Knockout of <i>dhx38</i> Causes Inner Ear Developmental Defects in Zebrafish by Mengmeng Ren, Xiang Chen, Liyan Dai, Jiayi Tu, Hualei Hu, Xiaohan Sun, Jiong Luo, Pei Li, Yiyang Fu, Yuejie Zhu, Weiqiang Sun, Zhaohui Tang, Mugen Liu, Xiang Ren, Qunwei Lu

“…Disruptions in this process can result in both syndromic and non-syndromic forms of hearing loss. …”
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Comparison of Hyperbaric 0.5% Levobupivacaine and Hyperbaric 0.75% Ropivacaine for Intrathecal Use in Infraumbilical Surgeries: A Randomised Clinical Study by Tejash H Sharma, Jagrati Jain, Priya Kishnani, Richa Tailor, Sara Mary Thomas

“…The sedative effects, arterial oxygen saturation (SpO2) and respiratory rate were comparable in both groups. Intraoperatively, haemodynamics were more stable in Group-R compared to Group-L. …”
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SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors by Raymond Cespuglio, Anna Gorlova, Konstantin Zabegalov, Kirill Chaprov, Evgeniy Svirin, Kseniia Sitdikova, Alisa Burova, Boris Shulgin, Ksenia Lebedeva, Alexei V. Deikin, Sergey Morozov, Tatyana Strekalova

“…Background: The inheritance of the short SLC6A4 allele, encoding the serotonin transporter (SERT) in humans, increases susceptibility to neuropsychiatric and metabolic disorders, with aging and female sex further exacerbating these conditions. Both central and peripheral mechanisms of the compromised serotonin (5-HT) system play crucial roles in this context. …”
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Evaluation de la qualité de vie des femmes souffrant d’une fistule obstétricale à Kinshasa [Evaluation of the quality of life of women with obstetric fistula in Kinshasa] by Jonathan Enguta Mwenzi, Ruth Bukabau Babuya, Francine Manyonga Sabowa

“…English Abstract: Background-Obstetric fistula is a major maternal health problem that significantly affects women both physically and mentally. The objective of the study was to assess the quality of life of women with obstetric fistula and to identify the socio-demographic factors. …”
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Identification of PET/CT radiomic signature for classification of locally recurrent rectal cancer: A network-based feature selection approach by Sara Dalmonte, Maria Adriana Cocozza, Dajana Cuicchi, Daniel Remondini, Lorenzo Faggioni, Paolo Castellucci, Andrea Farolfi, Emilia Fortunati, Alberta Cappelli, Riccardo Biondi, Arrigo Cattabriga, Gilberto Poggioli, Stefano Fanti, Gastone Castellani, Francesca Coppola, Nico Curti

“…Our results confirmed the efficiency of radiomic features in predicting LRRC, with CT features outperforming PET features in identifying the characteristic texture of LRRC. The combination of both yielded no performance improvement.…”
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Dynamics of Somatic and Comorbid Mental Disorders (Distress, Anxiety, Somatisation and Depression) in Patients with Irritable Bowel Syndrome during Therapy with Alimemazine: Result... by V. T. Ivashkin, O. Z. Okhlobystina, M. V. Mayevskaya, O. S. Shifrin, Z. A. Mamieva, Yu. E. Azimova

“…The Four-Dimensional Symptom Questionnaire (4DSQ) was used to assess the dynamics and effectiveness of the treatment in terms of the patients’ mental state, while the “7 symptoms per 7 days” (“7 × 7”) questionnaire was used to assess the dynamics of IBS symptoms and concomitant functional dyspepsia (FD). Both questionnaires were offered to the patients three times: before the start of the treatment and following 2 and 4 weeks of the therapy.Results. …”
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Colonic Oxidative and Mitochondrial Function in Parkinson’s Disease and Idiopathic REM Sleep Behavior Disorder by C. Morén, Í. González-Casacuberta, J. Navarro-Otano, D. Juárez-Flores, D. Vilas, G. Garrabou, J. C. Milisenda, C. Pont-Sunyer, M. Catalán-García, M. Guitart-Mampel, E. Tobías, F. Cardellach, F. Valldeoriola, A. Iranzo, E. Tolosa

“…Nonsignificant trends to CI decrease in both iRBD (45.69±18.15; 23% decrease) and PD patients (37.57±12.41; 37% decrease) were found compared to controls (59.51±12.52, p: NS). …”
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Global research trends in Chinese medicine for the treatment of non-alcoholic fatty liver disease (NAFLD): A bibliometric study by Kangjie li, Jie Wang, Ming Dang, Runxin Ren, Maomao Fu, Jing Wang, Qiao Zhang, Chongbo Zhao

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Incidence of type 2 diabetes and metabolic syndrome by Occupation – 10-Year follow-up of the Gutenberg Health Study by Juliane Bauer, Janice Hegewald, Karin Rossnagel, Sylvia Jankowiak, Michaela Prigge, Julian Chalabi, Matthias Nübling, Alice Freiberg, Merle Riechmann-Wolf, Pavel Dietz, Philipp S. Wild, Thomas Koeck, Manfred E. Beutel, Norbert Pfeiffer, Karl J. Lackner, Thomas Münzel, Konstantin Strauch, Philipp Lurz, Oliver Tüscher, Julia Weinmann-Menke, Stavros Konstantinides, Andreas Seidler

“…There was also a high incidence of both type 2 diabetes and metabolic syndrome in “cleaners” (16.5% and 34.8%) and “drivers and mobile plant operators” (14.8% and 41.2%). …”
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Automatic approach-avoidance tendency toward physical activity, sedentary, and neutral stimuli as a function of age, explicit affective attitude, and intention to be active by Farajzadeh, Ata, Goubran, Miriam, Beehler, Alexa, Cherkaoui, Noura, Morrison, Paula, de Chanaleilles, Margaux, Maltagliati, Silvio, Cheval, Boris, Miller, Matthew W., Sheehy, Lisa, Bilodeau, Martin, Orsholits, Dan, Boisgontier, Matthieu P.

“…Taken together, these results suggest that both age and explicit attitudes can affect the general tendency to approach physical activity stimuli and to avoid sedentary stimuli. …”
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The practice and exploration of SPOC-based online-offline mixed teaching mode in Traditional Chinese Medicine nursing teaching (基于SPOC的线上-线下混合式教学模式在中医护理教学中的实践与探索)... by WANG Li (王黎), MA Xueling (马雪玲), WANG Zhen (王臻), CHEN Hong (陈宏), WENG Zhiwen (翁志文), WANG Junxiang (王俊翔)

“…In addition, interview was conducted to several students who were taught with online-offline mixed teaching mode, which means the effects of online-offline mixed teaching mode were evaluated from both subjective and objective perspectives. Results Before and after the implementation of the online-offline mixed teaching mode, there were significant differences in students' total scores (P<0. 01), formative assessment scores (P<0. 05) and operational assessment scores (P<0. 01), while there were no significant differences in summative assessment scores, daily homework scores and experimental report scores (P>0. 05). …”
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Topological Analysis of Brain Glucose Metabolic Connectivity Networks of Patients with Type 2 Diabetes Mellitus Combined with Mild Cognitive Impairment by LIANG Shengxiang, YANG Junchao, ZHANG Yusi, YIN Xiaolong, HUANG Li, LI Zuanfang

“…Mini-mental state examination (MMSE) score, everyday cognition: the patient-reported memory (EcogPtMem) score, everyday cognition: the study partner-reported memory (EcogSPMem) score, and fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET) images of both groups were included from the ANDI database. …”
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Differential Role of NKG2A/HLA-E Interaction in the Outcomes of Bladder Cancer Patients Treated with <i>M. bovis</i> BCG or Other Therapies by Inmaculada Ruiz-Lorente, Lourdes Gimeno, Alicia López-Abad, Pedro López Cubillana, Tomás Fernández Aparicio, Lucas Jesús Asensio Egea, Juan Moreno Avilés, Gloria Doñate Iñiguez, Pablo Luis Guzmán Martínez-Valls, Gerardo Server, Belén Ferri, José Antonio Campillo, María Victoria Martínez-Sánchez, Alfredo Minguela

“…<b>Background</b>: Immunotherapy is gaining great relevance in both non-muscle-invasive bladder cancer (NMIBC), with the use of bacille Calmette–Guerin (BCG), and in muscle-invasive BC (MIBC) with anti-checkpoint therapies blocking PD-1/PD-L1, CTLA-4/CD80-CD86, and, more recently, NKG2A/HLA-E interactions. …”
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Stratégies de manipulation d'outil chez les humains et les bonobos by Ameline Bardo, Anthony Borel, Helene Meunier, Mathilde Lemaire, Emeline Lempereur, Jean Pascal Guery, Emmanuelle Pouydebat

“…La main humaine est considérée comme unique au travers certaines spécificités fonctionnelles comme l’individualisation des doigts et la capacité de saisir avec puissance un outil entre le pouce et le côté latéral de l'index. Cependant, les primates non-humains présentent de grandes capacités de manipulations. …”
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Assessing Facial Thermal Nociceptive Response in Female Dogs After Elective Ovariohysterectomy Anesthetized with Isoflurane and Treated with Cannabidiol and Meloxicam Analgesia by Alejandro Casas-Alvarado, Patricia Mora-Medina, Ismael Hernández-Avalos, Julio Martínez-Burnes, Agatha Miranda-Cortes, Adriana Domínguez-Oliva, Daniel Mota-Rojas

“…G1: Placebo group (<i>n =</i> 16); G2: Group receiving intravenous meloxicam as premedication (0.2 mg Kg⁻¹) and every 24 h postoperatively 0.1 mg Kg⁻¹ (<i>n =</i> 16); G3: Group treated with CBD (<i>n =</i> 16) at a dose of 2 mg kg⁻¹ orally every 12 h; and G4: Group medicated with the combination of both treatments (<i>n =</i> 16). All treatments were administered for 48 h postoperatively. …”
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Nursing cooperation in root canal retreatment of infected root canals (护理配合在感染根管再治疗中的应用效果) by LI Yuling (李玉玲), LUAN Xiaoyu (栾晓宇), ZHANG Weihong (张卫红), WANG Qian (王倩)

“…Conclusion A comprehensive and refined management of nursing cooperation may help shorten the operation time of root canal retreatment, reduce the risk of infection, relieve of fatigue of both dentists and patients, and improve the comfort of patient during the treatment. …”
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Differential Signature of the Centrosomal MARK4 Isoforms in Glioma by Ivana Magnani, Chiara Novielli, Laura Fontana, Silvia Tabano, Davide Rovina, Ramona F. Moroni, Dario Bauer, Stefania Mazzoleni, Elisa A. Colombo, Gabriella Tedeschi, Laura Monti, Giovanni Porta, Silvano Bosari, Carolina Frassoni, Rossella Galli, Lorenzo Bello, Lidia Larizza

“…Accordingly, only MARK4L is expressed in brain neurogenic regions. Moreover, while both MARK4 isoforms are localised to the centrosome and midbody in glioma and normal cells, the L isoform exhibits an additional nucleolar localisation in tumour cells. …”
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Exploring Future Pandemic Preparedness Through the Development of Preventive Vaccine Platforms and the Key Roles of International Organizations in a Global Health Crisis by Jihee Jeon, Eunyoung Kim

“…It should include a balanced investment in both novel technologies such as mRNA and viral vector-based vaccines and traditional platforms. …”
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Changes in the functionality of tear film and autorefractometry reading after instillations of artificial tear products of different viscosity by V.V. Brzheskiy, E.L. Efimova, M.A. Kopylova, P.V. Kocharina, A.A. Primak, V.P. Nikolaenko

“…As early as 30 sec after instillation of both artificial tear preparations, breakup-free time tended to increase, while the area of tear film destabilization tended to reduce. …”
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Prominent efficacy and good safety of sequential CD19 and CD22 CAR-T therapy in relapsed/refractory adult B-cell acute lymphoblastic leukemia by Tingting Yang, Yetian Dong, Mingming Zhang, Jingjing Feng, Shan Fu, Pingnan Xiao, Ruimin Hong, Huijun Xu, Jiazhen Cui, Simao Huang, Guoqing Wei, Delin Kong, Jia Geng, Alex H. Chang, He Huang, Yongxian Hu

“…Grade ≥ 3 hematological adverse events occurred at comparable rates after both infusions. Cytokine release syndrome was observed in 78.3% and 39.1% of patients after CD19 and CD22 CAR-T therapy, respectively. …”
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