network analysis was used to identify the network structure of depressive symptoms and anxiety symptoms. …”
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Urinary incontinence (UI) in older women in low- and middle-income countries: a rapid review and case study from Burkina Faso by Arthi Kozhumam, Mamadou Bountogo, Dina Goodman Palmer, Carolyn Grieg, Carolyn Grieg, Carolyn Grieg, Maxime Inghels, Maxime Inghels, Sandra Agyapong-Badu, Sandra Agyapong-Badu, Cristina Osborne, Guy Harling, Guy Harling, Guy Harling, Guy Harling, Till Bärnighausen, Till Bärnighausen, Till Bärnighausen, David Rapp, David Rapp, Molly Beestrum, Justine Davies, Justine Davies, Justine Davies, Lisa R. Hirschhorn

“…Multivariable analysis revealed that UI was more common among women who were not currently married and decreased with higher education levels. Both the rapid review and survey highlight the burden of UI among older women in LMICs, particularly as they age beyond 60. …”
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Micronutrient levels of global tropical reef fish communities differ from fisheries capture by Conor Waldock, Eva Maire, Camille Albouy, Vania Andreoli, Maria Beger, Thomas Claverie, Katie L. Cramer, David A. Feary, Sebastian C. A. Ferse, Andrew Hoey, Nicolas Loiseau, M. Aaron MacNeil, Matthew McLean, Camille Mellin, Simon Ahouansou Montcho, Maria Lourdes Palomares, Santiago de laPuente, Mark Tupper, Shaun Wilson, Laure Velez, Jessica Zamborain‐Mason, Dirk Zeller, David Mouillot, Loïc Pellissier

“…Improving fisheries reporting and monitoring of reef fish assemblages will advance the understanding of micronutrient mismatches, which overall indicate a weak uptake of nutritional goals in fisheries practices. The decoupling between micronutrients in ecosystems and in fisheries catches indicates that social, economic, and biodiversity management goals are not shaped around nutritional targets—but this is key to achieve a sustainable and healthy planet for both people and nature. …”
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Application of mind-mapping combined with scenario simulation method in clinical teaching and training of cardiopulmonary resuscitation skills of nursing students (思维导图联合情景模拟的教学方式在... by ZHAO Lina (赵丽娜), LIU Ai (刘爱), WANG Honghong (王虹虹), WANG Xiaojie (王小杰), TONG Lu (佟璐), ZHANG Ji (张继), ZUO Lin (左琳), MING Yue (明月), CHEN Xinxin (陈鑫鑫), WANG Yuanyuan (王媛媛)

“…There were remarkable increase in the Critical Thinking Disposition Inventory-Chinese Version Scales in both two groups after training, and scores of each subscale in the study group were higher than those in the control group (P＜0. 01). …”
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Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar s... by Efstratios Koutroumpakis, Mohamed A. Naser, Abdallah Sherif Radwan Mohamed, Salman A. Eraj, Andrea Jarre, Jay C. Shiao, Mona Kamal, Subha Perni, Jack P. Phan, William H. Morrison, Steven J. Frank, G.Brandon Gunn, Adam S. Garden, Anita Deswal, Jun-ichi Abe, David I. Rosenthal, Elie Mouhayar, Clifton D. Fuller

“…Isodose lines from treatment plans were projected onto both scans, facilitating the delineation of carotid artery subvolumes in 5 Gy increments (i.e. received 50–55 Gy, 55–60 Gy, etc.). …”
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Assessing environmental change and population declines of large wading birds in southwestern India by K.M. Aarif, Aymen Nefla, K.A. Rubeena, Yanjie Xu, Zakher Bouragaoui, M. Nasser, C.T. Shifa, T.R. Athira, K. Jishnu, Jasmine Anand, Seerangan Manokaran, P.P. Moosa, Anu Gopinath, Omer R. Reshi, K.M. Rajaneesh, H. Byju, Thadickal V. Joydas, Karuppasamy P. Manikandan, Mohd Irfan Naikoo, Christian Sonne, Sabir Bin Muzaffar

“…Sediment phosphorous adversely affected both the biotic variables and the density of waterbirds. …”
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Pyrolysis conversion of crown-ether-based covalent networks to kagome metal-organic frameworks on Au(111) and Ag(111) by Yifan Liang, Jianing Wang, Ruoting Yin, Zhengya Wang, Xiaoqing Wang, Jie Meng, Shijing Tan, Chuanxu Ma, Qunxiang Li, Bing Wang

“…Electronic characterizations reveal the presence of both regular and diatomic kagome lattices, together with distinct quantum-dot states emerging in the pore regions. …”
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Reliability of the OMERACT Giant cell arteritis Ultrasonography Score (OGUS): results of a patient-based exercise involving experts and non-experts in vascular ultrasonography by Christian Dejaco, Stavros Chrysidis, Sara Monti, Cristina Ponte, Peter Mandl, Lene Terslev, Bhaskar Dasgupta, Alojzija Hočevar, Christina Duftner, Wolfgang Schmidt, Carlos Pineda, Eugenio De Miguel, Andreas P Diamantopoulos, Helen Keen, Kati Mykkänen, George A Bruyn, Wolfgang Hartung, Maria Antonietta D’Agostino, Nikitas Gkikopoulos, Luca Seitz, Adela-Cristina Sarbu, Eva Manger, Berit Dalsgaard Nielsen, Norbert Redlinger, Veerendra Chadachan, Maria Correyero, Giovanni Fulvio, Vesselina Kurteva, Paolo Mercatelli, Irina Midtgard, Raili Muller, Duriad Reffat

“…Expert inter-reader ICC of the OGUS was 0.60 in both rounds, 0.40 in round 1 and 0.51 in round 2 for the Southend score and 0.45 and 0.52, respectively, for the Halo count. …”
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VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment by Cheng Cheng, Qingrui Zha, Linmao Sun, Tianming Cui, Xinyu Guo, Changjian Xing, Zhengxiang Chen, Changyong Ji, Shuhang Liang, Shengwei Tao, Junhui Chu, Chenghui Wu, Qi Chu, Xuetian Gu, Ning Zhang, Yumin Fu, Shumin Deng, Yitong Zhu, Jiabei Wang, Yao Liu, Lianxin Liu

“…Our findings reveal that VCP suppresses the activation, expansion, and cytotoxic capacity of CD8+T cells both in vitro and in vivo, significantly contributing to the immunosuppressive nature of the TME. …”
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Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties by Jan Šťastný, Ángela Morellá-Aucejo, Ángela Morellá-Aucejo, Ángela Morellá-Aucejo, Tomáš Skala, Andrea Bernardos, Andrea Bernardos, Andrea Bernardos, Petr Maršík, Araceli Lérida-Viso, Araceli Lérida-Viso, Araceli Lérida-Viso, Jaroslav Matějka, Anna Mascellani Bergo, María Dolores Marcos, María Dolores Marcos, María Dolores Marcos, Ramón Martínez-Máñez, Ramón Martínez-Máñez, Ramón Martínez-Máñez, Ivan Jablonský, Pavel Klouček

“…Mushrooms of the genus Ganoderma are known for diverse biological activities, demonstrated both traditionally and experimentally. Their secondary metabolites have shown cytotoxic potential across different cancer cell lines. …”
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Outcomes of anterior cruciate ligament reconstruction surgery from private and public healthcare services in AustraliaKey points by Thomas J. West, Andrea M. Bruder, Kay M. Crossley, Michael A. Girdwood, Laura K. To, Jamon L. Couch, Mark J. Scholes, Sebastian C.S. Evans, Melissa J. Haberfield, Christian J. Barton, Ewa M. Roos, Alysha De Livera, Adam G. Culvenor

“…Future research should consider potential disparities in outcomes between participants using differing healthcare services both clinically and when recruiting participants into research studies evaluating outcomes post-ACLR.…”
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T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis by Yang X, Zhou Y, Zhou F, Bao L, Wang Z, Li Z, Ding F, Kuang H, Liu H, Tan S, Qiu X, Jing H, Liu S, Ma D

“…We found that ApoEVs are enriched with CD39 and CD73 on their membranes, which enable the hydrolysis of extracellular ATP to adenosine both in vitro and in vivo. The adenosine generated by ApoEVs inhibits the inflammatory response and promotes osteogenesis through A2BR and downstream PKA signaling.Conclusion: T cell-derived ApoEVs are enriched with CD39 and CD73, enabling them to hydrolyze extracellular ATP to adenosine, thereby promoting bone regeneration via A2BR and PKA signaling pathway. …”
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Assessment framework to predict sensitivity of marine calcifiers to ocean alkalinity enhancement – identification of biological thresholds and importance of precautionary principle... by N. Bednaršek, H. van de Mortel, G. Pelletier, G. Pelletier, M. García-Reyes, R. A. Feely, A. G. Dickson, A. G. Dickson

“…There are large uncertainties in both short- and long-term outcomes related to potential environmental impacts, which would ultimately have an influence on the social license and success of OAE as a climate strategy. …”
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Lightweight Apple Leaf Disease Detection Algorithm Based on Improved YOLOv8 by LUO Youlu, PAN Yonghao, XIA Shunxing, TAO Youzhi

“…[Methods]YOLOv8n model was selected to detect various leaf diseases such as brown rot, rust, apple scab, and sooty blotch that apples might encounter during growth. …”
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