Deep application of controlled-release urea increases the yield and saponin content of Panax notoginseng by regulating soil nitrate distribution by Yun-xia Su, Yun-xia Su, Yun-xia Su, Ping Zhao, Li-jie Jia, Li-jie Jia, Li-jie Jia, Yuan-feng Cao, Guan-ze Liu, Guan-ze Liu, Jun-wen Chen, Jun-wen Chen, Sheng-chao Yang, Sheng-chao Yang, Yan-li Zhou, Guang-qiang Long, Guang-qiang Long, Guang-qiang Long

“…Structural equation modeling indicated that soil NO3⁻-N supply in specific microareas directly affected the N uptake and increased total saponin content by increasing root length and surface area, thus boosting yield.ConclusionThis study identifies that the deep application of CRU at a depth of 6 cm has the potential to enhance both yield and quality of P. notoginseng and highlights that the spatial-temporal matching of soil NO₃⁻-N and plant roots was the key to applying CRU to ensure high yield and quality.…”
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AICpred: Machine Learning-Based Prediction of Potential Anti-Inflammatory Compounds Targeting TLR4-MyD88 Binding Mechanism by Lucindah N. Fry-Nartey, Cyril Akafia, Ursula S. Nkonu, Spencer B. Baiden, Ignatus Nunana Dorvi, Kwasi Agyenkwa-Mawuli, Odame Agyapong, Claude Fiifi Hayford, Michael D. Wilson, Whelton A. Miller, Samuel K. Kwofie

“…The AdaBoost and decision tree models also excelled with accuracies ranging from 0.981 to 0.992, balanced accuracies between 0.921 and 0.944, and recall scores between 0.845 and 0.891 on both training and test datasets. The XGBoost model was deployed as AICpred and was used to screen compounds that have been reported to have positive effects on mitigating the hyperinflammation-associated cytokine storm, which is a key factor in COVID-19. …”
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Evaluation on Carbon Sequestration Capacity of 30 Common Landscaping Tree Species in Beijing by Jing QIAN, Sidong SHEN, Shuxin FAN, Li DONG

“…Actively responding to the issue of climate change, China has put forward the carbon peaking and carbon neutrality goals for carbon emission reduction. Landscaping trees play an important role in increasing urban natural carbon sinks and neutralizing urban anthropogenic carbon emissions. …”
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Social Progress and Economic Growth based on Simultaneous Equations of Panel Data by Seyed Ehsan Hosseinidoust, Akbar Khodabakhshi, Saeedeh Ahmadi

“…Finally, according to the results obtained from both models, which confirm the existence of a positive and significant relationship between the social progress index and GDP per capita, it can be concluded that there is a complementary relationship between these two variables…”
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Des vestiges d’un possible aqueduc à Lyon, à l’angle des rues Appian et des Fossés-de-Trion by Tony Silvino

“…At the same time, these structures do not appear to be roads, for example connecting the Trion valley in the north-west to Point-du-Jour plateau in the south-east, since there are no signs of hardtop preparation at the bottom of the structures. Finally, both of them appear to have been closed very quickly.The remnants that have provided the most information for the interpretation of the structures are the ones found within them, more specifically the fragments of earthenware pipe. …”
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Can system dynamics explain long-term hydrological behaviors? The role of endogenous linking structure by X. Zhou, Z. Sheng, K. Manevski, K. Manevski, K. Manevski, R. Zhao, R. Zhao, Q. Zhang, Y. Yang, S. Han, J. Liu, J. Liu, Y. Yang, Y. Yang, Y. Yang

“…The system dynamics' structure successfully captured the slow hydrological behaviors under both natural and human-intervention scenarios, demonstrating a self-sustained oscillation arising within the system's boundary. …”
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Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort st... by Kai Guo, Qi Wang, Lin Zhang, Rui Qiao, Yujia Huo, Lipeng Jing, Xiaowan Wang, Zixuan Song, Siyu Li, Jinming Zhang, Yanfang Yang, Jinli Mahe, Zhengran Liu

“…A U-shaped association was observed between TyG-BMI levels and both rapid FI trajectory and higher frail risk, with BMI being the primary factor. …”
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Ucp1 Ablation Improves Skeletal Muscle Glycolytic Function in Aging Mice by Jin Qiu, Yuhan Guo, Xiaozhen Guo, Ziqi Liu, Zixuan Li, Jun Zhang, Yutang Cao, Jiaqi Li, Shuwu Yu, Sainan Xu, Juntong Chen, Dongmei Wang, Jian Yu, Mingwei Guo, Wenhao Zhou, Sainan Wang, Yiwen Wang, Xinran Ma, Cen Xie, Lingyan Xu

“…To understand the potential crosstalk, RNA‐seq and metabolomic analysis were performed on adipose tissue and muscle in aging mice and revealed that creatine levels are increased both in iWAT and muscle of UCP1 KO mice. Interestingly, molecular analysis and metabolite tracing revealed that creatine biosynthesis is increased in iWAT while creatine uptake is increased in muscle in UCP1 KO mice, suggesting creatine transportation from iWAT to muscle. …”
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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…Intervention effects were assessed by both random-effects and fixed-effect model meta-analyses, risk of bias assessments were performed by two independent review authors using Cochrane’s risk of bias tool V.2 and the certainty of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation.Results We included 28 trials randomising a total of 7872 participants. …”
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Blood-based prognostic scores and early dynamics under immunotherapy to select patients with metastatic solid tumors for continuing immune check-point inhibition: a prospective lon... by Javier García-Corbacho, Alberto Indacochea, Iván Victoria, Débora Moreno, Laura Angelats, Azucena E. González Navarro, Laura Mezquita, Fara Brasó-Maristany, Patricia Galván, Begoña Mellado, Nuria Viñolas, Tamara Sauri, Miquel Nogué, Barbara Adamo, Joan Maurel, Estela Pineda, Lydia Gaba, Oscar Reig, Neus Basté, Esther Sanfeliu, Manel Juan, Aleix Prat, Francesco Schettini

“…Retaining a good LIPI or experiencing a shift towards a better prognostic class was associated to improved OS (p = 0.009) and PFS (p = 0.006). …”
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High SUVs Have More Robust Repeatability in Patients with Metastatic Prostate Cancer: Results from a Prospective Test-Retest Cohort Imaged with 18F-DCFPyL by Rudolf A. Werner, Bilêl Habacha, Susanne Lütje, Lena Bundschuh, Takahiro Higuchi, Philipp Hartrampf, Sebastian E. Serfling, Thorsten Derlin, Constantin Lapa, Andreas K. Buck, Markus Essler, Kenneth J. Pienta, Mario A. Eisenberger, Mark C. Markowski, Laura Shinehouse, Rehab AbdAllah, Ali Salavati, Martin A. Lodge, Martin G. Pomper, Michael A. Gorin, Ralph A. Bundschuh, Steven P. Rowe

“…Moreover, LN-based SUVmean also achieved the best wCOV (3.8%), which was significantly reduced when compared to osseous lesions (7.8%, P<0.0001). This was also noted for SUVmax (wCOV, LN 8.8% vs. bone 12.0%, P<0.03). …”
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Whole-genome sequencing reveals transmission pattern and drug resistance of Mycobacterium tuberculosis intra- or inter-hosts by Feng Ding, Wanfei Liu, Chi Wu, Chi Wu, Wensi Zhang, Shuyan Chen, Shuyan Chen, Wenjie Lai, Wenjie Lai, Jiayao Qu, Jiayao Qu, Qiang Lin, Shuihua Lu, Jiuxin Qu, Jiuxin Qu

“…Drug susceptibility testing (DST) was performed using both phenotypic DST (pDST) and molecular DST (mDST). …”
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Design and validation of a questionnaire on habits, health and exercise in the use of baby carriers by Yaiza Taboada-Iglesias, María del Carmen Iglesias-Pérez, Águeda Gutiérrez-Sánchez

“…Introduction: Understanding the characteristics and implications of the use of baby carriers can help health care providers understand the habits of their patients and provide guidance to improve quality of life in both children and caregivers. The aim of our study was to design and validate the first self-administered questionnaire to assess babywearing habits and their impact on health and physical activity as a means to monitor musculoskeletal complaints in caregivers. …”
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The effects of self-management intervention based on Information-Motivation-Behavioral model in patients receiving targeted therapy for lung cancer (基于IMB模型的自我管理干预在肺癌靶向治疗患者中的应用)... by ZHANG Junli (张俊丽), ZHAO Jian (赵健), JING Dan (井丹), AN Juan (安娟), HAN Lijun (韩丽军)

“…Results The scores of disease knowledge questionnaire, Strategies Used by People to Promote Health (SUPPH)and Generic Quality of Life Inventory-74 (GQOLI-74) were decreased in both two groups after intervention, and scores of relevant assessment in the study group were higher than those in the control group(P＜0. 05). …”
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Marine sponge symbiotic bacterial bioremediation against heavy metal pollutants in tiger prawns; Penaeus monodon culture medium by I. Marzuki, I. Pratama, R. Asaf, A. Athirah, K. Nisaa, N. Nurbaya, M. Muslimin, N. Nurhidayah, S. Suwardi, A. Sahrijanna, K. Kamaruddin

“…The health of the tiger prawns was evaluated by observing signs of tissue damage.FINDINGS: Among all the treatments, Treatment I with copper ion exposure had the highest average specific growth rate of the tiger prawns in terms of weight and body length, followed by Treatment II with lead ion exposure and Treatment III with a combination of both pollutants (the lowest). The intersection of copper and lead ion concentrations in the tiger prawns and cultivation media occurred in the cultivation period of 15–20 days. …”
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A meta-analysis of randomized controlled trials: evaluating the efficacy of isokinetic muscle strengthening training in improving knee osteoarthritis outcomes by Wanqin Guo, Jingyang Gao, Dawazhuoma, Xiuling Mi, Ciwang, Bianba

“…We systematically reviewed the RCTs in both Chinese and English and evaluated the quality of the included literature. …”
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El rol de los actores sociales y sus implicancias en la configuración territorial de Moquehue, Neuquén, Argentina by Celia Viviana Torrens, Elsie Marcela Jurio, Vanesa Yanina Cappelletti, Germán Gabriel Pérez, Daiana Elcira Cara Plá, Gimena Nathalie Cuevas, María Silvina Hauw, Pablo Alejandro Leyes

“…A partir de estas actividades se inicia el poblamiento permanente de la zona y aparecen los primeros comercios, a fin de cubrir las nuevas demandas. La naturaleza dotó a la región de una belleza paisajística que es puesta en valor desde la década del ́70, cuando la población de localidades cercanas empieza a usufructuar turísticamente la región. …”
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Combining Innovative Bioink and Low Cell Density for the Production of 3D-Bioprinted Cartilage Substitutes: A Pilot Study by Christel Henrionnet, Léa Pourchet, Paul Neybecker, Océane Messaoudi, Pierre Gillet, Damien Loeuille, Didier Mainard, Christophe Marquette, Astrid Pinzano

“…ECM synthesis was maximal on D56 for both glycosaminoglycans and type II collagen, particularly in the presence of a combination of TGF-β1 and BMP-2. …”
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Impact of HER2 Expression on the Prognosis of Muscle-Invasive Bladder Cancer Patients Treated with Bladder-Preservation Comprehensive Therapy by Yatong Chen, Fei Luo, Tingji Zhang, Jian Li

“…The incidence rates of any-grade and grade ≥ 3 adverse reactions were both lower in the RC48-ADC group than in the GC treatment group. …”
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Factors associated with non-response and nutritional status of non-responders at 6-month post-discharge: a cohort study nested in a MUAC-based nutrition programme for acutely malno... by Maguy Daures, Jérémie Hien, Cécile Cazes, Rodrigue Alitanou, Laure Saillet, Benjamin Séri, Ahmad Ag Mohamed Aly, Oumarou Maidadji, Atté Sanoussi, Aboubacar Mahamadou, Mathias Altmann, Kevin Phelan, Renaud Becquet, Susan Shepherd

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