Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…Inactivating or knocking down USP7 significantly enhances the anti-myeloma effects of SEL both in vitro and in vivo. Conclusion In conclusion, our findings underscore the essential role of XPO1 degradation in the anti-myeloma efficacy of SEL and establish a research foundation for targeting USP7 to improve the effectiveness of SEL-based therapies in MM.…”
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A randomised controlled implementation trial of the feasibility and effectiveness of school staff delivery of a selective substance use and mental health program during the COVID-1... by Lucinda Grummitt, Kirsty Rowlinson, Joanne Cassar, Chloe Conroy, Louise Birrell, Lexine Stapinski, Emma Louise Barrett, Julia Macauley, Maree Teesson, Nicola C. Newton, Erin V. Kelly

“…Most RE-AIM domains showed high ratings, with school staff showing good adherence and confidence in delivery. However, teachers reported difficulties with feasibility, particularly a lack of time. …”
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Quantification of ecosystem services from mangrove silvofishery by E. Sumarga, D. Rosleine, G.B. Hutajulu, R.P. Plaurint, Tsabita ., M. Basyuni, S.H. Larekeng, M.F. Taqiyudin, N.N. Shohihah, H. Ali

“…The aim of this study was to assess the four primary services rendered by the Blanakan mangrove silvofishery area in Subang District, West Java: carbon sequestration, fisheries productivity, nature-based tourism, and bird sanctuary.METHODS: Carbon storage was calculated by conducting vegetation surveys and utilizing allometric equations, which took into account both aboveground and belowground biomass. During the vegetation survey, data regarding the types of mangrove plants and the diameter of each tree at breast height was gathered. …”
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Correlations among hope, fertility quality of life and negative emotions for couples undergoing their first in vitro fertilization–embryo transfer: a cross-sectional analysis by Hui Ye, Jing Zhao, Yujie Zou, Xiaorun Song, Mi Xu, Yu Zhang, Lili Zhang, Gaohua Wang

“…The mutual influence of spouses should not be overlooked in clinical practice, and psychological support for both partners should be emphasized.…”
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Role of Absorbable Polysaccharide Hemostatic Powder in the Prevention of Complications After Axillary Lymph Node Dissection in Breast Cancer Patients: A Multicenter Retrospective A... by Simona Parisi, Francesco Saverio Lucido, Francesca Fisone, Roberto Ruggiero, Salvatore Tolone, Francesco Iovino, Antonio Santoriello, Federico Maria Mongardini, Maddalena Paolicelli, Ludovico Docimo, Claudio Gambardella

“…<i>Conclusions</i>: The adsorbable hemostatic powder proved to be effective both in reducing the volume of drained fluid postoperatively and in decreasing the number and volume of reported seromas during the US follow-up.…”
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A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…For sotorasib versus docetaxel, our estimation showed no difference in QALYs (1.28 QALYs for both treatments), as the reduced adverse events reported in CodeBreak 200 for sotorasib had a minimal impact on the QALYs in our calculation. …”
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100 essential questions for the future of agriculture by Yuming Hu, Taolan Zhao, Yafang Guo, Meng Wang, Kerstin Brachhold, Chengcai Chu, Andrew Hanson, Sachin Kumar, Rongcheng Lin, Wenjin Long, Ming Luo, Jian Feng Ma, Yansong Miao, Shaoping Nie, Yu Sheng, Weiming Shi, James Whelan, Qingyu Wu, Ziping Wu, Wei Xie, Yinong Yang, Chao Zhao, Lei Lei, Yong‐Guan Zhu, Qifa Zhang

“…We emphasise the critical importance of interdisciplinary and multidisciplinary research that integrates both basic and applied sciences and bridges the gaps among various stakeholders for achieving sustainable agriculture.…”
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Effect of Arthrospira platensis (Spirulina) as a dietary supplement during transition period in dairy buffaloes by Giuseppe De Rosa, Vittoria L. Barile, Carmela M.A. Barone, Claudia Lambiase, Francesco Serrapica, Giovanna De Matteis, Emanuela Rossi, Corrado Pacelli

“…As expected, the sampling time significantly affected both BAP and d-ROMs (p<0.001), with the highest BAP value at 90 d and the lowest d-ROMs at 30 d before calving. …”
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Targeted intra-tumoral hyperthermia using uniquely biocompatible gold nanorods induces strong immunogenic cell death in two immunogenically ‘cold’ tumor models by Barry E. Kennedy, Erin B. Noftall, Cheryl Dean, Alexander Roth, Kate N. Clark, Darren Rowles, Kulbir Singh, Len Pagliaro, Carman A. Giacomantonio, Carman A. Giacomantonio, Carman A. Giacomantonio

Subjects: “…gold nanorods…”
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Generation of Insulin-Producing Cells from Canine Adipose Tissue-Derived Mesenchymal Stem Cells by Takahiro Teshima, Keiji Okamoto, Kazuho Dairaku, Tomokazu Nagashima, Masaki Michishita, Ryohei Suzuki, Hirotaka Matsumoto, Hidekazu Koyama

“…New cell-based therapy using MSCs for diabetes mellitus is anticipated as an alternative treatment option to insulin injection or islet transplantation in both human and veterinary medicine. Several protocols were reported for differentiation of MSCs into insulin-producing cells (IPCs), but no studies have reported IPCs generated from canine MSCs. …”
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Human and Machine: A View through Kant's Use of Regulative Reason by Ümit Taştan

“…Since artificial intelligence cannot model both the use of regulative reasoning and intuitive thinking, it is subjected to the brute search method. …”
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Assembly mechanisms, not species pool, shape β-diversity of soil methanotrophic communities in steppes of China by Yongping Kou, Zhe Feng, Huan Li, Yanjiao Liu, Yanjiao Liu, Lin Xu, Lin Xu, Xiangzhen Li

“…While biodiversity patterns across geographical gradients are often attributed both to local assembly processes and regional species pools, the distinct roles of these factors in shaping soil aerobic methanotrophic diversity remain underexplored.MethodsUsing amplicon sequencing and bioinformatics analysis, this study focuses on comparing the relative importance of species pool and community assembly processes in shaping soil methanotrophic communities across three distinct plateaus in China: the Loess Plateau, the Qinghai-Tibetan Plateau, and the Inner Mongolian Plateau. …”
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Phase transitions, Dirac and Weyl semimetal states in Mn1−x Ge x Bi2Te4 by A. M. Shikin, N. L. Zaitsev, T. P. Estyunina, D. A. Estyunin, A. G. Rybkin, D. A. Glazkova, I. I. Klimovskikh, A. V. Eryzhenkov, K. A. Kokh, V. A. Golyashov, O. E. Tereshchenko, S. Ideta, Y. Miyai, Y. Kumar, T. Iwata, T. Kosa, K. Kuroda, K. Shimada, A. V. Tarasov

“…These calculations were performed for both antiferromagnetic (AFM) and ferromagnetic (FM) ordering types while the spin-orbit coupling (SOC) strength was varied or a strain (compression or tension) along the c-axis was applied. …”
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Distribution and bioaccumulation of prometryn in simulated aquatic ecosystems by Jiaqi Peng, Jiaqi Peng, Jiaqi Peng, Ruiqi Fan, Ruiqi Fan, Ruiqi Fan, Yuanyuan Ren, Yuanyuan Ren, Yuanyuan Ren, Yan Yang, Yan Yang, Yan Yang, Xin Zhang, Saisai Wang, Yingchun Mu, Yingchun Mu, Yingchun Mu, Bo Cheng, Bo Cheng, Bo Cheng

“…The research aims to explore the bioaccumulation dynamics of prometryn across both biotic and abiotic components of the ecosystem, providing a comprehensive understanding of its environmental persistence and accumulation in aquatic organisms and sediments. …”
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Matching Phosphorus Fertilizer Types with Soil Type in Rice Cultivation Optimizes Yield, Soil Phosphorus Availability, and Phosphorus Fertilizer Use Efficiency by Shiyu Peng, Xinyao Zhang, Le Sun, Rushan Chai, Chaochun Zhang, Xiaohui Chen, Laichao Luo, Kadambot H. M. Siddique

“…Fluvo-aquic soil and yellow-cinnamon soils were used in a rice pot trial to compare five P fertilizer types: single superphosphate (SSP), diammonium phosphate (DAP), calcium magnesium phosphate (CMP), triple superphosphate (TSP), and ammonium polyphosphate (APP), alongside a no P, control (CK). …”
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Metagenomic insights into the development of microbial communities of straw and leaf composts by Anastasiia K. Kimeklis, Anastasiia K. Kimeklis, Grigory V. Gladkov, Olga V. Orlova, Tatiana O. Lisina, Alexey M. Afonin, Alexey M. Afonin, Tatiana S. Aksenova, Arina A. Kichko, Alla L. Lapidus, Evgeny V. Abakumov, Evgeny V. Abakumov, Evgeny E. Andronov

“…MAGs from Bacteroidota (Chitinophaga and Ohtaekwangia) and Actinomycetota (Streptomyces) were found in both composts, while those from Bacillota (Pristimantibacillus) were specific for leaf litter. …”
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Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch by inhibiting spinal oxidative stress and synaptic plasticity via SIRT1-β-catenin pathway in... by Linlin Zhang, Fangshi Zhao, Yize Li, Zhenhua Song, Lingyue Hu, Yuanjie Li, Rui Zhang, Yonghao Yu, Guolin Wang, Chunyan Wang

“…Herein, we strikingly report that both hydrogen gas (2 %) inhalation and hydrogen-rich saline (5 mL/kg, intraperitoneal) injection prevent and alleviate persistent dermatitis-induced itch, diabetic itch and cholestatic itch. …”
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The reliability and quality of short videos as health information of guidance for lymphedema: a cross-sectional study by Xuchuan Zhou, Gejia Ma, Xuefeng Su, Xinyi Li, Xinyi Li, Wenfei Wang, Linxi Xia, Linxi Xia, Chen Yang, Chen Yang, Bin Liu

“…The GQS and modified DISCERN tool were used to assess video quality and reliability respectively, with medical professionals scoring higher on both metrics (z = 3.127, p = 0.002; z = 2.010, p = 0.044). …”
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Cryo-EM structure of an activated GPR4–Gs signaling complex by Yitong Ma, Yijie Wang, Mengyuan Tang, Yuan Weng, Ying Chen, Yueming Xu, Shuxiao An, Yiran Wu, Suwen Zhao, Huanhuan Xu, Dali Li, Mingyao Liu, Weiqiang Lu, Heng Ru, Gaojie Song

“…Here we report cryo-electron microscopy (cryo-EM) structures of active zebrafish GPR4 at both pH 6.5 and 8.5, each highlighting a distribution of histidine and acidic residues at the extracellular region. …”
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Diagnostic Value of Measurements of Median Nerve Diameter at the Site of the Maximal Stenosis in Carpal Tunnel Syndrome by Fryźlewicz A, Rusin G, Rudnicki W, Ułamek-Kozioł M, Antczak J

“…CTS was also associated with more distal localization of maximal stenosis. Both SI diameter and SI CSA were higher in patients, however the discriminative effect of SI CSA was stronger. …”
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