ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3 by Shiyang Wang, Xi Wu, Wenxin Bi, Jiuzhi Xu, Liyuan Hou, Guilin Li, Yuwei Pan, Hanfu Zhang, Mengzhen Li, Sujuan Du, Mingxin Zhang, Di Liu, Shuiling Jin, Xiaojing Shi, Yuhua Tian, Jianwei Shuai, Maksim V. Plikus, Moshi Song, Zhaocai Zhou, Lu Yu, Cong Lv, Zhengquan Yu

“…Taken together, these findings demonstrate how mtROS promotes CRC progression by activating YAP via a post-transcriptional positive feedback loop between PGAM5 and MST3, both of which can serve as potential targets for developing next-generation anti-colon cancer therapeutics.…”
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Rectal temperature and heat transfer dynamics in the eye, face, and breast of broiler chickens exposed to moderate heat stress by Moustafa Yehia, Amani Askri, Ahlem Achour, Jean-Michel Allard Prus, Véronique Ouellet, Nabeel Alnahhas

“…Ts varied significantly across anatomical regions (P < 0.001), and core-to-skin and skin-to-air gradients differed between regions under both conditions (P < 0.001). Strong correlations were observed between Tr and Ts (r = 0.88, 0.89, and 0.92 for Tsb, Tse, and Tsf, respectively), suggesting Ts as a strong predictor of Tr. …”
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SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer by Lutfi H. Alfarsi, Rokaya El Ansari, Busra Erkan, Ali Fakroun, Madeleine L. Craze, Mohammed A. Aleskandarany, Kiu Wai Cheng, Ian O. Ellis, Emad A. Rakha, Andrew R. Green

“…SLC1A5 mRNA and SLC1A5 protein expression were strongly correlated in luminal B, HER2 + and triple-negative BC (TNBC). Both high SLC1A5 mRNA and SLC1A5 protein expression were associated with larger tumour size, higher grade, and positive axillary lymph node metastases (P < 0.01). …”
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Risk factors for ocular biological parameters in Chinese preschool children: a cohort study from the Beijing whole childhood eye study by Xi Qin, Yunyun Sun, Yunyun Sun, Shana Wang, Xiaolan Xie, Lei Gao, Huijian Li, Huijian Li, Ruihua Wei, Jing Fu, Jing Fu, Bidan Zhu

“…A longer AL and larger CR were associated with greater height (both p &lt; 0.001). The AL/CR ratio increased with age (p &lt; 0.001). …”
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Comparative Effects of Glenzocimab and Eptifibatide on Bleeding Severity in 2 Mouse Models of Intracranial Hemorrhage by Sébastien Dupont, Héloïse Lebas, Sabrina Mavouna, Eloïse Pascal, Astride Perrot, Adrien Cogo, Marie‐Charlotte Bourrienne, Carine Farkh, Mialitiana Solo Nomenjanahary, Véronique Ollivier, Fatima Zemali, Bernhard Nieswandt, Stéphane Loyau, Martine Jandrot‐Perrus, Eric Camerer, Jean‐Philippe Desilles, Mikael Mazighi, Yacine Boulaftali, Benoît Ho‐Tin‐Noé

“…Conversely, eptifibatide caused a significant increase in intracranial bleeding in both models, and a drastic increase in death after hyperglycemia‐induced hemorrhagic transformation of cerebral ischemia–reperfusion injury. …”
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Revisiting water resources management in the Mandara Mountains by Diane Madomguia, Esther Laurentine Nya, Emma Laureane Njomou-Ngounou, Nadège Gatcha-Bandjun, Tulinave Burton Mwamila, Jules Balna, Emina Halimassia, Jules Metsebo, Wilfried Arsène Letah Nzouebet, Raoul Rodrigue Tchoumbe, André Firmin Bon, Willis Gwenzi, Chicgoua Noubactep

“…The results show that RWH is an affordable, applicable, and attractive tool for both rural and urban communities to sustainably solve the long-lasting problem of lack of safe drinking water in the Mandara Mountains. …”
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Recombinant Anti-PF4 Antibodies Derived from Patients with Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT) Facilitate Research and Laboratory Diagnosis of VITT by Luisa Müller, Venkata A. S. Dabbiru, Lucy Rutten, Rinke Bos, Roland Zahn, Stefan Handtke, Thomas Thiele, Marta Palicio, Olga Esteban, Marta Broto, Tom Paul Gordon, Andreas Greinacher, Jing Jing Wang, Linda Schönborn

“…Chemiluminescence assays and both anti-PF4 IgG and anti-PF4 IgG/heparin ELISA showed concentration-dependent PF4 binding of all six rAbs, however, with different reactivities among them. …”
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Comparative analysis of ChatGPT and Gemini (Bard) in medical inquiry: a scoping review by Fattah H. Fattah, Fattah H. Fattah, Abdulwahid M. Salih, Abdulwahid M. Salih, Ameer M. Salih, Ameer M. Salih, Saywan K. Asaad, Saywan K. Asaad, Abdullah K. Ghafour, Rawa Bapir, Rawa Bapir, Rawa Bapir, Berun A. Abdalla, Berun A. Abdalla, Snur Othman, Sasan M. Ahmed, Sasan M. Ahmed, Sabah Jalal Hasan, Yousif M. Mahmood, Fahmi H. Kakamad, Fahmi H. Kakamad, Fahmi H. Kakamad

Subjects: “…ChatGPT…”
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A dosimetric comparison of non-coplanar volumetric modulated arc therapy and non-coplanar fixed field intensity modulated radiation therapy in hippocampus-avoidance whole-brain rad... by Huaqu Zeng, MinZhi Zhong, Zongyou Chen, Shukui Tang, Zunbei Wen

“…There was no significant difference in the Dmax to the left and right hippocampus between VMAT and IMRT (p&gt;0.05), but VMAT significantly increased the D100% (p&lt;0.05) compared with IMRT. …”
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Laboratory Rotational Spectroscopy Leads to the First Interstellar Detection of Singly Deuterated Methyl Mercaptan (CH2DSH) by Hayley A. Bunn, Silvia Spezzano, Laurent H. Coudert, Jean-Claude Guillemin, Yuxin Lin, Christian P. Endres, Brant Billinghurst, Olivier Pirali, Jes Jørgensen, Valerio Lattanzi, Paola Caselli

“…We report an extensive rotational spectroscopic analysis of singly deuterated methyl mercaptan (CH _2 DSH) using both millimeter and far-infrared synchrotron spectra to achieve a global torsional analysis of the three lowest torsional substates ( e _0 , e _1 , and o _1 ) of this nonrigid species. …”
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Burden of alopecia areata in China, 1990–2021: Global Burden of Disease Study 2021 by Xiangqian Li, Huixin Liu, Wenhui Ren, Qijiong Zhu, Peng Yin, Lijun Wang, Jianzhong Zhang, Jinlei Qi, Cheng Zhou, Lishao Guo

“…Additionally, the ASPR and ASDR were 224.61 per 100,000 population (95% UI, 216.73–232.65 per 100,000 population) and 7.41 per 100,000 population (95% UI, 4.85–10.44 per 100,000 population), respectively; both of these rates were higher than the global averages. …”
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Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington's disease by Carlos Cepeda, Sandra M. Holley, Joshua Barry, Katerina D. Oikonomou, Vannah-Wila Yazon, Allison Peng, Deneen Argueta, Michael S. Levine

“…Indeed, structural and functional abnormalities have been observed during brain development in both humans and animal models of HD. However, a concurrent study of cortical and striatal development in a genetic model of HD is still lacking. …”
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Polo-like Kinase 1 Expression as a Biomarker in Colorectal Cancer: A Retrospective Two-Center Study by Lana Jajac Brucic, Vesna Bisof, Majana Soce, Marko Skelin, Ivan Krecak, Andjela Nadinic, Branka Vrbicic, Zivana Puljiz, Suzana Hancic, Slavko Gasparov

“…Elevated expression of polo-like kinase 1 (PLK-1) has been linked to advanced disease stages and poorer treatment outcomes, including resistance to both chemotherapy and radiotherapy. However, data on PLK-1 expression in EOCRC compared to LOCRC remain limited. …”
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Prokaryotic diversity of the rhizosphere from Argentinean wine-producing regions by Andres Martin Toscani, Monica Oyuela Aguilar, Constanza Rey, Ramiro Eugenio Rocco Welsh, Alex Gobbi, Maria Florencia del Papa, Liliana Carmen Semorile, Lars Hestbjerg Hansen, Mariano Pistorio

“…We used next-generation sequencing methods, concentrating the analysis on two relevant cultivars, Malbec and Cabernet Sauvignon. Both varietals have attracted significant interest in recent research given their distinctive characteristics, which vary according to the geographic growing region. …”
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Long-term hypoxic atmosphere enhances the stemness, immunoregulatory functions, and therapeutic application of human umbilical cord mesenchymal stem cells by Qi-Ming Huang, You-Qiong Zhuo, Zhong-Xin Duan, Yin-lin Long, Jia-Nan Wang, Zhou-hang Zhang, Shao-Yong Fan, Yong-Ming Huang, Ke-Yu Deng, Hong-Bo Xin

“…The comparison between both atmospheres systematically analyzed the biological functions of MSCs, mainly including stemness maintenance, immune regulation, and resistance to chondrocyte apoptosis, and studied their joint function and anti-inflammatory effects in osteoarthritis (OA) rats constructed by collagenase II. …”
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Impact of endometrial thickness and its combined effect with maternal age on singleton adverse neonatal outcomes in frozen–thawed embryo transfer cycles by Jie Wang, Jie Wang, Lina Gao, Lina Gao, Qiaoyun Huang, Qiaoyun Huang, Weihua Jiang, Weihua Jiang, Linjun Chen, Linjun Chen, Shanshan Wang, Shanshan Wang

“…BackgroundThin endometrial thickness (EMT) and advanced age are both common risk factors for adverse neonatal outcomes (ANOs). …”
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Advanced TiO2-polypyrrole nanostructures enhance glucose detection accuracy with cutting-edge non-enzymatic electrochemical capabilities by Ashima Thakur, Sweety Pal, Usha Sharma, Ajit Sharma, Meenakshi Choudhary, Mukesh C. Joshi, Herma Dina Setiabudi, Prabal Pratap Singh, Atheesha Singh, Sudheesh K. Shukla

“…The developed non-enzymatic glucose detection sensor demonstrated sensitivity of 678.57 μAmM−1cm2 with linear range of 0 mM to 5.5 mM The enhanced performance is attributed to the synergistic effects of both the metallic as well as polymer moieties in the nanocomposite, where polypyrrole provides an outstanding conductive network for an efficient electron transfer, while TiO2 offers an active Centre for oxidation of glucose molecule. …”
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Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling by Adolf Koudelka, Gregory J. Buchan, Veronika Cechova, James P. O’Brien, Emily R. Stevenson, Crystal E. Uvalle, Heng Liu, Steven R. Woodcock, Steven J. Mullett, Cheng Zhang, Bruce A. Freeman, Stacy L. Gelhaus

“…Despite the expression of catalytically active enzymes required for LXA4 synthesis, both LXA4 and its 15-oxo-LXA4 metabolite were undetectable in all conditions. …”
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Enhancing surveillance for dengue fever in Oyo State, Nigeria – a one health approach by Olawale Sunday Animasaun, Joseph Ojonugwa Shaibu, Busayo Kayode Akomolafe, Olamide Priscilla Animasaun, Piring’ar Mercy Niyang, Olukemi Titilope Olugbade, Akinfemi Oyewumi Akinyode, Ibukun Akinsola Omisakin, Adedapo Olufemi Adeogun, Rosemary Ajuma Audu

“…Conclusion The study reveals a significant burden of DENV in Oyo State. The presence of both IgM and IgG antibodies suggests past exposure and possible recent circulation of the virus. …”
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Molecular Data Confirm the Occurrence of the Allochthonous <i>Gambusia holbrooki</i> (Pisces: Poeciliidae) in Sicily and the Maltese Archipelago by Luca Vecchioni, Mirko Liuzzo, Arnold Sciberras, Jeffrey Sciberras, Justin Formosa, Alan Deidun, Gabriele Giacalone, Vincenzo Arizza, Marco Arculeo, Federico Marrone, Francesco Paolo Faraone

“…In the 1920s and 1930s, both <i>G. holbrooki</i> and <i>G</i>. <i>affinis</i> were asynchronously introduced from the United States into Europe and subsequently translocated globally as biocontrol agents of the malaria vector (i.e., the larvae of the <i>Anopheles</i> mosquitoes), with dramatic consequences for the inland water native fauna. …”
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