Effects of typical plant growth regulator chlormequat chloride on alkaloidal compounds in Corydalis yanhusuo and molecular mechanisms by Zixuan Du, Jiayin Cao, Jie Meng, Heng Zhou, Qing Hu, Ling Li, Yun Liao, Shui Miao, Wenting Li, Shen Ji, Tongshuai Wang

“…The differential compounds identified in both control and treated groups of C. yanhusuo were primarily alkaloids, as determined by non-targeted metabolomics analysis. …”
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Long-term trends and patterns in ultra-processed food consumption among Korean adults from 1998 to 2022 by Hyeseung Lee, Yesol Yim, Yerin Cho, Jiyeon Oh, Soeun Kim, Yejun Son, Hyesu Jo, Seohyun Hong, Masoud Rahmati, Hanseul Cho, Jiyoung Hwang, Dong Keon Yon

“…From 1998 to 2022, the fat content of both ultra-processed and non-ultra-processed foods significantly increased, rising from 26.24 to 28.15% for ultra-processed foods (mean difference: 1.91% [95% CI, 1.33–2.49%]) and from 16.81 to 22.26% for non-ultra-processed foods (mean difference: 5.45% [95% CI, 4.99–5.91%]). …”
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Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study by J. Furuzawa-Carballeda, D. Aguilar-León, A. Gamboa-Domínguez, M. A. Valdovinos, C. Nuñez-Álvarez, L. A. Martín-del-Campo, A. B. Enríquez, E. Coss-Adame, A. E. Svarch, A. Flores-Nájera, A. Villa-Baños, J. C. Ceballos, G. Torres-Villalobos

“…Type III achalasia patients exhibited the highest inflammatory response versus types I and II. Prevalence of both anti-myenteric antibodies and HSV-1 infection in achalasia patients was 100% versus 0% in controls. …”
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Mechanisms of L-citrulline on phosphodiesterase 5 in erectile dysfunction intervention by Abdulhakeem Olarewaju Sulyman, Olawale Moshood Aliyu, Emmanuel Oladipo Ajani, Yusuf Folohunsho Abdulkareem, Isaac Ade Afe, Fathia Oluwakemi Abdulyakeen, Halimat Yusuf Lukman, Saheed Sabiu, Karishma Singh, Kuben Naidoo

“…Kinetic analyses further elucidated citrulline's non-competitive inhibition pattern while molecular dynamics analysis afforded assessment of the binding stability of citrulline with PDE5, both providing insights into its mechanism of action. …”
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Improved SED-fitting Assumptions Result in Inside-out Quenching at z ~ 0.5 and Quenching at All Radii Simultaneously at z ~ 1 by Alexander de la Vega, Susan A. Kassin, Camilla Pacifici, Stéphane Charlot, Emma Curtis-Lake, Jacopo Chevallard, Timothy M. Heckman, Anton M. Koekemoer, Weichen Wang

“…We then perform radial SED fits to multiband flux profiles measured from Hubble Space Telescope images for 1440 galaxies at 0.4 <  z  < 1.5 of stellar masses 10 ^10 –10 ^11.5 M _⊙ using both the traditional and the more physically motivated assumptions. …”
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Application of nursing interventions based on Orem support-education system theory for patients with autogenous arteriovenous fistula for hemodialysis (Orem支持-教育系统理论在血液透析患者自体动静脉内瘘护... by YANG Ting (杨婷), SUN Minglei (孙明磊), LU Hongxia (陆红霞)

“…Results After the intervention, the score of assessment of self-care behaviors with arteriovenous fistula in hemodialysis (ASBHD-AVF) increased in both two groups and ASBHD-AVF score was significantly higher in the intervention group than that in the control group (P＜0. 05). …”
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Application of psychological intervention combined with wet compress of Traditional Chinese Medicine in nursing of patients with diabetic foot ulcer (心理干预联合中药塌渍技术在糖尿病足溃疡护理中的应用)... by WANG Xiuyan (王秀燕), CAO Hongjing (曹红京), LI Ning (李宁), LI Yueru (李月茹), LI Jing (李静), YANG Kun (杨坤), LI Lin (李林), TANG Hong (汤虹)

“…The VAS score was decreased in both two groups after intervention, and VAS score in the observation group was lower than that in the control group(P＜0. 01). …”
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Cerebral vascular shunting and oxygen metabolism in sickle cell disease by Alexander K. Song, Wesley T. Richerson, Megan A. Aumann, Spencer L. Waddle, R. Sky Jones, Samantha Davis, Lauren Milner, Chelsea Custer, L. Taylor Davis, Sumit Pruthi, Dann Martin, Lori C. Jordan, Manus J. Donahue

“…Participants with VHS of 2, indicative of the most rapid arteriovenous transit, had significantly reduced blood oxygen content (CaO2; 10.90 ± 1.69 mL O2/100 mL blood), oxygen extraction fraction (OEF; 33.52% ± 5.54%), and cerebral metabolic rate of oxygen consumption (CMRO2; 2.91 ± 0.69 mL O2/100 g tissue per minute) compared with their counterparts with VHS = 0 (CaO2 = 12.42 ± 1.58 mL O2/100 mL blood; OEF = 39.03% ± 3.80%; CMRO2 = 3.77 ± 0.84 mL O2/100 g tissue per minute) or VHS = 1 (CaO2 = 11.86 ± 1.73 mL O2/100 mL blood; OEF = 36.37% ± 5.11%; CMRO2 = 3.59 ± 0.78 mL O2/100 g tissue per minute). Both pediatric and adult patients with SCD presenting with greater imaging evidence of vascular shunting had mildly reduced OEF and CMRO2. …”
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Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial by Ben J Marais, Joel Negin, James Johnston, Virginia Wiseman, Greg J Fox, Thu Anh Nguyen, Binh Hoa Nguyen, Viet Nhung Nguyen, Justin Beardsley, Guy Barrington Marks, Kavindhran Velen, Tho Dang, Hoang Anh Nguyen, Dinh Hoa Vu, Thu Thuong Do, Cuong Pham Duc, Huu Lan Nguyen, Huu Thuong Pham, Warwick Britton

“…Participants will be individually randomised to an intervention arm, comprising use of an mHealth application for treatment support, or a ‘standard care’ arm. In both arms, patients will be managed by the national TB programme according to current national treatment guidelines. …”
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An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing by Jacob W. Fleming, Molly C. McCloskey, Kevin Gray, David R. Nash, Vincent Leung, Christos Michas, Shawn M. Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcquire, Mark Bothwell, David L. Mack, Nicholas A. Geisse, Alec S.T. Smith

“…Variability of the EC50 values between 2 different iPSC differentiations of both cell types and 2 users was less than 2 %. Further testing with the acute neurotoxins acetylcholine mustard and d-tubocurarine validated the biological relevance of the postsynaptic machinery of the model. …”
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Straw return combined with water-saving irrigation increases microbial necromass accumulation by accelerating microbial growth-turnover in Mollisols of paddy fields by Peng Chen, Junzeng Xu, Kechun Wang, Zhongxue Zhang, Zhaoqiang Zhou, Yawei Li, Tiecheng Li, Tangzhe Nie, Qi Wei, Linxian Liao

“…Despite this treatment enhancing microbial respiration, strong positive correlations were found between soil organic carbon (SOC) content and both microbial growth rate and necromass accumulation. …”
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Comparative abundance and diversity of populations of the Pseudomonas syringae and Soft Rot Pectobacteriaceae species complexes throughout the Durance River catchment from its French Alps sources to its delta by Morris, C.E., Lacroix, C., Chandeysson, C., Guilbaud, C., Monteil, C., Piry, S., Rochelle Newall, E., Fiorini, S., Van Gijsegem, F., Barny, M.A., Berge, O.

“…Here we have compared the seasonal dynamics of populations of the Pseudomonas syringae (Psy) and the Soft Rot Pectobacteriaceae (SRP) species complexes along a 270 km stretch of the Durance River from the upstream alpine reaches to the downstream agricultural production areas at the confluence with the Rhone River at Avignon. …”
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Interaction of dietary replacements of fishmeal by protein blend and feeding frequency on growth performance and protein utilization of gibel carp (Carassius gibelio var. CAS V) by Yongning Yu, Yu Wang, Junyan Jin, Dong Han, Xiaoming Zhu, Haokun Liu, Zhimin Zhang, Yunxia Yang, Shouqi Xie

“…Overall, feeding frequency interacted synergistically with blended proteins to influence growth and protein utilization in gibel carp, and a protein blend with a ratio of 1:1:6:4 was a superior alternative to fishmeal at both feeding frequencies. Future strategies aimed at replacing dietary fishmeal should consider the role of feeding frequency as a critical factor.…”
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Nature and prevalence of long-term conditions in people with intellectual disability: retrospective longitudinal population-based study by Ashley Akbari, Navjot Kaur, Rania Kousovista, Gemma Lewin, Emeka Abakasanga, Rishika Shivamurthy, Georgina Cosma, Gyuchan Jun, Satheesh Gangadharan

“…When hospital episodes were analysed, epilepsy, diabetes, chronic airway disease and mental illness were commonly treated conditions during hospital admission across both sexes. Conditions which were less prevalent in the intellectual disability cohort, but which were treated during ≥6% of total hospital admissions include cancer, cardiac arrhythmias and cerebral palsy.Conclusions This study establishes a range of 40 relevant long-term conditions for people with intellectual disability through an iterative process, which included a review of the available literature and a series of discussions with a Professional Advisory Panel and Patient and Public Involvement groups of this research project. …”
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Prevalence and prognostic value of ventricular conduction delay in heart failure with preserved ejection fraction by Anouk Achten, Jerremy Weerts, Johan van Koll, Mohammed Ghossein, Sanne G.J. Mourmans, Arantxa Barandiarán Aizpurua, Antonius M.W. van Stipdonk, Kevin Vernooy, Frits W. Prinzen, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Vanessa P.M. van Empel

“…Longer QRS duration but not larger QRS area was associated with more adverse outcomes on both categorical and continuous scales (HR per 5 ms increase = 1.06, P = 0.033). …”
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Development of a Russian version of the Minnesota low vision reading chart by I.R. Stepanets, A.N. Kulikov, S.A. Koskin, D.I. Zhilchuk

“…No statistically significant differences were found between all parameters measured with the use of test charts 1 and 2 (р&gt;0.05). </p> <p> <b>Conclusion</b>: the developed MNREAD-R test charts can be used for Russian speaking population to measure RA, MRS, ACC and RT. …”
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The ArcB kinase sensor participates in the phagocyte-mediated stress response in Salmonella Typhimurium by Coral Pardo-Esté, Coral Pardo-Esté, Francisca Urbina, Nicolas Aviles, Nicolas Pacheco, Alan Briones, Carolina Cabezas, Vicente Rojas, Valentina Pavez, Yoelvis Sulbaran-Bracho, Yoelvis Sulbaran-Bracho, Alejandro A. Hidalgo, Juan Castro-Severyn, Juan Castro-Severyn, Claudia P. Saavedra

“…Our results show that ArcB influences the expression of genes associated with fatty acid degradation, protein secretion, cysteine and H2S biosynthesis, and translation, both in vitro and under conditions found within neutrophils. …”
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Agricultural GDP exposure to drought and its machine learning-based prediction in the Jialing River Basin, China by Xinzhi Wang, Qingxia Lin, Zhiyong Wu, Yuliang Zhang, Changwen Li, Ji Liu, Shinan Zhang, Songyu Li

“…Cropland has shifted from higher exposure to long-term drought to higher exposure to short-term, frequency drought. (3) Among the four machine learning models, the Bayesian model demonstrated superior performance in precipitation and temperature predictions, respectively, while the BiGRU model exhibited the best performance in long-term predictions of evaporation and soil moisture. (4) The central and southern regions will further increase in agricultural GDP exposure to both meteorological and agricultural droughts from 2021 to 2030, with exposures anticipated to increase by 20.2–34.8 % compared to the period from 2011 to 2020. …”
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Incidence and temporal trends of out-of-hospital cardiac arrest in Shenzhen, China (2011–2018) by Hong Zhu, Junpeng Liu, Tianqi Yang, Yan Zhang, Yanjun Xu, Yunfeng Xu, Hao Wu, Li Li, Yufeng Luo, Cai Wen, Tao Yu

“…Conclusions: OHCA incidence in Shenzhen is lower than both domestic and international levels but increasing. …”
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Which muscle is the external rotation compensator after superior capsular reconstruction? by Nattakorn Mahasupachai, MD, Nobuyuki Yamamoto, MD, PhD, Atsushi Arino, MD, Jun Kawakami, MD, PhD, Rei Kimura, MD, Toshimi Aizawa, MD, PhD

“…There was a significant negative correlation between ER strength and the severity of both preoperative and postoperative fatty changes in the teres minor (r = −0.258, P = .065, 95% CI = −1.0 to −0.042 and r = −0.323, P = .028, 95% CI = −1.0 to −0.113, respectively). …”
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