Efek Pemberian Vitamin C terhadap Gambaran Histopatologi Hati Tikus Wistar yang Terpapar Timbal Asetat by Arifuddin ., Aswiyanti Asri, Elmatris .

“…Statistically administration of both dose vitamin C did not give significant difference (p = 0.379).The conclusion of this study show  there is the effect of protection from administration of vitamin C to microscopic Wistar rat liver which exposed to lead acetate</em></p><p><strong><em>Keywords: </em></strong><em>lead acetate, histopathology of liver, vitamin C, plumbum acetate, Manja Roenigk</em><em></em></p></div><em><br clear="all" /> </em>…”
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Urinary Incontinence in Men with Stroke: A Cross-Sectional Study by İsmail Uysal, Özgür Nadiye Doğrukök, Yalcin Golcuk, Fatih Özden, Mehmet Özkeskin, Miray Başer, Bircan Yücekaya, Zeynep Nisa Karakoyun

“…According to these scores, both UI questionnaire results were slightly above the reference cut-off value. …”
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Iron triggers TvPI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Tric... by Kuan-Yi Wu, Yen-Ju Chen, Shu-Fan Lin, Hong-Ming Hsu

“…Beyond cytoadherence, during host-parasite interactions, TvArf220 influenced both contact-dependent and -independent cytotoxicity, as well as phagocytotic capacity, contributing to the cytopathogenesis of human vaginal epithelial cells. …”
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Results of replacing fish meal with insect protein in carp feeds by O. Deren, O. Bernakevych, L. Bobeliak, N. Hrytsyshyna, M. Koryliak

“…The productive, morphological, hematological and antioxidant parameters of the fish body of experimental and control groups were determined. Findings. During both stages of the study, the temperature, oxygen, and hydrochemical conditions did not differ significantly between the experimental and control variants and met fish farming standards. …”
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Comparative transcriptomic rhythms in the mouse and human prefrontal cortex by Jennifer N. Burns, Jennifer N. Burns, Aaron K. Jenkins, Xiangning Xue, Kaitlyn A. Petersen, Kaitlyn A. Petersen, Kyle D. Ketchesin, Kyle D. Ketchesin, Megan S. Perez, Megan S. Perez, Chelsea A. Vadnie, Madeline R. Scott, Madeline R. Scott, Marianne L. Seney, Marianne L. Seney, George C. Tseng, Colleen A. McClung, Colleen A. McClung

“…Nevertheless, we find that basic biological processes are enriched for rhythmic transcripts across species, with key differences between regions and sexes.DiscussionTogether, this work highlights both the evolutionary conservation of transcriptomic rhythms and the advancement of the human PFC, underscoring the importance of considering cross-species differences when using animal models.…”
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Hydrological niche separation between two coexisting shrubs in an extremely arid region by Mingyan Fan, Hai Zhou, Lihui Tian, Heng Ren, Bing Liu, Xibin Ji, Xiangyan Feng, Qiyue Yang, Huli Gu

“…Additionally, the C. mongolicum exhibited a significant dependence on deep soil water (about 26 %) and groundwater (over 30 %); while N. sphaerocarpa has a significant response to precipitation, its proportion of shallow soil water is more than 40 % after heavy precipitation events, in seasons with less precipitation, it relied on groundwater for survival. Both species had a dynamic HNS, the hydrological niche overlap index exhibited a decreasing and then increasing trend; but HNS was low during the dry season, indicating that HNS was affected by precipitation. …”
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Pancreatoduodenectomy without Vascular Resection in Patients with Primary Resectable Adenocarcinoma and Unilateral Venous Contact: A Matched Case Study by Luca Morelli, Raffaella Berchiolli, Simone Guadagni, Matteo Palmeri, Niccolò Furbetta, Desirée Gianardi, Matteo Bianchini, Niccola Funel, Giovanni Caprili, Luca Emanuele Pollina, Giulio Di Candio, Franco Mosca, Gregorio Di Franco, Alfred Cuschieri

“…Isolated local recurrence rate was 2/40 (5%) in both groups. Additionally, there were no statistical differences in the systemic progression of the disease (42.5% sPD vs. 45% nvrPD, p=0.82) or local plus synchronous systemic disease rates (2.5% sPD vs. 7.5% nvrPD, p=0.30). …”
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Predictors of developing severe COVID-19 among hospitalized patients: a retrospective study by Hussain Abduljaleel Alkhalifa, Ehab Darwish, Zaenb Alsalman, Aman Alfaraj, Abdullah Alkhars, Fatimah Alkhalifa, Mohammed Algaraash, Ahmed Mohammed Elshebiny, Emad Alkhoufi, Khaled Mohamed Amin Elzorkany

“…Comparative tests as well as both univariate and multivariate logistic regression analyses were performed to identify risk factors for developing severe COVID-19 and poor outcomes.ResultsBased on the comparative statistical tests patients with severe COVID-19 were statistically significantly associated with older age and had higher respiratory rate, longer hospital stay, and higher prevalence of diabetes than non-severe cases. …”
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Zipper Pattern: An Investigation into Psychotic Criminal Detection Using EEG Signals by Gulay Tasci, Prabal Datta Barua, Dahiru Tanko, Tugce Keles, Suat Tas, Ilknur Sercek, Suheda Kaya, Kubra Yildirim, Yunus Talu, Burak Tasci, Filiz Ozsoy, Nida Gonen, Irem Tasci, Sengul Dogan, Turker Tuncer

“…<b>Conclusions:</b> In this regard, the proposed ZPat-based XFE model achieved both high classification performance and interpretability. …”
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Composition of antifungal volatile organic compounds in Sextonia rubra fruit by molecular networks by Levasseur, Marceau, Santerre, Cyrille, Segret, Juliette, Elie, Nicolas, Genty, Christophe, Estevez, Yannick, Amusant, Nadine, Houël, Emeline, Eparvier, Véronique, Touboul, David

“…Our methodology proved to be efficient to annotate the compounds detected complementary to the use of MassHunter Unknown Analysis.Hydrolate and dried fruit both displayed a rich and diverse HS-SPME-GC-MS sesquiterpenic profile, alongside with moderate antimicrobial activity towards the filamentous fungus Tricophyton rubrum for the hydrolate.…”
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Nerve repair with polylactic acid and inosine treatment enhance regeneration and improve functional recovery after sciatic nerve transection by Fellipe Soares dos Santos Cardoso, Guilherme dos Santos Maria, Fernanda Marques Pestana, Ricardo Cardoso, Bruna dos Santos Ramalho, Bruna dos Santos Ramalho, Luiza dos Santos Heringer, Tiago Bastos Taboada, Ana Maria Blanco Martinez, Fernanda Martins de Almeida, Fernanda Martins de Almeida

“…This resulted in greater compound muscle action potential amplitude and nerve conduction velocity, leading to preservation of muscle and neuromuscular junction integrity, and consequently, the recovery of motor and sensory function.ConclusionOur findings suggest that inosine may enhance regeneration and improve both motor and sensory function recovery after nerve transection when repaired with a poly-lactic acid conduit. …”
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Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long‐Term Cardiovascular Mortality by Mieke C. Louwe, Chrysostomi Gialeli, Annika E. Michelsen, Sverre Holm, Andreas Edsfeldt, Karolina Skagen, Tove Lekva, Maria Belland Olsen, Vigdis Bjerkeli, Therese Schjørlien, Kristine Stø, Xiang Yi Kong, Tuva B. Dahl, Per H. Nilsson, Peter Libby, Pål Aukrust, Tom Eirik Mollnes, Thor Ueland, Mona Skjelland, Isabel Gonçalves, Bente Halvorsen

“…Although patients with carotid atherosclerosis had elevated levels of properdin compared with controls, within these patients, low plasma levels of properdin (ie, <median levels of properdin in the patient group) were significantly associated with cardiovascular mortality. This was seen in both the Discovery (HR 2.31, P=0.019) and the Validation cohort (hazard ratio [HR], 2.81, P=0.014). …”
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Genome-wide association study unravels mechanisms of brain glymphatic activity by Shu-Yi Huang, Yi-Jun Ge, Peng Ren, Bang-Sheng Wu, Weikang Gong, Jing Du, Shi-Dong Chen, Ju-Jiao Kang, Qing Ma, Arun L. W. Bokde, Sylvane Desrivières, Hugh Garavan, Antoine Grigis, Herve Lemaitre, Michael N. Smolka, Sarah Hohmann, IMAGEN Consortium, Jian-Feng Feng, Ya-Ru Zhang, Wei Cheng, Jin-Tai Yu

“…Genetic signals located at the 2p23.3 locus yielded significantly concordant effects in both young and aging cohorts. Genetic correlation and polygenic overlap analyses indicate a common underlying genetic mechanism between the ALPS-index, ventricular volumes, and cerebrospinal fluid tau levels, with GMNC (3q28) and C16orf95 (16q24.2) as the shared genetic basis. …”
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Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma by Michaela Plath, Martina A. Broglie, Diana Förbs, Sandro J. Stoeckli, Wolfram Jochum

“…P16INK4a showed a higher DOR to predict HR-HPV DNA positivity than pRB, cyclin D1 and p53. Both the p16INK4a/pRB and the p16INK4a/pRB/cyclin D1/p53 signatures had lower DOR than p16INK4a alone. …”
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles by Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas

“…Upon examining cholesterol as a mediator of EV biogenesis, we delineated a pathway whereby ERK1/2 acted by phosphorylating sterol regulatory element-binding protein-2 that transcriptionally induced 7-dehydrocholesterol reductase expression, thus raising cholesterol abundance at both cellular and EV levels. Notably, inhibition of MEK or cholesterol synthesis, which impaired TGF-β-induced EV secretion, sensitized cancer cells to chemotherapeutic drugs. …”
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Detection of 5 Kinds of Genes Related to Plasmid-Mediated Quinolone Resistance in Four Species of Nonfermenting Bacteria with 2 Drug Resistant Phenotypes by De-Song Ming, Qing-Qing Chen, Xiao-Ting Chen

“…The carrying rate of the class 1 integron was not significantly different between strains of multidrug resistance and pandrug resistance (P>0.05). Both acc(6′)-Ib-cr and intI1 were detected in 6 strains, which were negative for qnrA, intI2, and intI3. …”
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Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression a... by Carltin Chun Ting Kwok, Heidi Ka Ying Lo, Ching Yui Chan, Joe Kwun Nam Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng, Chung Ho, Brian Man Ho Leung, Wilfred Shone Horn Wong, Zoe Hoi Shuen Yu, Edwin Ho Ming Lee, Wing Chung Chang

“…Results Overall BZRA prescription prevalence significantly increased (AAPC: 5.70% [95%CI: 5.31-6.54%]), from 1.88 in 2000 to 5.69 in 2020, uniformly across both sexes. Young adults (18–24 years-old) displayed the highest prescription prevalence, followed by adolescents (12–17 years-old) and children (4–11 years-old). …”
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Productive performance in Italian Mediterranean buffaloes after partially replacing dietary starch with simple sugars by Roberta Matera, Gabriele di Vuolo, Giuseppina Pedota, Luca de Luise, Mariateresa Marra, Luca Borzacchiello, Ludovica Capoluongo, Gianluca Neglia

“…Sixty lactating buffaloes located on a commercial farm in Caserta province were divided into two groups according to days in milk (DIM), parity, and milk yield (MY), recorded both in the previous two weeks and the previous lactation: Group C (Control; n=30; 48.7±4.1 DIM; average MY: 13.69±0.5 kg) and group T (Treated; n=30; 49.4±4.3 DIM; average MY: 13.65±0.5 kg). …”
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Evaluation of twin-arginine translocation substrate proteins as potential antigen candidates for serodiagnosis of brucellosis by Yao Wu, Yao Wu, Xin Yan, Mingjun Sun, Xiaohan Guo, Jiaqi Li, Xiangxiang Sun, Xiangxiang Sun, Mengda Liu, Mengda Liu, Haobo Zhang, Haobo Zhang, Wenlong Nan, Weixing Shao, Fangkun Wang, Xiaoxu Fan, Xiaoxu Fan, Shufang Sun

“…Meanwhile, the combined protein group showed the strongest ability to detect Brucella in sheep serum, achieving an accuracy of 88.10%. Both the combined protein group and YxeI displayed no cross-reactivity with rabbit serum immunized against Yersinia enterocolitica O9, Escherichia coli O157:H7, Mycobacterium tuberculosis, Vibrio cholerae, Legionella, and Salmonella, indicating relatively good specificity.ConclusionThe findings of this study suggest that Tat substrate proteins serve as promising candidate antigens with significant potential value for the clinical diagnosis of brucellosis.…”
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Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study by Pedro Romero-Aroca, Marc Baget-Bernaldiz, Raul Navarro-Gil, Antonio Moreno-Ribas, Aida Valls-Mateu, Ramon Sagarra-Alamo, Joan F. Barrot-De La Puente, Xavier Mundet-Tuduri

“…The UACR has a better association with diabetic retinopathy than the eGFR, although both are important risk factors for diabetic retinopathy.…”
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