Clinical trial to compare safety and tolerability between intravenous infusion and bolus intravenous injection of ApTOLL in healthy volunteers by Macarena Hernández-Jiménez, Samuel Martín-Vílchez, Gina Mejía-Abril, Manuel Roman, Sergio Luquero-Bueno, David Piñeiro, Marc Ribó, Francisco Abad-Santos, Dolores Ochoa

“…Maximum concentration was detected at the end of the infusion/injection, and mean half-life was 9.5 h for both routes of administration. These results show that safety and pharmacokinetic profiles were comparable between intravenous infusion and bolus injection of ApTOLL, supporting a change of the route of administration for future clinical practice (ClinicalTrials.gov: NCT05569720).…”
Get full text

Differential management and associations of dyslipidaemia and hypertension by glycaemic status in urban South Africans by N Peer, L Kotzé-Hörstmann, J Hill, A-P Kengne

“…Prevalence of hypertension (BP ≥140/90 mmHg or on treatment) and dyslipidaemia (raised low-density lipoprotein cholesterol >3 mmol/L or on treatment) was highest in KD (89% and 83%) compared with NDD (64% and 74%) and normoglycaemia (66% for both) (p<0.001). Detected or known hypertension was highest in KD (97.4%), followed by NDD (88.9%) and normoglycaemia (80.3%). …”
Get full text

Deciphering Gas Dynamics and Star Formation in a z = 1.1 Main-sequence Spiral Galaxy with ALMA and JWST by Zhaoran Liu, Tadayuki Kodama, Takahiro Morishita, Kianhong Lee, Fengwu Sun, Mariko Kubo, Zheng Cai, Yunjing Wu, Zihao Li

“…Utilizing data from the Atacama Large Millimeter/submillimeter Array and JWST NIRCam wide field slitless spectroscopy, we explore both ionized gas and molecular gas within this galaxy. …”
Get full text

Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis by Kang Zheng, Zexu Chen, Wen Sun, Bin Liu, Danping Fan, Qingqing Guo, Hui Luo, Jiawen Shen, Li Li, Xiaojuan He, Shuang Kou, Xiaoya Li, Guoming Pang, Hongchuan Zhao, Cheng Lu

“…In vivo experiments demonstrated that HGT ameliorated the symptoms in CIA mice and decreased the production of inflammatory cytokines in both mice ankle joints and serum. Furthermore, HGT effectively inhibited the activation of IL-12R and STAT4 on IL-12 signaling pathway. …”
Get full text

Screening of Efficient Antifreeze Agents to Prevent Low-Temperature Stress in Vines by Yali Zhang, Mengyao Han, Langjie Wu, Haoyu Wang, Yanying Liang, Xianhang Wang, Zhumei Xi

“…Compared to the control (water), all four antifreeze agents significantly reduced the relative conductivity and malondialdehyde content in the tender shoots of both grape varieties, increased the Fv/Fm ratio, enhanced osmotic adjustment substance levels, and improved antioxidant enzyme activity. …”
Get full text

A novel minimally invasive neurosurgical cranial fixation device for improved accuracy of intraventricular catheter placement: an experimental animal study by Atai Daniel, Matan Coronel, Segev Peer, Ben Grinshpan, Soner Duru, Jose L. Peiro, James L. Leach, Elena Abellán, Carolyn M. Doerning, David Zarrouk, Francesco T. Mangano

“…Methods An experimental device for catheter insertion and fixation was designed and tested in both ex-vivo and in-vivo conditions to assess accurate cannulation of the ventricle and to test the strength of fixation to the skull. …”
Get full text

STAT4, TRAF3IP2, IL10, and HCP5 Polymorphisms in Sjögren’s Syndrome: Association with Disease Susceptibility and Clinical Aspects by Serena Colafrancesco, Cinzia Ciccacci, Roberta Priori, Andrea Latini, Giovanna Picarelli, Francesca Arienzo, Giuseppe Novelli, Guido Valesini, Carlo Perricone, Paola Borgiani

“…A genetic risk profile was developed considering the risk alleles. Both the variant alleles of rs7574865 in the STAT4 gene and rs3099844 in the HCP5 gene were significantly more prevalent in patients than in controls (OR=1.91 and OR=2.44, respectively). …”
Get full text

Improving the diagnostic accuracy of referrals for papilloedema (DIPP) study: protocol for a mixed-methods study by Luke Bennetto, Beth Stuart, Jonathan Benger, Matthew J Ridd, Helen Bolton, William Hollingworth, Michael Bowen, Amar Shah, Samuel William David Merriel, Alyson Huntley, Victoria Wilson, Maria Theresa Redaniel, Paul Roy, Denize Atan, Frank Moore, Olivia Skrobot, Mary-Ann Sherratt, Marcia Lucraft, Christina Stokes

“…This article describes the protocol for gathering evidence of current referral practices and pathways for people suspected to have papilloedema in England and the development of guidelines based on this evidence and extensive engagement with community- and hospital-based healthcare professionals, patients, and the public.Methods and analysis Both qualitative and quantitative data will be collected from Freedom of Information requests to Integrated Care Boards across England about how they organise their community and hospital services for people with suspected papilloedema, with and without headache. …”
Get full text

Influence of land cover change on atmospheric organic gases, aerosols, and radiative effects by R. Vella, R. Vella, M. Forrest, A. Pozzer, A. Pozzer, A. P. Tsimpidi, T. Hickler, T. Hickler, J. Lelieveld, J. Lelieveld, H. Tost

“…Secondary organic aerosols (SOAs) resulting from BVOC oxidation affect the radiation budget both directly, through the scattering and absorption of sunlight, and indirectly, by modifying cloud properties. …”
Get full text

Improved Mechanical Performances of Hastelloy C276 Composite Coatings Reinforced with SiC by Laser Cladding by Yuqing Tang, Zheng Lu, Xuan Zhang, Xihuai Wang, Shengbin Zhao, Mingdi Wang

“…These acicular crystals tend to extend away from the residual SiC powder particles, and the grain size in this region is smaller and more densely distributed. This indicates that both melted and unmelted SiC powder particles can contribute to refining the grain structure of the cladding layer. …”
Get full text

Parental Mental Health and Child Maltreatment in the COVID-19 Pandemic: Importance of Sampling in a Quantitative Statistical Study by Lara Engelke, Claudia Calvano, Steffi Pohl, Sibylle Maria Winter, Babette Renneberg

“…MethodsIn 2020, we simultaneously conducted 2 studies: (1) a web-based survey using a convenience sample of 4967 parents of underage children, primarily recruited via social media, and (2) a study using a quota sample representative of the German adult population with underage children (N=1024), recruited through a combination of telephone interviews and computer-assisted web interviews. In both studies, the same questionnaire was used. To evaluate the impact of sampling, we compared the results on outcomes (parental stress, subjective health, parental mental health, general stress, pandemic-related stress, and the occurrence of child maltreatment) between the 2 samples. …”
Get full text

Identification of genetic variants of the IL18R1 gene in association with COPD susceptibility by Jiaoyuan Xu, Meilan Xian, Linhui Huang, Yamei Zheng, Lei Zhang, Jie Zhao, Jie Chen, Siguang Li, Lingsang Lin, Yi Zhong, Zehua Yang, Haihong Wu, Tian Xie, Yipeng Ding

“…Multifactor dimensionality reduction (MDR) software was applied to calculate the interaction of SNP-SNP on COPD risk.Results IL18R1 rs9807989 (OR = 0.42, p < .001), rs3771166 (OR = 0.40, p < .001) and rs6543124 (OR = 0.44, p < .001) were associated with the reduced COPD risk, while rs2287037 (OR = 2.71, p < .001) and rs2058622 (OR = 2.06, p < .001) might be the risk-increasing factor for COPD occurrence in both the overall analysis and subgroup analysis (age, gender, drinking, and smoking). …”
Get full text

Effects of temporal, spatial, and environmental factors on ciliates community in northeastern South China Sea, with notes on co-occurrence patterns of environment, phytoplankton, and ciliate by Weiwei Liu, Zijun Cheng, Shaowei Wen, Gang Li, Zhixin Ke, Daning Li, Yehui Tan

“…This study improves our understanding for the mechanisms of community structuring of microzooplankton in the open sea across both space and time.IMPORTANCECiliates are important components of microplanktons and play a crucial role in global nutrient cycling. …”
Get full text

Construction and evaluation of the prediction model for advanced disease in well-differentiated colorectal neuroendocrine neoplasms less than 2 cm in diameter by Hongda Yin, Yanan Chen, Wei Zhao, Fuqiang Zhao, Zhijun Huang, Aimin Yue, Zhijie Wang

“…Conclusions: The prediction model had good value for identifying advanced disease from well-differentiated colorectal NENs smaller than 2 cm.…”
Get full text

Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network me... by Yuhua Jiang, Yingying Wang, Sijia Ma, Linlin Qian, Yeteng Jing, Xi Chen, Jinsheng Yang

“…Moreover, the incidence of adverse events (AEs) was similar to that observed in the control group, which included both placebo and potent statin groups, with no significant differences identified in our study (P &gt; 0.05).ConclusionsThe combination of PCSK9 inhibitors with robust statins like rosuvastatin and atorvastatin markedly decreases LDL-C levels in patients with hyperlipidemia when compared to placebo or monotherapy. …”
Get full text

Taxonomic composition and biodiversity of the gut microbiome from patients with irritable bowel syndrome, ulcerative colitis, and asthma by A. Y. Tikunov, A. N. Shvalov, V. V. Morozov, I. V. Babkin, G. V. Seledtsova, I. O. Voloshina, I. P. Ivanova, A. V. Bardasheva, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…To date, the association of an imbalance of the intestinal microbiota with various human diseases, including both diseases of the gastrointestinal tract and disorders of the immune system, has been shown. …”
Get full text

Polarization variable terahertz metasurface along the propagation path by Jitao Li, Jingyu Liu, Zhen Yue, Jie Li, Chenglong Zheng, Fan Yang, Hui Li, Yating Zhang, Yan Zhang, Jianquan Yao

“…The proposed design achieved a linearly polarized terahertz wave including both LCP and RCP components with a precise phase difference Δφ at each point within a certain range along the z-axis. …”
Get full text

The alphavirus determinants of intercellular long extension formation by Caroline K. Martin, Judy J. Wan, Peiqi Yin, Thomas E. Morrison, William B. Messer, Vanessa Rivera-Amill, Jonathan R. Lai, Nina Grau, Félix A. Rey, Thérèse Couderc, Marc Lecuit, Margaret Kielian

“…Our results showed that both the viral E2 and E1 envelope proteins were required for ILE formation, while viral proteins 6K and transframe, and cytoplasmic nucleocapsid formation were dispensable. …”
Get full text

Association between poor oral health and deterioration of appetite in older age: results from longitudinal analyses of two prospective cohorts from the UK and USA by Sheena E Ramsay, Olia Papacosta, S Goya Wannamethee, John C Mathers, Peter H Whincup, Lucy Lennon, Ziyi Cai, Suruchi G Ganbavale, Robert Weyant

“…In the BRHS, sustained poor/deterioration in oral health markers (self-rated oral health, dry mouth, eating or chewing difficulty, food avoidance, loose denture/s) over the follow-up were associated with sustained poor/deterioration of appetite.Conclusion Oral health is a potentially important contributor to maintaining good appetite in older age.…”
Get full text

Short-term effects of olive-mill-wastes-derived biochars amendment and arbuscular mycorrhizal fungi inoculation on growth of maize (Zea mays) and mycorrhizal colonization by Minkosse, Christiane, Langenfeld, Aude, Azzaz, Ahmed Amine, Jeguirim, Mejdi, El-Bassi, Leila, Akrout, Hanene, Jellali, Salah, Ghimbeu, Camélia Matei, Nassr, Najat

“…This effect is more pronounced when the biochar is made from IROP. Both the AMF and biochars treatments did not significantly enhance the growth of maize plants, biomass production, and leaf chlorophyll contents. …”
Get full text