Quais et ouvrages portuaires romains de Rouen/Rotomagus (Seine-Maritime) by Marie-Clotilde Lequoy

“…Both rescue operations took place under extremely difficult conditions, in 1979 (dir. …”
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Surgical interventions for spontaneous supratentorial intracerebral haemorrhage: a systematic review and network meta-analysisResearch in context by Jiayidaer Huan, Minghong Yao, Yu Ma, Fan Mei, Yanmei Liu, Lu Ma, Xiaochao Luo, Jiali Liu, Jianguo Xu, Chao You, Hunong Xiang, Kang Zou, Xiao Liang, Xin Hu, Ling Li, Xin Sun

“…Moderate certainty evidence from NMA suggested that compared with CMT, both ES (RR 1.51, 95% CI 1.18–1.93; RD 9.4%, 95% CI 3.3–17.1) and MIPS (RR 1.48, 95% CI 1.24–1.76; RD 15.7%, 95% CI 7.9–24.9) improved good functional outcome at 6 months, and both ES (RR 0.66, 95% CI 0.52–0.85; RD −17.0%, 95% CI −24.0 to −7.5) and CC (RR 0.75, 95% CI 0.60–0.94; RD −6.3%, 95% CI −10.1 to −1.5) reduced mortality at 6 months, whereas MIPS and DC showed a trend, although not statistically significant, towards a reduction in mortality. …”
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Effects of Climatic Conditions and Agronomic Practices on Health, Tuber Yield, and Mineral Composition of Two Contrasting Potato Varieties Developed for High and Low Input Producti... by Gultekin Hasanaliyeva, Ourania Giannakopoulou, Juan Wang, Marcin Barański, Enas Khalid Sufar, Daryl Knutt, Jenny Gilroy, Peter Shotton, Halima Leifert, Dominika Średnicka-Tober, Ismail Cakmak, Levent Ozturk, Bingqiang Zhao, Per Ole Iversen, Nikolaos Volakakis, Paul Bilsborrow, Carlo Leifert, Leonidas Rempelos

“…The study also found that, compared to the Cu-fungicides permitted for late blight control in organic production, application of synthetic chemical fungicides permitted and widely used in conventional production resulted in significantly lower late blight severity in Sante but not in Sarpo mira. Results from both ANOVA and redundancy analysis (RDA) indicate that the effects of climatic (precipitation, radiation, and temperature) and agronomic (fertilization and crop protection) explanatory variables on crop health and yield differed considerably between the two varieties. …”
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Assessment of hemodynamic disturbances and impaired ventricular filling in asymptomatic fontan patients: A 4D flow CMR study by Li-Wei Hu, Xiaodan Zhao, Shuang Leng, RongZhen Ouyang, Qian Wang, Ai-Min Sun, Yi-Man Liu, Wei Dong, Liang Zhong, Yu-Min Zhong

“…The parameters of FSV normalized to the ventricular end-diastolic volume (KEiEDV) were found to be significantly lower in Fontan patients (all P < 0.05). In both left ventricle (LV) and biventricular (BiV) Fontan subgroups, direct flow was identified as an independent predictor of LV diastolic dysfunction (AUC=0.76, Sensitivity=86 %, Specificity=70 %). …”
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Germline Human Leukocyte Antigen Status is Associated With Immunotherapy-Induced Pneumonitis and Treatment Response in Patients With Non–Small Cell Lung Cancer With High Programmed... by Alvin H.K. Cheung, MBBS, PhD, Zeta Mui, MPhil, Walter W. Yeung, PhD, Chit Chow, PhD, Mandy F. Yu, BSc, Olivia H. Chen, MD, PhD, Kit-Yee Wong, MPhil, Fuda Xie, MPhil, Yat Ming Lau, MBBS, Alfred S-L. Cheng, PhD, Wei Kang, PhD, Ka-Fai To, MBChB, Tony S. Mok, MD, Molly S.C. Li, MBBS

“…Conclusion: Taken together, this study evaluated the impact of HLA status in both germline and tumor samples in patients with NSCLC with high programmed death-ligand 1 expression, and the high incidence of immunotherapy-induced pneumonitis in patients expressing the HLA-DPB1∗02 allele may suggest a routine HLA typing and closer monitoring in this patient subset.…”
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AKRASIJA IR SUBJEKTAS EGONOMIKOJE by Zenonas Norkus

“…Rather, it is pursuing the goal to exhaust the remaining epistemic potential of the "intentional stance". …”
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Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry by Li-Jun Ji, Jin-Yu Hu, Yan-Mei Zeng, Qian Ling, Jie Zou, Cheng Chen, Liang-Qi He, Xiao-Yu Wang, Hong Wei, Xu Chen, Yi-Xin Wang, Yi Shao, Yao Yu

“…The average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale (HADS). …”
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Preoperative and intraoperative neuromonitoring and mapping techniques impact oncological and functional outcomes in supratentorial function-eloquent brain tumours: a systematic re... by Asfand Baig Mirza, Amisha Vastani, Rishabh Suvarna, Sami Rashed, Aws Al-Omari, Engelbert Mthunzi, Feras Fayez, Nicala Rampersad, Josephine Jung, Alba Díaz Baamonde, José Siado Mosquera, Ali Elhag, Francesco Marchi, Richard Gullan, Keyoumars Ashkan, Ranjeev Bhangoo, Francesco Vergani, Ana Mirallave-Pescador, José Pedro Lavrador

“…Interpretation: A combined POM&IONM approach is responsible for higher rates of GTR in patients with language eloquent tumours and in both awake and asleep craniotomy techniques regardless of the tumour functional eloquence. …”
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Gli1+ Cells Residing in Bone Sutures Respond to Mechanical Force via IP3R to Mediate Osteogenesis by Xiaoyao Huang, Zihan Li, Peisheng Liu, Meiling Wu, An-qi Liu, Chenghu Hu, Xuemei Liu, Hao Guo, Xiaoxue Yang, Xiaohe Guo, Bei Li, Xiaoning He, Kun Xuan, Yan Jin

“…In this study, rapid maxillary expansion (RME) mouse models and mechanical stretch loading cell models were established using two types of transgenic mice which are able to label Gli1+ cells, and we found that Gli1+ cells participated in mechanical force-induced osteogenesis both in vivo and in vitro. Besides, we found mechanical force-induced osteogenesis through inositol 1,4,5-trisphosphate receptor (IP3R), and we observed for the first time that inhibition of Gli1 suppressed an increase in mechanical force-induced IP3R overexpression, suggesting that Gli1+ cells participate in mechanical force-induced osteogenesis through IP3R. …”
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Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin by Jichao Sun, Dinglan Wu, Liuhai Zheng, Huifang Wang, Jihao Zhou, Guangwei Shi, Jingbo Ma, Yuke Jiang, Zhiyu Dong, Jiexuan Li, Yuan-Qiao He, Chengchao Xu, Zhijie Li, Jigang Wang

“…A candidate Nb with high binding affinity to both human and mouse ERp57 was used for constructing CAR-NK cells. …”
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The PANORAMIC Survey: Pure Parallel Wide Area Legacy Imaging with JWST/NIRCam by Christina C. Williams, Pascal A. Oesch, Andrea Weibel, Gabriel Brammer, Aidan P. Cloonan, Katherine E. Whitaker, Laia Barrufet, Rachel Bezanson, Rebecca A. A. Bowler, Pratika Dayal, Marijn Franx, Jenny E. Greene, Anne Hutter, Zhiyuan Ji, Ivo Labbé, Sinclaire M. Manning, Michael V. Maseda, Mengyuan Xiao

“…This represents the largest on-sky time investment of any Cycle 1 GO extragalactic NIRCam imaging program by nearly a factor of 2. …”
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Artificial intelligence-enhanced comprehensive assessment of the aortic valve stenosis continuum in echocardiographyResearch in context by Jiesuck Park, Jiyeon Kim, Jaeik Jeon, Yeonyee E. Yoon, Yeonggul Jang, Hyunseok Jeong, Youngtaek Hong, Seung-Ah Lee, Hong-Mi Choi, In-Chang Hwang, Goo-Yeong Cho, Hyuk-Jae Chang

“…We developed and validated an artificial intelligence (AI)-based system for evaluating AS that is effective in both resource-limited and advanced settings. Methods: We created a dual-pathway AI system for AS evaluation using a nationwide echocardiographic dataset (developmental dataset, n = 8427): 1) a deep learning (DL)-based AS continuum assessment algorithm using limited 2D TTE videos, and 2) automating conventional AS evaluation. …”
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Accurate space-based NO_<i>x</i> emission estimates with the flux divergence approach require fine-scale model information on local oxidation chemistry and profile shapes by F. Cifuentes, F. Cifuentes, H. Eskes, E. Dammers, E. Dammers, C. Bryan, F. Boersma, F. Boersma

“…Here we test the capability of the FDA to reproduce known <span class="inline-formula">NO_<i>x</i></span> emissions from synthetic <span class="inline-formula">NO₂</span> column retrievals generated with the LOTOS-EUROS chemistry transport model over the Netherlands at high spatial resolution of about <span class="inline-formula">2×2</span> <span class="inline-formula">km</span> during summer. …”
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Practice patterns among early-career primary care (ECPC) physicians and workforce planning implications: protocol for a mixed methods study by Richard J Gibson, Tara Sampalli, Tara Kiran, Richard H Glazier, Agnes Grudniewicz, Kimberlyn McGrail, David Snadden, Ian Scott, M Ruth Lavergne, Laurie J Goldsmith, David Rudoler, Emily Gard Marshall, Megan Ahuja, Doug Blackie, Fred Burge, Steve Hawrylyshyn, Lindsay Hedden, Jacalynne Hernandez-Lee, Kathleen Horrey, Mike Joyce, Adrian MacKenzie, Maria Mathews, Rita McCracken, Madeleine McKay, Charmaine McPherson, Goldis Mitra, Gail Tomblin Murphy, Sabrina T Wong

“…Mixed methods integration both within the study and as an end-of-study step will inform how practice intentions, choices and patterns are interrelated and inform policy recommendations.Ethics and dissemination This study was approved by the Simon Fraser University Research Ethics Board with harmonised approval from partner institutions. …”
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Exploring the role of methylation-driven gene IFFO1 in pancreatic adenocarcinoma diagnosis, prognosis and cellular functions by XU Ziqi, HU Ruizhi, LI Junjian, WANG Hongxia, SANG Youzhou

“…TCGA survival analysis demonstrated that patients with high methylation or low expression of IFFO1 had poorer overall survival (P&lt;0.05). Both GO and GSEA analyses indicated that the pathway “Negative regulation of cell migration” was enriched in patients with high IFFO1 expression. …”
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Abcb1 is involved in the efflux of trivalent inorganic arsenic from brain microvascular endothelial cells by Man Lv, Ziqiao Guan, Jia Cui, Xinbo Ma, Kunyu Zhang, Xinhua Shao, Meichen Zhang, Yanhui Gao, Yanmei Yang, Xiaona Liu

“…Increased arsenic levels were observed in mice exposed to 25 mg/L or 50 mg/L of sodium arsenite (NaAsO2) in drinking water, and both arsenic uptake and efflux were detected in bEnd.3 cells treated with 16 μmol/L NaAsO2. …”
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The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial by Gansheng Tan, Anna L Huguenard, Kara M Donovan, Phillip Demarest, Xiaoxuan Liu, Ziwei Li, Markus Adamek, Kory Lavine, Ananthv K Vellimana, Terrance T Kummer, Joshua W Osbun, Gregory J Zipfel, Peter Brunner, Eric C Leuthardt

“…Therefore, this study assessed the impact of both acute and repetitive taVNS on cardiovascular function. …”
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Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity by Said Mougari, Valérie Favède, Camilla Predella, Olivier Reynard, Stephanie Durand, Magalie Mazelier, Edoardo Pizzioli, Didier Decimo, Francesca T. Bovier, Lauren M. Lapsley, Candace Castagna, Nicole A. P. Lieberman, Guillaume Noel, Cyrille Mathieu, Bernard Malissen, Thomas Briese, Alexander L. Greninger, Christopher A. Alabi, N. Valerio Dorrello, Stéphane Marot, Anne-Geneviève Marcelin, Ana Zarubica, Anne Moscona, Matteo Porotto, Branka Horvat

“…The peptide-protected mice develop cross-reactive neutralizing antibodies against both SARS-CoV-2 used for the initial infection and recently circulating variants, and are completely protected from a second lethal infection, suggesting that they developed SARS-CoV-2-specific immunity. …”
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Surgeons are apprehensive to use DCD lungs despite similar post-transplant outcomes: A 20-year UNOS retrospective analysis by J. Sam Meyer, MSc, Oliver K. Jawitz, MD, MHS, Yury Peysakhovich, MD, Dan Aravot, MD, Matthew G. Hartwig, MD, MHS, Yaron D. Barac, MD, PhD

“…A history of diabetes for over 10 years was strongly associated with non-use for DCD lungs (OR, 0.87, P = 0.71), whereas an under 10-year history was associated with increased use (OR 2.33, P = 0.008, OR 1.07 P = 0.819).Lungs from donors ages 40–49 are more likely to be procured than those <30 or >50 in both DBD and DCD. However, likelihood of procurement is 1.84 [95% 1.42, 2.38, p < 0.001] times higher in 40–49-year-old vs. <30-year-old donors when comparing DBD vs. …”
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Prolonged venous transit is associated with worse neurological recovery in successfully reperfused large vessel strokes by Janet Mei, Hamza Adel Salim, Dhairya A. Lakhani, Licia Luna, Aneri Balar, Mona Shahriari, Nathan Z. Hyson, Francis Deng, Adam A. Dmytriw, Adrien Guenego, Vaibhav Vagal, Victor C. Urrutia, Elisabeth B. Marsh, Hanzhang Lu, Risheng Xu, Rich Leigh, Dylan Wolman, Gaurang Shah, Benjamin Pulli, Kambiz Nael, Gregory W. Albers, Max Wintermark, Jeremy J. Heit, Tobias D. Faizy, Argye E. Hillis, Raf Llinas, Vivek Yedavalli

“…PVT+ was defined as Tmax ≥10 s in the superior sagittal sinus, torcula, or both. The primary outcome was continuous NIHSS percent change and dichotomous NIHSS percent change ≥70%. …”
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