Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled tri... by Karen J. Bosma, Myriam Lafreniere-Roula, Arlene Jiang, Anna Heath, Yongdong Ouyang, Kaitlyn Wade, Pingzhao Hu, Karen E. A. Burns, Claudio M. Martin, Yoanna Skrobik, Sorcha Mulligan, Kevin E. Thorpe, Laurent Brochard, members of the Canadian Critical Care Trials Group and the REVA Network

“…Trial registration ClinicalTrials.gov Identifier: NCT02447692 prospectively registered May 19, 2015.…”
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Impaired Mitochondrial Bioenergetics Function in Pediatric Chronic Overlapping Pain Conditions with Functional Gastrointestinal Disorders by Gisela Chelimsky, Pippa Simpson, Liyun Zhang, Doug Bierer, Steve Komas, Balaraman Kalyanaraman, Thomas Chelimsky

“…Prospective longitudinal studies can likely discern whether these findings represent deconditioning, true mitochondrial dysfunction, or both.…”
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Protective Effects of Gynostemma pentaphyllum Saponins on Liver Injury in Guinea Pigs of Hyperlipemia Based on Oxidative Stress by Tianyi DAI, Donglian LIU, Xingmin QIN, Chengling GAO, Jiayi LI, Hailing KUANG

“…The fluorescence expression of Nrf2 and HO-1 proteins in both the high and low dose groups of GPs significantly increased (P<0.01). …”
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Effect of molases addition on survival and growth of tiger shrimp Penaeus monodon Fab. larva treated with SKT-b Vibrio probiotic bacteria by , Widanarni, Wira H Saputra, Dinamella Wahjuningrum

“…This experiment was done both in vitro and in vivo. In vitro tests performed by growing bacteria in media containing molasses, fish meal and premix. …”
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Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients by Carla De Benedittis, Mattia Bellan, Martina Crevola, Elena Boin, Matteo Nazzareno Barbaglia, Venkata Ramana Mallela, Paolo Ravanini, Elisa Ceriani, Stefano Fangazio, Pier Paolo Sainaghi, Michela Emma Burlone, Rosalba Minisini, Mario Pirisi

“…All participants underwent genotyping for PNPLA3 and HSD17B13 gene variants. Both univariate and multivariate analyses of risk factors for advanced disease and HCC were performed. …”
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How to build a framework to establish a patient research partner network in rheumatology research: a report of a 2-year implementation project by Maarten de Wit, Oliver Distler, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Muriel Elhai, Rucsandra Dobrota, Adrian Ciurea, Caroline Ospelt, Raphael Micheroli, Dania Diem, Stefan Dudli, Kristina Buerki, Stacey Grealis, Melpomeni Toitou, Silke Ludwig, Chantal Britt, Florian Klett, Isabelle Steeb, Tanja Maletic, Andreas Eisenring, Penelope Jane Timpert-Argust, Eva Camarillo-Retamosa

“…This approach benefited both PRPs and researchers and might serve as a guide for other centres.…”
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Balance Changes in Adult Cancer Survivors Participating in a 16-Week Therapeutic Yoga Program by Mark J. Miller BS, Daniel C. Hughes PhD, Nydia T. Darby DPT, Tim Calderon MS, Darpan I. Patel PhD, Monica C. Serra PhD, Amelie G. Ramirez Dr. PH, Alexis Ortiz PT, PhD, Gustavo J. Almeida PT, PhD

“…Results: Of the 29 participants included, 22 (76%) completed post-assessments. Changes in both balance assessment conditions were not statistically significant (eyes opened: 80.06 ± 374.99, p  = .702; eyes closed: −1.82 ± 24.01, p  = .068). …”
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Effects of innovative modular prone positioning tools in patients with acute respiratory distress syndrome due to COVID-19 during awake prone position: a prospective randomized con... by Dunbing Huang, Huan Tian, Wei Song, Jiaqi Wang, Zizhe Yao, Lize Xiong, Cai Jiang, Anren Zhang, Xiaohua Ke

“…Additionally, the comfort, incidence of adverse events, and treatment efficacy in both groups were evaluated. Results The observation group had shorter the daily duration spent on executing the AW-PP (2.74 ± 0.86 min vs. 4.64 ± 1.02 min, P < 0.001), longer the daily total AW-PP (8.52 ± 1.01 h vs. 6.03 ± 0.66 h, P < 0.001), longer the daily duration until the first position adjustment (59.89 ± 12.73 min vs. 36.57 ± 8.69 min, P < 0.001), and lower the daily frequency of position adjustments during the AW-PP (11.03 ± 2.67 vs. 17.95 ± 2.58, P < 0.001) in comparison with the control group. …”
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Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China by Nan Chang, Wenzhong Huang, Yanlin Niu, Zhihu Xu, Yuan Gao, Tingting Ye, Zihao Wang, Xiaohui Wei, Yuming Guo, Qiyong Liu

“…In mixed epidemic regions, both scenarios require attention. These findings provide novel scientific evidence for the formulation and implementation of region-specific HFRS prevention policies. …”
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MicroRNA Expression in Cutaneous Lupus: A New Window to Understand Its Pathogenesis by Silvia Méndez-Flores, Janette Furuzawa-Carballeda, Gabriela Hernández-Molina, Gustavo Ramírez-Martinez, Nora E. Regino-Zamarripa, Blanca Ortiz-Quintero, Luis Jiménez-Alvarez, Alfredo Cruz-Lagunas, Joaquín Zúñiga

“…A downregulation of miR-150, miR-1246, and miR-21 in both CLE varieties vs. HD was determined.…”
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Association between monocyte-lymphocyte ratio and all-cause and cardiovascular mortality in patients with chronic kidney diseases: A data analysis from national health and nutritio... by Wenwu Liu, Shuwei Weng, Chenghui Cao, Yuting Yi, Yue Wu, Daoquan Peng

“…The aim of this study was to investigate the association between MLR and both all-cause mortality and cardiovascular disease (CVD) mortality in patients with CKD.Methods This study analyzed data from National Health and Nutrition Examination Survey 2003-2010. …”
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Towards a cervical cancer-free future: women’s healthcare decision making and cervical cancer screening uptake in sub-Saharan Africa by Bright Opoku Ahinkorah, Abdul-Aziz Seidu, Richard Gyan Aboagye, Bernard Yeboah-Asiamah Asare, Joshua Okyere, Bupe Mwamba

“…We employed multilevel binary logistic regression modelling.Setting Sub-Saharan Africa.Participants Women aged 15–49 years in Benin (n=5282), Côte d’Ivoire (n=1925), Cameroon (n=7558), Kenya (n=6696), Namibia (n=1990) and Zimbabwe (n=5006).Primary outcome measures Cervical cancer screening uptake.Results The overall prevalence of cervical cancer screening across the six sub-Saharan African countries was 13.4%. …”
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Associations between social determinants of health and mental health disorders among U.S. population: a cross-sectional study by S. Tanarsuwongkul, J. Liu, M. Spaulding, K. Perea-Schmittle, M. Lohman, Q. Wang

“…Having no health insurance was associated with lower odds of both MD and AD (aOR, 0.48; 95% confidence interval [CI], 0.46–0.51 and aOR, 0.44; 95% CI, 0.42–0.47, respectively). …”
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Pembrolizumab hybrid dosing is non-inferior to flat dosing in advanced non-small cell lung cancer: a real-world, retrospective bicenter cohort study by Egbert F Smit, Willemijn S M E Theelen, Michiel M Smeenk, Vincent van der Noort, Jeroen M A Hendrikx, Hanieh Abedian Kalkhoran

“…Hybrid dosed patients received either 100, 150 or 200 mg pembrolizumab every 3 weeks or double every 6 weeks depending on their weight: &lt;65 kg, 65–90 kg or &gt;90 kg, respectively. Standard-of-care flat dosed patients received 200 mg every 3 weeks or 400 mg every 6 weeks. …”
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Triploid striped catfish Pangasianodon hypophthalmus: growth performance and gonadal development by Yusran Ibrahim, Dinar Tri Soelistyowati, Odang Carman

“…As conclusion, diploid and triploid striped catfish P. hypophthalmus growth performance did not differ up to the age of 11 months, although some sterility symptoms were observed in both male and female.   Keywords: diploid, triploid, growth, gonad, Pangasianodon hypophthalmus     ABSTRAK   Penelitian ini bertujuan untuk mengevaluasi performa pertumbuhan dan perkembangan gonad ikan patin siam Pangasianodon hypophthalmus diploid dan triploid. …”
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T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint pr... by Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev

“…This was demonstrated to occur via two differential mechanisms: first by translocation of galectin-9 onto the cell surface followed by its proteolytic shedding and second due to autophagy followed by lysosomal secretion. For both mechanisms a protein carrier/trafficker was required, since galectin-9 lacks a secretion sequence. …”
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Hubungan Riwayat Pola Pemberian ASI dengan Tingkat Kecerdasan Anak SD di SDN 01 Sawahan Kecamatan Padang Timur Kota Padang by Syntia Ambelina, Chundrayetti ., Nur Indrawati Lipoeto

“…There are 16.3% of children had a both breastfeeding pattern history and 83.7% of children had a lack breastfeeding patterns history. …”
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Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cel... by Graciela Ruiz, Heriberto A. Valencia-González, Delia Pérez-Montiel, Felipe Muñoz, Rodolfo Ocadiz-Delgado, Jorge Fernández-Retana, Carlos Pérez-Plasencia, Osbaldo Reséndis-Antonio, Patricio Gariglio, Alejandro García-Carrancá

“…Finally, we analyzed and compared both transcript and protein expression profiles of these factors within a cohort of patients with cervical cancer. …”
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Mortality and immunological indicators of men who have sex with men living with HIV on antiretroviral therapy: a 10-year retrospective cohort study in Southern China by Huaxiang Lu, Huanhuan Chen, Shujia Liang, Yuhua Ruan, He Jiang, Jinghua Huang, Guangjie Tan, Xiuling Wu, Jianjun Li, Chen Gong, Qiuying Zhu, Guanghua Lan

“…Conclusions Mortality among MSM PLHIV on ART in Guangxi is relatively low, and both high viral loads and low CD4+/CD8+ T cell ratios during treatment and at recent follow-up are strongly predictive of a serious prognosis and should be closely monitored.…”
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Study on the value of gastrin 17 and aldehyde dehydrogenase 1 in gastric juice for early diagnosis in gastric cancer by Yanfang Wang, Yanfang Wang, Hui Liu, Hui Liu, Xiang Li, Juan Jin, Bo Yan, Bo Yan

“…The development of gastric cancer was significantly influenced by elevated levels of ALDH1 and G-17 in gastric juice (OR= 1.095, 1.018; both P &lt;0.05); the AUCs for the combined diagnosis of gastric cancer and elevated levels of G-17 and ALDH1 in gastric juice were 0.792, 0.757, and 0.695, respectively.ConclusionThe development of gastric cancer is influenced by increased levels of ALDH1 and G-17 in gastric juice. …”
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