NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma by Chao-Yan Yao, Hang-Tian Tao, Jin-Jin He, Feng-Yi Zhu, Cui-Qing Xie, Yu-Na Cheng, Ji-Qin Li, Zhuang-Zhuang Liu, Chun-Yu Hou, Xue-Li Liu, Yong-Li Fan, Dong Fang, Xin-Rui Lv

“…Results NUAK1 expression was negatively correlated with CD8+ T cell infiltration in tumor tissues from HCC patients and mice xenograft model. Both gain and loss of functions have identified NUAK1 promoted PD-L1 expression at transcriptional level in HCC cells. …”
Get full text

Producing hydrogen from biomass and seawater using immobilized carbon nitride photocatalysts by Ana L. Machado, Ricardo A. Oliveira, Goran Dražić, Joana C. Lopes, Cláudia G. Silva, Joaquim L. Faria, Maria J. Sampaio

“…Despite a slight decrease in H₂ evolution compared with the powdered catalysts, the use of immobilized photocatalyst exhibited remarkable stability in both ultrapure water and seawater, maintaining its performance across multiple reuse cycles. …”
Get full text

Transfer of Cytoplasmic Male Sterility to the Female Parents of Heat- and Drought-Resilient Maize (<i>Zea mays</i> L.) Hybrids by Ayyanagouda Patil, Kushal Gowda, Shivananda T. Lakshman, Prakash H. Kuchanur, Gajanan Saykhedkar, Sudha Krishnan Nair, Kisan B. Jadhav, Sharanabasappa Yeri, Gururaj Sunkad, Jayaprakash M. Nidagundi, Vinayan Madhumal Thayil, Pervez H. Zaidi

“…When the near-isogenic CMS lines of both populations are compared for agro-morphological traits with their recurrent parents, the agronomic qualities of recurrent parents, as well as the attributes of distinctness, uniformity and stability, are shown. …”
Get full text

SETTING PERILAKU ADAPTASI PADA SEKOLAH PASCA PANDEMI DI KOTA PONTIANAK by Muhammad Nurhamsyah Nurhamsyah, Lestari, Syaiful Muazir, Rudiyono, M. Ridha Alhamdani

“…Penelitian ini dilakukan pada 4 objek yaitu SD 14 Kecamatan Pontianak Kota, SD 56 Kecamatan Pontianak Barat, SMP 2 Kecamatan Pontianak Selatan, dan SMP 10 Kecamatan Pontianak Selatan. …”
Get full text

Current trends of unicompartmental knee arthroplasty (UKA): choosing between robotic-assisted and conventional surgeries and timing of procedures by Kelvin S. C. Cheung, Kai Chun Augustine Chan, Amy Cheung, Ping Keung Chan, Michelle Hilda Luk, Kwong Yuen Chiu, Henry Fu

“…Robotic-assisted UKA (Mako and Navio/Cori) has shown an increasing utilization since 2022 in both unilateral (16.0% to 25.9%) and bilateral operations (17.8% to 29.0%). …”
Get full text

Combined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma by Jian‐Hua Wang, Shu‐Ting Huang, Lan Zhang, Zi‐Gang Liu, Rong‐Xin Liang, Sen‐Wei Jiang, Yi‐Nan Jiang, Xing‐Juan Yu, Yu‐Chuan Jiang, Xi‐Zhao Li, Pei‐Fen Zhang, Zhe‐Sheng Wen, Min Zheng

“…The combination of high CD47 and CD133 expression was a reliable independent prognostic factor for both OS (HR = 1.940, 95% CI = 1.399‐2.690, P < 0.0001) and progression‐free survival (HR = 1.883, 95% CI = 1.384‐2.562, P < 0.0001). …”
Get full text

An Areal Assessment of Subseafloor Carbon Cycling in Cold Seeps and Hydrate-Bearing Areas in the Northern South China Sea by Yanping Zhang, Min Luo, Yu Hu, Hongbin Wang, Duofu Chen

“…Reaction-transport simulations indicate that the rates of organic matter degradation and carbonate precipitation are comparable in the three areas, while the rates of AOM vary over several orders of magnitude (AOM: 8.3-37.5 mmol·m-2·yr-1 in Dongsha, AOM: 12.4-170.6 mmol·m-2·yr-1 in Xisha, and AOM: 9.4-30.5 mmol·m-2·yr-1 in Shenhu). Both the arithmetical mean and interpolation mean of the biogeochemical processes were calculated in each area. …”
Get full text

Worldwide variations in the knowledge and use of fluoroscopy during percutaneous nephrolithotomy—should we do better? A survey by the European Association of Urology Section for Ur... by Otaš Durutovic, Guohua Zeng, Bhaskar Somani, Simon Choong, Giorgio Mazzon, Di Gu, Zeeshan Hameed, TP Rajeev, Bogomir Milojevic, Davide Brusa, Tiago Ribeiro Oliveira, Sergio Pereira, Nariman Gadzhiev, Ali Serdar Gozen, Evangelos Liatsikos, Panagiotis Kallidonis, Uros Bumbasirevic, Andreas Skolarikos

“…More efforts should be addressed to improve these results, reducing the risk related to excessive radiation exposure for both surgical staff and patients in order to minimize health related issues.…”
Get full text

Therapeutic and Safety Evaluation of Combined Aqueous Extracts of Azadirachta indica and Khaya senegalensis in Chickens Experimentally Infected with Eimeria Oocysts by J. G. Gotep, J. T. Tanko, G. E. Forcados, I. A. Muraina, N. Ozele, B. B. Dogonyaro, O. O. Oladipo, M. S. Makoshi, O. B. Akanbi, H. Kinjir, A. L. Samuel, T. E. Onyiche, G. O. Ochigbo, O. B. Aladelokun, H. A. Ozoani, V. Z. Viyoff, C. C. Dapuliga, A. A. Atiku, P. A. Okewole, D. Shamaki, M. S. Ahmed, C. I. Nduaka

“…The phytochemical screening revealed the presence of tannins, saponins, cardiac glycosides, and steroids in both extracts. In addition, alkaloids and flavonoids were present in Azadirachta indica. …”
Get full text

Comparative Analysis of Multiple Hydrological Models in Assessing Climate Change Impacts on the Mille Watershed, Awash Basin, Ethiopia by Asmare Belay Nigussie, Mihiretie Ayana, Dessalegn Worku Ayalew, Gerawork Feleke, Asnake Enawgaw Amognehegn, Anteneh Yayeh Adamu, Andualem Endalew, Tewodrose Desale Meselaw, Shankar Karuppannan

“…The study examines three global circulation models (MIROC-6, CMCC, and MRI) operating under two shared socioeconomic pathways emission scenarios (SSP2-4.5 and SSP5-8.5) for both mid-term (near future) (2041–2070) and long-term (far future) (2071–2100) periods. …”
Get full text

Genetic and biochemical analysis of severe hypertriglyceridemia complicated with acute pancreatitis or with low post-heparin lipoprotein lipase mass by Takashi Suzuki, Makoto Kurano, Akari Isono, Takuya Uchino, Yohei Sayama, Honami Tomomitsu, Daiki Mayumi, Ruriko Shibayama, Toru Sekiguchi, Naoki Edo, Kiyoko Uno-Eder, Kenji Uno, Koji Morita, Toshio Ishikawa, Kazuhisa Tsukamoto

“…In a patient with a history of AP, SNP rs199953320 resulting in LMF1 nonsense mutation and APOE rs7412 causing apolipoprotein E2 were both found in heterozygous form. Three patients were homozygous for APOA5 rs2075291, and one was heterozygous. …”
Get full text

Modulating tumor-associated macrophages through CSF1R inhibition: a potential therapeutic strategy for HNSCC by Kaiting Chen, Xiaochen Li, Shuyi Dong, Yu Guo, Ziyin Luo, Shi-Min Zhuang, Jie Liu, Tianrun Liu, Jing Liao, Weiping Wen

“…In vivo, the antitumor efficacy of CSF1R inhibitors was tested in mouse HNSCC tumor model, both as monotherapy and in combination with cisplatin, to evaluate potential synergistic effects. …”
Get full text

Robot-assisted pyeloplasty and laparoscopic pyeloplasty in children: A comparison of single-port-plus-one and multiport surgery by Jianglong Chen, Jianglong Chen, Huihuang Xu, Huihuang Xu, Shan Lin, Shan Lin, Shaohua He, Shaohua He, Kunbin Tang, Kunbin Tang, Zhixiang Xiao, Zhixiang Xiao, Di Xu, Di Xu

“…There were no differences in fasting time, the length of time that a ureteral catheter remained in place, or the number of postoperative complications.ConclusionOur study shows that both robotic multiple-port and single-port-plus-one approaches are comparable, with laparoscopic multiple-port and single-port approaches equally effective in resolving OUPJ in children. …”
Get full text

Hollow Salt Prepared Through Spray Drying with Alginate Enhances Salinity Perception to Reduce Sodium Intake by Qian Jiang, Jiayi Yan, Chen Song, Yunning Yang, Guangyuan Chen, Fanhua Kong, Jingfeng Yang, Shuang Song

“…Moreover, the conductivity monition revealed that the hollow salt exhibited a more rapid dissolution in water and its alginate component increased the adhesive retention of sodium ions on the tongue surface, which both effectively enhanced the sensory perception. …”
Get full text

Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu’s arteritis by Shuning Guo, Jiehan Li, Shurui Pang, Jing Li, Xinping Tian

“…The decreased secretion of MMP2 may potentially prompt the intimal infiltration of inflammatory cells within the vascular wall, offering a novel therapeutic opportunity by tackling both inflammatory responses and the neointimal overgrowth associated with TAK arterial damage. …”
Get full text

Robotic-assisted surgery and kinematic alignment in total knee arthroplasty (RASKAL study): a protocol of a national registry-nested, multicentre, 2×2 factorial randomised trial as... by Ian A Harris, Samuel J MacDessi, Aziz Bhimani, Darren B Chen, Ian Harris, Michelle Lorimer, David Parker, Tamara Hooper, Richard Boyle, Jonathan Mulford, Daniel Franks, Gregory C Wernecke, Durga Bastiras, Emma Heath, Anthony Leong, Brett Fristch, David Penn, George Kirsh, John Limbers, Julian Yu, Maurice Guzman, Peter McEwen

“…This study aims to assess the effectiveness of RAS, KA or both to improve clinical outcomes, functional measures, radiographic precision and prosthetic survivorship when compared with current gold standards of surgical care.Methods and analysis A national registry-nested, multicentre, double-blinded, 2×2 factorial, randomised trial will be undertaken with 300 patients undergoing primary unilateral TKA performed by 15 surgeons. …”
Get full text

Pseudomonas aeruginosa alkyl quinolone response is dampened by Enterococcus faecalis by Maggie M. Fink, Abigail A. Weaver, Dharmeshkumar Parmar, Jon E. Paczkowski, Lingyun Li, Maggie K. Klaers, Ella A. Junker, Elizabeth A. Jarocki, Jonathan V. Sweedler, Joshua D. Shrout

“…The bacteria Pseudomonas aeruginosa and Enterococcus faecalis are both prevalent pathogens in wound, urinary tract, and bacteremic infections. …”
Get full text

Insidensi Tuberkulosis Paru pada Pasien Diabetes Melitus Tipe 2 di Ruang Rawat Inap Penyakit Dalam RSUP Dr. M. Djamil Padang by Dina Fitri Fauzia, Masrul Basyar, Asman Manaf3 Manaf

“…</strong></p><p><strong>Kata kunci: </strong>insidensi, tuberkulosis paru, diabetes melitus tipe 2</p><p> </p><p><strong><em>Abstract</em></strong></p><p>Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. Type 2 DM makes up about 80% of all cases of DM. …”
Get full text

Country economic status is strongly associated with burn survival - validation of the (modified) ABSI by Julia Elrod, Christoph Mohr, Ludvik Branski, Joshua M. Peterson, Fionna M. Wood, Dale W. Edgar, Pius Agbenorku, Shobha Chamania, Anant Sharma, Flavio N. Novaes, Jean Bosco Katabogama, Michael Boettcher, Konrad Reinshagen, Ingo Koenigs

“…The participating countries were classified based on the HDI and mortality was predicted using both the original and the modified ABSI. Results After removal of incomplete data, 74,460 sets remained for the analysis. …”
Get full text

A Digital Parenting Intervention With Intimate Partner Violence Prevention Content: Quantitative Pre-Post Pilot Study by Moa Schafer, Jamie Lachman, Paula Zinser, Francisco Antonio Calderón Alfaro, Qing Han, Chiara Facciola, Lily Clements, Frances Gardner, Genevieve Haupt Ronnie, Ross Sheil

“…Intersections shared by the 2 forms of violence have led to calls for joint programming efforts to prevent both IPV and violence against children. Parenting programs have been identified as a key entry point for addressing multiple forms of family violence. …”
Get full text