Spatiotemporal range dynamics and conservation optimization for endangered medicinal plants in the Himalaya by Fu-Lv Liu, Winnie Wanjiku Mambo, Jie Liu, Guang-Fu Zhu, Raees Khan, Abdullah, Shujaul Mulk Khan, Lu Lu

“…Our results showed that the habitat of most medicinal plants in the Himalaya have expanded their habitat range from the Last Glacial Maximum to the present, with a substantial contraction projected in both future scenarios. Six species migrated northwards towards high elevation, while four species migrated southwards. …”
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Satisfactory Evaluation of Call Service Using AI After Ureteral Stent Insertion: Randomized Controlled Trial by Ukrae Cho, Yong Nam Gwon, Seung Ryong Chong, Ji Yeon Han, Do Kyung Kim, Seung Whan Doo, Won Jae Yang, Kyeongmin Kim, Sung Ryul Shim, Jaehun Jung, Jae Heon Kim

“…Secondary outcomes included satisfaction with the AI-assisted reassurance-call service, also measured using a Likert scale, and the level of satisfaction (Likert scale and Visual Analogue Scale [VAS]) and anxiety (State-Trait Anxiety Inventory and VAS) related to managing complications for both groups. ResultsOf the 28 recruited patients (14 in each group), 1 patient in group 2 dropped out. …”
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Tasquinimod suppresses tumor cell growth and bone resorption by targeting immunosuppressive myeloid cells and inhibiting c-MYC expression in multiple myeloma by Marie Törngren, Rong Fan, Eline Menu, Helena Eriksson, Karin Vanderkerken, Andrew Chantry, Hatice Satilmis, Niels Vandewalle, Emma Verheye, Philip Vlummens, Anke Maes, Catharina Muylaert, Elke De Bruyne, Holly Evans, Nathan De Beule, Dirk Hose, Ken Maes, Karine Breckpot, Kim De Veirman

“…We aimed to gain more insights into its mechanisms of action both on the myeloma cells and the immune microenvironment.Methods We analyzed the effects of tasquinimod on MM cell viability, cell proliferation and downstream signaling pathways in vitro using RNA sequencing, real-time PCR, western blot analysis and multiparameter flow cytometry. …”
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Early prediction of long COVID-19 syndrome persistence at 12 months after hospitalisation: a prospective observational study from Ukraine by Dmytro Chumachenko, Tetyana Chumachenko, Oleksii Honchar, Tetiana Ashcheulova

“…At 1 month postdischarge, the persisting differences included marginally higher LV GLS, mitral E/e’ ratio and significantly higher levels of both resting and exertional physical symptoms versus patients who reported complete recovery. …”
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Thermoresponsive Gels with Rosemary Essential Oil: A Novel Topical Carrier for Antimicrobial Therapy and Drug Delivery Applications by Ludovic Everard Bejenaru, Adina-Elena Segneanu, Cornelia Bejenaru, Ionela Amalia Bradu, Titus Vlase, Dumitru-Daniel Herea, Marius Ciprian Văruţ, Roxana Maria Bălăşoiu, Andrei Biţă, Antonia Radu, George Dan Mogoşanu, Maria Viorica Ciocîlteu

“…The gels were evaluated for key physicochemical properties, including pH, gelation temperature, viscosity, and rheological behavior. Both formulations exhibited thermoresponsive gelation at skin-compatible temperatures (27.6 °C and 32.9 °C), favorable pH levels (6.63 and 6.40), and shear-thinning behavior suitable for topical application. …”
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The influence of the El Niño phenomenon on appearance of large-scale forest fires and their ecological consequences by L. F. Chernogor, A. N. Nekos, G. V. Titenko, L. L. Chornohor

“…It is due to global warming, which is associated with both natural and anthropogenic phenomena and processes There is another mechanism of global impact on the weather, abnormally high summer temperatures, severity and frequency of droughts, intensity and frequency of forest fires and their consequences. …”
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The CYP4/20-HETE/GPR75 axis in the progression metabolic dysfunction-associated steatosis liver disease (MASLD) to chronic liver disease by James P. Hardwick, Byoung-Joon Song, Paul Rote, Charles Leahy, Yoon Kwang Lee, Alexandra Rudi Wolf, Danielle Diegisser, Victor Garcia

“…Bioactive arachidonic metabolites have diverse roles in the progression of MASLD. Both secreted levels of 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acid (EET) are elevated in patients with liver cirrhosis.MethodsCLD samples were evaluated for changes in free fatty acids (FFA), cholesterol, bilirubin, bile acid, reactive oxygen species (ROD), lipid peroxidation, myeloperoxidase activity and hydroxyproline levels to evaluate the degrees of liver damage and fibrosis. …”
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Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures by Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer, Heather A. Enright

“…We found that exposure to TNF-α produced both a concentration-independent and concentration-dependent response in neural activity. …”
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Impact of Enhanced Recovery After Surgery Protocol Compliance on Outcome After Pancreatic Surgery: Results From a Certified ERAS Center by Alina S. Ritter, MD, Thilo Welsch, MD, FACS, MBA, Freya Brodersen, MSc, Julia Auinger, MD, Parisa Moll-Khosrawi, MD, Mara R. Goetz, MD, Jan Bardenhagen, MD, Christine Nitschke, MD, Tobias Schneider, BSc, Björn Wellge, MD, Anna Suling, PhD, Faik G. Uzunoglu, MD, Asmus Heumann, MD, Felix Nickel, MD, Thilo Hackert, MD, Jakob R. Izbicki, MD

“…The pancreatic ERAS protocol can be sustainably implemented and applied to both, PD and non-PD cases. A high level of compliance with the ERAS protocol after pancreatic resections correlated with improved outcomes but was achieved by less than one-fifth of patients. …”
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LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer by Théophile Ponchel, Emma Loeffler, Julien Ancel, Audrey Brisebarre, Nathalie Lalun, Véronique Dalstein, Anne Durlach, Gaëtan Deslée, Stéphane Dedieu, Myriam Polette, Béatrice Nawrocki-Raby

“…Experiments of FHIT silencing showed that FHIT regulated LRP1 expression both at the mRNA and protein levels in lung cell lines. …”
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Ibero-American consensus statement on migraine treatment by José Miguel Láinez, Oscar Pradilla, Pablo Irimia, Fidel Sobrino, Michel Volcy, Pedro Kowaks, Ildefonso Rodríguez Leyva, Fiorella Martín, Lucía Zavala, Alex Espinoza

“…Conclusions: A series of recommendations were agreed upon for the treatment of episodic migraine and chronic migraine, both for the acute management of attacks and for their prevention. …”
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Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3 by Peipei Li, Zhini Zhu, Yong Wang, Xuyuan Zhang, Chuanhui Yang, Yalan Zhu, Zixuan Zhou, Yulin Chao, Yonghui Long, Yina Gao, Songqing Liu, Liguo Zhang, Pu Gao, Qianhui Qu

“…In humans, thiamine transporters SLC19A2 and SLC19A3 primarily regulate cellular uptake of both vitamins. Genetic mutations in these transporters, which cause thiamine and pyridoxine deficiency, have been implicated in severe neurometabolic diseases. …”
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Concentration-dependent effects of immunomodulatory cocktails on the generation of leukemia-derived dendritic cells, DCleu mediated T-cell activation and on-target/off-tumor toxici... by Hazal Aslan Rejeski, Hazal Aslan Rejeski, Anne Hartz, Anne Hartz, Elias Rackl, Elias Rackl, Lin Li, Lin Li, Christoph Schwepcke, Christoph Schwepcke, Kai Rejeski, Kai Rejeski, Christoph Schmid, Christoph Schmid, Andreas Rank, Andreas Rank, Jörg Schmohl, Doris Kraemer, Peter Bojko, Helga Maria Schmetzer, Helga Maria Schmetzer

“…Acute myeloid leukemia (AML) remains a devastating diagnosis in clear need of therapeutic advances. Both targeted dendritic cells (DC) and particularly leukemia-derived dendritic cells (DCleu) can exert potent anti-leukemic activity. …”
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Lattes/Lattara (Hérault), comptoir étrusque du littoral languedocien by Éric Gailledrat, Ariane Vacheret

“…Although the plans of the buildings have not yet been completely excavated, the existence of multiple-room houses, forming a rectangular insula, can be assumed. Both the metrics and the overall plan have close parallels in Etruria, and more specifically with the Fonteblanda seaport, on the Tuscan coast. …”
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Association of Sociodemographic Factors With Overtriage, Undertriage, and Value of Care After Major Surgery by Tyler J. Loftus, MD, Matthew M. Ruppert, MS, Benjamin Shickel, PhD, Tezcan Ozrazgat-Baslanti, PhD, Jeremy A. Balch, MD, Kenneth L. Abbott, MD, Die Hu, MS, Adnan Javed, MD, Firas Madbak, MD, Faheem Guirgis, MD, David Skarupa, MD, Philip A. Efron, MD, Patrick J. Tighe, MD, William R. Hogan, MD, Parisa Rashidi, PhD, Gilbert R. Upchurch, Jr, MD, Azra Bihorac, MD

“…Unique sociodemographic phenotypes within both overtriage and undertriage cohorts had similar outcomes and value of care, suggesting that triage decisions, rather than patient characteristics, drive outcomes and value of care. …”
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Effect of Different Doses of Intrathecal Nalbuphine as Adjuvant to Hyperbaric Bupivacaine on Characteristics of Subarachnoid Block in Pelvic and Lower Limb Orthopaedic Surgeries: A... by Anupama Kumari, Shraddha Jogani, Nilesh Shah, Sara Mary Thomas

“…The sedative effects, arterial oxygen saturation (SpO2) and respiratory rate were comparable in both groups. Intraoperatively, haemodynamics were more stable in Group-R compared to Group-L. …”
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Hepatocellular carcinoma risk scores for non-viral liver disease: A systematic review and meta-analysis by Laura Burke, Alexander Hinkson, Vincent Haghnejad, Rebecca Jones, Richard Parker, Ian A. Rowe

“…Impact and implications:: The recent EASL policy statement emphasises the potential of risk-based surveillance to reduce both hepatocellular carcinoma (HCC)-related deaths and surveillance costs. …”
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Integrated metabolome and transcriptome analysis reveals potential mechanism during the bud dormancy transition of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsi... by Huan Guan, Huan Guan, Yuhuan Zhao, Yuhuan Zhao, Qing Chen, Qianqian Zhang, Qianqian Zhang, Pengpeng Yang, Pengpeng Yang, Shuying Sun, Shuying Sun, Guilin Chen, Guilin Chen

“…Hsiao (AMM) is an important medicinal plant that is used for both medicine and food. It is widely used in Asia and South Asia. …”
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Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation by Ying Zhu, Jiao Li, Tao Zhang, Lei Zhao, Min Jin, Jinghua Ren, Jing Tang, Haihong Wang, Zhenyu Lin, Qing Liang, Ruiqi Li, Biying Zhang, Qingling Hua, Guojie Xu, Jiayuan Chen, Lanqing Wang, Dejun Zhang, Dandan Yu

“…We also demonstrated that CEMIP restricted CD8+ T-cell antitumor activities both in vitro and in vivo due to impaired MHC-I-mediated antigen presentation. …”
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Personalized allele-specific antisense oligonucleotides for GNAO1-neurodevelopmental disorder by Inna Shomer, Nofar Mor, Shaul Raviv, Noga Budick-Harmelin, Tanya Matchevich, Sharon Avkin-Nachum, Yoach Rais, Rebecca Haffner-Krausz, Ariela Haimovich, Aviv Ziv, Reut Fluss, Bruria Ben-Ze’ev, Gali Heimer, Denis N. Silachev, Vladimir L. Katanaev, Dan Dominissini

“…We systemically screened allele-specific antisense oligonucleotides (ASOs) targeting the mutated allele to identify a potent and specific sequence using both reporter-based platforms and a patient-derived cellular model. …”
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