Meta-analysis of the clinicopathologic features of endometrial cancer molecular staging by Xiaoxia Yin, Xiaoxia Yin, Bing Luo, Bing Luo, Yong Li, Yong Li

“…Patients with CNL were more likely to be found to have pathological features of early-stage endometrial cancer and good prognosis, and CNL was present in large numbers in both early-stage and late-stage endometrial cancers. …”
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YafN-YafO toxin-antitoxin system contributes to stress resistance and virulence of avian pathogenic Escherichia coli by Qiubo Chen, Yunyan Sun, Qianlong Xing, Zhengliang Li, Song Gao, Qingqing Gao

“…These results demonstrate that the YafN-YafO is an active type II TA system in APEC E058, contributing to both stress resistance and virulence. Targeting this system could offer a novel strategy for controlling APEC infections.…”
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Mechanical Ventilator-Associated Pneumonia in the COVID-19 Pandemic Era: A Critical Challenge in the Intensive Care Units by Mircea Stoian, Adina Andone, Sergiu Rareș Bândilă, Danusia Onișor, Sergiu Ștefan Laszlo, Gabriela Lupu, Alina Danielescu, Dragoș-Florin Baba, Anca Meda Văsieșiu, Andrei Manea, Adina Stoian

“…The Clinical Pulmonary Infection Score (CPIS) strongly correlates with developing MDR pathogens in both patient groups.…”
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Real-world clinical outcome of unresectable locally advanced & de-novo metastatic pancreatic ductal adenocarcinoma: a multicentre retrospective study by Mohamed Aseafan, Ali H. Alfakeeh, Emad Tashkandi, Mervat Mahrous, Mohammed Alghamdi, Bader Alshamsan, Marwan Al-Hajeili, Safwan Bakhsh, Kanan Alshammari, Fahad A. Almugbel, Abdulhameed H. Alfagih, Ahmed Allehebi, Mohamed Montaser, Mohamed Hamdy Elsafty, Khaled Abd Elaziz Elnaghi, Ibrahim Issa, Eesa Bakshi, Sadeem AlSubaie, Bandar AlMutairi, Hoda Mokhtar, Mohamed Aboelatta, Nedal Bukhari, Ali M. Alzahrani, Tusneem Elhassan, Ali Alqahtani, Shouki Bazarbashi

“…Conclusions This real-world study confirms that clinical outcomes for locally advanced unresectable and metastatic PDAC in Saudi Arabia are consistent with international data, with FOLFIRINOX showing superior outcomes over gemcitabine-based regimens. However, both treatments reflect the persistent poor prognosis of PDAC, underscoring the need for novel therapeutic strategies. …”
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OsLAP3/OsSTRL2, encoding a rice strictosidine synthase, is required for anther cuticle formation and pollen exine patterning in rice by Dai-bo Chen, Ran Zhou, Ran Zhou, Hui-min Wang, Pei-pei Zhang, Zheng-fu Yang, Zheng-fu Yang, Dan-dan Xuan, Ying-xin Zhang, Xiao-deng Zhan, Li-yong Cao, Li-yong Cao, Shi-hua Cheng, Lian-ping Sun, Lian-ping Sun

“…Furthermore, lipid profiling demonstrated a marked reduction in both wax and cutin content. These findings establish OsLAP3 as a critical regulator of fatty acid synthesis and highlight its role in anther cuticle formation and pollen exine development. …”
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Analyzing the serum biochemical factors that influence early neurological deterioration in ischemic Stroke patients and developing a nomogram prediction model by Xiaoni Zhan, Yunyun Xu, Rongrong Ma

“…Based on the National Institutes of Health Stroke Scale (NIHSS) in the United States, patients were categorized into two groups: END (n=69) and non-END (n=151). Both groups' basic demographics, medical history, and biochemical test results were compared. …”
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Senile cataract — features of development and outcomes of surgical treatment in patients with hepatitis B and C viruses by B.N. Hatsukova, G.M. Chernakova, S.A. Kochergin, E.A. Kleshcheva, E.Yu. Malinnikova, K.K. Kyuregyan, M.M. Mikhailov

“…The experimental group (control group) consisted of 10 patients with the absence of diagnostically significant levels of antibodies to HBV and HCV in blood serum. All patients in both groups twice underwent a standard ophthalmologic examination, as well as optical coherence tomography (OCT) of the macular area and optic disc, Humphrey Visual Field, and visocontrastometry. …”
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Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor by Xin Xu, Hui Yu, Mingyi Yang, Jiale Xie, Ke Xu, Erliang Li, Xianjie Wan, Jiachen Wang, Guoqiang Wang, Ying Pan, Peng Xu, Junfei Guo

“…These findings underscore obesity as the primary shared risk factor, highlighting the importance of weight management as a key strategy for mitigating the risks of both conditions. Future research should aim to validate these findings in diverse populations and explore other metabolic pathways that may contribute to these complex associations.…”
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p38/JNK Is Required for the Proliferation and Phenotype Changes of Vascular Smooth Muscle Cells Induced by L3MBTL4 in Essential Hypertension by Chaowei Hu, Kun Zuo, Kuibao Li, Yuanfeng Gao, Mulei Chen, Roumu Hu, Ye Liu, Hongjie Chi, Hongjiang Wang, Yanwen Qin, Xiaoyan Liu, Jiuchang Zhong, Jun Cai, Xinchun Yang, Jing Li

“…In L3MBTL4 transgenic rats, we found that the elevated blood pressure, increased left ventricular hypertrophy, and thickened vascular media layer were significantly relieved by both p38 and JNK inhibitors. Meanwhile, increased cell proliferation, advanced cell cycle progression, greater migratory capability, and synthetic phenotype were observed in L3MBTL4 overexpressed VSMCs, which could be blocked by either p38 or JNK inhibitor. …”
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Microcirculatory depth of focus measurement shows reduction of tissue edema by albumin resuscitation in burn patients by Olcay Dilken, Annemieke Dijkstra, Göksel Güven, Bülent Ergin, Nicole Trommel, Margriet E. van Baar, Helma WC Hofland, Can Ince, Cornelis H. van der Vlies

“…This study shows that sublingual microcirculation measurements can quantify both tissue perfusion and edema. Methods: This prospective observational study was conducted between November 2018 and December 2019 in the intensive care unit of Maasstad Hospital Burn Center, Rotterdam, The Netherlands. …”
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Does age still matter? An age-group comparison of self-efficacy, initial interest and performance when learning bystander resuscitation in secondary schools

“…No differences were found between age groups for self-efficacy, outcome expectancies and interest (p > 0.05). In both groups, self-efficacy and positive outcome expectancies improved, but negative expectancies as well as the students’ interest did not. …”
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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“….- Potent anti-tumor effects are seen both in vitro and in vivo.Keywords: Calcium ion load, controlled-release nanomaterials, two-layer protective shell, pH responsive drug release, reactive oxygen species, anti-cancer…”
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Isolation, identification, and pathogenicity tests of pathogenic bacterial associated with black body syndrome in white barramundi Lates calcarifer B. by Akmal Izwar, Sri Nuryati, Rahman, Rini Purnomowati

“…P. stutzeri L01 and V. harveyi were the most virulent bacteria with a bacterial density of 107 CFU/mL. Both bacteria were used for pathogenicity test with three treatments: injection of P. stutzeri L01, V. harveyi, mix P. stutzeri L01 and V. harveyi, and phosphatebuffered saline as control. …”
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Biodiversity Patterns of Rocky Coastal and Human-Made Structures in Gheshm Shorelines; Role of Slope and Tidal Levels Characteristics in Determining Patterns of Biodiversity by Marzieh Razaghi, Ali Nasrolahi, Ehsan Kamrani, Mohammad Sharif Ranjbar, Amir Vazirizadeh

“…In examining the cleaner species in both natural and artificial habitats, it was found that the distribution and growth of the algae Padina sp. on artificial substrates had significantly decreased compared to natural ones. …”
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Similarities and Differences between ICME-driven Shocks Observed by VEX (∼0.72 au) and WIND (∼1.0 au) by Mengsi Ruan, Pingbing Zuo, Zilu Zhou, Jiayun Wei, Xueshang Feng, Yi Wang, Qi Xu, Xiaojun Xu, Zhengyang Zou, Zhenning Shen

“…The yearly occurrence of ICME-driven shocks at both ∼0.72 and ∼1 au roughly follows the sunspot cycle, while the magnetic field ratio does not show such a correspondence. …”
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Physics-Informed Neural Networks for Modal Wave Field Predictions in 3D Room Acoustics by Stefan Schoder

“…It outperformed the finite element analysis and the standard PINN in terms time needed to obtain the solution, needing 15 min and 30 s on an AMD Ryzen 7 Pro 8840HS CPU (AMD, Santa Clara, CA, USA) for the FEM, compared to about 20 min (standard PINN) and just under a minute of the feature-engineered PINN, both trained on a Tesla T4 GPU (NVIDIA, Santa Clara, CA, USA).…”
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Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model by Wei Xu, Yang Zhou, Ling Lin, Dongyin Yuan, Yingqi Peng, Li Li, Wenjun Xiao, Zhihua Gong

“…Here, we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice model. Both these types of black tea could lower the content of blood glucose and increase the content of hepatic glycogen by upregulating the proteins and mRNA expression of phosphatidylinositol-4,5-bisphosphate3-kinase, glycogen synthase, protein kinase B and phosphoinositide-dependent protein kinase-1 and downregulating the protein and mRNA expression of glycogen synthase kinase 3β. …”
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To what extent does the CO₂ diurnal cycle impact flux estimates derived from global and regional inversions? by S. Munassar, S. Munassar, S. Munassar, C. Rödenbeck, M. Gałkowski, M. Gałkowski, F.-T. Koch, F.-T. Koch, K. U. Totsche, K. U. Totsche, S. Botía, C. Gerbig

“…To the extent that FLUXCOM-X diurnal cycles are realistic at all latitudes and for the station set including many continental stations as used in our inversions here, we conclude that ignoring the diurnal variations in the land CO<span class="inline-formula">₂</span> flux leads to overestimation of both CO<span class="inline-formula">₂</span> sources in the tropical lands and CO<span class="inline-formula">₂</span> sinks in the temperate zones.…”
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A synthetic biological secondary metabolite, Lycogenâ¢, produced and extracted from Rhodobacter sphaeroides WL-APD911 in an optimizatioal scale-up strategy by Cheng-Chin Wang, Shi-Ying Huang, Shu-Hung Huang, Zhi-Hong Wen, Jyun-Ying Huang, Wen-Sheng Liu, Hui-Min David Wang

“…Further, the batch fermentation is carried out in both 5 L and 20 L fermentors to study the scale-up process factors to be adopted. …”
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High Spatiotemporal Near‐Infrared II Fluorescence Lifetime Imaging for Quantitative Detection of Clinical Tumor Margins by Zhen Chen, Linjian Huang, Duyang Gao, Zhouzhou Bao, Dehong Hu, Wei Zheng, Jing Chen, Jiuling Liao, Hairong Zheng, Zonghai Sheng

“…Notably, NIR‐II FLT imaging demonstrates superior accuracy (90%) and consistency in defining tumor margins compared to NIR‐II FL imaging (58%) in both SK‐OV‐3 tumor‐bearing mice and clinical tumor samples. …”
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