Prediction and Treatment of Difficult Cases in Colorectal Endoscopic Submucosal Dissection by Yutaka Inada, Naohisa Yoshida, Munehiro Kugai, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Hideyuki Konishi, Nobuaki Yagi, Yuji Naito, Naoki Wakabayashi, Akio Yanagisawa, Yoshito Itoh

“…Furthermore, we divided all cases into 5 periods according to experience of ESDs and investigated the rates of difficult and perforation cases. Results. In view of both procedure time and procedure speed, there were significant differences about mean tumor size, rates of severe fibrosis and perforation, and en bloc resection rate between the two groups. …”
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Cell culture expansion media choice affects secretory, protective and immuno-modulatory features of adipose mesenchymal stromal cell-derived secretomes for orthopaedic applications by Enrico Ragni, Andrea Papait, Michela Maria Taiana, Paola De Luca, Giulio Grieco, Elsa Vertua, Pietro Romele, Cecilia Colombo, Antonietta Rosa Silini, Ornella Parolini, Laura de Girolamo

“…The aim of this study is therefore to evaluate, in the OA context, the differences in secretome composition and potential after adipose-MSCs (ASCs) cultivation in both standard (FBS and hPL) and two next generation (S/X) GMP-ready supplements. …”
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Multimodal data deep learning method for predicting symptomatic pneumonitis caused by lung cancer radiotherapy combined with immunotherapy by Mingyu Yang, Jianli Ma, Chengcheng Zhang, Liming Zhang, Jianyu Xu, Shilong Liu, Jian Li, Jiabin Han, Songliu Hu

“…The clinical information model based on RF had an AUC of 0.525, with a 95% confidence interval of 0.479-0.572. When both radiomic features and clinical information were combined in a model based on RF, the AUC improved slightly to 0.611, with a 95% confidence interval of 0.566-0.652.ConclusionsIn this study, a deep neural network-based multimodal fusion model improved the prediction performance compared to traditional radiomics. …”
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Bioactive Molecules from the Invasive Blue Crab <i>Callinectes sapidus</i> Exoskeleton: Evaluation of Reducing, Radical Scavenging, and Antitumor Activities by Francesco Longo, Alessandro Attanzio, Laura Marretta, Claudio Luparello, Serena Indelicato, David Bongiorno, Giampaolo Barone, Luisa Tesoriere, Ilenia Concetta Giardina, Giulia Abruscato, Manuela Perlotti, Lucie Branwen Hornsby, Vincenzo Arizza, Mirella Vazzana, Aiti Vizzini, Chiara Martino, Angelica Listro, Vinicius Queiroz, Antonio Fabbrizio, Paolo Salvatore Francesco Ciaccio, Stella Maria Cascioferro, Francesca Di Gaudio, Manuela Mauro

“…No significant differences were observed among the tested biomolecules in their activity in scavenging the radical 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). Both bio-phenolic compounds and astaxanthin exhibited dose-dependent cytotoxicity on CaCo-2 (IC₅₀ = 12.47 and 18 µg/mL) and HepG2 (IC₅₀ = 10.25 and 1.26 µg/mL) cell lines, while only bio-phenols showed no cytotoxic effect on differentiated CaCo-2 cells up to 20 µg/mL. …”
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Acceptability and feasibility of two interventions in the MooDFOOD Trial: a food-related depression prevention randomised controlled trial in overweight adults with subsyndromal sy... by Ulrich Hegerl, Edward Watkins, Miquel Roca, Matthew Owens, Mariska Bot, Ingeborg Annemarie Brouwer, Elisabeth Kohls, Brenda Penninx, Gerard van Grootheest, Mieke Cabout, Margalida Gili, Marjolein Visser, Bep Verkerk, Nadine Paans, Carisha Thesing, Deborah Gibson-Smith, Melany Horsfall, Lena Weiss, Amy Romijn, Hannah Bunce, Owain Winfield, Harriet Bunker-Smith, Fern Durbridge, Caterina Versari Molinares, Atikah Sapar, Miquel Tortella, Clara Homar Covas, M Angeles Pérez-Ara, Adoración Castro Gracia, José Luis Reig, Jana Hoesel, Ezgi Dogan, Sabrina Baldofski, Nicole Mauche

“…There were statistically significant reductions in depressive symptoms for those who both adhered to the F-BA intervention and had a history of depression (B=−0.08, SE=0.03, p=0.012) versus those who had no history of depression. …”
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Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling by Katherine A. Kentistou, Brandon E. M. Lim, Lena R. Kaisinger, Valgerdur Steinthorsdottir, Luke N. Sharp, Kashyap A. Patel, Vinicius Tragante, Gareth Hawkes, Eugene J. Gardner, Thorhildur Olafsdottir, Andrew R. Wood, Yajie Zhao, Gudmar Thorleifsson, Felix R. Day, Susan E. Ozanne, Andrew T. Hattersley, Stephen O’Rahilly, Kari Stefansson, Ken K. Ong, Robin N. Beaumont, John R. B. Perry, Rachel M. Freathy

“…We identify 9 genes; 5 with fetal-only effects on birth weight, 1 with maternal-only effects, 3 with both, and observe directionally concordant associations in an independent sample. …”
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Dietary calcium intake in primary hyperparathyroidism and in its normocalcemic variant: a case-control study by Nicolò Bisceglia, Nicolò Bisceglia, Matteo Malagrinò, Matteo Malagrinò, Anna Piazza, Anna Piazza, Giulia Vandi, Giulia Vandi, Andrea Repaci, Uberto Pagotto, Uberto Pagotto, Guido Zavatta, Guido Zavatta

“…NHPT diagnosis was based on multiple determinations of both total and albumin-corrected serum calcium.InterventionsAdministration of all the following during routine endocrine consultation: a country-specific food-frequency questionnaire (LOC), the International Osteoporosis Foundation Calcium Calculator (IOF) and the National Osteoporosis Foundation calcium questionnaire (NOF).Main outcome measuresAny association between dietary calcium intake and clinical, radiological, or biochemical features.ResultsAll three questionnaires confirmed that NHPT patients had similar calcium intake as those with PHPT or controls. …”
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L’ensemble monumental du Pâtis à Vieillevigne (Loire-Atlantique) : un nouvel exemple de complexe sur cour laténien en Gaule by Yann Dufay-Garel, Marie Grall, Sandrine Paradis-Grenouillet, Rémy Wassong

“…The building was accessed via two imposing gates located in the centre of its western and eastern wings, in line with the entrances to the enclosure. …”
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Dynamics of endothelial function in patients with arterial hypertension with different cardiovascular risk against the background of antihypertensive therapy by N.O. Pertseva, T.S. Turlyun, N.A. Sanina

“…In patients of subgroup 1a (n=29) and subgroup 2a (n=35) – the main subgroups – the therapy necessarily included the angiotensin II receptor antagonist losartan potas­sium in a dosage of 50-150 mg/day, depending on the blood pressure level. …”
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A Turbo‐Charging System‐Like Contrast Agent for MRI‐Guided STING Pathway‐Activated Cancer Immunotherapy by Bin Ren, Sihua Yan, Zongheng Li, Ya Huang, Haobin Cai, Jing Yang, Qingdeng Fan, Chunmei Chen, Fanchao Que, Guochao Wu, Lin Huang, Ruilong Zhou, Jiaoyang Zhu, Chenggong Yan, Gang Liu, Zheyu Shen, Shipeng Ning

“…Poly(acrylic acid) (PAA) is used to coordinate with Gd3+, forming a Gd/PAA macrochelate. Both Gd/PAA macrochelate and SR717 are conjugated to cystamine (CA) to obtain SR717‐CA@Gd/PAA self‐assembled nanoparticles (SAN), which are termed as Turbo S because of its similarity with the Turbo‐charging system of cars. …”
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Atmospheric oxidation of 1,3-butadiene: influence of seed aerosol acidity and relative humidity on SOA composition and the production of air toxic compounds by M. Jaoui, K. Nestorowicz, K. Nestorowicz, K. J. Rudzinski, M. Lewandowski, T. E. Kleindienst, J. Torres, E. Bulska, W. Danikiewicz, R. Szmigielski

“…Total secondary organic carbon and carbon yield decreased with increasing RH under both acidified and non-acidified seed conditions. …”
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Acceptability, feasibility, and effectiveness of internet-based cognitive behavior therapy for obsessive–compulsive disorder (OCD-NET): a naturalistic pilot trial during the COVID-... by Elisabeth Kohls, Sabrina Baldofski, Julia Scholl, Oskar Flygare, Lina Lundström, Ursula Beyrich-Kolbus, Marc Steinbrecher, Christian Rück, Christine Rummel-Kluge

“…Abstract Background Cognitive behavior therapy (CBT) is the gold-standard treatment for obsessive–compulsive disorder (OCD). …”
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Identification of an immunological signature of long COVID syndrome by Gisella Guerrera, Manolo Sambucci, Eleonora Timperi, Mario Picozza, Andrea Misiti, Andrea Misiti, Roberta Placido, Silvia Corbisiero, Silvia D’Orso, Andrea Termine, Carlo Fabrizio, Francesca Gargano, Sharon Eleuteri, Luisa Marchioni, Veronica Bordoni, Luigi Coppola, Marco Iannetta, Chiara Agrati, Giovanna Borsellino, Luca Battistini

“…This analysis assessed both innate and adaptive immune features, identifying potential biomarkers for LC syndrome. …”
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Trends in infections detected in women with cervicitis over a decade by Lenka A. Vodstrcil, Lenka A. Vodstrcil, Lenka A. Vodstrcil, Erica L. Plummer, Erica L. Plummer, Thuy Vy Nguyen, Thuy Vy Nguyen, Christopher K. Fairley, Christopher K. Fairley, Eric P. F. Chow, Eric P. F. Chow, Eric P. F. Chow, Tiffany R. Phillips, Tiffany R. Phillips, Catriona S. Bradshaw, Catriona S. Bradshaw, Catriona S. Bradshaw

“…Of the 665 (82%) cases tested for all four infections, 268 (40%) had one infection and 73 (11%) had &gt;1 infection detected. Of the 517/665 (78%) non-chlamydial/non-gonococcal cases, 164 (32%) had BV and 16 (3%) had M. genitalium as the sole infections detected; a further 13 cases (3%) were co-infected with BV and M. genitalium. …”
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La nécropole de Vannes/Darioritum : données inédites sur les pratiques funéraires armoricaines dans un secteur occupé du ier au ive s. apr. J.-C. by Annaïg Le Martret, Marie Grall, Vanessa Brunet

“…At Vannes, it seems that both practices remained in use, albeit to a very limited degree, throughout the life of the necropolis. …”
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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain bacteria, potentially causing sticky stool by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

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Study on the effect of Chinese herbal medicine stick beating therapy on the motor function and activity of daily living of stroke patients in convalescent period (药棒循经敲打对脑卒中恢复期患者肢体... by LI Chunhong (李春红)

“…Results Scores of BI and Fugl-Meyer scale increased in both groups after intervention, and Scores of BI and Fugl-Meyer scale in the observation group were higher than those in the control group(P＜0. 05). …”
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Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection by Ning Zhou, Jingchen Yu, Xujiao Liu, Chengxi Li, Huang Tang, Lin Lyu, Chengwei Wu, Yana Chen, Jian Zhang, Jinjing Ni, Danni Wang, Jing Tao, Wenjuan Wu, Yu Zhang, Yun Feng, Yanjie Chao, Jie Lu, Ping He, Yu-Feng Yao

“…Summary: As an opportunistic pathogen, Pseudomonas aeruginosa can cause both acute and chronic infections that are notoriously difficult to treat. …”
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Progress of research on aviation kerosene preparation using bioethanol by Pan LI, Yu ZHAO, Xingguo WU, Lulu ZHANG, Junhao HU, Wei CHEN, Jing BAI, Chun CHANG, Shuqi FANG

“…Biobased aviation kerosene can be classified into the following types according to its production technology: oil to jet (OTJ), gas to jet (GTJ), alcohol to jet (ATJ), and sugar to jet (STJ) fuels. …”
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Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer by Lulu Zhang, Lulu Zhang, Xiyuan Guo, Xiyuan Guo, Xiaoke Sun, Jue Liao, Qin Liu, Yingchun Ye, Zhihui Yang, Ratchada Cressey, Qing He, Qing Yuan, Qing Yuan

“…Finally, we assessed the effects of combined blockade of PD1 and IL-6 on macrophage recruitment in a zebrafish macrophage model and CD8+ T cell function and tumor growth in PBMC humanized mouse model.ResultsThe expression of exhaustion markers on CD8+ T cells was found to be notably higher in both tumor and paraneoplastic tissues compared to peripheral blood. …”
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