Patient Voices: Multimethod Study on the Feasibility of Implementing Electronic Patient-Reported Outcome Measures in a Comprehensive Cancer Center by Cinzia Brunelli, Sara Alfieri, Emanuela Zito, Marco Spelta, Laura Arba, Linda Lombi, Luana Caselli, Augusto Caraceni, Claudia Borreani, Anna Roli, Rosalba Miceli, Gabriele Tine', Ernesto Zecca, Marco Platania, Giuseppe Procopio, Nicola Nicolai, Luigi Battaglia, Laura Lozza, Morena Shkodra, Giacomo Massa, Daniele Loiacono, Giovanni Apolone

“…Trial RegistrationClinicalTrials.gov NCT03968718; https://clinicaltrials.gov/study/NCT03968718…”
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Response to Aflibercept Therapy in Three Types of Choroidal Neovascular Membrane in Neovascular Age-Related Macular Degeneration: Real-Life Evidence in the Czech Republic by Jan Nemcansky, Alexandr Stepanov, Michal Koubek, Miroslav Veith, Yun Min Klimesova, Jan Studnicka

“…The primary outcome of our study is that the treatment with aflibercept in nAMD patients led to statistically significant improvement in BCVA and to a decrease in CRT throughout the follow-up period in both occult and classic types of CNV. The minimally classic type of CNV demonstrated a poorer functional and anatomical response to treatment.…”
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Efficacy and safety of the metformin-mazindol anorectic combination in rat by Argüelles-Tello Federico, Roa-Coria José Eduardo, Zúñiga-Romero Ángel, Huerta-Cruz Juan Carlos, Quiñonez-Bastidas Geovanna Nalley, Flores-Murrieta Francisco Javier, Rocha-González Héctor Isaac, Reyes-García Juan Gerardo

“…In addition, the interaction index confirmed the additive anorectic effect between both drugs. A single oral dose of ED40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. …”
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In vivo reduction of biofilm seeded on orthopaedic implants: safety and efficacy of portable electromagnetic induction heating by Enrique Cordero García-Galán, Marina Medel-Plaza, José J. Pozo-Kreilinger, Héctor Sarnago, Óscar Lucía, Alicia Rico-Nieto, Jaime Esteban, Enrique Gomez-Barrena

“…Assessment of side effects, including thermal necrosis of adjacent tissue, would determine transferability into clinical practice. Our goal was to assess bone necrosis and antibacterial efficacy of induction heating on biofilm-infected implants in an in vivo setting. …”
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Localización de nuevos asentamientos humanos y sectores productivos en la meseta patagónica argentina by Luis Alberto Bertani, María de los Ángeles Tesoniero, Lorena Alicia Conejeros Bilbao

“…El sector ocupa 2500,0 has y se localiza en el sector norte del futuro lago entre las cota de 8,0 y 38,0 m, por debajo del nivel de la meseta que circunda al bajo del Gualicho, ubicada a 160,0 msnm. …”
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Diagnostic accuracy of two-dimensional shear wave elastography and point shear wave elastography in identifying different stages of liver fibrosis in patients with metabolic dysfun... by Xiangyi Xu, Yiqing Zhang, Qiwei Zhu, Yuchen Xie, Yuanyuan Zhou, Bingtian Dong, Chaoxue Zhang

“…The pooled specificity of pSWE and 2-D SWE for these stages were 0.83 (95% CI 0.76-0.88), 0.87 (95% Cl: 0.81-0.92), and 0.91 (95% CI 0.86-0.94) for pSWE, and 0.76 (95% CI 0.66-0.84), 0.76 (95% CI 0.69-0.82), and 0.83 (95% CI 0.78-0.85) for 2-D SWE, respectively. In conclusion, both 2-D SWE and pSWE demonstrated high diagnostic performance in identifying various stages of liver fibrosis in MASLD patients. …”
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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…Abstract Introduction Validated patient-reported outcome measures (PROMs) are crucial for assessing patients’ experiences in the healthcare system. Both clinically and theoretically, patient-centered consultations are essential in patient-care, and are often suggested as the optimal strategy in caring for patients with multimorbidity. …”
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The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker by Hao-ming He, Ying-ying Xie, Qiang Chen, Yi-ke Li, Xue-xi Li, Sun-jing Fu, Na Li, Yan-ru Han, Yan-xiang Gao, Jin-gang Zheng

“…Individuals with high TyG and high ABSI (TyG > 9.04 and ABSI > 0.085) were at the highest cardiovascular mortality risk both in individuals with (HR = 1.714, 95% CI 1.123–2.616) and without diabetes (HR = 1.402, 95% CI 1.003–1.960), suggesting a synergistic effect. …”
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A dual role of Cohesin in DNA DSB repair by Michael Fedkenheuer, Yafang Shang, Seolkyoung Jung, Kevin Fedkenheuer, Solji Park, Davide Mazza, Robin Sebastian, Hiroyuki Nagashima, Dali Zong, Hua Tan, Sushil Kumar Jaiswal, Haiqing Fu, Anthony Cruz, Supriya V. Vartak, Jan Wisniewski, Vittorio Sartorelli, John J. O’Shea, Laura Elnitski, Andre Nussenzweig, Mirit I. Aladjem, Fei-Long Meng, Rafael Casellas

“…Cohesin, a multi-subunit protein complex, plays a crucial role in both chromosome organization and DNA repair by creating architectural loops through chromatin extrusion. …”
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Dietary caloric input and tumor growth accelerate senescence and modulate liver and adipose tissue crosstalk by José Xavier do Nascimento Júnior, Júlia da Conceição Gomes, Ricardo Imbroisi Filho, Helber de Maia Valença, Jéssica Ristow Branco, Amanda Bandeira Araújo, Amanda de Oliveira Esteves Moreira, Letícia Diniz Crepaldi, Larissa Pereira Paixão, Alan C. Ochioni, Thainá M. Demaria, João Gabriel Bernardo Leandro, Livia Marques Casanova, Mauro Sola-Penna, Patricia Zancan

“…Conversely, lifespan-extending strategies, such as caloric restriction, impose beneficial effects on both processes. Here, we investigated the metabolic consequences of hypercaloric-induced aging on tumor growth in female mice. …”
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Source distribution, ecological risks, and controlling factors of heavy metals in river sediments: Receptor model-based study in a transboundary river basin by Abu Reza Md Towfiqul Islam, Abu Hena Md Fazla Rabbi, Amit Hasan Anik, Rahat Khan, Md Abdullah Al Masud, Grara Nedjoud, Abubakr M. Idris, Md Naimur Rahman, Venkatramanan Senapathi

“…Recognizing the transboundary nature of metal pollution, the current study underscores the imperative for continuous and vigilant monitoring, coupled with the implementation of robust management practices. The interplay of both anthropogenic and geogenic factors necessitates a comprehensive approach to effectively and sustainably combat HM contamination.…”
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Deficit irrigation enhances yield and water productivity of apples by inhibiting excessive vegetative growth and improving photosynthetic performance by Shenglin Wen, Ningbo Cui, Yaosheng Wang, Daozhi Gong, Liwen Xing, Zongjun Wu, Yixuan Zhang, Zhihui Wang

“…The I-W15 %, II-W15 %, II-W30 %, and IV-W15 % treatments synergistically improve both apple yield and WP, suggesting that these DDI treatments could be recommended for growers aiming to achieve sustainable apple production.…”
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Influence of Anti-TNF and Disease Modifying Antirheumatic Drugs Therapy on Pulmonary Forced Vital Capacity Associated to Ankylosing Spondylitis: A 2-Year Follow-Up Observational St... by Alberto Daniel Rocha-Muñoz, Aniel Jessica Leticia Brambila-Tapia, María Guadalupe Zavala-Cerna, José Clemente Vásquez-Jiménez, Liliana Faviola De la Cerda-Trujillo, Mónica Vázquez-Del Mercado, Norma Alejandra Rodriguez-Jimenez, Valeria Díaz-Rizo, Viviana Díaz-González, Ernesto German Cardona-Muñoz, Ingrid Patricia Dávalos-Rodríguez, Mario Salazar-Paramo, Jorge Ivan Gamez-Nava, Arnulfo Hernan Nava-Zavala, Laura Gonzalez-Lopez

“…George’s Respiratory Questionnaire at 24 months. Results. Both DMARDs and anti-TNF + DMARDs groups had similar baseline values in FVC%. …”
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Hubungan Tingkat Pengetahuan dan Sikap dengan Tindakan Pencegahan Osteoporosis pada Wanita Usila di Kelurahan Jati by Sri Ganesh Rajaratenam, Rose Dinda Martini, Nur Indrawati Lipoeto

“…Data processed by the chi-square statistical tests using SPSS.Results of univariate analysis level of knowledge obtained both elderly osteoporotic women (87.5%) level of knowledge is less (12.5%), good attitudes about osteoporosis (86.5%) less attitude (13.5%), good preventive measures (88,5%) less precautions (11.5%). …”
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Implementasi Robotic Process Automation untuk Proses Rekrutmen Mahasiswa Magang by Tri Susanto, Heru Ramdhani, Yosef Gunawan, Muhammad Hatta Eka Putra

“…Proses rekrutmen ini ada 2 langkah proses yang dilakukan yaitu proses seleksi administrasi dan proses seleksi  wawancara sehingga perlu dibuatkan sebuah bot RPA untuk mengotomatisasi masing-masing proses tersebut. …”
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Arthroplasty registries at a glance: an initiative of the International Society of Arthroplasty Registries (ISAR) to facilitate access, understanding, and reporting of registry dat... by Anne Lübbeke, Lotje A Hoogervorst, Perla J Marang-van de Mheen, Heather A Prentice, Ola Rolfson, Rob G H H Nelissen, Arnd Steinbrück, Gearoid McGauran, Christophe Barea, Kajsa Erikson, Alma B Pedersen, Martyn Porter

“…Of those, 2/3 were national registries. 23 captured both hip and knee arthroplasties and 10 captured shoulder arthroplasties. …”
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Identifying health risk determinants and molecular targets in patients with idiopathic pulmonary fibrosis via combined differential and weighted gene co-expression analysis by Abu Tayab Moin, Md. Asad Ullah, Jannatul Ferdous Nipa, Mohammad Sheikh Farider Rahman, Afsana Emran, Md. Minhazul Islam, Swapnil Das, Tawsif Al Arian, Mohammad Mahfuz Enam Elahi, Mukta Akter, Umme Sadea Rahman, Arnab Halder, Shoaib Saikat, Mohammad Jakir Hosen

“…Regulatory signatures, including transcription factor and microRNA interactions, were also explored, alongside the identification of potential drug targets.ResultsA total of 275 and 167 DEGs were identified across two datasets, with 67 DEGs common to both. These genes exhibited distinct expression patterns across tissues and were associated with pathways such as extracellular matrix organization, collagen fibril formation, and cell adhesion. …”
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Interleukin-32 positive immune and resident cells in kidney samples from lupus patients: a pilot study by Simona Truglia, Simona Truglia, Francesco Ciccia, Silvia Mancuso, Antonella Capozzi, Aroldo Rizzo, Francesca Romana Spinelli, Fulvia Ceccarelli, Tania Colasanti, Cristina Garufi, Francesca Miranda, Maurizio Sorice, Cristiano Alessandri, Fabrizio Conti

“…Interleukin-32 (IL-32), a cytokine involved in both innate and adaptive immune responses, has been widely considered in autoimmune-inflammatory rheumatic diseases. …”
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Study of water pollution parameters in the dry and rainy seasons on the pollution index of the Mesuji River, Lampung, Indonesia by Abu Rosid Istomi, Suharso, Buhani, Tugiyono, Heri Satria, Emi Artika, Annisaa Siti Zulaicha

“…Conclusions: While most stations met COD and DO standards during the rainy season, only one met these standards in the dry season. pH levels failed to meet standards in both seasons, and phosphate levels varied. The pollution index classified the river as polluted in the dry season and lightly polluted in the rainy season, highlighting the need for effective pollution management strategies.…”
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A SARS‐CoV‐2 EG.5 mRNA vaccine induces a broad‐spectrum immune response in mice by Hongyu Wang, Qinhua Peng, Xinxian Dai, Zhifang Ying, Xiaohong Wu, Xinyu Liu, Hongshan Xu, Jia Li, Leitai Shi, Jingjing Liu, Yunpeng Wang, Danhua Zhao, Yanqiu Huang, Lihong Yang, Ren Yang, Guangzhi Yue, Yue Suo, Qiang Ye, Shouchun Cao, Yuhua Li

“…Our results show that two doses of 5 µg CoV072 or a single dose of 15 µg CoV072 both induced broad‐spectrum cross‐protection ability in mice. …”
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