Neoadjuvant atezolizumab + chemotherapy for resectable NSCLC: 3-year clinical update of phase II clinical trial results and translational findings by Benjamin Izar, Justin F Gainor, Mark M Awad, Codruta Chiuzan, Anjali Saqi, Catherine A Shu, Katja Schulze, Brian S Henick, Naiyer A Rizvi, Samyukta Mallick, Yohanna Georgis, Peter D Koch, Stephanie Izard, Robert F Garofano, Cheryl V Wong, Jessica Grindheim, Joshua R Sonett, Alison M Taylor

“…Reduced copy number of STK11 and KEAP1, both residing on chromosome 19p, was observed in ~1/3 of tumors. …”
Get full text

Investigating the Effect of Chicken Manure and Potassium Sulfate on the Physiological Properties of Fenugreek )Trigonella foenum-graecum L.( Medicinal Plant by Mohammad hossein Aminifard, Sajjad Nadafa, Hassan Hassan, Mehdi Jahani

“…The highest levels of both treatments caused an increase of 83.76% and 93.28% of seed and biological yield compared to no fertilization (control level).ConclusionIn general, it can be concluded that among the simple effects, the highest amount of traits was related to chicken manure, and among the investigated levels in two treatments, the highest yield of fenugreek dry matter was obtained with the consumption of 2000 kg/ha of chicken manure and 5 per thousand Soluptas.…”
Get full text

Investigating the Effect of Solanum lycopersicum L. (Tomato) Pomace on Growth Performance and some Blood Indices of Broiler Chickens by Meta-Analysis Method by Zahra Sahragard, seyyed javad Hosseini-vashan, Hossein Naeemipour Younesi, Seyyed Homayon Farhangfar

“…Then the statistical analysis of the data was done in the CMI (CMA) software. Both fixed and random effects models were used to combine the effect size. …”
Get full text

Identification and expression analysis of the heat shock proteins Hsp70, Hsp90, and Hsp90b in Litopenaeus vannamei under low-temperature stress by Min Peng, Hui Wang, Shuiping Wen, Zheng Liang, Zheng Huang, Bin Zhang, Tianchong Chen, Qingyun Liu, Qiangyong Li, Yuan Meng, Yuliu Huang, Chunling Yang, Digang Zeng, Manyuan Li, Weilin Zhu, Yongzhen Zhao

“…During low-temperature stress, hsp70 and hsp90 expression levels increased gradually in both families, while hsp90b expression decreased. …”
Get full text

Trends in Mental Health Outcomes of College Students Amid the Pandemic (Roadmap mHealth App): Longitudinal Observational Study by Gautham Jayaraj, Xiao Cao, Adam Horwitz, Michelle Rozwadowski, Skyla Shea, Shira N Hanauer, David A Hanauer, Muneesh Tewari, Kerby Shedden, Sung Won Choi

“…However, significant decreases were noted by Year III for both depression (Year I mean 7.78, SD 5.65 vs Year III mean 6.21, SD 4.68; t108=–2.90; P=.01) and anxiety (Year I mean 6.61, SD 4.91 vs Year III mean 5.62, SD 4.58; t116=–2.02; P=.046). …”
Get full text

4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models by Ignacio Melero, Alvaro Teijeira, Christian Klein, Maria E Rodriguez-Ruiz, Christina Claus, Pablo Umana, Tamara Tanos, Carlos E De Andrea, Carlos Luri-Rey, Paloma Sanchez-Mateos, Leticia Fernández-Rubio, María Collantes, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Antonio Rullan, Jon Ander Simon, Eneko Garate-Soraluze, Claudia del Pilar Herrero

“…Background Ionizing radiation (IR) is a double-edged sword for immunotherapy as it may have both immunosuppressive and immunostimulatory effects. …”
Get full text

Negative valuation of ambiguous feedback may predict near-term risk for suicide attempt in Veterans at high risk for suicide by Catherine E. Myers, Catherine E. Myers, Rokas Perskaudas, Rokas Perskaudas, Vibha Reddy, Chintan V. Dave, Chintan V. Dave, John G. Keilp, Arlene King, Kailyn Rodriguez, Kailyn Rodriguez, Lauren St. Hill, Rachael Miller, Alejandro Interian, Alejandro Interian

“…Computational modeling revealed that patients with upcoming ASA tended to view ambiguous outcomes as similar to weak punishment, while OtherSE and noSE both tended to view the ambiguous outcome as similar to weak reward. …”
Get full text

Characteristics of Traditional Human Settlement Landscapes on Bedrock Islands in Guangdong Based on the “Ao” Unit by Ying PAN, Linxi CHEN, Ying SHI

“…ObjectiveThe objective of this research is to contribute to the strategic goal of transforming China into a strong maritime nation by enhancing the understanding and management of the ocean, and by fostering innovation in marine science and technology. …”
Get full text

Effects of Intrathecal Bupivacaine with Adjuvants Midazolam versus Magnesium Sulphate in Tibia Fibula Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Aanal Sha, Dushyant Chavda, Dinesh K Chauhan

“…In terms of complications, bradycardia was noted in a few cases in group BM after giving spinal anaesthesia. …”
Get full text

Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…These results were critical to both suppressing the secretion of inflammatory cytokines and restoring the intestinal function. …”
Get full text

Preparedness, prevention and control related to zoonotic avian influenza by EFSA Panel on Animal Health and Animal Welfare (AHAW), ECDC, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Eleonora Nannoni, Søren Saxmose Nielsen, Romolo Nonno, Anja B. Riber, Jan Arend Stegeman, Karl Ståhl, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Claire Brugerolles, Thorsten Wolff, Anna Parys, Erika Lindh, Neus Latorre‐Margalef, Marie‐Anne Rameix Welti, Ralf Dürrwald, Ramona Trebbien, Sylvie Van der Werf, Magnus Gisslén, Isabella Monne, Alice Fusaro, Claire Guinat, Alessio Bortolami, Leonidas Alexakis, Theresa Enkirch, Olov Svartstrom, Katriina Willgert, Francesca Baldinelli, Ludovica Preite, Malin Grant, Alessandro Broglia, Angeliki Melidou

“…AI viruses (AIVs) carrying multiple adaptive mutations and traits belonged to both low and highly pathogenic subtypes, mainly to A(H9N2), A(H7N9), A(H5N6) and A(H3N8), were sporadic and primarily detected in Asia. …”
Get full text

Peptide platform for 3D-printed Ti implants with synergistic antibacterial and osteogenic functions to enhance osseointegration by Chenying Cui, Yifan Zhao, Jingyu Yan, Ziyang Bai, Guning Wang, Yingyu Liu, Yurong Xu, Lihong Zhou, Kaifang Zhang, Yanling Mi, Binbin Zhang, Xiuping Wu, Bing Li

“…This design enables specific targeting, localized delivery, prevention of peptide release into circulation, and functional integrity through linker retention. In both in vitro and in vivo infected bone defect models, 3DTi-NFP implants demonstrated excellent biocompatibility and achieved over 90 % bactericidal efficiency against S. aureus and E. coli. …”
Get full text

Validation of ACC/AHA and ESC Sudden Cardiac Death Risk Guidelines in Diverse Hypertrophic Cardiomyopathy Cohort: Stratification HCM Study by Murillo Oliveira Antunes, Fabio Fernandes, Edmundo Arteaga-Fernandez, Félix José Alvarez Ramires, Vinicius Machado Correia, Juliano Novaes Cardoso, Cristhian Espinoza Romero, Henrique Martins Sousa, Marília Taily Soliani, Matheus Ramos Ramos Dal Piaz, Anna Danielle Rodrigues Gandarella, Ruiza Gonçalves Rocha Teixeira, Charles Mady, Caio Assis Moura Tavares, Patricia O. Guimarães, Vagner Madrini Junior

“…The primary outcome occurred in 12% of the high-risk group identified by the ACC/AHA guidelines and 13% of the high-risk group identified by the ESC guidelines. Both guidelines showed low discriminatory power for SCD risk in this Brazilian cohort, with AUC values of 0.634 and 0.581 for the ACC/AHA and ESC guidelines, respectively. …”
Get full text

The Comparison of Cost-Effectiveness Between Magnetic Resonance Spectroscopy and Provocative Discography in the Identification of Chronic Low Back Pain Surgery Candidates by Wilson L, Beall DP, Eastlack RK, Berven S, Lotz JC

“…The cost-effectiveness demonstrated strong MRS-Nociscan dominance, meaning it was both cost saving and a better clinical success. The strong cost-effectiveness dominance for MRS+Nociscan diagnosis answers the budgetary questions for insurers and health systems considering adoption of this new diagnostic tool.Keywords: cost, cost-effectiveness, lumbar spine, diagnostics, outcomes, discography…”
Get full text

Exploring the potential of black soldier fly live larvae as a sustainable protein source for laying hens: A comprehensive study on egg quality by Arianna Cattaneo, Erminia Sezzi, Marco Meneguz, Roberto Rosà, Davide Santori, Sofia Cucci, Rosalba Roccatello, Francesca Grosso, Stefano Mercandino, Valeria Zambotto, Eugenio Aprea, Pavel Solovyev, Luana Bontempo, Angela Trocino, Gerolamo Xiccato, Sihem Dabbou

“…The age of the hens strongly affected egg quality traits (P<0.001), mainly the egg weight, shell weight, shell thickness, eggshell-breaking strength, and eggshell redness (a*) and yellowness (b*), besides the metabolic profile of both egg yolk and albumen. Considering the interaction diet * age of hens, only a few significant effects occurred on egg quality attributes and FA profile. …”
Get full text

Fatty Acids of Erythrocyte Membranes and Blood Serum as Possible Predictors of Exacerbation in Patients with Inflammatory Bowel Diseases by M. V. Kruchinina, M. F. Osipenko, A. I. Valuyskikh, E. Yu. Valuiskikh, I. O. Svetlova

“…In the acute stage, patients with IBD have a higher total content of saturated fatty acids (SFAs) in erythrocyte membranes compared to the control group (p = 0.006), and, on the contrary, lower levels of unsaturated fatty acids (UFAs) (p = 0.005), mainly due to polyunsaturated FAs (PUFAs) (p = 0.026), namely omega-6 PUFAs (p = 0.011).Remission of IBD is associated with an increase in the level of a number of SFAs in the blood serum — margaric C17:0 (p = 0.024), arachidic acid (C20:0) — in erythrocyte membranes and serum (p = 0.0001 and p = 0.019, respectively), with a decrease in the total content of monounsaturated FAs in erythrocyte membranes (p = 0.022), an increase in the total concentration of PUFAs due to both omega-3 PUFAs (p = 0.0008) and omega-6 PUFAs (p = 0.033) in erythrocyte membranes compared with a group of healthy individuals.The exacerbation stage in patients with IBD examined over time is associated with higher levels of stearic FA C18:0 (p = 0.005), SFA/UFA (p = 0.034) and SFA/PUFA (p = 0.039) ratios in erythrocyte membranes, serum level of arachidic FA C20:0 (p = 0.008), and, on the contrary, lower content of UFAs in erythrocyte membranes — eicosapentaenoic C20:5n-3 (p = 0.0023), eicosadienoic C20:2n-6 (p = 0.0027), hexadecadienoic C16:2n-6 (p = 0.006), docosatetraenoic C22:4n-6 (p = 0.008) and alpha-linolenic C18:3n-3 (p = 0.039).A combined “panel” of fatty acids, including the levels of C20:2n-6, C18:0 in erythrocyte membranes and the content of C20:0 in blood serum, provided an AUC of 0.683 (95 % CI: 0.500–0.844), sensitivity 91.4 %, specificity 68.3 %.Levels of C20:5n-3, C20:2n-6, C18:0, C16:2n-6, C22:4n-6, C18:3n-3 fatty acids, SFA/UFA and SFA/PUFA ratios in erythrocyte membranes and content C20:0 in blood serum, used as biomarkers — predictors of the development of exacerbation in patients with IBD who were in remission, predicted the development of exacerbation of IBD after 2–4 months in the case of maximally changed levels of FAs, after 6–8 months — with moderately changed levels FAs, maintaining remission for 12 months — with minimally changed FAs levels.Conclusion. …”
Get full text

Microenvironmental G protein‐coupled estrogen receptor‐mediated glutamine metabolic coupling between cancer‐associated fibroblasts and triple‐negative breast cancer cells governs t... by Chongwu He, Meixi Peng, Xiaoqiang Zeng, Hanzhi Dong, Zhengkui Sun, Jiawei Xu, Manran Liu, Liyan Liu, Yanxiao Huang, Zhiqiang Peng, Yu‐An Qiu, Chunling Jiang, Bin Xu, Tenghua Yu

“…This glutamine is then secreted into the extracellular matrix and absorbed by TNBC cells, enhancing their viability, motility, and chemoresistance both in vitro and in vivo. TNBC cells further metabolize the glutamine through the glutamine transporter (ASCT2) and glutaminase (GLS1) axes, which, in turn, promote mitochondrial activity and tumour progression. …”
Get full text

Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort by Antonio Liguori, Giorgio Esposto, Maria Elena Ainora, Irene Mignini, Raffaele Borriello, Linda Galasso, Mattia Paratore, Maria Cristina Giustiniani, Laura Riccardi, Matteo Garcovich, Antonio Gasbarrini, Luca Miele, Maria Assunta Zocco

“…The fibrosis diagnostic accuracy of both S-Shearwave Imaging and 2D-SWE was good to optimal with AUROCs of 0.81 and 0.70 for significant fibrosis (≥F2), 0.94 and 0.91 for severe fibrosis (≥F3), respectively. …”
Get full text

Easy, fast and reproducible Stochastic Cellular Automata with chouca by Génin, Alexandre, Dupont, Guillaume, Valencia, Daniel, Zucconi, Mauro, Ávila-Thieme, M. Isidora, Navarrete, Sergio A., Wieters, Evie A.

“…Exact and mean-field simulations can be run, and both numerical and graphical results can be easily exported. …”
Get full text

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels by Arnaud PJ Giese, Wei-Hsiang Weng, Katie S Kindt, Hui Ho Vanessa Chang, Jonathan S Montgomery, Evan M Ratzan, Alisha J Beirl, Roberto Aponte Rivera, Jeffrey M Lotthammer, Sanket Walujkar, Mark P Foster, Omid A Zobeiri, Jeffrey R Holt, Saima Riazuddin, Kathleen E Cullen, Marcos Sotomayor, Zubair M Ahmed

“…These interactions have been proposed to be functionally relevant across mechanosensory organs and vertebrate species. Here, we show that both CIB2 and CIB3 can form heteromeric complexes with TMC1 and TMC2 and are integral for MET function in mouse cochlea and vestibular end organs as well as in zebrafish inner ear and lateral line. …”
Get full text