MiR-3664-3p through suppressing ABCG2, CYP3A4, MCL1, and MLH1 increases the sensitivity of colorectal cancer cells to irinotecan by Elham Farrokhnazar, Sahar Moghbelinejad, Reza Najafipour, Ladan Teimoori-Toolabi

“…However, a reduction in CYP3A4 expression was noted in the final resistant lines from both cell lines. …”
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A real-world study to assess the disease control of moderate to severe atopic dermatitis in patients receiving dupilumab therapy, with atopic dermatitis control tool in Gulf countr... by Amani Alfalasi, Ahmed Ameen, Atlal Al Lafi, Ayman El Gendi, Waqas Saad, Ahmed Ismail, Ayman Al Naeem, Srikumar Goturu, Nasser Al-Ahmed, Hussein Abdel Dayem, Arti Nanda, Amira Tawdy, Lulwa Alogayell, Mohamed Iraqi, Nasser Abdul Hay, Manar El Enezi, Subash Walkhinde, Marwa Kamal, Muna Aldhuhoori, Asem Almesfer, Amira Abd Elwhab, Khalid Ali Al Hawsawi, Ahmad Barakat, Sahar Chmayse, Mohammed Hafiz, Zahir Chouikrat, Monica Fahmy

“…Also, patient satisfaction improved significantly, with 65.3% reporting “Very Good” or “Excellent” PGATE scores in the 24th week compared to 20.3% at the baseline (p < 0.001). …”
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Impact of Cordyceps sinensis on coronary computed tomography angiography image quality and renal function in a beagle model of renal impairment by Peiji Song, Peiji Song, Kun Li, Xiaodie Xu, Guifeng Zhang, Zengkun Wang, Linbing Sun, Zekai Zhao, Ting Li, Ximing Wang, Zhangyong Xia, Zhangyong Xia, Zhangyong Xia, Zhangyong Xia

“…No statistically significant differences in image quality were observed among the four groups (P &gt; 0.05). In Groups A and D, significant changes were observed in renal function parameters, as well as in D, D*, f, and R2* values, both pre- and post-CCTA (P &lt; 0.05). …”
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Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis by Alberto González-González, Itziar Álvarez-Iglesias, Daniel García-Sánchez, Monica Dotta, Ricardo Reyes, Ana Alfonso-Fernández, Alfonso Bolado-Carrancio, Patricia Díaz-Rodríguez, María Isabel Pérez-Núñez, José Carlos Rodríguez-Rey, Jesús Delgado-Calle, Flor M. Pérez-Campo

“…Proteomic analysis revealed both soluble and vesicular fractions of hCM-Smurf1 were enriched with proteins essential for ossification and extracellular matrix organization, enhancing osteogenic differentiation. …”
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Cognitive decline in relation to later-life high temperature exposure in a Chinese nationwide cohort by Yu-Qian Huang, Lian-Sheng Zhang, Ji-Xing Yang, Fang Wang, Ya-Qi Wang, Li-Feng Zhu, Yuan-Yuan Zhang, Bo-Ning Deng, Qian-Qian Xiang, Yun-Quan Zhang

“…Temperature exposure prior to cognitive tests was assessed using both average temperatures and heat days exceeding predefined temperature thresholds. …”
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A 3D Clinical Face Phenotype Space of Genetic Syndromes Using a Triplet-Based Singular Geometric Autoencoder by Soha S. Mahdi, Eduarda Caldeira, Harold Matthews, Michiel Vanneste, Nele Nauwelaers, Meng Yuan, Giorgos Bouritsas, Gareth S. Baynam, Peter Hammond, Richard Spritz, Ophir D. Klein, Michael Bronstein, Benedikt Hallgrimsson, Hilde Peeters, Peter Claes

“…This allows for the selection of an optimal number of CFPS dimensions as well as improving the classification capacity of the CFPS, which outperforms the linear metric learning baseline in both syndrome classification and generalization to novel syndromes. …”
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Machine learning helps reveal key factors affecting tire wear particulate matter emissions by Zhenyu Jia, Jiawei Yin, Tiange Fang, Zhiwen Jiang, Chongzhi Zhong, Zeping Cao, Lin Wu, Ning Wei, Zhengyu Men, Lei Yang, Qijun Zhang, Hongjun Mao

“…The random forest (RF) model was developed and displayed good prediction performance with an R2 of 0.84 and 0.78 for PM2.5 and PM2.5-10 on the test set, respectively. …”
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Effect of Traditional Chinese Medicine nursing intervention on vertigo in patients with acute stroke (急性中风患者眩晕中医护理干预效果观察) by FU Jingna (付景娜), YANG Junhang (杨俊行), GENG Qingwen (耿庆文), CHEN Cheng (陈程), SONG Ying (宋颖), ZHAO Yazheng (赵亚争), SUN Yi (孙祎)

“…The routine TCM nursing interventions such as acupoint application and auricular point pressing therapy were conducted to relieve the symptom of vertigo among patients in both two groups, and an additional TCM intervention of massage therapy was carried out in the observation group. …”
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Application of PDCA cycle in continuous quality improvement of nursing inventory records in the operating room (PDCA循环法在手术室护理清点记录单持续质量改进中的应用)... by YIN Bei (尹蓓), WANG Yaling (王雅玲), QIU Murong (邱慕蓉)

“…Quality control by using PDCA cycle is effective to improve the qualified rate of nursing inventory records in the operating room, safeguard the legitimate rights and interests of both medical staffs and patients, and promote the continuous improvement of medical care quality. …”
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Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38 by Knut Husø Lauritzen, Knut Husø Lauritzen, Kuan Yang, Michael Frisk, Mieke C. Louwe, Maria Belland Olsen, Maria Belland Olsen, Mathias Ziegler, William E. Louch, Bente Halvorsen, Bente Halvorsen, Pål Aukrust, Pål Aukrust, Arne Yndestad, Øystein Sandanger, Øystein Sandanger

“…However, the NLRP3 inflammasome is not compromised in CD38-/- bone marrow-derived macrophages compared to corresponding WT cells, and apigenin moderated IL-1β release in both genotypes. DiscussionOur data support that apigenin attenuates NLRP3 activation independently of CD38. …”
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Spectroscopic analysis (UV-VIS-NIR) for predictive modeling of macro and micronutrients in grapevine leaves by J.I. Manzano, M. Rodríguez-Febereiro, M. Fandiño, M. Vilanova, J.J. Cancela

“…The ultraviolet (UV) range played a minor role, highlighting the predominant importance of the VIS-NIR regions in spectroscopic analyses.Finally, the results support the potential of this technique for swiftly and non-invasively predicting both macro and micronutrient levels in grapevine plants, and facilitate the fertilization planning using variety-specific reference levels, or precision viticulture adapted to site-specific demands, including spatial intra-plot variability.…”
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Prevalence of Dermatophytosis and Antifungal Activity of Ethanolic Crude Leaf Extract of Tetradenia riparia against Dermatophytes Isolated from Patients Attending Kampala Internati... by Taufik Kakande, Yonah Batunge, Emmanuel Eilu, Ambrose Shabohurira, Justus Abimana, Saheed Adekunle Akinola, Reagan Muhwezi, Abubakar Sunusi Adam, Sarah Kemuma Onkoba, Adamu Almustapha Aliero, Collins Atuheire, Charles Drago Kato, Ibrahim Ntulume

“…Thirty-one (31) fungal isolates were obtained which included both dermatophyte and non-dermatophyte fungi. T. verrucosum had highest distribution 6 (19.35%) among dermatophytes species while Aspergillus spp. were found to have highest distribution 7 (22.58%) among non-dermatophyte species. …”
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Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model by Shunan Wang, Ming Shen, Bo Pang, Bo Zhou, Yuan Yuan, Mei Lu, Xiangling Deng, Min Yang, Shufang Liu, Qiong Wang, Mei Xue, Qisheng Xia, Zhixin Zhang

“…In our animal model experiments, DNAJC12 gene knockout mice exhibited a complete absence of DNAJC12 expression at both mRNA and protein levels. These knockout mice showed significant deficits in learning and memory performance as assessed by the Morris water maze test. …”
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Changes in alcohol consumption among Belgian adults participating in the internet-based one-month-abstinence campaign ‘Tournée Minérale’ by Annelies Thienpondt, Jelle Van Cauwenberg, Joris Van Damme, Gera E. Nagelhout, Benedicte Deforche

“…Participants’ baseline drinking level moderated changes in alcohol consumption. Both short and medium term increases in alcohol consumption were observed among those with a low drinking level (those who drank 0 to < 4 glasses at baseline), while short and medium term decreases were observed among those with higher drinking levels, i.e. those with moderate (≥ 4 to ≤ 10 glasses), high (> 10 to ≤ 17 glasses) and highest (> 17 glasses) drinking level at baseline. …”
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Spot Versus 24-Hour Urine Osmolality Measurement in Autosomal Dominant Polycystic Kidney Disease: A Diagnostic Test Study by Ayub Akbari, Sriram Sriperumbuduri, Shreepryia Mangalgi, Vijay Joshi, Manish Sood, Amos Buh, Mohan Biyani, Christopher McCudden, Gregory L. Hundemer, Pierre Antoine Brown

“…Urine osmolality (osm) measures are surrogate markers of AVP activity. Both 24-hour and spot urine samples are used as indicators of AVP suppression. …”
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Decomposing the Poor-Non-Poor Gap in the Prevalence of Undiagnosed and Untreated Hypertension Among Bangladeshi Population by Mosiur Rahman, Mahfuza Khatun, Asrafun Naher Pinkey, Syed Emdadul Haque, Farhana Akhter Liza, Md. Nuruzzaman Haque, Prosannajid Sarkar, Tapan Kumar Roy, G. M. Rabiul Islam, Md. Rashed Alam, Mahmudul Hasan, Izzeldin Fadl Adam, Nguyen Huu Chau Duc, Saber Al-Sobaihi, Abid Hasan

“…The prevalence of hypertension, both diagnosed and undiagnosed, as well as its untreated states, were the outcome variables. …”
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Lightweight Tea Shoot Picking Point Recognition Model Based on Improved DeepLabV3+ by HU Chengxi, TAN Lixin, WANG Wenyin, SONG Min

“…The specific implementation steps entailed the feeding of image inputs through the improved network, whereupon MobilenetV2 was utilized to extract both shallow and deep features. Deep features were then fused via the ECA_ASPP module for the purpose of multi-scale feature integration, reinforcing the model's resilience to intricate backgrounds and variations in tea shoot morphology. …”
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In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives by Héverton Mendes Araújo, Gabriel Acácio de Moura, Yasmim Mendes Rocha, Cristian Vicson Pinheiro Gomes, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Larissa Deadame de Figueiredo Nicolete, Emanuel Paula Magalhães, Ramon R.P.P.B. de Menezes, Roberto Nicolete

“…Cytotoxicity in B16–F10 and BMDMs cells was assessed using the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT method. 1,2,4-oxadiazole derivative 2 exhibited antiproliferative effects on both cell lines, being 2.6 times more selective for B16–F10. …”
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Comparative efficacy of incretin drugs on glycemic control, body weight, and blood pressure in adults with overweight or obesity and with/without type 2 diabetes: a systematic revi... by Song Liu, Jiaqiang Hu, Chen Zhao, Hang Liu, Chunyang He

“…Non-diabetic participants showed more pronounced improvements in both weight and blood pressure. Safety analysis revealed that Tirzepatide had a favorable safety profile and all agents showed no significant impact on serious adverse events compared to placebo.ConclusionsMulti-receptor drugs demonstrated substantial therapeutic potential in weight management, glycemic control, and blood pressure regulation in adults with overweight or obesity, with or without diabetes, with a generally favorable safety profile.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024554005.…”
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Lithuanian, Russian, Polish istoriography with respect to the Poland - Lithuania union by Mečislovas Jučas

“…Signing the Krėva treaty in 1385, Jogaila did not think about incorporating Lithuania into Poland but intended to rule both states by himself. Thus, in 1385, only a personal inter-state relationship was stated (A. …”
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