Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease by Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Xiaoyan Sun, Hao Song, Jing Xu, Shuijun Zhang, Hongyang Wang, Jing Fu

“…We identified an ALB+KRT7+ epithelial population that expressed both hepatocyte and biliary markers significantly expanded in ALD livers. …”
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Solar Flares Triggered by a Filament Peeling Process Revealed by High-resolution GST Hα Observations by Mia Mancuso, Ju Jing, Haimin Wang, Wenda Cao

“…Both flares are ejective, i.e., accompanied by coronal mass ejections (CMEs). …”
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A broad assessment of forty-one skin phenotypes reveals complex dimensions of skin ageing by Jun Yan Ng, Qi Yi Ambrose Wong, Jun Jie Lim, Dingyu Cen, Jia Yi Karen Wong, Yi Ying Eliza Lim, Yang Yie Sio, Kavita Reginald, Yee-How Say, Fook Tim Chew

“…In this broad assessment of skin ageing, we first described the prevalence of forty-one signs of skin ageing and then characterised in detail both the prevalence and severity distribution of ten key skin ageing phenotypes. …”
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Dietary intakes, food behaviours, and health indicators among Métis youth in Manitoba, Canada by Chantal Perchotte, Olena Kloss, Joyce Slater, Alan Katz, Bhanu Pilli, Aynslie Hinds, Marcelo L Urquia, Julianne Sanguins, Chris Green, Jaime Cidro, Dan Chateau, Nathan Nickel, Thomas Falkenberg

“…Conclusions: The dietary intakes observed in this study, both among Métis and non-Métis youth, are concerning. …”
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The effect of a comprehensive intervention on anthropometric indices, dietary intake, and physical activity of adolescent boys with overweight by Fatemeh Sadat Hashemi Javaheri, Zahra Mousavi, Saeideh Mohammadi, Arezoo Amjadi, Khadijeh Abbasi Mobarakeh, Seyedeh Hayedeh Mousavi Shalmani, Mahdieh Torkaman, Masoomeh Alsadat Mirshafaei, Sara Khoshdooz, Zahra Saeedirad, Naser Kalantari, Parmis Mirzaei, Saeid Doaei, Nastaran Keshavarz Mohammadi, Maryam Gholamalizadeh

“…Conclusion A comprehensive lifestyle modification intervention which covers both school and individual levels may positively influence BMI, body fat, calorie intake, and distance and duration of physical activity in adolescents. …”
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Acetylation of proximal cysteine-lysine pairs by alcohol metabolism by Courtney D. McGinnis, Peter S. Harris, Brenton I.M. Graham, John O. Marentette, Cole R. Michel, Laura M. Saba, Richard Reisdorph, James R. Roede, Kristofer S. Fritz

“…A murine model of ALD was employed to quantify hepatic cysteine redox changes and lysine acetylation, revealing that alcohol metabolism significantly reduced the cysteine thiol proteome and increased protein acetylation. Interrogating both cysteine redox and lysine acetylation datasets, 1280 protein structures generated by AlphaFold2 represented by a 3D spatial matrix were used to quantify the distances between 557,815 cysteine and lysine residues. …”
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Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma by Simin Li, Yang Wang, Rui Sun, Debora Franceschi, Hongying Pan, Chenxuan Wei, Anthony Chukwunonso Ogbuehi, Bernd Lethaus, Vuk Savkovic, Sebastian Gaus, Rüdiger Zimmerer, Dirk Ziebolz, Gerhard Schmalz, Xiao Jiang

“…Five-year overall survival outcomes were compared in both HPV+ and HPV- subsets. Results. 20,978 high-quality individual cells passed quality control. …”
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Metode Deteksi Pokok Pohon Secara Automatis pada Citra Perkebunan Sawit Menggunakan Model Convolutional Neural Network (CNN) pada Perangkat Lunak Sistem Informasi Geografis by Samuel Samuel, Kestrilia Rega Prilianti, Hendry Setiawan, Prasetyo Mimboro

“…Abstract Oil palm plantations are one of the businesses that are in demand by both local and international industries. Oil palm plantations in Indonesia with very large lands are a very potential source of income for the country. …”
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Characterization and Analysis of 2-(2-Phenylethyl)chromone Derivatives and Sesquiterpenoids from Agarwood of Four “Qi-Nan” Clones (<i>Aquilaria sinensis</i>) with Different Inducti... by Ming Li, Zhou Hong, Shengjie Wang, Daping Xu, Zinong Yang, Zhihui Li, Houzhen Hu, Suxin Li

“…This study compared the changes in the chemical composition of four “Qi-Nan” clones of <i>A. sinensis</i> after 6, 12, and 24 months of induction through GC-QTOF-MS, the chemical composition and structure types of the four “Qi-Nan” clones were mainly 2-(2-phenylethyl)chromone derivatives (PECs) and Sesquiterpenoids (SESs), with the prolongation of induction time, the content of SESs increased, while the content of PECs decreased. Both the differences among clones and the induction time of “Qi-Nan” agarwood influence its chemical composition, which in turn affects the quality of the agarwood. …”
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Osilodrostat treatment in patients with Cushing’s disease of Asian or non-Asian origin: a pooled analysis of two Phase III randomized trials (LINC 3 and LINC 4) by Akira Shimatsu, Beverly MK Biller, Maria Fleseriu, Rosario Pivonello, Eun Jig Lee, Rattana Leelawattana, Jung Hee Kim, Rama Walia, Yerong Yu, Zhihong Liao, Andrea Piacentini, Alberto M Pedroncelli, Peter J Snyder

“…Improvements in cardiovascular and metabolic-related parameters, physical manifestations of hypercortisolism, and quality of life were similar in both groups. Most common adverse events (AEs) were adrenal insufficiency (44.6%) in Asian and nausea (45.5%) in non-Asian patients. …”
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Deep learning-based CT radiomics predicts prognosis of unresectable hepatocellular carcinoma treated with TACE-HAIC combined with PD-1 inhibitors and tyrosine kinase inhibitors by Linan Yin, Ruibao Liu, Wei Li, Shijie Li, Xunbo Hou

“…The calibration curve demonstrated that the combination model was significantly superior to both the radiomics and clinical models. Conclusions The study provides a CT-based radiomics model that can predict PFS for patients with uHCC treated with TACE-HAIC combined with PD-1 and TKIs.…”
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Explainable machine learning for modeling of net ecosystem exchange in boreal forests by E. Ezhova, T. Laanti, A. Lintunen, P. Kolari, T. Nieminen, I. Mammarella, K. Heljanko, K. Heljanko, M. Kulmala

“…We show that even though the statistical scores of some models can be very good, the results should be treated with caution, especially when applied to upscaling. …”
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Unpacking the benefits of black soldier fly frass fertilizer towards nematode suppression and potato production by Emmanuel O. Anedo, Emmanuel O. Anedo, Emmanuel O. Anedo, Dennis Beesigamukama, Benson Mochoge, Nicholas K. Korir, Solveig Haukeland, Solveig Haukeland, Xavier Cheseto, Moses Nyongesa, Patrick Pwaipwai, Sevgan Subramanian, Abdou Tenkouano, Betty Kibaara, Chrysantus M. Tanga

“…The same treatment reduced the PCN reproduction rate by 20% and 75% compared to NPK + nematicide and SAFI, respectively. Both BSFFF and NPK+nematicide treatments achieved comparable suppression of the number of eggs and infective juveniles (J2) per cyst-1 and eggs g-1 of soil. …”
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Crab bioturbation alters the community assemblies of abundant and rare bacteria on an intertidal wetland in the Yellow River estuary by Zhikang Wang, Yongqi Wang, Jisong Yang, Jisong Yang, Junfen Yan, Kaixin Yang, Zhonghua Ren, Wei Wang, Yang He, Min Li, Junfei Zhan, Bo Guan, Xuehong Wang, Yunzhao Li, Di Zhou, Buli Cui, Junbao Yu

“…Furthermore, we discovered that the assembly processes of abundant subcommunities were primarily influenced by stochastic processes, while rare subcommunity assemblies were collectively shaped by both stochastic and deterministic processes. In conclusion, our study elucidates the mechanism by which crab bioturbation mediates the distinct assembly processes of abundant and rare subcommunities, and underscores the importance of considering rare bacteria when evaluating the ecological functions of intertidal wetlands.…”
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Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis by Spyridon N. Karkavitsas, Marianne Göger-Neff, Maria Kawula, Kemal Sumser, Benjamin Zilles, Martin Wadepohl, Guillaume Landry, Christopher Kurz, Wolfgang G. Kunz, Olaf Dietrich, Lars H. Lindner, Margarethus M. Paulides

“…For each pair, precision was quantified using phase data from both echoes (‘dual-echo’) or only one (‘single-echo’) in- or excluding body fat pixels in the field drift correction region of interest. …”
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Changes in levels of urokinase receptor and other components of fibrinolytic system in brain tissues in urokinase gene-knockout mice with B16/F10 melanoma growing together with chr... by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, N. D. Cheryarina, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, L. A. Nemashkalova

“…Combination of CNP with melanoma in uPA-/- mice, regardless of their gender, down-regulated levels of uPAR and PAI-I on the average by 1.5 and 2.0 times, respectively (p &lt; 0.05), and up-regulated PAP on the average by 2.2 times (p &lt; 0.05) compared to the levels in animals with CNP; in uPA+/+ animals, similar decline of uPAR by 3.7 times (p &lt; 0.05) was registered only in males, and an increase of PAI-I by 2.0 times (p &lt; 0.05) was noted in all mice.Conclusion. Changes in the studied parameters in the brain tissue of urokinase gene-knockout animals in response to stress factors indicate the role of the brain urokinase system in the response to both CNP and melanoma growth, and the gender specificity of these changes may be another factor that conditions gender differences in the risk of occurrence and course of cutaneous melanoma.…”
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Bifurcation analysis of multistability and hysteresis in a model of HIV infection by I. V. Mironov, M. Yu. Khristichenk, Yu. M. Nechepurenko, D. S. Grebennikov, G. A. Bocharov

“…In particular, the results of the study of the HIV-1 infection model for parameter sets corresponding to different phenotypes of disease dynamics (typical, long-term non-progressing and rapidly progressing courses) indicate that an effective functional treatment (cure) of HIV-1-infected patients requires the development of a personalized approach that takes into account both the properties of the HIV-1 quasispecies population and the patient’s immune status.…”
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Role of Chest X-Ray in Coronavirus Disease and Correlation of Radiological Features with Clinical Outcomes in Indian Patients by Satyanand Sathi, Richa Tiwari, Savita Verma, Anil Kumar Garg, Virendra Singh Saini, Manoj Kumar Singh, Amit Mittal, Devinder Vohra

“…A severity index in the form of maximum radiological assessment of lung edema (RALE) score was calculated for each lung, and scores of both the lungs were summed to obtain a final score. …”
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Smoking and secondhand smoke exposure and carotid intima-media thickness: Baseline data from the Aidai Cohort Study in Japan by Makoto Saito, Yoshihiro Miyake, Keiko Tanaka, Chisato Nagata, Hidenori Senba, Yasuko Hasebe, Toyohisa Miyata, Takashi Higaki, Eizen Kimura, Bunzo Matsuura, Osamu Yamaguchi, Ryuichi Kawamoto

“…Conclusions Active smoking, especially pack-years of smoking, was positively associated with carotid wall thickening in both sexes. Such positive associations with maximum CIMT were found only in men; however, interactions between smoking and sex were not significant.…”
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Cochlear Implantation in Single-Sided Deafness and Asymmetric Hearing Loss: 12 Months Follow-up Results of a European Multicenter Evaluation by Thomas Wesarg, Antje Aschendorff, Regina Baumgaertel, Julia Böttcher, Liesbeth De Coninck, Ingeborg Dhooge, Ann Dierckx, Thomas Klenzner, Philipp Schörg, Georg Sprinzl, Freya Swinnen, Nicolas Verhaert, Annelies Vermeiren, Simone Volpert, Andrzej Zarowski, Arne Ernst

“…Data up to 12 months post activation were collected. Results: In both SSD and AHL subjects, CI significantly improved sound localization for sound sources on the implant side, and thus overall sound localization. …”
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