miR‐130a‐3p regulated TGF‐β1‐induced epithelial‐mesenchymal transition depends on SMAD4 in EC‐1 cells by Xiaokang Tian, Qian Fei, Mingyu Du, Hongming Zhu, Jinjun Ye, Luxi Qian, Zhiwei Lu, Wenjun Zhang, Yan Wang, Fanyu Peng, Jie Chen, Baoling Liu, Qian Li, Xia He, Li Yin

“…Here we found that knocked down SMAD4 could partially reverse TGF‐β‐induced migration, invasion, and EMT progression in the ESCC cell line EC‐1. miR‐130a‐3p, which directly targets SMAD4, is down‐regulated in ESCC. miR‐130a‐3p inhibits the migration and invasion of EC‐1 cells both in vitro and in vivo. Finally, miR‐130a‐3p inhibits TGF‐β‐induced EC‐1 cell migration, invasion, and EMT progression in a SMAD4‐dependent way. …”
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Gender differences in robotic surgery for rectal cancer: A retrospective study by Muhammad Ali, Wei Wang, Liuhua Wang, Bin Liu, Jun Ren, Daorong Wang

“…These findings underscore the importance of gender-specific considerations in both surgical approaches and post-operative care for rectal cancer patients undergoing robotic surgery.…”
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Association of Estimated Glomerular Filtration Rate (eGFR) and High-Sensitivity C-Reactive Protein (Hs-CRP) with the Risk of New-Onset Atrial Fibrillation in Patients with Diabetes by Liu Y, Liu H, Sun D, Zheng Y, Tse G, Chen K, Qiu J, Wu S, Liu T

“…Ying Liu,1,* Hongmin Liu,1,2,* Dongkun Sun,1,* Yi Zheng,1 Gary Tse,1,3,4 Kangyin Chen,1 Jiuchun Qiu,1 Shouling Wu,2 Tong Liu1 1Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, People’s Republic of China; 2Department of Cardiology, Kailuan General Hospital, Tangshan, 063001, People’s Republic of China; 3School of Nursing and Health Sciences, Hong Kong Metropolitan University, Hong Kong, People’s Republic of China; 4Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Research Institute, Hong Kong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tong Liu, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People’s Republic of China, Email liutong@tmu.edu.cn; liutongdoc@126.com Shouling Wu, Department of Cardiology, Kailuan General Hospital, Tangshan, 063001, People’s Republic of China, Email drwusl@163.comBackground: Both renal function decline and systemic inflammation may synergistically increase the risk of atrial fibrillation (AF). …”
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Demographic and clinical impact on preoperative BREAST-Q ePROM completion and baseline outcomes in women undergoing breast cancer surgery: a quantitative descriptive study at a Dan... by Karin Piil, Volker Jürgen Schmidt, Stine Thestrup Hansen, Lone Bak Hansen, Anna Mejldal, Julie Hougaard Prüsse, Lotte Gebhard Ørsted

“…The BREAST-Q is a PROM in questionnaire format, developed and validated to assess satisfaction and quality of life for breast surgery patients.The hypothesis tested is that considering disparities in geography, age and education among responders is essential for capturing a diverse patient population in future Patent-Reported Outcome Measures initiatives, examining how these characteristics are associated with Patent-Reported Outcome Measures utilisation and outcomes.Design Quantitative descriptive study.Setting Electronic Patient-Reported Outcome Measures were collected between 6 September 2021 and 5 September 2022 from patients recruited from an outpatient clinic at a Plastic- and Breast Surgery Department at a University Hospital in Denmark.Participants Participants include a total of 629 Danish-speaking women diagnosed with breast cancer and scheduled for breast cancer surgery, with a final participation rate of 468.Intervention Preoperative ePROMs and demographic data were collected between September 2020 and 2021 through patients’ secure national digital post-box.Main outcome measures Demographic variables of both responders and non-responders were assessed using t-tests, Mann-Whitney U tests and χ2 tests. …”
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Perbedaan Efektivitas Parasetamol Oral Dengan Tramadol Oral Sebagai Tatalaksana Nyeri Pasca Operasi Transurethral Resection of The Prostate by Ismail Muhammad, Alvarino Alvarino, Nasman Puar, Hafni Bachtiar

“…After a statistical test at 3 hours, 5 hours, 7 hours after spinal anesthesia, we conclude that there was no significant difference in pain intensity on the 2 groups with P> 0.05. While the incidence of nausea and allergies also had no significant difference in both groups. …”
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A Case of Euthyroid Graves’ Ophthalmopathy in a Patient Sero-Negative for TSH Receptor Autoantibody by Asami Hotta, Tomohiro Tanaka, Haruka Kato, Shota Kakoi, Yuki Shimizu, Chie Hasegawa, Akiko Hayakawa, Satoshi Yasuda, Kento Ogawa, Shunsuke Ito, Hideomi Ohguchi, Takashi Yagi, Hiroyuki Koyama, Mihoko Kawamura, Kazuhiko Sugitani, Yuichiro Ogura, Takashi Joh, Kenro Imaeda

“…Serum thyroid function tests and 99mTc uptake were both within the normal range. Anti-thyroid autoantibodies were all negative except for the cell-based assay for serum TSH receptor stimulating activity. …”
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Application of enhanced recovery after surgery in the perioperative nursing of elderly patients undergoing hip replacement (加速康复外科理念在老年髋关节置换术围手术期护理中的应用)... by XIN Lan (信岚), TANG Bi (唐碧), CHEN Mingying (陈明英)

“…Results The ADL score and HSS score were significantly increased in both two groups at 2 weeks after intervention(P＜0. 05), and the VAS Score was decreased significantly at 2 weeks after intervention(P＜0. 05). …”
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Estimating stomatal conductance of citrus orchard based on UAV multi-modal information in Southwest China by Quanshan Liu, Zongjun Wu, Ningbo Cui, Shunsheng Zheng, Shouzheng Jiang, Zhihui Wang, Daozhi Gong, Yaosheng Wang, Lu Zhao, Renjuan Wei

“…The Black-winged Kite Algorithm (BKA) was employed to optimize both the Extreme Learning Machine (ELM) and Kernel Extreme Learning Machine (KELM) models. …”
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Impact of diabetes on clinical outcome of patients with heart failure undergoing ICD and CRT procedures: results from the German Device Registry by Elif Kaya, Jochen Senges, Matthias Hochadel, Lars Eckardt, Dietrich Andresen, Hüseyin Ince, Stefan G. Spitzer, Thomas Kleemann, Sebastian S.K. Maier, Werner Jung, Christoph Stellbrink, Tienush Rassaf, Reza Wakili

“…Unadjusted and adjusted analyses revealed similar all‐over intrahospital periprocedural complication rates in both groups (4.1% vs 3.9%). Unadjusted Kaplan–Meier survival analysis showed higher all‐cause mortality after 1 year (9.0% vs 6.3%; log‐rank P = 0.001) with higher MACCE rates (10.0% vs 7.3%; P < 0.001) in the DM group versus non‐DM patients. …”
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Serine/threonine protein kinase mediates rifampicin resistance in Brucella melitensis through interacting with ribosomal protein RpsD and affecting antioxidant capacity by Yaqin Yuan, Wenqing Ning, Junjie Chen, Jiquan Li, Tianqi Xue, Cuihong An, Lingling Mao, Guangzhi Zhang, Shizhong Zhou, Jiabo Ding, Xiaowen Yang, Jianqiang Ye

“…ABSTRACT Brucellosis, a zoonotic disease, has re-emerged in both humans and animals, causing significant economic losses globally. …”
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Therapeutic potential of the neutralizing monoclonal antibody 45G3 against encephalomyocarditis virus by Yanfang Zhang, Zhiying Wang, Yaohui Fang, Qiong Zhu, Jie Fu, Sijing Hu, Jiayin Jin, Min Zhou, Xijia Liu, Danna Zhang, Shouwei Huang, Yali Deng, Lingling Xie, Shu Shen, Jing Ye, Fei Deng, Shengbo Cao

“…In this study, we evaluated the neutralizing effects of a monoclonal antibody derived from the spleens of mice immunized with EMCV virus-like particles (VLPs), both in vitro and in vivo. Using recombinant DNA technology, we engineered a baculovirus system to express EMCVs P12A and 3C, facilitating the production of VLPs in Sf9 cells. …”
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Effects of Digital Storytelling Package on Students’ Motivation and Attitude to Christian Religious Studies (CRS) in Junior Secondary Schools by Adetunmbi L. Akinyemi, Jonathan Iyanuoluwa Makinde

“…Additionally, there was a significant effect observed from the digital storytelling package on both the motivation and attitude of students (F (2; 61) = 29.67; p = 0.49 for motivation, and F (2; 61) = 32.49; p = 0.52 for attitude). …”
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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer by Changli Qian, Gordon J Freeman, Tao Jiang, Ursula Matulonis, Ziying Lin, Hye-Jung Kim, Anniina Färkkilä, Hua Yu, Xin Cheng, Panagiotis A Konstantinopoulos, Antons Martincuks, Joyce F Liu, Qiwei Wang, Liya Ding, Michael J Kearns, Shaozhen Xie, Inga-Maria Launonen, Thomas M Roberts, Jean J Zhao

“…Markedly increased populations of protumor macrophages are found in BRCA-deficient ovarian tumors that rendered resistance to PARPi in both murine models and patients. Mechanistically, PARP inhibition elevates the STAT3 signaling pathway in tumor cells, which in turn promotes protumor polarization of TAMs. …”
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F. NIETZSCHE: VALIOS SIEKTI GALIOS PRINCIPAS by Arūnas Mickevičius

“…It is at the same time both determined and determiner. Nietzschean „slave“ and „master“ moralities are based upon active and reactive forces. …”
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Field-based evidence for the prevalence of soil antibiotic resistomes under long-term antibiotic-free fertilization by Yuhao Fu, Fang Hu, Fang Wang, Min Xu, Zhongjun Jia, Wulf Amelung, Zhi Mei, Xiaozeng Han, Marko Virta, Xin Jiang, James M. Tiedje

“…Despite the influence of various factors like bacterial communities, soil properties, heavy metals, and MGEs, the MGEs had the most significant standardized effects on shaping ARGs through both direct and indirect pathways. Our findings indicates that while of antibiotic-free manure can lower the risk of antibiotic residues and promote sustainable farming practices, it may not fully eliminate the prevalence of ARGs, highlighting the need for more comprehensive strategies to address antibiotic resistance in agriculture rather than simply prohibiting the use of antibiotics.…”
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LoCS-Net: Localizing convolutional spiking neural network for fast visual place recognition by Ugur Akcal, Ugur Akcal, Ugur Akcal, Ivan Georgiev Raikov, Ekaterina Dmitrievna Gribkova, Ekaterina Dmitrievna Gribkova, Anwesa Choudhuri, Anwesa Choudhuri, Seung Hyun Kim, Mattia Gazzola, Rhanor Gillette, Rhanor Gillette, Ivan Soltesz, Girish Chowdhary, Girish Chowdhary, Girish Chowdhary

“…Our approach offers a simpler training pipeline while yielding significant improvements in both training and inference times compared to SOTA SNNs for VPR. …”
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Longitudinal impact of past-year reproductive coercion on contraceptive use dynamics in Sub-Saharan Africa: evidence from eight population-based cohortsResearch in context by Shannon N. Wood, Haley L. Thomas, Georges Guiella, Rosine Mosso, Peter Gichangi, Simon P.S. Kibira, Fredrick Makumbi, Pierre Z. Akilimali, Funmilola M. OlaOlorun, Elizabeth Omoluabi, Michele R. Decker

“…Cross-sectional studies on the magnitude of RC across sub-Saharan Africa have noted associations with contraceptive use. No studies have longitudinally examined RC experiences as related to future contraceptive dynamics, including discontinuation or forgoing use altogether. …”
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Identification of Plasma Absorbed Components of Qingxin Zishen Prescription by UPLC-Q-TOF MS by Yu HU, Juan SHANG, Xue-jiao LI, Yun-hua FENG, Kai-cheng XIE, Wei-feng YAO, Jian-dong ZOU, Yun CHEN, Su LU, Mei-juan XU

“…The MS and MS2 analysis were performed with the electrospray ionization (ESI) source under both positive and negative ion modes from m/z 100 to 1300. …”
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Reflections and trajectories for interdisciplinary research on the energy transition by Cesare Sposito, Francesca Scalisi

“…In this context, which must always look forward, we must design our best political and systemic actions to promote the need to innovate by using the Planet’s resources well and consciously. The goals of climate neutrality by 2050 and the reduction of CO2 emissions by 55% (compared to the 1990 level) by 2030 (European Commission, 2019, 2021) pose the European Union, and even more so the rest of the world, with several complex issues, including a significant increase in ‘clean’ energy production from alternative and renewable sources, the reduction of energy poverty, greater security of energy supply and a drastic decrease in dependence on energy imports; at the same time, the aim is to foster modern economic growth decoupled from the use of non-renewable resources, the creation of new jobs, and to generate environmental and health benefits, objectives with inevitable cultural, political, economic, production, technological and social implications to be addressed both within one’s borders and in foreign policy. …”
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Implementation and validation of a new qPCR assay to detect imported human Plasmodium species by Camille Cordier, Samia Hamane, Théo Ghelfenstein-Ferreira, Sarah Dellière, Élodie Da Silva, Blandine Denis, Sandrine Houzé, Valentin Joste, Alexandre Alanio

“…In this study, we developed a combined molecular tool based on both detection of all human plasmodial species (Plasmodium spp.) and P. falciparum. …”
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