Upregulation of HSP90α in the lungs and circulation in sarcoidosis by Takuma Isshiki, Takuma Isshiki, Takuma Isshiki, Motoko Sunakawa, Megan Vierhout, Megan Vierhout, Anmar Ayoub, Anmar Ayoub, Pareesa Ali, Pareesa Ali, Safaa Naiel, Safaa Naiel, Shion Miyoshi, Asghar Naqvi, Nathan Hambly, Kazuma Kishi, Kjetil Ask, Kjetil Ask, Martin R. J. Kolb

“…HSP90α concentrations in the circulation were correlated with biomarkers of disease stage. Both primary and immortalized macrophages showed a high capacity for secreting extracellular HSP90α.ConclusionThese results demonstrate that macrophages in the lungs of sarcoidosis patients produce high levels of HSP90α, suggesting HSP90α as a potential biomarker and therapeutic target.…”
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Geohazard features of the Aeolian Island slopes and the North-Eastern Sicily offshore by Fabiano Gamberi, Daniele Casalbore, Michael Marani, Marzia Rovere, Alessandro Bosman, Marilena Calarco, Giacomo Dalla Valle, Elisa Leidi, Eleonora Martorelli, Alessandra Mercorella, Martina Pierdomenico, Claudia Romagnoli, Chiara Adami, Francesco Giuseppe Falese, Andrè Fascetti, Valentina Ferrante, Michela Ingrassia, Erika Lai, Cristian Montanaro, Andrea Sposato, Francesco Latino Chiocci

“…In this paper, we present the maps: ‘The submerged portions of the Aeolian volcanic islands and the north-eastern Sicilian margin’, located in the south-eastern Tyrrhenian Sea. Both areas are affected by active geological processes, which represent important geohazards elements. …”
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Investigating service delivery and perinatal outcomes during the low prevalence first year of COVID-19 in a multiethnic Australian population: a cohort study by Vincent W Lee, N Wah Cheung, Dharmintra Pasupathy, Sarah J Melov, James Elhindi, Therese M McGee, Seng Chai Chua, Justin McNab, Thushari I Alahakoon

“…Composite adverse neonatal outcomes were marginally higher (aOR 1.08; 95% CI 1.00 to 1.15, p=0.04) and full breastfeeding rates at hospital discharge reduced by 15% (aOR 0.85; 95% CI 0.80 to 0.90, p<0.001).Conclusion Despite a low prevalence of COVID-19, both positive and adverse obstetric outcomes were observed that may be related to changes in service delivery and interaction with healthcare providers. …”
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Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration by Ting Shen, Jacob W. Vogel, Vivianna M. Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S. Phillips, Lauren Massimo, Edward B. Lee, David J. Irwin, Corey T. McMillan

“…Methods We employed an integrative imaging transcriptomics approach to identify both disparate and shared transcriptomic signatures associated with cortical thickness in bvFTD with C9orf72 repeat expansions or pathogenic variants in GRN or MAPT. …”
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Global assessment of leukemia care quality: insights from the quality of care index (QCI) from 1990 to 2021Research in context by Yuzhe Pan, Qian Liu, Nan Zhang, Shuang Peng, Xinqi Li, Fuling Zhou

“…Findings: Between 1990 and 2021, both the age-standardized incidence rate (ASIR) and age-standardized death rate (ASDR) for leukemia exhibited a consistent decline. …”
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The lamprey habenula provides an extreme example for the temporal regulation of asymmetric development by Lucile Guichard, Ronan Lagadec, Léo Michel, Hélène Mayeur, Michaël Fuentès, Jordan Pain, Noah Heier, Quentin Rougemont, Maria Celina Rodicio, Antón Barreiro-Iglesias, Antón Barreiro-Iglesias, Patrick Blader, Michael Schubert, Sylvie Mazan

“…As in gnathostomes, Wnt signaling may be involved in the regulation of this unique, asymmetric mode of development, since β-catenin shows asymmetric and highly dynamic nuclear distributions both in neural progenitors and differentiated neuronal precursors of the two habenular subdomains. …”
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Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects by Tomoyuki Hara, Yuya Fujishima, Hitoshi Nishizawa, Yusuke Kawachi, Takashi Nakamura, Seigo Akari, Yoshiyuki Ono, Hirotaka Watanabe, Taka-aki Sakaue, Yoshinari Obata, Hirofumi Nagao, Shiro Fukuda, Takashi Kanamoto, Mitsuyoshi Takahara, Naoto Katakami, Ken Nakata, Iichiro Shimomura

“…In the WBVE-alone intervention, the study subjects performed 20-min of WBVE. In the OGTT → WBVE intervention, a 75-g oral glucose load (OGL) was administered 30 min prior to the start of the WBVE intervention. …”
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Evaluation of seasonal variation, effect of extraction solvent on phytochemicals and antioxidant activity on Rosmarinus officinalis grown in different agro-ecological zones of Kiam... by Zelipha N. Kabubii, James M. Mbaria, Mbaabu P. Mathiu, John M. Wanjohi, Evans N. Nyaboga

“…Methods The leaves of R. officinalis were harvested from six purposively selected sites in four agro-ecological zones of Kiambu County, Kenya both in the wet and the dry seasons. Phytochemicals were extracted in 80% methanol, 80% ethanol, and distilled water. …”
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Cork and Compost as Mitigators of Soil Compaction from Trampling in Urban Green Areas: Effects on Plant Growth and Soil Functionality by Bianca Rompato, Lucia Mondanelli, Ermes Lo Piccolo, Claudia Cocozza, Giovanni Mastrolonardo, Laura Giagnoni, Gregorio Fantoni, Alessandro Bizzarri, Barbara Mariotti, Leonardo Verdi, Alberto Maltoni, Francesco Ferrini, Giacomo Certini

“…Five soil treatments were compared: control (no compaction and amendments), soil compaction without amendments, and compaction with amendments including cork, compost, or a combination of both. Soil and plant physiological responses were analyzed during the summer months, focusing on soil gas exchange, temperature, moisture, microbial respiration, enzymatic activity, leaf gas exchange, leaf chlorophyll fluorescence, chlorophyll content, and maximum daily trunk shrinkage. …”
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Genomic analysis and antibiotic resistance of a multidrug-resistant bacterium isolated from pharmaceutical wastewater treatment plant sludge by Ningyu Sun, Hu Gao, Xinbo Zhang, Zeyou Chen, Anping Peng

“…N4 exhibited high resistance to both antibiotics and metals, with minimum inhibitory concentrations (MICs) of chloramphenicol and cefazolin reaching 1024 mg·L−1 and MICs of Cu2+ and Zn2+ reaching 512 mg·L−1. …”
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Techno-economic studies of low GWP-organic Rankine cycle for low-level geothermal waste heat utilization in Remote Island of Indonesia by Fefria Tanbar, Rusdi Febriyanto, Hifni Mukhtar Ariyadi, Ariyana Dwiputra Nugraha, Arionmaro Asi Simaremare, Eko Supriyanto, Meiri Triani, Muhammad Akhsin Muflikhun

“…This study thermodynamically and economically assessed two ORC systems: Binary Cycle-Organic Rankine Cycle (BC-ORC) and Recuperator (BC-ORCR), both using low global warming potential (GWP) working fluids of R1233zd (E), R1224yd (Z), R1234ze (Z), R1234ze (E), R1243zf, and R1234yf, paired with air- and water-cooled condensers. …”
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Effect of Cluster Needling of Scalp Acupuncture Combined with Walking Training on Walking Ability of Stroke Patients under Different Task by CHEN Jing, LI Jingge, LI Boning, LIU Xiaomeng, CAO Manting, LI Hui

“…ObjectiveTo observe the effect of cluster needling of scalp acupuncture combined with walking training on walking ability of stroke patients under single-task walking (STW) and dual-task walking (DTW) paradigm.MethodsA total of 78 inpatients with non-acute stroke who were treated in the the Third Affiliated Hospital of Zhejiang Chinese Medicine University from September 2019 to April 2021, which were divided into the control group and the observation group according to the random number table method, with 39 cases in each group. Both groups received conventional treatment for cerebrovascular disease, the control group received walking training on the basis of conventional treatment, 40 minutes a time, once a day, five days a week, continuous treatment for four weeks, including antigravity muscle training, lower limb weight-bearing support training, lower limb step training of affect side and standing center of gravity transfer training, etc. …”
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A two‐phase epigenome‐wide four‐way gene–smoking interaction study of overall survival for early‐stage non‐small cell lung cancer by Leyi Chen, Xiang Wang, Ning Xie, Zhongwen Zhang, Xiaowen Xu, Maojie Xue, Yuqing Yang, Liya Liu, Li Su, Maria Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Ruyang Zhang

“…Meanwhile, the four‐way interaction improved the discrimination ability for the prognostic prediction model, as indicated by the area under the receiver operating characteristic curve (AUC) for both 3‐ and 5‐year survival. In summary, we identified a four‐way interaction associated with NSCLC survival among pack‐year of smoking, cg05293407TRIM27, cg00060500KIAA0226 and g16658473SHISA9, providing novel insights into the complex mechanisms underlying NSCLC progression.…”
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Prevention Of Breast and Endometrial cancer using Total Diet Replacement (PROBE-TDR) trial: protocol for a randomised controlled trial by Robert Clarke, Emma J Crosbie, Basil G Issa, John Belcher, Helen Clarke, Anthony Howell, Michelle Harvie, Hannah Harrison, Cheryl Lombardelli, Suzanne Krizak, Katharine Sellers, Yit Y Lim, Caroline Parkin, Shruthi Patel, Anthony J Maxwell, Julie Wisely, Sacha J Howell

“…The trial will also assess longer-term adherence and weight loss success across the 12-month programme in both the immediate and control groups.Ethics and dissemination Approval for this study has been obtained from the Health Research Authority and Health and Care Research Wales (approval 20/NW/0095). …”
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Penerapan SMOTE untuk Mengatasi Imbalance Class dalam Klasifikasi Kepribadian MBTI Menggunakan Naive Bayes Classifier by Mutiara Persada Pulungan, Andi Purnomo, Aliyah Kurniasih

“…The evaluation results showed low performance of the Naive Bayes Classifier algorithm for the Artisan and Guardian classes, but both for the Rational and Idealist classes. The Logistic Regression algorithm has the highest accuracy of 79% and better performance overall, although it is still low for the Artisan and Guardian classes. …”
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Bottom Trawling and Multi‐Marker eDNA Metabarcoding Surveys Reveal Highly Diverse Vertebrate and Crustacean Communities: A Case Study in an Urbanized Subtropical Estuary by Jack Chi‐Ho Ip, Hai‐Xin Loke, Sam King Fung Yiu, Meihong Zhao, Yixuan Li, Yitao Lin, Chun‐Ming How, Jiezhang Mo, Meng Yan, Jinping Cheng, Vincent Chi‐Sing Lai, Leo Lai Chan, Kenneth Mei Yee Leung, Jian‐Wen Qiu

“…Among the detected fish at species level, 70 species were detected by both approaches, 32 species were detected by trawling only, and 142 species were detected by the eDNA approach only. …”
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Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control by Helena Escuin-Ordinas, Ignacio Melero, Marisol Quintero, Jose Luis Perez-Gracia, Maite Alvarez, Maria E Rodriguez-Ruiz, Miguel F Sanmamed, Paloma Sanchez-Mateos, Inmaculada Rodríguez López, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Eneko Garate-Soraluze, Victor Diaz Pascual, Leire Arbea Moreno

“…Local immunotherapy, by injecting various pathogen-associated molecular patterns, has shown efficacy both preclinically and clinically. BO-112 is a viral mimetic based on nanoplexed double-stranded RNA (poly I:C) which exerts immune-mediated antitumor effects in mice and humans on intratumoral delivery. …”
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Effects of population aging on quality of life and disease burden: a population-based study by Jun-Yan Xi, Bo-Heng Liang, Wang-Jian Zhang, Bo Yan, Hang Dong, Yuan-Yuan Chen, Xiao Lin, Jing Gu, Yuan-Tao Hao

“…The HALE and DALY projections were generated using both the Bayesian age-period-cohort models and the population prediction models. …”
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L-Theanine Extends the Lifespan of <i>Caenorhabditis elegans</i> by Reducing the End Products of Advanced Glycosylation by Zhihang Huang, Haiming Jing, Yan Pan, Hongxia Cai, Wenjing Zhang, Jingyuan Zhu, Nan Zhang, Dan Wu, Wentao Xu, Hexiang Qiu, Huihui Bao, Guojun Li, Junyu Ning, Bo Xian, Shan Gao

“…Through an AGE-level analysis, we observed that L-theanine, when administered during early adulthood, notably extended the lifespan of <i>Caenorhabditis elegans</i> under both normal and high-glucose-induced stress conditions. …”
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Evaluation of the Efficacy of Stem Cell Therapy in Ovariectomized Osteoporotic Rats Based on Micro-CT and Dual-Energy X-Ray Absorptiometry: A Systematic Review and Meta-Analysis by Zhencheng Xiong, Ping Yi, Jialiang Lin, Shengfeng Qiu, Li Shu, Chi Zhang

“…Compared with the OVX group, both stem cell transplantation groups had higher bone mineral density (BMD) (BMSCs: SMD=2.01, 95% CI: [1.38, 2.63], P<0.001, I2=76.6%; ADSCs: SMD=2.24, 95% CI: [0.79, 3.69], P=0.003, I2=86.7%) and bone volume/total volume (BV/TV) (hUCB-MSCs: SMD=1.71, 95% CI: [0.97, 2.44], P<0.001, I2=0%; ADSCs: SMD=2.16, 95% CI: [0.27, 4.04], P=0.025, I2=82.6%). …”
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