Local Exosome Inhibition Potentiates Mild Photothermal Immunotherapy Against Breast Cancer by Qian Chen, Yanan Li, Jiameng Hu, Zhenyu Xu, Shengyi Wang, Naicong Cai, Mengjiao He, Yifang Xiao, Yuan Ding, Mengjuan Sun, Chunjiayu Li, Yiyang Cao, Zhongyuan Wang, Fang Zhou, Guangji Wang, Chen Wang, Jiasheng Tu, Haiyang Hu, Chunmeng Sun

“…Notably, it accelerates the release of tumor cell‐derived exosomes (TEX) and upregulates PD‐L1 expression on both tumor cells and TEX. Consequently, it is proposed that locally inhibiting TEX release is crucial for overcoming the adverse effects of mild PTT, thereby enhancing ICB therapy. …”
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Spatial and temporal heterogeneity of soil respiration in a bare-soil Mediterranean olive grove by S. Aranda-Barranco, S. Aranda-Barranco, P. Serrano-Ortiz, P. Serrano-Ortiz, A. S. Kowalski, A. S. Kowalski, E. P. Sánchez-Cañete, E. P. Sánchez-Cañete

“…To study spatial variability, the automatic chambers were distributed equally under the canopy (<span class="inline-formula"><i>R</i>_{s  Under-Tree}</span>) and in the center of the alley (<span class="inline-formula"><i>R</i>_s Alley</span>), and the gradient of <span class="inline-formula"><i>R</i>_s</span> between both locations was measured in several manual campaigns in addition to angular changes about the olive trees. …”
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Synthesis, Characterization, and Cytotoxic Activity of New Lanthanum(III) Complexes of Bis-Coumarins

“…This analysis showed that in the <mml:math alttext="$chem{La(III)}$"> <mml:mtext>La</mml:mtext><mml:mrow><mml:mo>(</mml:mo> <mml:mrow> <mml:mtext>III</mml:mtext> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow> </mml:math> complexes, the ligands coordinated to the metal ion through both deprotonated hydroxyl groups. On the basis of the <mml:math alttext="$ u({C}={O})$"> <mml:mi>&#x03BD;</mml:mi><mml:mrow><mml:mo>(</mml:mo> <mml:mrow> <mml:mtext>C</mml:mtext><mml:mo>=</mml:mo><mml:mtext>O</mml:mtext> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow> </mml:math> red shift observed, participation of the carbonyl groups in the coordination with the metal ion was also suggested. …”
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Multi-observatory Study of Young Stellar Energetic Flares (MORYSEF): No Evidence for Abnormally Strong Stellar Magnetic Fields after Powerful X-Ray Flares by Konstantin V. Getman, Oleg Kochukhov, Joe P. Ninan, Eric D. Feigelson, Vladimir S. Airapetian, Abygail R. Waggoner, L. Ilsedore Cleeves, Jan Forbrich, Sergio A. Dzib, Charles J. Law, Christian Rab, Daniel M. Krolikowski

“…Our findings reveal magnetic field strengths at the stellar surface typical of nonflaring PMS stars, ruling out the need for abnormally strong fields during flares. Both PMS and solar flares deviate from the L _X –Φ law, with PMS flares exhibiting a more pronounced deviation, primarily due to their much larger active regions on the surface and larger flaring loop volumes above the surface compared to their solar counterparts. …”
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Kappa-carrageenan as immunostimulant to control infectious myonecrosis (IMN) disease in white shrimp Litopenaeus vannamei by Dian Febriani, . Sukenda, Sri Nuryati

“…The first stage of this study evaluated the different dose of k-carrageenan administration i.e. 5, 10, and 15 g/kg feed for four weeks of rearing period, while the later studied evaluated about the frequency of administration i.e. daily, seven days interval, and 14-days interval for five weeks of rearing period. Both stages had positive and negative control and performed in complete randomized design. …”
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Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia With the Circadian Rhythm of Myocardial Infarction by Xiaochen Liu, Bin Wang, Wen Hao, Yuyao Qiu, Qian Guo, Yingying Guo, Qingjie Xin, Jingyao Fan, Bin Que, Wei Gong, Wen Zheng, Xiao Wang, Shaoping Nie

“…Only in patients with both moderate/severe OSA and nocturnal hypoxemia, including oxygen desaturation index ≥15, minimum oxygen saturation ≤86%, and total sleep time with saturation <90% ≥2%, the incidence of MI onset between midnight to 5:59 am was significantly increased. …”
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Dog demography and ecology with reference to rabies in the Amhara region, Ethiopia by Liuel Yizengaw Adnie, Wudu Temesgen Jemberu, Adane Bahiru Woreta, Adugna Berju, Araya Mengistu, Zeleke Tesema Wondie, Wassie Molla, Sefinew Alemu Mekonnen

“…Community residence and age of respondents were associated with rabies occurrence (p < 0.05), while zone was associated with both dog ownership and rabies occurrence at p-value <0.05. …”
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Diagnosis, treatment, surgical practices and review of the literature in rare coagulation factor deficiencies by Hüseyin Avni Solgun

“…Among totally 19 patients, FX deficiency-P17 had a null mutation of FX gene and FV deficiency-P3 had a missense mutation of FV gene has been detected those both were severe deficencies. The medical genetics of the sibling patients with combined FVII deficency and hypofibrinogenemia have been evaluated, but the genetic results have not been completed yet. …”
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Reduced Glutathione Promoted Growth Performance by Improving the Jejunal Barrier, Antioxidant Function, and Altering Proteomics of Weaned Piglets by Zhimei Tian, Yiyan Cui, Miao Yu, Dun Deng, Zhenming Li, Xianyong Ma, Mingren Qu

“…GSH2 significantly decreased glucose content but increased the content of triglyceride and cholesterol in the plasma. Both GSH1 and GSH2 improved the jejunal mucosa architecture (villus height, crypt depth, and the ratio of villus height to crypt depth), tight junction protein (<i>ZO</i>-1 and <i>Occludin</i>), and antioxidant capacity (CAT and MDA), and the effects were superior to ABX. …”
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Validity of a machine learning estimation of blood volumes during altitude training by Basile Moreillon, Bastien Krumm, Lena Mettraux, Julian Wackernell, James Spragg, Martin Faulhaber, Raphael Faiss

“…Predicted PV and Hbmass were both significantly correlated to measured PV and Hbmass (R2=0.53, p<0.001; R2=0.26; p<0.001; respectively) with an estimated PV decrease of -162 ± 232 mL. …”
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Hemolymph microbiota and immune effectors’ expressions driven by geographical rearing acclimation of the aquacultured Penaeus stylirostris by Valérie Perez, Viviane Boulo, Julien De Lorgeril, Dominique Pham, Dominique Ansquer, Gwenola Plougoulen, Valentine Ballan, Jean-Sébastien Lam, Océane Romatif, Jeremy Le Luyer, Corinne Falchetto, Caline Basset, Stanley Flohr, Moana Maamaatuaiahutapu, Marc André Lafille, Christophe Lau, Denis Saulnier, Nelly Wabete, Nolwenn Callac

“…Then, understanding the microbiota, its dynamic according to the environmental conditions and its link to the immunity would help to react to potential dysbiosis of aquacultured species. While the gut microbiota is highly studied, in marine invertebrates the hemolymph microbiota is often set aside even if it remains an important actor of the hemolymph homeostasis. …”
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4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

“…These symptoms included a notable increase in both the number of calcified tissues and osteophytes (p < 0.001), an enlargement of the calcified meniscus and synovial tissue volume (p < 0.001), and thickening of the synovial lining layer attributable to M1 macrophage accumulation (p = 0.035). …”
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Evaluating CNN Architectures for the Automated Detection and Grading of Modic Changes in MRI: A Comparative Study by Li‐peng Xing, Gang Liu, Hao‐chen Zhang, Lei Wang, Shan Zhu, Man Du La Hua Bao, Yan‐ni Wang, Chao Chen, Zhi Wang, Xin‐yu Liu, Shuai Zhang, Qiang Yang

“…The remaining 30 patients had MRIs obtained from both Philips and United Imaging scanners from June 2022 to March 2023, forming Dataset 2. …”
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Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer by Guo Z, Li G, Shen L, Pan J, Dou D, Gong Y, Shi W, Sun Y, Zhang Y, Ma K, Cui C, Li W, Liu Q, Zhu X

“…The photothermal performance, cellular uptake and distribution, cytotoxicity, anti-tumor effects, and mechanism of action of GDNPs@ICG were investigated both in vitro and in vivo.Results: GDNPs@ICG were taken up by tumor cells via a lipid-dependent pathway. …”
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F. NIETZSCHE: VALIOS SIEKTI GALIOS PRINCIPAS by Arūnas Mickevičius

“…It is at the same time both determined and determiner. Nietzschean „slave“ and „master“ moralities are based upon active and reactive forces. …”
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Novel digital droplet inverse PCR assay shows that natural clearance of hepatitis B infection is associated with fewer viral integrations by Dong Li, Vikki Ho, Chiao-Fang Teng, Hung-Wen Tsai, Yuanyuan Liu, Sarah Bae, Harout Ajoyan, Jochen M. Wettengel, Ulrike Protzer, Brian S. Gloss, Rebecca J. Rockett, Rafid Al Asady, Jane Li, Simon So, Jacob George, Mark W. Douglas, Thomas Tu

“…Total DNA extracts from both liver resections (n = 32; 14 HBsAg-negative and 18 HBsAg-positive) and fine-needle aspirates (FNA, n = 10; 2 HBsAg-negative and 8 HBsAg-positive) were analysed. …”
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Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target by Chao Xu, Litao Liang, Guoqing Liu, Yanzhi Feng, Bin Xu, Deming Zhu, Wenbo Jia, Jinyi Wang, Wenhu Zhao, Xiangyu Ling, Yongping Zhou, Wenzhou Ding, Lianbao Kong

“…Experimentally, MORF4L1 was demonstrated to enhance cancer stemness by activating the Hedgehog signaling pathway, as supported by both in vitro and in vivo assays. Conclusion ACRRGs, particularly MORF4L1, play crucial roles in modulating HCC progression, offering new insights into the molecular mechanisms driving HCC and potential therapeutic targets. …”
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Green and Innovative Extraction: Phenolic Profiles and Biological Activities of Underutilized Plant Extracts Using Pulsed Electric Fields and Maceration by Noelia Pallarés, Houda Berrada, Emilia Ferrer, Wahiba Rached, José Pinela, Filipa Mandim, Tania C. S. P. Pires, Tiane C. Finimundy, Francisco J. Barba, Lillian Barros

“…Antioxidant potential was observed in both methods, with TBARS IC₅₀ values ranging from 17 to 79.5 µg/mL. …”
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Optimasi Convolutional Neural Network Untuk Deteksi Covid-19 pada X-ray Thorax Berbasis Dropout by I Gede Totok Suryawan, I Putu Agus Eka Darma Udayana

“…Then, this architecture was tested on chest X-ray data of COVID-19 survivors and compared with other architectures that both used a deep learning approach. It proved that when this system was tested with COVID-19 thorax x-ray public database data, the classifier that used this architecture could achieve an accuracy rate of 95.20% followed by precision and recall value reaching 94.80% and 94.80%. respectively and last but not least F-score of 95.18% and Negative Predictive value of 95.60%  It could also save training time up to 62% compared to other deep learning architectures. …”
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15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity by Kan Chen, Jingjing Li, Junshan Wang, Yujing Xia, Weiqi Dai, Fan Wang, Miao Shen, Ping Cheng, Yan Zhang, Chengfen Wang, Jing Yang, Rong Zhu, Huawei Zhang, Yuanyuan Zheng, Jie Lu, Zhuoyi Fan, Yingqun Zhou, Chuanyong Guo

“…In this study, we investigated both effects of 15d-PGJ2 and its protection mechanism in concanavalin A- (ConA-) induced autoimmune hepatitis in mice. …”
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