Dynamic Imprints of Colliding-wind Dust Formation from WR 140 by Emma P. Lieb, Ryan M. Lau, Jennifer L. Hoffman, Michael F. Corcoran, Macarena Garcia Marin, Theodore R. Gull, Kenji Hamaguchi, Yinuo Han, Matthew J. Hankins, Olivia C. Jones, Thomas I. Madura, Sergey V. Marchenko, Hideo Matsuhara, Florentin Millour, Anthony F. J. Moffat, Mark R. Morris, Patrick W. Morris, Takashi Onaka, Marshall D. Perrin, Armin Rest, Noel Richardson, Christopher M. P. Russell, Joel Sanchez-Bermudez, Anthony Soulain, Peter Tuthill, Gerd Weigelt, Peredur M. Williams

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Strong-lensing Analysis of SPT-CL J2325−4111 and SPT-CL J0049−2440, Two Powerful Cosmic Telescopes (RE > 40″) from the SPT Clusters Sample by Guillaume Mahler, Keren Sharon, Matthew Bayliss, Lindsey. E. Bleem, Mark Brodwin, Benjamin Floyd, Raven Gassis, Michael D. Gladders, Gourav Khullar, Juan D. Remolina González, Arnab Sarkar

“…From the lensing analysis, we measure a projected mass density within 500 kpc of M (<500 kpc) = (7.30 ± 0.07) × 10 ^14 M _⊙ and $M(\lt 500\,\mathrm{kpc})=7.1{2}_{-0.19}^{+0.16}\times 1{0}^{14}$ M _⊙ for these two clusters, and subhalo mass ratios of 0.12 ± 0.01 and $0.2{1}_{-0.05}^{+0.07}$ , respectively. Both clusters produce a large area with high magnification ( μ ≥ 3) for a source at z = 9, ${{ \mathcal A }}_{|\mu |\geqslant 3}^{{\rm{lens}}}=4.9{3}_{-0.04}^{+0.03}$ arcmin ^2 and ${{ \mathcal A }}_{|\mu |\geqslant 3}^{{\rm{lens}}}=3.6{4}_{-0.10}^{+0.14}$ arcmin ^2 , respectively, placing them in the top tier of strong-lensing clusters. …”
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A Model for Bank Management Performance Appraisal with the Advanced Technologies Approach (Meta-Synthesis Method) by Ehsan Kiani Ghalehno, Habibollah Salarzehi, Bahareh Naseri, Abdolali Keshtegar

“…It inevitably interprets that both existing commercial techniques and monetary management are not excluded from this change (Singh , 2022). …”
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Immunotherapeutic Potential of the Yellow Fever Virus Vaccine Strain 17D for Intratumoral Therapy in a Murine Model of Pancreatic Cancer by Alina S. Nazarenko, Yulia K. Biryukova, Kirill N. Trachuk, Ekaterina A. Orlova, Mikhail F. Vorovitch, Nikolay B. Pestov, Nick A. Barlev, Anna I. Levaniuk, Ilya V. Gordeychuk, Alexander S. Lunin, Grigory A. Demyashkin, Petr V. Shegai, Andrei D. Kaprin, Aydar A. Ishmukhametov, Nadezhda M. Kolyasnikova

“…<b>Methods</b>: The cytopathic effect of YFV 17D on mouse syngeneic pancreatic cancers cells were studied both in vitro and in vivo and on human pancreatic cancers cells in vitro. …”
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Clinical validation of an artificial intelligence algorithm for classifying tuberculosis and pulmonary findings in chest radiographs by Thiago Fellipe Ortiz de Camargo, Thiago Fellipe Ortiz de Camargo, Guilherme Alberto Sousa Ribeiro, Guilherme Alberto Sousa Ribeiro, Maria Carolina Bueno da Silva, Luan Oliveira da Silva, Pedro Paulo Teixeira e Silva Torres, Denise do Socorro Rodrigues da Silva, Mayler Olombrada Nunes de Santos, William Salibe Filho, Marcela Emer Egypto Rosa, Magdala de Araujo Novaes, Thiago Augusto Massarutto, Osvaldo Landi Junior, Elaine Yanata, Marcio Rodrigues da Cunha Reis, Gilberto Szarf, Pedro Vieira Santana Netto, Joselisa Peres Queiroz de Paiva

“…Notably, both Groups reported minimal influence of the algorithm on their decisions in most cases.…”
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Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…Treatments included methimazole, inorganic iodine, and both low and high doses of SHSY administered via gavage. …”
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SARS-CoV-2 excretion and genetic evolution in nasopharyngeal and stool samples from primary immunodeficiency and immunocompetent pediatric patients by Haifa Khemiri, Ilhem Ben Fraj, Alessio Lorusso, Najla Mekki, Iolanda Mangone, Mariem Gdoura, Adriano Di Pasqual, Cesare Cammà, Valeria Di Lollo, Asma Cherni, Henda Touzi, Amel Sadraoui, Zina Meddeb, Nahed Hogga, Imen Ben Mustapha, Mohamed-Ridha Barbouche, Monia Ouederni, Henda Triki, Sondes Haddad-Boubaker

“…Patients with antibody and combined deficiencies, exhibited the most prolonged shedding periods in both nasopharyngeal and stool samples and one patient presented complications and fatal outcome. …”
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IOP-lowering and neuroprotective treatment for glaucoma: reality and prospects by A.E. Egorov, N.G. Glazko, A.B. Movsisyan

“…It was demonstrated that elevated intraocular pressure (IOP) is still an important and well-studied risk factor for vision loss in both open-angle and angle-closure glaucoma. Management algorithms for glaucoma which consider disease progression include three major principles, i.e., IOP lowering to achieve target IOP, maintenance and improvement of ocular blood flow, and neural retinal protection. …”
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Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary... by Hadar Klein, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Alon Kaplan, Yoash Chassidim, Yftach Gepner, Matthias Blüher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Ilan Shelef, Lu Qi, Jun Li, Frank B. Hu, Meir J. Stampfer, Iris Shai

“…After 18 months of lifestyle intervention, both VATcm2 and VAT% loss were significantly associated with decreased triglycerides, HbA1c, ferritin, and liver enzymes, and increased HDL-c levels beyond weight loss (FDR < 0.05). …”
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Construction of feature selection and efficacy prediction model for transformation therapy of locally advanced pancreatic cancer based on CT, 18F-FDG PET/CT, DNA mutation, and CA19... by Liang Qi, Xiang Li, Jiayao Ni, Yali Du, Qing Gu, Baorui Liu, Jian He, Juan Du

“…Among them, 65 patients had efficacy evaluation results after 4 treatment cycles, 54 patients had complete baseline PET/CT images, 51 patients had complete DNA mutation detection results, and 34 patients had both complete PET/CT images and DNA mutation detection results. …”
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Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response by Hend Jarras, Isalie Blais, Benjamin Goyer, Wilfried W. Bazié, Wilfried W. Bazié, Henintsoa Rabezanahary, Mathieu Thériault, Kim Santerre, Marc-André Langlois, Jean-François Masson, Joelle N. Pelletier, Joelle N. Pelletier, Nicholas Brousseau, Nicholas Brousseau, Denis Boudreau, Sylvie Trottier, Sylvie Trottier, Mariana Baz, Mariana Baz, Caroline Gilbert, Caroline Gilbert

“…In addition, the IL-8 response was significantly different depending on the season when the visit occurred, for both COVID-19 vaccinated and unvaccinated individuals.DiscussionThis study highlights that innate immune responses can be affected by SARS-CoV-2 vaccination and fluctuate seasonally.…”
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Cardiac diffusion-weighted and tensor imaging: A consensus statement from the special interest group of the Society for Cardiovascular Magnetic Resonance by Erica Dall’Armellina, Daniel B. Ennis, Leon Axel, Pierre Croisille, Pedro F. Ferreira, Alexander Gotschy, David Lohr, Kevin Moulin, Christopher T. Nguyen, Sonja Nielles-Vallespin, William Romero, Andrew D. Scott, Christian Stoeck, Irvin Teh, Elizabeth M. Tunnicliffe, Magalie Viallon, Victoria Wang, Alistair A. Young, Jürgen E. Schneider, David E. Sosnovik

“…CMR can determine changes in microstructure by quantifying: a) mean diffusivity (MD)—measuring the magnitude of diffusion; b) fractional anisotropy (FA)—specifying the directionality of diffusion; c) helix angle (HA) and transverse angle (TA)—indicating the orientation of the cardiomyocytes; d) absolute sheetlet angle (E2A) and E2A mobility—measuring the alignment and systolic-diastolic mobility of the sheetlets, respectively.This document provides recommendations for both clinical and research cDWI and cDTI, based on published evidence when available and expert consensus when not. …”
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CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance by Xuemeng Xu, Qiu Peng, Zongyao Ren, Yaqian Han, Xianjie Jiang, Zhu Wu, Shiming Tan, Wenjuan Yang, Linda Oyang, Xia Luo, Jinguan Lin, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Hao Tian, Yujuan Zhou, Qianjin Liao

“…Our study demonstrated that circRNF13 is correlated with increased tumor grade and stage in oral cancer. Results from both in vitro and in vivo experiments indicated that circRNF13 enhances cancer cell proliferation and tumor growth, while concurrently diminishing tumor sensitivity to cisplatin. …”
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TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…The resulting T-cell products were assessed for phenotypic and functional characteristics.Results We identified an optimal Ag-scaffold for expansion of T-cells for ACT, carrying pMHC and interleukin-2 (IL-2) and IL-21, with which we efficiently expanded both virus-specific and tumor-specific CD8+ T cells from peripheral blood of healthy donors and patients, respectively. …”
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Effectiveness of ertugliflozin during Ramadan fasting in patients with type 2 diabetes mellitus: a real-world study (ErtuRamadan study) by Md Faruque Pathan, Nazma Akter, Marufa Mustari, M. Saifuddin, Mirza Sharifuzzaman, Mohammad Motiur Rahman, Mohammed Ripon, S. M. Mohiuddin, A. B. M. Kamrul-Hasan, Mohammad Abdul Hannan, Muhammad Shah Alam, Samira Mahjabeen, Faria Afsana, Muhammed Abu Bakar, Tahniyah Haq, Afsar Ahammed, Samir Kumar Talukder, Sourav Sarkar, Shahjada Selim

“…Patients attended a baseline visit one month before the first day of Ramadan and a follow-up visit within one month after the last day of Ramadan. Both visits included history taking, physical examinations, and laboratory tests. …”
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Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts by Lewis Steell, Stefanie J. Krauth, Sayem Ahmed, Grace O. Dibben, Emma McIntosh, Peter Hanlon, Jim Lewsey, Barbara I. Nicholl, David A. McAllister, Susan M. Smith, Rachael Evans, Zahira Ahmed, Sarah Dean, Colin Greaves, Shaun Barber, Patrick Doherty, Nikki Gardiner, Tracy Ibbotson, Kate Jolly, Paula Ormandy, Sharon A. Simpson, Rod S. Taylor, Sally J. Singh, Frances S. Mair, Bhautesh D. Jani, the PERFORM research team

“…Health service delivery planning and future intervention design and risk assessment of people with MLTCs should consider both LTC counts and MLTC clusters to better meet the needs of specific populations.…”
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Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease by Rui Wang, Yuanyuan Li, Yuting Jiang, Xiaona Liu, Hongqi Feng, Zhe Jiao, Bingyun Li, Chang Liu, Yuncheng Shen, Fang Chu, Chenpeng Zhu, Dianjun Sun, Wei Zhang

“…Abstract Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, influenced by both environmental and genetic factors. Single nucleotide polymorphism (SNP) in the human genome may influence the risk of developing COPD and the response to treatment. …”
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Association of genetic variations in the NOS1 gene with insomnia, sleep duration and obstructive sleep apnea-related clinical quantitative traits by YUAN Haolin, LI Niannian, HU Junhui, SHEN Jinhong, GAO Zhenfei, GUAN Jian, LIU Feng, YIN Shankai

“…Although rs11615756 showed a notable negative correlation solely with the quantity of NREM stages 2 and 3, both rs11615756 and rs7305526 showed significant correlations with some respiratory events and oxygen traits after stratification according to the severity of OSA.Conclusion·Genetic variants of NOS1 gene are respectively associated with human sleep duration traits and OSA-related variables, suggesting that NOS1 gene plays a crucial regulatory role in human sleep and clinical quantitative traits of OSA. …”
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MiR-216a-3p inhibits the cytotoxicity of primary natural killer cells by Rowan Abdelbary, Rowan Abdelbary, Manon Ragheb, Manon Ragheb, Shereen A. El Sobky, Nagwa El-Badri, Nourhan Aboud, Ahmed Tawheed, Asmaa Gomaa, Mona Zidan, Ramy K. Aziz, Abd Elrahman Abouzid, Radwa Ayman Salah, Mohamed El-Kassas, Imam Waked, Ahmed Moustafa, Ahmed Moustafa, Injie Omar Fawzy, Nada El-Ekiaby, Ahmed Ihab Abdelaziz

“…Thus, we evaluated FOXO-1 expression upon mimicking miR-216a-3p in control NK cells that showed significant downregulation of FOXO-1 on both RNA and protein levels.ConclusionIn conclusion, we report miR-216-3p as a negative regulator of NK cell cytotoxicity.…”
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Impact of healthy lifestyle on diabetes incidence among adults of different socioeconomic status in Guizhou province: a prospective cohort study by Yiying WANG, Min CHEN, Lieqiang ZHANG, Xin WANG, Wei ZHAN, Yunxi PAN, Xiaodeng ZHAO, Tao LIU

“…Among adults with an SES score of ≥ 12, those with 4 and 5 or more healthy lifestyle factors had 50.4% (HR = 0.496, 95%CI: 0.276 – 0.894) and 71.4% (HR = 0.286, 95%CI: 0.110 – 0.740) lower diabetes risk, respectively compared with those with 2 or fewer factors. ConclusionsBoth higher SES and more healthy lifestyle factors can reduce the risk of diabetes among adults in Guizhou province. …”
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