YOLOX-SwinT algorithm improves the accuracy of AO/OTA classification of intertrochanteric fractures by orthopedic trauma surgeons by Xue-Si Liu, Rui Nie, Ao-Wen Duan, Li Yang, Xiang Li, Le-Tian Zhang, Guang-Kuo Guo, Qing-Shan Guo, Dong-Chu Zhao, Yang Li, He-Hua Zhang

“…With the assistance of AI, the subgroup classification accuracy of both SOTS and JOTS was significantly improved, and JOTS achieved the same level as SOTS. …”
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Potential public health impacts of gonorrhea vaccination programmes under declining incidences: A modeling study. by Lin Geng, Lilith K Whittles, Borame L Dickens, Martin T W Chio, Yihao Chen, Rayner Kay Jin Tan, Azra Ghani, Jue Tao Lim

“…Sensitivity analyses indicated that VaR had the greatest public health impact with the highest number of averted cases per dose for vaccines of any efficacy or duration of protection (or both), although VoD and VoD(H) saved more vaccine resource and had the highest number averted MSM cases per dose for highly protective vaccines of long protection.…”
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Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway by Xiaomei Zhong, Yibin Sun, Yanxiang Lin, Shan Deng, Huan Wang, Xian Zhou, Jinjian Lu, Yanfang Zheng, Ruoyin Luo, Mingqing Huang, Jianyuan Song

“…Meyer and Panax notoginseng (Burkill) F.H. Chen ex C.H. Chow, both species belonging to genus Panax in the Araliaceae family. …”
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Efficacy and safety of single and double catheter intrathecal drug delivery systems in patients with refractory neck and abdominal cancer pain by Qin Li, Huaiming Wang, Qiju Li, Maoxia Xu, Bo Zhong, Xin Hu, Jiang Zou, Pengjiu Feng, Aimin Zhang

“…The preliminary findings of this study, both single- and double-catheter IDDS effectively manage cancer pain in neck and abdominal cancer patients without increasing adverse events. …”
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Definiri ale metaforei – metaforismului – demetaforizării by Violeta Bercaru

“…Mystère, lacune, symbole établi dans la vérité des choses d’après le romantique Coleridge, s’harmonise dans le structuralisme philosophique avec ce que Paul Ricoeur définit par une référence suspendue génératrice à son tour d’une référence déployée, nouvelle, métaphorique, qui repésente le côté positif d’une stratégie negative, la métaphore vive. …”
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Identification of novel pQTL‐SNPs associated with lung adenocarcinoma risk: A multi‐stage study by Yutong Wu, Huiwen Xu, Liping Mao, Rongrong Zhao, Junfeng Chu, Lili Huang, Wendi Zhang, Yiran Liu, Qiong Chen, Xiaobo Tao, Siqi Li, Shenxuan Zhou, Anhui Ning, Zhenyu Li, Tian Tian, Lei Zhang, Jiahua Cui, Guangyu Tian, Minjie Chu

“…Meanwhile, the expression of their corresponding target proteins were all decreased in both plasma and tumor tissues of LUAD cases, which may play a role of tumor suppressor proteins. …”
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CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis by Ying Zhang, Ruiwei Yao, Mingyi Li, Chongkai Fang, Kunliang Feng, Xiuru Chen, Jinan Wang, Rui Luo, Hanqian Shi, Xinqiu Chen, Xilin Zhao, Hanlin Huang, Shuwei Liu, Bing Yin, Chong Zhong

“…Moreover, the inhibition of SLC7A11 mirrored the effect of circTTC13 knockdown, whereas ferroptosis inhibition mimicked the effect of circTTC13 overexpression. Both circTTC13 and SLC7A11 were highly expressed in drug-resistant HCC cells, and circTTC13 silencing induced ferroptosis and reversed sorafenib resistance in explant tumors. …”
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Beyond the current state of just-in-time adaptive interventions in mental health: a qualitative systematic review by Claire R. van Genugten, Claire R. van Genugten, Melissa S. Y. Thong, Melissa S. Y. Thong, Melissa S. Y. Thong, Wouter van Ballegooijen, Wouter van Ballegooijen, Wouter van Ballegooijen, Annet M. Kleiboer, Annet M. Kleiboer, Donna Spruijt-Metz, Arnout C. Smit, Mirjam A. G. Sprangers, Mirjam A. G. Sprangers, Yannik Terhorst, Yannik Terhorst, Heleen Riper, Heleen Riper, Heleen Riper

“…Regarding the current state of studies, initial findings on usability, feasibility, and effectiveness appear positive.ConclusionsJITAIs for mental health are still in their early stages of development, with opportunities for improvement in both development and testing. For future development, it is recommended that developers utilize complex analytical techniques that can handle real-or near-time data such as machine learning, passive monitoring, and conduct further research into empirical-based decision rules and points for optimization in terms of enhanced effectiveness and user-engagement.…”
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Intrathecal Clonidine versus Dexmedetomidine as Adjuvants to Hyperbaric Ropivacaine in Lower Limb Orthopaedic Surgeries: A Randomised Clinical Study by Priya Kishnani, Aiman Monaf, Kalpesh Pati, Jatin Patel, Sara Mary Thomas

“…Materials and Methods: This randomised clinical study was conducted in a teritary care facility at the Operation Theatre (OT) complex in the Department of Anaesthesiology at Dhiraj Hospital, Smt. …”
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Implementing adaptive e-learning for newborn care in Tanzania: an observational study of provider engagement and knowledge gains by Peter Andrew Meaney, Christine Lynn Joyce, Ambrose Agweyu, Joseph R Mwanga, Marc Berg, Adolfine Hokororo, Hanston Ndosi, Alex Dahlen, Theopista Jacob, Florence Salvatory Kalabamu, Rishi Mediratta, Boris Rozenfeld, Zachary Haines Smith, Neema Chami, Namala Mkopi, Castory Mwanga, Enock Diocles

“…Median clinical experience was 4 years (IQR 1–9) and 45 (23%) had previous in-service training for both newborn essential and sick newborn care. Efficacy was 42% (SD ±17%). …”
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Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

“…We also examined the Cmax and AUC0-t of RS-SNEDDS in the brain and it was found to be 2.90 ± 0.171 μg/mL and 18.18 ± 1.68 μg/mL*hr respectively.Conclusion: This study concludes that the RS-SNEDDS improves brain tissue concentration and oral bioavailability, both of which increase therapeutic potential. Keywords: rhein, bioavailability, solubility, nanoemulsion, drug release, pharmacokinetic…”
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Effect of peer support nursing on improvement of caregiver preparedness for care of low anal fistula in infants (同伴支持式护理提升婴儿低位肛瘘照顾者准备度的研究)... by GUO Yufan (郭雨凡), WANG Yanmei (王晏美), LI Jianan (李佳楠), LAI Lixia (来丽霞), WANG Yanzhi (王艳芝)

“…Caregivers of infants in both control group and observation group received routine health education before discharge from hospital, and those in the observation group were given peer support nursing. …”
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Exploring coupling effects of rainfall and surface roughness on the sheet flow velocity by Enshuai Shen, Gang Liu, Qiong Zhang, Chenxi Dan, Chang Liu, Hairu Li, Ya Liu, Xueming Qu, Xiaolin Xia, Dandan Liu, Zhen Guo, Xining Zhao

“…The results showed that the roughness of the bed surface had a more pronounced effect on reducing the mean velocity compared to the surface velocity in both cases with and without raindrop impact. The raindrop impact notably reduced the flow velocity near the water surface, while the mean velocity slightly decreased or remained almost constant with increasing rainfall intensity. …”
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Impaired hemodynamic forces assessed by routine CMR and its determinants in different duration T2DM patients with normal LV function and myocardial strain by Guozhu Shao, Guozhu Shao, Guozhu Shao, Yukun Cao, Yukun Cao, Yukun Cao, Yue Cui, Yue Cui, Yue Cui, Hongyan Li, Heshui Shi, Heshui Shi, Heshui Shi

“…LVGLS was significantly decreased in late T2DM patients (p < 0.05), but HDF Strength (RMS) L-S (%) was significantly increased compared with early T2DM patients. Both HDF Strength (RMS) L-S (%) and HDF Strength (RMS) A-B (%) value were independently related to the extent of LGE (β = 0.435, p = 0.001; β = −0.329, p = 0.006, respectively). …”
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Intraspecific variation and new morphological characters revealed by multimodal imaging analysis on the Late Cretaceous coleoid Dorateuthis syriaca by Alison J. Rowe, Isabelle Kruta, Loïc Villier, Pierre Gueriau, Marie Radepont, Oulfa Belhadj, Katharina Müller, Romain Jattiot, Dirk Fuchs, Thomas Clements, Sylvain Charbonnier, Isabelle Rouget

“…Despite being the most abundant coleoid from these localities, the taxon lacks clear, unambiguous diagnostic characteristics of both the gladius, and soft tissue anatomy. The absence of a defined character complex for the species has led to inconsistencies in the literature and the need for a reappraisal. …”
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Biosynthesis and activity of Zn-MnO nanocomposite in vitro with molecular docking studies against multidrug resistance bacteria and inflammatory activators by Samy Selim, Tarek M. Abdelghany, Mohammed S. Almuhayawi, Mohammed K. Nagshabandi, Muyassar K. Tarabulsi, Mohammed Yagoub Mohammed Elamir, Asmaa A. Alharbi, Soad K. Al Jaouni

“…Alterations in the ultrastructure of the treated K. pneumoniae by Zn-MnO nanocomposite were recorded. Both the values of minimum inhibitory concentration (MIC) and minimum bactericidal concentration of Zn-MnO nanocomposite extended from 15.62 to 125 µg/mL employing the examined bacteria. …”
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Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study by Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal

“…Dupilumab is a human monoclonal antibody that targets both IL-4 and IL-13 signaling. It is currently indicated for the treatment of asthma, atopic dermatitis, and EoE. …”
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Structure and Expression of Two Sex-Related dmrt Genes in Oxyeleotris lineolata by Jiajia FAN, Dongmei MA, Huaping ZHU, Minghui LIN, Zaixuan ZHONG, Yuanyuan TIAN

“…The results showed that the expression location of the two genes in the testis were identical, and both had strong expression signals in the spermatogonia. …”
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Superior suspensory complex of the shoulder reconstruction for acute and chronic acromioclavicular joint dislocations: the Queensland Unit for Advanced Shoulder Research 3-tunnel t... by Helen Ingoe, MBBS, FRCS Eng, MD, MSc, PGCert, Jashint Maharaj, MBBS, MPHTM, FRSPH, Nagmani Singh, MBBS, MS, Kathir Azhagan Stalin, MBBS, MS, MRCS, DNB, Kristine Italia, MD, FPOA, Roberto Pareyon, MD, Mohammad N. Jomaa, MD, Kenneth Cutbush, MBBS, FRACS, FAOrthA, Ashish Gupta, MBBS, MSc, FRACS

“…Conclusion: The QUASR 3-Tunnel Technique with LARS artificial ligament is a safe and efficient technique for both acute and chronic ACJ reconstruction, lateral clavicle fractures with coracoclavicular ligament disruption and complex revision cases with favorable outcomes at the mid-term follow-up.…”
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Association between long-term ambient air pollution exposure and the incidence of breast cancer: A meta-analysis based on updated evidence by Ruohan Wang, Peihan Wang, Yongkang Zhou, Yinan Wang, Chengdong Xu, Zhenbo Wang, Wei Wang

“…The associations of NO2, PM2.5, and PM10 with estrogen/progesterone receptor-positive (ER+/PR+) breast cancer were not significantly different from those with estrogen/progesterone receptor-negative (ER–/PR–) breast cancer. Exposure to both NO2 and PM2.5 was associated with breast cancer incidence in Europe, whereas in North America, only NO2 exposure showed a significant association. …”
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