Persistent and emerging threats to Arctic biodiversity and ways to overcome them: a horizon scan by Tanya A. Lemieux, Jackson D.R. Coles, Anne L. Haley, Michelle L. LaFlamme, Sara K. Steel, Kara M. Scott, Jennifer F. Provencher, Courtney Price, Joseph R. Bennett, Isabel C. Barrio, Helen S. Findlay, Simon J. Goodman, Blake Matthews, Joacim Näslund, David. A. Pearce, Robert D. Hollister, Mark L. Mallory, Paul A. Smith, Gabriela Schaepman-Strub, Steven J. Cooke

“…Arctic biodiversity is under threat from both climate-induced environmental change and anthropogenic activity. …”
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Establishment of political and diplomatic relations between Lithuania and France in 1918-1920: Exchange of mistrust by Vilma Bukaitė

“…The emerged obstacle in the way of annexing the seaboard areas with the Port of Klaipėda resulted in the Lithuanian government's dissatisfaction, which in turn raised new difficulties for a benevolent cooperation with both the French government and its respective mission. …”
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Development of a latency model for HIV-1 subtype C and the impact of long terminal repeat element genetic variation on latency reversal by Shreyal Maikoo, Robert-Jan Palstra, Krista L. Dong, Tokameh Mahmoudi, Thumbi Ndung'u, Paradise Madlala

“…Our data suggests that genetic variation both within and between HIV-1 subtypes influences latency reversal. …”
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Analysis of early effects of human APOE isoforms on Alzheimer’s disease and type III hyperlipoproteinemia pathways using knock-in rat models with humanized APP and APOE by Metin Yesiltepe, Tao Yin, Marc Tambini, Hanmei Bao, Meixia Pan, Cristina d’Abramo, Luca Giliberto, Xianlin Han, Luciano D’Adamio

“…APOE also plays key role in lipid metabolism, affecting both peripheral and central systems, particularly in lipoprotein metabolism in triglyceride and cholesterol regulation. …”
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Formation of forest mensuration indicators of Pseudotsuga menziesii (Mirb.) Franco in artificial plantations of the western region of Ukraine by Iurii Debryniuk, Stepan Myklush, Yuriy Myklush

“…Furthermore, the correlation between Pseudotsuga menziesii presence and the stand growing stock within the studied age range demonstrates a notably high value (> 0.91) applying both to the plantations as a whole and specifically to the proportion of growing stock of Douglas fir within them. …”
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Direct anterior approach (DAA) vs. conventional approaches in total hip arthroplasty: A RCT meta-analysis with an overview of related meta-analyses. by Philip Lazaru, Simon Bueschges, Nikolai Ramadanov

“…Our aim was to draw definitive conclusions by conducting both a fixed and random model meta-analysis of quality randomized controlled trials (RCTs) and by comparison with related meta-analyses.…”
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Beyond first-line therapy: efficacy and safety outcomes of continuing immunotherapy in extensive stage small cell lung cancer after PD-L1 inhibitor progression by Jianfeng Peng, Xueying Zhai, Xiaomei Liu, Zhaoqin Huang, Yimeng Wang, Peizhu Wu, Ran Gao, Xiangjiao Meng

“…A more pronounced OS benefit with IBP was noted within specific patient subgroups.…”
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Projeto de extensão universitária ‘SaúHDe renal’: Efeitos na qualidade de vida e na aptidão física by Jordana Letícia Buratti, Thaís Severo Dutra, Moane Marchesan Krug, Clara Suemi da Costa Rosa, Paulo Ricardo Moreira, Robelius De-Bortoli, Rodrigo de Rosso Krug

“…The QOL was assessed for the SF-36 questionnaire. Both groups obtained significant improvements in physical fitness and QOL. …”
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Unravelling hybridization in Phytophthora using phylogenomics and genome size estimation by Kris Van Poucke, Annelies Haegeman, Thomas Goedefroit, Fran Focquet, Leen Leus, Marília Horta Jung, Corina Nave, Miguel Angel Redondo, Claude Husson, Kaloyan Kostov, Aneta Lyubenova, Petya Christova, Anne Chandelier, Slavcho Slavov, Arthur de Cock, Peter Bonants, Sabine Werres, Jonàs Oliva Palau, Benoit Marçais, Thomas Jung, Jan Stenlid, Tom Ruttink, Kurt Heungens

“…Our method was also valuable for species identification at an unprecedented resolution and further allowed correct naming of misidentified isolates. We used both a concatenation- and a coalescent-based phylogenomic method to construct a reliable phylogeny using the GBS data of 140 non-hybrid Phytophthora isolates. …”
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Radiofrequency ablation vs. cryoablation for pediatric atrioventricular nodal reentrant tachycardia in the era of three-dimensional electroanatomical mapping by Yao-Wei Chan, Chieh-Mao Chuang, Chieh-Mao Chuang, Pi-Chang Lee, I-Hsin Tai, I-Hsin Tai, I-Hsin Tai, Ying-Hsuan Peng, Ying-Hsuan Peng, Wen-Po Fan, Wen-Po Fan, Yu-Shin Lee, Ming-Chih Lin, Ming-Chih Lin, Sheng-Ling Jan, Sheng-Ling Jan, Yun-Ching Fu, Yun-Ching Fu, Shih-Ann Chen, Shih-Ann Chen

“…Recurrence rates were 2.9% in the RF group and 0% in the Cryo group (p > 0.99), with no difference in AVNRT-free survival. …”
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A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas by Kun Xiao, Yan Cao, Zhihai Han, Yuxiang Zhang, Laurence Don Wai Luu, Liang Chen, Peng Yan, Wei Chen, Jiaxing Wang, Ying Liang, Xin Shi, Xiuli Wang, Fan Wang, Ye Hu, Zhengjun Wen, Yong Chen, Yuwei Yang, Haotian Yu, Lixin Xie, Yi Wang

“…In contrast, mild bacterial pneumonia exhibits an effective humoral immune response characterized by the expansion of T follicular helper and T helper 2 cells, facilitating B cell activation and antibody production. Although both disease groups display T cell exhaustion, mild cases maintained robust cytotoxic CD8+T cell function, potentially reflecting a compensatory mechanism. …”
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Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears by Anastasia A. Artyukh, Mikhail K. Ivanov, Mikhail K. Ivanov, Sergei E. Titov, Sergei E. Titov, Victoria V. Dzyubenko, Sergey E. Krasilnikov, Sergey E. Krasilnikov, Anastasia O. Shumeikina, Anastasia O. Shumeikina, Anastasia O. Shumeikina, Nikita A. Afanasev, Anastasia V. Malek, Sergei A. Glushkov, Eduard F. Agletdinov

“…BackgroundCervical screening, aimed at detecting precancerous lesions and preventing cancer, is based on cytology and HPV testing. Both methods have limitations, the main ones being the variable diagnostic sensitivity of cytology and the moderate specificity of HPV testing. …”
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Yiqi Fumai Lyophilized injection protects cardiac contractility in a rat model of heart failure with reduced ejection fraction by modulating SERCA2 by Yongwei Nie, Lu Chen, Yanxin Zhang, Yuqing Yao, Zizhuo Xue, Na Guo, Meixiu Wan, Zhi Li, Chunhua Liu, Dekun Li, Aichun Ju

“…Background: Yiqi Fumai Lyophilized Injection (YQFM) is a plant-derived preparation that shows protective effects against cardiac dysfunction in both human and animal models. In heart failure (HF), proteins involved in Ca2+ regulation, such as sarcoplasmic/endoplasmic reticulum Ca2+ transporting protein 2 (SERCA2) and cardiac ryanodine receptor 2 (RyR2), are dysfunctional. …”
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Effect of Scalp-acupuncture Treatment on Language Reorganization in Poststroke Aphasia：A Functional Near-Infrared Spectroscopy by LIN Bingbing, NI Jinglei, XIONG Xiao, HUANG Yunshi, HUANG Jia

“…The control group received conventional speech rehabilitation therapy （speech training，language imitation，figure-word matching，numerical reading/writing/calculating and social communication skills training，etc. ），medication and health education; the observation group received scalp acupuncture on the basis of the control group，selecting the language function area （2/5 below the parietal anterior temporal diagonal line and the anterior temporal line），and then stabbing it either flatly or obliquely，and then retained for 30 minutes post-needling sensation （deqi），and the speech and language treatment was carried out by the speech rehabilitation therapist in the process. Both groups were treated for 30 min/session，once/day，5 times/week for 4 weeks. …”
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Efficacy of a reduced-dosage PRRS MLV vaccine against a NADC34-like strain of porcine reproductive and respiratory syndrome virus by Xinyu Yan, Jiayu Liu, Fengxiong Yue, Yan Lin, Yan Li, Wensi Wu, Shan Zhao, Xiaobo Huang, Qin Zhao, Yiping Wen, Sanjie Cao, Senyan Du, Nanfang Zeng, Qigui Yan

“…From the perspective of clinical score, gross lung lesions, and microscopic lesions, immunization with MLV vaccine can indeed relieve symptoms and lesions caused by the virus, and 0.1 dosage vaccination has a better effect in these aspects. Also, both dosages of MLV immunization shortened viremia with similar effects.DiscussionOur research suggests that the MLV vaccine can provide piglets with some protection against NADC34-like PRRSV and the 0.1 dosage Ingelvac PRRS MLV vaccination showed greater benefits in our study. …”
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Remote sensing-based maize growth process parameters revel the maize yield: a comparison of field- and regional-scale by Minghan Cheng, Xiuliang Jin, Chenwei Nie, Kaihua Liu, Tianao Wu, Yuping Lv, Shuaibing Liu, Xun Yu, Yi Bai, Yadong Liu, Lin Meng, Xiao Jia, Yuan Liu, Lili Zhou, Fei Nan

“…Moreover, the proposed method exhibited good spatial applicability (field-scale: Moran Index (MI) = -0.18; regional-scale: MI = 0.19). …”
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Large‐Vessel Occlusion Stroke Knowledge and Training for Stroke Severity Assessment Among Emergency Medical Services Personnel in the United States by Kaiz S. Asif, Robin Novakovic, Thanh N. Nguyen, Santiago Ortega‐Gutierrez, Youngran Kim, Amanda Jagolino‐Cole, Sushanth Aroor, Alicia Castonguay, Prateek Kumar, Ashutosh P. Jhadav, Dileep Yavagal, May Nour, Gabor Toth, Maxim Mokin, Sunil A. Sheth, Mouhammad A. Jumaa, Alhamza Al‐bayati, Mohamed Teleb, Ossama Y. Mansour, Shashvat M. Desai, Joshua Hartman, David S. Liebeskind, Ameer E. Hassan, Brijesh P. Mehta

“…Only 285 (26%) participants answered both LVO knowledge questions correctly, and only 128 (12%) respondents correctly identified all types of stroke centers with thrombectomy capability. …”
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Artificial intelligence for quantifying immune infiltrates interacting with stroma in colorectal cancer by Jing Yang, Huifen Ye, Xinjuan Fan, Yajun Li, Xiaomei Wu, Minning Zhao, Qingru Hu, Yunrui Ye, Lin Wu, Zhenhui Li, Xueli Zhang, Changhong Liang, Yingyi Wang, Yao Xu, Qian Li, Su Yao, Dingyun You, Ke Zhao, Zaiyi Liu

“…We proposed the Deep-immune score, which reflected both tumor stroma proportion and the infiltration of immune cells in the stroma region. …”
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Long-term effectiveness of radiofrequency renal denervation in patients with resistant arterial hypertension (10-year follow-up results) by O.L. Rekovets, Yu.M. Sirenko, O.O. Torbas, S.M. Kushnir, G.F. Prymak

“…After 2, 5, and 10 years, all patients reached the target blood pressure level both in the office and with ABPM. Patients reduced the number of antihypertensive drugs from 5.50 ± 0.18 to 3.50 ± 0.30 – after 5 years and 3.67 ± 0.18 – after 10 years after RDN. …”
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Evaluating the effects of dietary glutamine on performance, carcass traits, blood biochemistry, and intestine morphology in laying quail by Ewa Tomaszewska, Kamil Drabik, Kornel Kasperek, Piotr Dobrowolski, Monika Hułas-Stasiak, Renata Pyz-Łukasik, Waldemar Paszkiewicz, Monika Ziomek, Janine Donaldson, Katarzyna Dobrowolska, Artur Burmaczuk, Justyna Batkowska, Marcin B. Arciszewski, Siemowit Muszyński

“…This study investigated the effects of dietary glutamine (Gln) supplementation on the performance, carcass characteristics, blood biochemistry, intestinal morphology, and gut microbiota of laying quail over a 12-week period, with analyses conducted after 6 and 12 weeks of supplementation. …”
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