Enhancing immunotherapy through PD‐L1 upregulation: the promising combination of anti‐PD‐L1 plus mTOR inhibitors by Anna Hernández‐Prat, Alejo Rodriguez‐Vida, Laura Cardona, Mengjuan Qin, Oriol Arpí‐Llucià, Luis Soria‐Jiménez, Sílvia Menendez, Fabricio Gerel Quimis, Miguel Galindo, Edurne Arriola, Marta Salido, Nuria Juanpere‐Rodero, Federico Rojo, Aura Muntasell, Joan Albanell, Ana Rovira, Joaquim Bellmunt

“…TAK‐228 promoted the secretion of epidermal growth factor (EGF) and interferon‐β (IFNβ), both linked to PD‐L1 protein induction. Blocking EGF and IFNβ receptors reversed the TAK‐228‐induced PD‐L1 increase. …”
Get full text

SO₂ emissions derived from TROPOMI observations over India using a flux-divergence method with variable lifetimes by Y. Chen, Y. Chen, R. J. van der A, J. Ding, H. Eskes, J. E. Williams, N. Theys, A. Tsikerdekis, P. F. Levelt, P. F. Levelt, P. F. Levelt

“…We present a monthly SO<span class="inline-formula">₂</span> emission inventory for India covering December 2018 to November 2023 based on the Tropospheric Monitoring Instrument (TROPOMI) Level-2 COBRA SO<span class="inline-formula">₂</span> dataset, using an improved flux-divergence method and estimated local SO<span class="inline-formula">₂</span> lifetime, which includes both its chemical loss and dry deposition. We update the methodology to use the daily CAMS model output estimates of the hydroxyl-radical distribution as well as the measured dry deposition velocity to account for the variability in the tropospheric SO<span class="inline-formula">₂</span> lifetime. …”
Get full text

Alterations in physicochemical parameters of water and the growth performance of juvenile beluga Huso huso in earthen ponds by Hashem Noferesti, Hojatollah Jafaryan, Rahman Patimar, Hossein Adineh

“…The length and weight of the digestive tract were measured in both full and empty states. Water samples were collected weekly, and physicochemical parameters were analyzed using standard methods.Results and Discussion: Temperature (12.5 to 16.6°C), turbidity (0.50 to 50.92 NTU), dissolved oxygen (10.90 to 6.25 mg/L), pH (7.62 to 8.92), alkalinity (160 to 223 mg/L), phosphate (0.17 to 0.73 mg/L), nitrate (0.24 to 1.67 mg/L), and electrical conductivity (1240 to 1342 µmhos/cm) levels for the growth of beluga were within the optimal ranges. …”
Get full text

New avenues of preoperative evaluation before corneal refractive surgery during the COVID-19 pandemic by S.N. Sakhnov, O.A. Klokova, A.V. Piskunov, R.O. Damashauskas, M.S. Geidenrich, E.I. Dyakonova

“…&nbsp;No significant differences were revealed between refractometry readings produced by Visionix VX130+ and Topcon KR-800 in patients with myopia (p&gt;0.05). Both Visionix VX130+ and Nidek NT-530P (automated IOP measurements) produce two values, i.e., with and without corneal thickness. …”
Get full text

Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer by Bin Han, Fang-yuan Mao, Yong-liang Zhao, Yi-pin Lv, Yong-sheng Teng, Mubing Duan, Weisan Chen, Ping Cheng, Ting-ting Wang, Zhong-yuan Liang, Jin-yu Zhang, Yu-gang Liu, Gang Guo, Quan-ming Zou, Yuan Zhuang, Liu-sheng Peng

“…Natural killer (NK) cell activity is influenced by a complex integration of signaling pathways activated downstream of both activating and inhibitory surface receptors. …”
Get full text

Genomic insights into genetic diversity and seed coat color change in common bean composite populations by Eva Plestenjak, Eva Plestenjak, Mohamed Neji, Lovro Sinkovič, Vladimir Meglič, Barbara Pipan

“…The Fst values indicated a strong genetic differentiation, especially between the two standard varieties ETNA and Golden_Gate (Fst = 0.704) and the composite populations. …”
Get full text

A clean energy Korea by 2035: Transitioning to 80% carbon-free electricity generation by Won Young Park, Yong Hyun Song, Nikit Abhyankar, Hee Seung Moon, Umed Paliwal, Eunsung Kim, Nina Khanna, Sanghyun Hong, James Hyungkwan Kim, Kenji Shiraishi, Jiang Lin, Seung Wan Kim, Amol Phadke

“…We find that transitioning to 80% clean electricity—comprising 50% renewables and 30% nuclear—alongside investments in storage and transmission is both economically desirable and operationally feasible. …”
Get full text

Active ingredients and mechanisms of peony seed blended oil in diabetes treatment using Kunming mice: Insights from GC–MS, network pharmacology, and experimental verification by Yuning Gu, Fengliang Zhong, Tiantian Sun, Zirui Chang

“…Canola oil, with a higher level of Omega-3 polyunsaturated fatty acids, helps soften blood vessels and can prevent atherosclerosis, offering benefits for both cardiovascular and cerebrovascular health. Blending these oils can create a synergistic effect, maximizing their health benefits. …”
Get full text

The Impact of Fermented Quinoa Sourdough with Enterococcus Strains on the Nutritional, Textural, and Sensorial Features of Gluten-Free Muffins by Souraya Sakoui, Reda Derdak, Fatimazahra Jouga, Amal Dagni, Oana Lelia Pop, Dan Cristian Vodnar, Bernadette-Emőke Teleky, Maria Simona Chis, Carmen Rodica Pop, Laura Stan, Floricuta Ranga, Ramona Suharoschi, Abdelaziz Soukri, Bouchra El Khalfi

“…Gluten-free baked goods exhibit reduced texture and taste characteristics compared to their gluten-containing counterparts. …”
Get full text

A dataset of Zostera marina and Zostera noltei structure and functioning in four sites along the French coast over a period of 18 months by Lacoste, Elise, Ouisse, Vincent, Desroy, Nicolas, Allano, Lionel, Auby, Isabelle, Bajjouk, Touria, Bourdier, Constance, Caisey, Xavier, De Casamajor, Marie-Noelle, Cimiterra, Nicolas, Cordier, Céline, Curd, Amélia, Derrien, Lauriane, Droual, Gabin, Dubois, Stanislas, Foucault, Elodie, Foveau, Aurélie, Gaffet, Jean-Dominique, Ganthy, Florian, Gionaroli, Camille, Ignacio-Cifre, Rachel, Liabot, Pierre-Olivier, Messiaen, Gregory, Meteigner, Claire, Monnier, Benjamin, Van Paemelen, Robin, Pasquier, Marine, Rigouin, Loic, Rollet, Claire, Royer, Aurélien, Soissons, Laura, Tancray, Aurélien, Blanchet-Aurigny, Aline

“…As the most comprehensive and broadscale French dataset on seagrass structure and functioning  to date, it is useful for both data analysis and management actions.…”
Get full text

Factors Affecting Influenza and Pneumococcal Vaccination Rates in Hemodialysis Patients: A Multicenter Study by Selen T, Merhametsiz Ö, Öneç K, Ercan Z, İslam M, Altun G, Pınar M, Demir ME

“…There were 220 patients (20.1%) who had knowledge about both vaccines. Among the patients, 95 (17.3%) had received the pneumococcal vaccine, with 41.1% of them having received it five years ago or more. …”
Get full text

A Promising Approach to Ultra‐Flexible 1 Ah Lithium–Sulfur Batteries Using Oxygen‐Functionalized Single‐Walled Carbon Nanotubes by Junyoung Heo, Jeong‐Won Hong, Ha Won Gu, Junghwan Sung, Dong‐Hee Kim, Jung Hoon Kim, Sung Kang, You‐Jin Lee, Hye Young Choi, Doohun Kim, Kang‐Jun Baeg, Joong Tark Han, Jun‐Woo Park

“…Employing Ox‐SWCNTs in both cathodes and interlayers, the study achieves high‐capacity Li‐S pouch cells that consistently deliver a capacity of 1.06 Ah and a high energy density of 909 mAh g−1 over 50 charge‐discharge cycles. …”
Get full text

Brain iron deposition and cognitive decline in patients with cerebral small vessel disease : a quantitative susceptibility mapping study by Yian Gao, Changhu Liang, Qihao Zhang, Hangwei Zhuang, Chaofan Sui, Nan Zhang, Mengmeng Feng, Haotian Xin, Lingfei Guo, Yi Wang

“…Abstract Background Quantitative susceptibility mapping (QSM) can study the susceptibility values of brain tissue which allows for noninvasive examination of local brain iron levels in both normal and pathological conditions. Purpose Our study compares brain iron deposition in gray matter (GM) nuclei between cerebral small vessel disease (CSVD) patients and healthy controls (HCs), exploring factors that affect iron deposition and cognitive function. …”
Get full text

Standardization of the Agar Plate Method for Bacteriophage Production by Su Jin Jo, Young Min Lee, Kevin Cho, Seon Young Park, Hyemin Kwon, Sib Sankar Giri, Sung Bin Lee, Won Joon Jung, Jae Hong Park, Mae Hyun Hwang, Da Sol Park, Eun Jae Park, Sang Wha Kim, Jin Woo Jun, Sang Guen Kim, Ji Hyung Kim, Se Chang Park

“…Furthermore, its adaptability across different conditions and phages positions it as a potential standard tool for rapid and precise phage screening and propagation in both clinical and industrial settings.…”
Get full text

Clinical characteristics and prognosis of amyopathic dermatomyositis patients with interstitial lung disease: insights from a retrospective cohort by Yanan Ying, Tingting Wu, Long Wang, Yun Zhang, Yiming Yu, Zaichun Deng, Qunli Ding

“…The ADM with organizing pneumonia (OP) group (n = 23) had a greater percentage of females (7/16, p = 0.023) and higher alanine aminotransferase (30.30 ± 20.67 U/L, p = 0.039) and aspartate aminotransferase (53.35 ± 65.86 U/L, p = 0.003) levels than the control-OP group (n = 29). Both the ADM-NSIP and OP groups presented elevated lactate dehydrogenase (LDH) levels (290.61 ± 86.49 U/L, p = 0.009; 317.35 ± 181.32 U/L, p = 0.003, respectively) and increased anti-nuclear antibody (ANA) positivity rates (82.61%, p = 0.01; 73.91%, p < 0.001, respectively). …”
Get full text

Identification of common and specific fibrosis-related genes in three common chronic kidney diseases by Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong

“…Quantitative real-time PCR (qRT-PCR) was performed to validate the expression of the selected genes.Results Protein tyrosine phosphatase receptor type C (PTPRC), intercellular cell adhesion molecule-1 (ICAM1), vascular cell adhesion molecule-1 (VCAM1), interleukin 10 receptor alpha (IL10RA) and CC chemokine receptor 2 (CCR2) were identified as the potential common genes for kidney fibrosis in different types of CKD, while peroxisome proliferator-activated receptor alpha (PPARA), lactate oxidase (LOX), secreted phosphoprotein 1 (SPP1) were identified as the specific fibrosis-associated genes for DN, IgAN and MN respectively. qRT-PCR demonstrated that the expression levels of these selected genes were consistent with the NanoString analysis.Conclusions There were both commonalities and differences in the mechanisms of fibrosis in different types of CKD, the commonalities might be used as the common therapeutic targets for kidney fibrosis in CKD, while the differences might be used as the diagnostic markers for DN, IgAN and MN respectively. …”
Get full text

The natural immune molecules urinary Tamm–Horsfall protein and pentraxin 3 as predictors for recurrent urinary tract infection severity: a single-center self-control study by Zongping Li, Yingru Xu, Qian Wang, Gang Yuan, Jing Shu, Shiwei Liu, Xuezhong Gong

“…Urinary PTX3 levels decreased post-treatment in both groups after treatment than before (CLAT: 0.30 ± 0.13 vs. 1.04 ± 0.38; TLF: 0.29 ± 0.12 vs. 1.15 ± 0.36). …”
Get full text

FDFT1 inhibits macrophage M1 polarization and promotes colorectal cancer progression by GAO Yuan, HUANG Yulan, ZHAO Kun

“…There were no statistical differences in the proliferation, apoptosis and migration of MC38 cells in the control group (OE-NC and sh-NC) and the cells of the FDFT1 overexpression group and FDFT1 knockdown group (P>0.05). In both the subcutaneous tumor-bearing model and the model of intraperitoneal metastatic tumor, the mass weight was significantly heavier in the OE-FDFT1 group than the OE-NC group (P<0.01), and was notably smaller in the sh-FDFT1 group than the sh-NC group (P<0.01). …”
Get full text

A novel approach to digital characterisation of Tertiary Lymphoid Structures in colorectal cancer by Luis Munoz-Erazo, Luis Munoz-Erazo, Saem Mul Park, Saem Mul Park, Shelly Lin, Shelly Lin, Chun-Jen J. Chen, Chun-Jen J. Chen, Lisa Y. Y. Zhou, Lisa Y. Y. Zhou, Janet L. Rhodes, Janet L. Rhodes, Taesung Jeon, Sonya Fenton, John L. McCall, Roslyn A. Kemp, Roslyn A. Kemp, P. Rod Dunbar, P. Rod Dunbar

“…Multiplexed staining for CD20, CD3, CD8, Foxp3 and Ki-67 enabled us to identify B-cells, CD8+ T-cells, Foxp3– CD4 T-cells, and Foxp3+ CD4 Tcells in all sections, and quantify both the presence of these cell subsets in lymphocytic clusters and their degree of proliferation within those clusters.ResultsIn total we identified 524 lymphocytic clusters with morphology consistent with TLS. …”
Get full text

Implementing a Common Data Model in Ophthalmology: Mapping Structured Electronic Health Record Ophthalmic Examination Data to Standard Vocabularies by Justin C. Quon, MD, Christopher P. Long, MD, William Halfpenny, MBBS, MEng, Amy Chuang, MS, Cindy X. Cai, MD, MS, Sally L. Baxter, MD, MSc, Vamsi Daketi, MS, Amanda Schmitz, BS, Neil Bahroos, MS, Benjamin Y. Xu, MD, PhD, Brian C. Toy, MD

“…We identify specific subject categories that may benefit from increased granularity in the OMOP CDM and provide suggestions for facilitating consistency of standard concepts, with the goal of improving data standards in ophthalmology. …”
Get full text