The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study) by Taiji Hasegawa, Kenji Obayashi, Kimie Miyata, Tetsuo Ueda, Norio Kurumatani, Keigo Saeki, Nahoko Ogata, Hiroki Tsujinaka, Mariko Yamashita, Tomo Nishi, Nobuhiro Tone, Naonori Masuda, Yutarou Mizusawa, Masahiro Okamoto, Shinji Maruoka, Masashi Kojima, Toyoaki Matsuura

“…At present, clear intraocular lenses (IOLs) and blue-blocking IOLs are both widely used for cataract surgery; there is currently a lack of randomised controlled trials to determine whether clear or blue-blocking IOLs should be used.Methods and analysis This randomised controlled trial will recruit 1000 cataract patients and randomly allocate them to receive clear IOLs or blue-blocking IOLs in a ratio of 1:1. …”
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Association Between Metabolic Syndrome and Cardiac Autonomic Nervous Function and Cardiorespiratory Fitness in Older Adults: A Retrospective Observational Study with Propensity Sco... by Cui N, Li Q, Cheng J, Xing T, Shi P, Wang Y, Luo M, Dun Y, Liu S

“…Logistic regression analysis showed that MetS was significantly associated with HRR2, HRR3 (odds ratio [95% CI], 0.997 [0.995,0.999], both; P=0.009 and 0.005, respectively) and HRR6 (0.996 [0.994,0.998], P< 0.001). …”
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Subcytotoxic transepidermal delivery using low intensity cold atmospheric plasma by Ga Ram Ahn, Hyung-Joon Park, Yu Jin Kim, Min Gyo Song, Hye Sung Han, Woo Geon Lee, Hyuck Ki Hong, Kwang Ho Yoo, Joon Seok, Kyu Back Lee, Beom Joon Kim

“…This study demonstrated that LICAP treatment enhances transepidermal permeation of hEGF, apparently via both paracellular and transcellular routes. Under our study conditions, LICAP treatment seems to be a novel approach to facilitate TED with low safety concerns in vitro. …”
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Variations in the End-Use Quality of Whole Grain Flour Are Closely Related to the Metabolites in the Grains of Pigmented Wheat (<i>Triticum aestivum</i> L.) by Bin Wang, Jie Kang, Shuaiqi Wang, Fasih Ullah Haider, Yingxin Zhong, Peng Zhang

“…BW was also distinguished by its exceptionally high anthocyanin content, including cyanidin-3-O-(6-O-malonyl-beta-D-glucoside) (23.2 μg g⁻¹), cyanidin-3-O-glucoside (6.5 μg g⁻¹), and peonidin-3-O-glucoside (2.3 μg g⁻¹), which surpassed the levels found in both CW and GW (which approached zero). However, BW had lower gluten content, resulting in a greater weakening and reduced development and stability times. …”
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Strain rebound and inhomogeneity in glass-to-metal seals: Radial vs axial strain evolution by Keqian Gong, Zheng Liu, Zifeng Song, Chao Zhou, Zhangjing Shi, Siyue Nie, Weisong Zhou, He Yan, Zhichun Fan, Yong Zhang

“…These results underscore the anisotropic mechanical response of sealing glass within GTM seals, emphasize the value of FBG in situ monitoring for understanding strain evolution, and provide insights into enhancing the reliability of GTM seals across various applications.…”
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Cryptic transmission of a SARS-CoV-2 variant detected by wastewater surveillance in Panama by Melissa Gaitán, Yamitzel Zaldivar, Michelle Hernandez, Jessica Góndola, Oris Chavarría, Brechla Moreno, Danilo Franco, Rodrigo DeAntonio, Santiago Mirazo, Florencia Cancela, Maria Eugenia Barnett, Alexander A. Martinez, Juan Miguel Pascale, Sandra López-Vergès

“…This highlights the critical need to sustain both genomic surveillance programs beyond the pandemic in countries like Panama that serve as pivotal exchange hubs.…”
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Effects of an exercise program with augmented reality on functional fitness and physical activity of community-dwelling older adults by Soraia Ferreira, Soraia Ferreira, José Marmeleira, José Marmeleira, Jesus Del Pozo Cruz, Jesus Del Pozo Cruz, Nilton Leite, Nilton Leite, Alexandre Bernardino, Ana Moradell, Ana Moradell, Ana Moradell, Ana Moradell, Armando Raimundo, Armando Raimundo

“…The clinical effect sizes of the interventions were large for balance (ES = 1.19) in EG1 and for upper limb strength (ES = 1.24) in EG2, and medium for cardiorespiratory fitness (ES = 0.74), agility (ES = 0.50), and lower limb flexibility (ES = 0.65) in EG1, and lower limb strength (ES = 0.61) and cardiorespiratory fitness (ES = 0.79) in EG2.ConclusionBoth intervention programs led to improvements in several functional domains. …”
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Genetic Markers Associated to Dyslipidemia in HIV-Infected Individuals on HAART by Rosmeri K. Lazzaretti, Aline S. Gasparotto, Marina G. de M. Sassi, Carísi A. Polanczyk, Regina Kuhmmer, Jussara M. Silveira, Rossana P. Basso, Cezar A. T. Pinheiro, Mariângela F. Silveira, Eduardo Sprinz, Vanessa S. Mattevi

“…The mean values of the total cholesterol and LDL-C levels were associated with both the APOB SP Ins/Del (rs17240441) and APOB XbaI (rs693) polymorphisms. …”
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Adoption of Electric Vehicles and Forecasting Air Emissions in the Metropolitan Area of Mexico City by 2050 by Rodolfo Sosa Echeverría, Graciela Velasco Herrera, Pablo Sánchez Álvarez, Elías Granados Hernández, Gilberto Fuentes García, Victor Manuel Velasco Herrera, Rogelio González Oropeza, William Vicente Rodríguez, Jaime Gandarilla Ibarra, Rodrigo Rivera Rivera

“…Mexico City serves as a pilot laboratory where both the challenges and potential solutions to an issue affecting millions of citizens can be observed. …”
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A double dissociation between semantic and spatial cognition in visual to default network pathways by Tirso RJ Gonzalez Alam, Katya Krieger-Redwood, Dominika Varga, Zhiyao Gao, Aidan J Horner, Tom Hartley, Michel Thiebaut de Schotten, Magdalena Sliwinska, David Pitcher, Daniel S Margulies, Jonathan Smallwood, Elizabeth Jefferies

“…These pathways had distinctive locations in functional connectivity space: the semantic pathway was both further from unimodal systems and more balanced between visual and auditory-motor regions compared with the spatial pathway. …”
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Measured Resection as Gap Balance Method in Mobile‐Bearing Medial Unicompartmental Knee Arthroplasty: A Randomized Controlled Trial by Qian Liu, Jianhua Ren, Wenhui Zhang, Tangzhao Liang, Zhe Wang, Siwei Xie, Yuhang Li, Jianfeng Hou, Kun Wang, Ronghan He

“…Trial Registration ClinicalTrials.gov (NCT03815448)…”
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Expedited Colorectal Cancer Detection Through a Dexterous Hybrid CADx System With Enhanced Image Processing and Augmented Polyp Visualization by Akella Subrahmanya Narasimha Raju, K. Venkatesh, Ranjith Kumar Gatla, Marwa M. Eid, Aymen Flah, Zdenek Slanina, Ramy N. R. Ghaly

“…We applied Local Interpretable Model-Agnostic Explanations (LIME) visualizations to both datasets, which proved to be an insightful identification of regions that the model relied on during the polyp detection process. …”
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Fracturing simulation with different perforation positions at deep coal seam and roof/ floor rock — case study at the No.8 deep coal seam of a gas field in the Ordos basin by Dong XIONG, Jiayuan HE, Xinfang MA, Zhaoliang QU, Tiankui GUO, Shiyu MA

“…The hydraulic fractures in both mudstone and coal are extended in length. The perforation in limestone and mudstone requires a higher initiation pressure compared to the perforation in coal. …”
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Machine Learning Diagnostic Model for Hepatocellular Carcinoma Based on Liquid–Liquid Phase Separation and Ferroptosis-Related Genes by Wenchao Chen, Ting Zhu, Xiaofan Pu, Linlin Zhao, Senhao Zhou, Xin Zhong, Suihan Wang, Tianyu Lin

“…Fe2+ content and ROS levels were both significantly increased in the si-NRAS group when compared to those in the si-NC group (P < .01), while opposite results were observed for the protein level of GPX4 and GSH content. …”
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Analytical Methods for Atmospheric Carbonyl Compounds: A Review by Xiaoshuai Gao, Xin Zhang, Yan Nie, Jiemeng Bao, Junling Li, Rui Gao, Yunfeng Li, Wei Wei, Xiaoyu Yan, Yongxin Yan, Hong Li

“…In smog chamber simulation studies, the detection of carbonyl compounds is heavily influenced by both the sampling system and the chamber itself. …”
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Bioprocessing of organic wastes from poultry and bovine slaughterhouses as food substrate for Hermetia illucens larval development by A.P. Luperdi, S.S. Flores-Calla, X.J. Barriga, V. Rivera, I. Salazar, P.L. Manrique, J.E. Reátegui

“…Larvae were fed for 5 days and processed to make meal by drying and grinding; evaluating mortality, weight, size, proximal chemical composition, and apparent digestibility to determine the most viable substrate, analyzing effects and significance by multifactorial ANOVA and Kruskal-Wallis.FINDING: The results show Mortality (F = 917,81, p < 0,0001): T1 y T3 with 76,40 ± 2,86 (%) (F = 917,81, p < 0,0001), following T6 with 69,67 ± 4,55%, T7 with 24,00 ± 3,48%, T2 with 4,60 ± 1,92 %, T5 y T4, both with 4,20 ± 2,00 %. Weight (F = 825,62, p < 0,0001): T2 with 1,78 ± 0,22 gram outperformed the control T5 (1,76 ± 0,50 gram), T4 with 1,45 ± 0,06 g and T7 with 1,66 ± 0,07 gram. …”
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Effects of Ciprofol and Propofol General Anesthesia on Postoperative Recovery Quality in Patients Undergoing Ureteroscopy: A Randomized, Controlled, Double-Blind Clinical Trial by Shi S, Wu J, Wu Y, Han X, Dai H, Chen X, Sun Z, Wang F

“…Shuqi Shi,1,2,&ast; Jimin Wu,1,&ast; Yini Wu,1 Xin Han,1 Hong Dai,1 Xuedong Chen,3 Zhangnan Sun,4 Faxing Wang1,2 1Department of Anesthesiology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, Lishui, People’s Republic of China; 2Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Urology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, Lishui, People’s Republic of China; 4Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Faxing Wang, Department of Anesthesiology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, No. 15, Dazhong Street, Lishui, Zhejiang Province, 323000, People’s Republic of China, Email wfx2023@wmu.edu.cn Zhangnan Sun, Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China, Email 28703077@hebmu.edu.cnObjective: This study compares postoperative recovery quality between Ciprofol and Propofol, providing a reference for the clinical application of anesthetics.Methods: We randomized 112 patients undergoing ureteroscopic surgery into two groups: the Ciprofol group (Group C), with an induction dose of 0.4 mg/kg and a maintenance dose of 0.8– 1.5 mg/(kg·h), and the Propofol group (Group P), with an induction dose of 2 mg/kg and a maintenance dose of 4– 10 mg/(kg·h). Both groups received sevoflurane at a concentration of 1%. …”
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Effective rain rate model for analysing overestimated rain fade in short millimetre-wave terrestrial links due to distance factor by Asma Ali Budalal, Ibraheem Shayea, Md. Rafiqul Islam, Jafri Din, Abdulsamad Ebrahim Yahya, Yousef Ibrahim Daradkeh, Marwan Hadri Azmi

“…Several experimental results reported from different regions around the globe are used to validate the proposed model. The outcomes are in good agreement. The findings emphasize the importance of developing region-specific models that consider local meteorological variations, potentially offering significant improvements to the reliability and design of mm-wave communication systems and realizing the future goal of 6G wireless mobile fronthaul.…”
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Dopamine‐conjugated extracellular vesicles induce autophagy in Parkinson's disease by Jae Hoon Sul, Sol Shin, Hark Kyun Kim, Jihoon Han, Junsik Kim, Soyoung Son, Jungmi Lee, Seung Hyun Baek, Yoonsuk Cho, Jeongmi Lee, Jinsu Park, Donghoon Ahn, Sunyoung Park, Leon F. Palomera, Jeein Lim, Jongho Kim, Chanhee Kim, Seungsu Han, Ka Young Chung, Sangho Lee, Tae‐in Kam, Yunjong Lee, Jeongyun Kim, Jae Hyung Park, Dong‐Gyu Jo

“…Therapeutically, Dopa‐EVs administration led to the rescue of dopaminergic neuronal loss and amelioration of behavioural deficits in both 6‐hydroxydopamine (6‐OHDA) and α‐Syn PFF‐induced PD models. …”
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Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis by Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov

“…ObjectiveTo evaluate and quantitatively describe age-dependent homeostasis for a broad range of total T-cells and specific T-lymphocyte subpopulations in healthy human subjects.MethodsA systematic literature review was performed to identify and collect relevant quantitative information on T-lymphocyte counts in human blood and various organs. Both individual subject and grouped (aggregated) data on T-lymphocyte observations in absolute and relative values were digitized and curated; cell phenotypes, gating strategies for flow cytometry analyses, organs from which observations were obtained, subjects’ number and age were also systematically inventoried. …”
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