Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospec... by Noriyuki Kimura, Kotaro Sasaki, Teruaki Masuda, Takuya Ataka, Mariko Matsumoto, Mika Kitamura, Yosuke Nakamura, Etsuro Matsubara

“…Classification performance was similar in Model 1 (basic demographic characteristics and Mini Mental State Examination [MMSE] subscores) and Model 2 (demographic characteristics and blood test results) with a cross-validated mean ROC AUC (SD) of 0.70 (0.01) for both. Model 3 (demographic characteristics, blood test results, MMSE subscores) and Model 4 (Model 3 and ApoE4 phenotype) showed improved performance with a mean ROC AUC (SD) of 0.73 (0.01) and 0.76 (0.01), respectively. …”
Get full text

Modelling the air quality impacts of a zero emission zone scenario in the city of Milan by Andrea Piccoli, Valentina Agresti, Marco Bedogni, Giovanni Lonati, Guido Pirovano

“…Then we evaluated the benefits in terms of both air quality and citizens’ health. The assessment of the environmental and health effects is done thanks to a modelling suite composed of a road traffic, an emission, a hybrid air quality models, plus a fourth module for human health impacts. …”
Get full text

Integrated Impacts of Urban Spatial Form on Thermal Environment and Zonal Regulation under the Perspective of Spatial Heterogeneity by Yan Jinlong, Yin Chaohui, An Zihao, Zhang Simin, Wen Qian, Chen Weiqiang

“…First, the high-temperature areas in the main urban area of Wuhan are mainly located in the core area of the old city of Hankou and the Wuchang District, which are located on both sides of the Yangtze River, as well as in the industrial zones northeast and southwest of the city. …”
Get full text

Reims/Durocortorum, ville gauloise ? Hypothèses pour une nouvelle problématique des origines de l’agglomération by Robert Neiss

“…Recent investigations have reopened questions that remained unanswered and suggest the need for a systematic re-examination of the archaeological data and its implications. This includes both the data that was collected over the course of ancient discoveries, as well as during better documented, more recent excavations. …”
Get full text

NLRP3: a key regulator of skin wound healing and macrophage-fibroblast interactions in mice by Jiamin Zhao, Shuangyi Zhang, Zhiguo Gong, Wei Mao, Wenhui Bao, Qianru Li, Yunjie Bai, Feifei Gao, Shuang Feng

“…PGE2 levels were reduced in both NLRP3−/− macrophages and myofibroblasts. Supplementing NLRP3−/− conditioned media with PGE2 partially restored the impaired functions, suggesting that PGE2 acts as a downstream mediator of NLRP3-regulated macrophage-myofibroblast interactions. …”
Get full text

Black posterior vitreous detachment: A 10-year historical cohort of pigmented uveal tumors by Vicktoria Vishnevskia-Dai, Hila Goldberg, Michael Ostrovsky, Ofira Zloto, Rachel Shemesh

“…Conclusion: A pigmentary form of PVD may accompany both benign and malignant pigmented uveal tumors, affecting a wide range of patients. …”
Get full text

Empagliflozin-based quadruple oral therapy for type 2 diabetes: a prospective cohort study by Fatemeh Moosaie, Shiva Abedinzadeh, Soghra Rabizadeh, Kimia Daneshvar, Mohammadamin Noorafrooz, Fatemeh Alsadat Mojtahedi, Niloofar Deravi, Seyede Marzie Fatemi Abhari, Akam Ramezani, Alipasha Meysamie, Marzieh Hajibabaei, Sahar Karimpour Reyhan, Mahsa Abbaszadeh, Manouchehr Nakhjavani, Alireza Esteghamati

“…Blood pressure trends revealed significant reductions in both diastolic blood pressure (DBP) and mean arterial pressure (MAP), though systolic blood pressure (SBP) remained relatively stable. …”
Get full text

Outcomes of an Emergency Department opioid alternatives Program implemented within a safety-net hospital system by Magda Montague, Charlotte Hopson, Claire Layton, Jennifer Fishe, Ashley Norse, L. Kendall Webb, Petra Duran-Gehring, Andrew Bertrand, Jennifer Brailsford, Taylor Munson, Rui Wang, Nolan Menze, Katelyn Perl, Phyllis Hendry, Sophia Sheikh

“…Methods Demographics, opioid and opioid alternative utilization, hospital admission, 30-day ED returns and change in pain intensity score were collected from January 2019-March 2020 (pre-program implementation) and January 2021-March 2023 (post-program implementation) for both the ED aggregate and program target pain populations. …”
Get full text

Whole systems approaches to diet and healthy weight: A scoping review of reviews. by Gavin Breslin, Olujoke Fakoya, Wendy Wills, Nigel Lloyd, Charis Bontoft, Amander Wellings, Sian Harding, John Jackson, Katherine Barrett, Adam P Wagner, Lisa Miners, Honey-Anne Greco, Katherine E Brown

“…Common mathematical approaches include agent based or System Dynamic Modelling. Underlying both conceptual and mathematical models is an understanding how the elements of the complex systems impact each other to affect diet, healthy weight, and obesity. …”
Get full text

Foxtail millet supplementation improves glucose metabolism and gut microbiota in rats with high-fat diet/streptozotocin-induced diabetes by Xin Ren, Linxuan Wang, Zenglong Chen, Min Zhang, Dianzhi Hou, Yong Xue, Xianmin Diao, Ruihai Liu, Qun Shen

Subjects: Get full text

Droplets Cas13a‐RPA measurement delineates potential role for plasma circWDR37 in colorectal cancer by Jingsong Xu, Li Cao, Shuang Yang, Ying Jian, Yu Liu, Zhen Shen, Qian Liu, Xiang Chen, Min Li, Shun Li, Xiaolei Zuo, Min Li, Hua Wang

“…CircWDR37 is confirmed as a groundbreaking biomarker for both diagnosis and prognosis evaluation in CRC patients. …”
Get full text

Peripheral neuropathy in the phase 3 ASPEN study of Bruton tyrosine kinase inhibitors for Waldenström macroglobulinemia by Benjamin M. Heyman, Stephen S. Opat, Björn E. Wahlin, Meletios-Athanasios C. Dimopoulos, Jorge J. Castillo, Alessandra Tedeschi, Constantine S. Tam, Christian Buske, Roger G. Owen, Véronique Leblond, Judith Trotman, Gisoo Barnes, Wai Y. Chan, Jingjing Schneider, Heather Allewelt, Aileen Cohen, Jeffrey V. Matous

“…This trial was registered at www.clinicaltrials.gov as #NCT03053440.…”
Get full text

Insecticidal Activity and Chemical Composition of the Morinda lucida Essential Oil against Pulse Beetle Callosobruchus maculatus by Moses S. Owolabi, Eduardo Padilla-Camberos, Akintayo L. Ogundajo, Isiaka A. Ogunwande, Guido Flamini, Olaniyi K. Yusuff, Kirk Allen, Karen Isabel Flores-Fernandez, Jose Miguel Flores-Fernandez

“…M. lucida essential oil had a potent insecticidal activity (LC90 = 0.629 μg/mL) compared to both pesticides, Phostoxin (LC90 = 0.652 μg/mL) and Primo-ban-20 (LC90 = 0.726 μg/mL), at 24 h. …”
Get full text

The incremental value of aspartate aminotransferase/alanine aminotransferase ratio combined with CURB-65 in predicting treatment outcomes in hospitalized adult community-acquired p... by Huamei Zhou, Xuelei Zhu, Yi Zhang, Wenjuan Xu, Shiqun Li

“…The integration of AST/ALT into CURB-65 enhanced outcome prediction for both diabetic and non-diabetic CAP patients.…”
Get full text

Toward Sustainable Biocultural Ecotourism: An Integrated Spatial Analysis of Cultural and Biodiversity Richness in Colombia by Alejandra Echeverri, Natasha M. Batista, Stacie Wolny, Guido A. Herrera‐R, Federico Andrade‐Rivas, Allison Bailey, Anaid Cardenas‐Navarrete, Armando Dávila Arenas, Andres Felipe Díaz‐Salazar, Katherine Victoria Hernandez, Kelley E. Langhans, Bryam E. Mateus‐Aguilar, Dallas Levey, Andrew Neill, Oliver Nguyen, Andres Felipe Suárez‐Castro, Felipe Zapata, Natalia Ocampo‐Peñuela

“…Abstract Ecotourism plays a vital role in both economic development and depending on the scale, it can also aid environmental conservation. …”
Get full text

Linking weather and climate information services (WCIS) to Climate-Smart Agriculture (CSA) practices by Tafadzwanashe Mabhaudhi, Tinashe Lindel Dirwai, Cuthbert Taguta, Aidan Senzanje, Wuletawu Abera, Ajit Govid, Elliott Ronald Dossou-Yovo, Ermias Aynekulu, Vimbayi Grace Petrova Chimonyo

Get full text

Types of electronic nicotine delivery systems (ENDS) used by people of different age and smoking status groups: results from a US nationally representative survey by Lucy Popova, Robert T Fairman, David L Ashley, Zachary B Massey, Bai Cham, Ruiyan Luo, Mohammed Alqahtani, Scott Weaver

“…Similarly, 18–29 years old current (vs never) smokers had higher odds of reporting current regular use of refillable tanks (OR=1.80), refillable pods (OR=2.63), closed pods (OR=2.20) and drippers (OR=4.89; p<0.05).Conclusions Both age and smoking status were associated with current regular use of ENDS, especially for youth and young adults. …”
Get full text

Photometric Analysis of the Cataclysmic Variable Star LT Eri by Qi-Bin Sun, Sheng-Bang Qian, Li-Ying Zhu, Qin-Mei Li, Fu-Xing Li, Min-Yu Li, Ping Li

“…Our analysis reveals an outburst period of 14.7(31) days, with variable periods ranging from 11.62(4) to 22.15(13) days. Both long and short outbursts were detected, lasting approximately 18 and 10 days, respectively. …”
Get full text

Effects of Different Molasses Levels and Slow-Release Urea Combinations on Growth Performance, Serum Biochemistry, Rumen Fermentation, and Microflora of Holstein Fattening Bulls by Zhiyuan Xu, Shuaihong Li, Fangzhou Yu, Yinghao Huang, Tao Xie, Hanbing Bian, Longfei Lv, Yapeng Hu, Ruoran Tao, Caiyun Fan, Sijia Liu, Jianbo Cheng

“…The rumen pH of all treatment groups was lower than that of the CON (<i>p</i> < 0.05), whereas the concentrations of microbial crude protein (MCP), as well as acetic acid, propionic acid, and total volatile fatty acids (TVFA) were significantly higher in both the MMU and HMU (<i>p</i> < 0.05). The dominant phyla in each group were <i>Bacteroidetes</i>, <i>Firmicutes</i>, and <i>Patescibacteria</i>, and the relative abundance of <i>Bacteroidetes</i> in the MMU increased by 5.47% compared with that in the CON. …”
Get full text

Mechanism Analysis of Organic Matter Enrichment of Upper Ordovician-Lower Silurian Shale in the Upper Yangtze Area: Taking Jiaoye-1 Well in the Jiaoshiba Block as an Example by Xiaoxue Liu, Zhenxue Jiang, Kun Zhang, Yan Song, Lin Jiang, Shu Jiang, Qixiang Xuan, Ming Wen, Yizhou Huang, Xin Wang, Tianlin Liu, Xuelian Xie

“…On the other hand, the active volcanic activity brought volcanic ash which was beneficial to biological reproduction. Both of these factors led to higher biological productivity during this period. …”
Get full text