Aspergillus fumigatus Influences Gasdermin-D-Dependent Pyroptosis of the Lung via Regulating Toll-Like Receptor 2-Mediated Regulatory T Cell Differentiation by Wei Yan, Yi-si Zhao, Ke Xie, Yu Xing, Fang Xu

“…The expression of Foxp3 and TLR2 in the lung tissue of mice infected with A. fumigatus increased, and we observed that the proportion of Tregs in both A. fumigatus infection patients and mice was upregulated. …”
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High trophic similarity between non-native common carp and gibel carp in Turkish freshwaters: Implications for management by Sadi Aksu, Özgür Emiroğlu, Paride Balzani, J. Robert Britton, Esengül Köse, Irmak Kurtul, Sercan Başkurt, Oğuzcan Mol, Emre Çınar, Phillip J. Haubrock, Pinar Oztopcu-Vatan, Ali Serhan Tarkan

“…Here, we assessed the growth types, body conditions and trophic interactions via bulk carbon and nitrogen stable isotope analysis of common and gibel carp in both natural and artificial water bodies in Turkey. …”
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iRGD-Targeted Biosynthetic Nanobubbles for Ultrasound Molecular Imaging of Osteosarcoma by Liu T, Liang X, Liu W, Yang S, Cui T, Yan F, Li Z

“…Our in vitro and in vivo experiments showed the specifically binding ability of iRGD-sGVs to both vascular endothelial cells and tumor cells, producing the stronger and longer acoustic signals in tumors in comparison with the control probe. …”
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Uncertainty quantification in multi-parametric MRI-based meningioma radiotherapy target segmentation by Lana Wang, Zhenyu Yang, Zhenyu Yang, Dominic LaBella, Zachary Reitman, John Ginn, Jingtong Zhao, Justus Adamson, Kyle Lafata, Kyle Lafata, Kyle Lafata, Evan Calabrese, John Kirkpatrick, Chunhao Wang

“…The added SPU-Net uncertainty mapping revealed low uncertainty in accurate segments (e.g., within GTV or healthy tissue) and higher uncertainty in problematic areas (e.g., GTV boundaries, dural tail), providing valuable insights for potential manual corrections. …”
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Facilitators and barriers to reach and enrollment into a medically tailored meals program within a section 1115 Medicaid pilot: clinic staff perspectives by Sara C. Folta, Jessica Burch, Matthew Alcusky, Arlene S. Ash, Kurt Hager, Jean Terranova, Fang Fang Zhang, Oyedolapo Anyanwu, Zhongyu Li, Dariush Mozaffarian

“…For program (innovation) factors, facilitators included perceived positive effects on patient health outcomes and a relative advantage over both the status quo and other nutrition assistance programs; outreach by care team members rather than other staff; the eligibility criteria, which were viewed as appropriate and evidence-based; and the simplicity of the program, which aided communication with patients. …”
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Habitat radiomics based on CT images to predict survival and immune status in hepatocellular carcinoma, a multi-cohort validation study by Kun Chen, Chunxiao Sui, Ziyang Wang, Zifan Liu, Lisha Qi, Xiaofeng Li

“…Second, a total of 350 habitat radiomic models were constructed to select the optimal model. Then, both ROC curve analyses and Kaplan-Meier survival curve analyses were applied to assess the predictive performances. …”
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Hubungan Konsumsi Antioksidan dari Makanan dengan Beta-Amyloid Plasma sebagai Penanda Gangguan Fungsi Kognitif pada Lanjut Usia by Ratna D Siregar, Nur Indrawati Lipoeto, Yuliarni Syafrita

“…Metoda penelitian adalah cross sectional study terhadap 145 lansia umur ≥ 60 tahun, pada dua kecamatan di Kabupaten Lima Puluh Kota Sumatra Barat. Wawancara konsumsi antioksidan menggunakan Food Frequency Questionnaires (FFQ), fungsi kognitif diperiksa dengan Montreal Cognitive Assesment versi Indonesia (MoCA-Ina), Aβ40 dan Aβ42 plasma diperiksa dengan metode ELISA. …”
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Predictive markers of rapid disease progression and chemotherapy resistance in triple-negative breast cancer patients following postoperative adjuvant therapy by Tao Ma, Xiao-meng Hao, Hong-dan Chen, Min-hui Zheng, Xiao-geng Chen, Shuang-Long Cai, Jin Zhang

“…Logistic regression analysis was applied to determine potential markers predictive of rapid relapse post-chemotherapy. Both univariate and multivariate logistic regression analyses pinpointed several predictors of rapid relapse in TNBC patients post-chemotherapy. …”
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From sea to sky: understanding the sea surface temperature impact on an atmospheric blocking event using sensitivity experiments with the ICOsahedral Nonhydrostatic (ICON) model by S. Christ, M. Wenta, C. M. Grams, C. M. Grams, A. Oertel

“…This blocking event, which was associated with a winter heat wave with unprecedented temperatures in western Europe, was both preceded and accompanied by several rapidly intensifying extratropical cyclones originating in the Gulf Stream region and crossing the North Atlantic. …”
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Treatment of chronic hepatitis B: options, monitoring, special cases and adverse effects by Mateusz Litwin Litwin, Agnieszka Mikosińska, Jakub Parys, Patrycja Kałuziak, Aleksandra Witek, Martyna Kaźmierczak, Stanisław Jesionek, Marta Jajczak, Maciej Mossakowski

“…Aim of the study: The aim of this paper is primarily to systematize knowledge regarding the natural course of HBV infection and therapeutic options for chronic hepatitis B, both in adults and children. It also aims to highlight the principles of monitoring pharmacotherapy. …”
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Synthesis of Mg-, Al- and Mg/Al-date palm fronds modified biochars: characterization and investigations on phosphorus adsorption characteristics by Jellali, Salah, Hadroug, Samar, Al-Wardy, Malik, Hamdi, Helmi,  Al-Sabahi, Jamal, Bekri, Imene, Al-Raeesi, Ahmed, Hamdi, Wissem,  Jeguirim, Mejdi

“…The kinetic and isotherm experimental data modelling suggest that P recovery process was governed by both physical and chemical mechanisms. These P-loaded biochars have the potential to serve as promising fertilizers, offering a sustainable alternative to synthetic counterparts.…”
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Knowledge, attitudes and practices regarding pulmonary rehabilitation among patients with chronic respiratory diseases: a cross-sectional questionnaire-based study in a tertiary ho... by Xueli Bai, Yuan Chen, Xiansheng Liu, Lingling Wang, Xiaohong Zhang, Jie Ding, Lin Su, Ruiying Wang, Shuang Wei

“…SEM analysis showed that knowledge directly influenced attitudes (β=−0.538, p<0.001) and both knowledge (β=0.668, p<0.001) and attitudes (β=0.668, p<0.001) significantly influenced practices. …”
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Characterization of heart failure patients with reverse left ventricular remodelling post‐angiotensin receptor blockers/neprilysin inhibitors therapy by Leonid Maizels, Yishay Wasserstrum, Boris Fishman, Amitai Segev, David Ben‐Nun, Anan Younis, Dov Freimark, Israel Mazin, Avishay Grupper

“…Significant reduction in LV dimensions was noted in patients with lower initial LVEF, non‐ischaemic HF and no CRT. …”
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A1, an innovative fluorinated CXCR4 inhibitor, redefines the therapeutic landscape in colorectal cancer by Hossein Khorramdelazad, Kowsar Bagherzadeh, Ali Rahimi, Ali Darehkordi, Alireza Najafi, Milad Karimi, Majid Khoshmirsafa, Gholamhossein Hassanshahi, Elaheh Safari, Reza Falak

“…A1 effectively inhibited the proliferation of CT-26 cells, significantly reduced tumor cell migration, attenuated Treg infiltration, and suppressed IL-10 and TGF-β expression at both mRNA and protein levels in vivo. Notably, A1 outperformed AMD3100 in reducing tumor size and increasing survival rate in treated animals, with minimal side effects. …”
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Impact of Self-Management Clustered Care on Psychological and Birth Outcomes in Gestational Diabetes by Tang S, Wang S, Wu J, Hu S, Lu T, Zhu M, Li J, Xue F

“…We compared the differences in self-management ability, blood glucose concentration, delivery outcome, and psychological status.Results: Self-management ability scores were higher in both groups following the intervention than before the intervention (P< 0.001), and the increase was more notable in the study group (t=9.237, P< 0.001). …”
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Chinese burden of depressive disorders from 1990 to 2021 and prediction for 2030: analysis of data from the global burden of disease study 2021 by Na Yan, Caochen Zhang, Yihan Wang, Yuhao Wang, Yunjiao Luo, Yingxue Wang, Blen Dereje Shiferaw, Louisa Esi Mackay, Jingjing Wang, Jie Tang, Qingzhi Wang, Xiuyin Gao, Wei Wang

“…Results The age-standardized incidence (ASIR, AAPC: -0.35 [95%CI: -0.65, -0.04]), prevalence (ASPR, AAPC: -0.20 [95%CI: -0.24, -0.16]), and DAYLs (AAPC: -0.28 [95%CI: -0.51, -0.05]) rates of both sexes showed a downward trend from 1990 to 2021, despite a volatility growth in recent years (APC in 2019–2021 of ASPR: 0.96 [95%CI: 0.70, 1.23]). …”
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Effects of saffron-grape intercropping on saffron flower number and rhizosphere microbial community by Yuanyuan Tao, Guifen Zhou, Xingchang Zhang, Mengqing Feng, Liqin Li, Xiaodong Qian

“…Although there was no significant difference in diversity, intercropping increased the observed richness and biodiversity of both bacteria and fungi compared to monoculture. …”
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Modeling the determinants of attrition in a two-stage epilepsy prevalence survey in Nairobi using machine learning by Daniel M. Mwanga, Isaac C. Kipchirchir, George O. Muhua, Charles R. Newton, Damazo T. Kadengye, Abankwah Junior, Albert Akpalu, Arjune Sen, Bruno Mmbando, Charles R. Newton, Cynthia Sottie, Dan Bhwana, Daniel Mtai Mwanga, Damazo T. Kadengye, Daniel Nana Yaw, David McDaid, Dorcas Muli, Emmanuel Darkwa, Frederick Murunga Wekesah, Gershim Asiki, Gergana Manolova, Guillaume Pages, Helen Cross, Henrika Kimambo, Isolide S. Massawe, Josemir W. Sander, Mary Bitta, Mercy Atieno, Neerja Chowdhary, Patrick Adjei, Peter O. Otieno, Ryan Wagner, Richard Walker, Sabina Asiamah, Samuel Iddi, Simone Grassi, Sloan Mahone, Sonia Vallentin, Stella Waruingi, Symon Kariuki, Tarun Dua, Thomas Kwasa, Timothy Denison, Tony Godi, Vivian Mushi, William Matuja

“…Background: Attrition is a challenge in parameter estimation in both longitudinal and multi-stage cross-sectional studies. …”
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AI for IMPACTS Framework for Evaluating the Long-Term Real-World Impacts of AI-Powered Clinician Tools: Systematic Review and Narrative Synthesis by Christine Jacob, Noé Brasier, Emanuele Laurenzi, Sabina Heuss, Stavroula-Georgia Mougiakakou, Arzu Cöltekin, Marc K Peter

“… BackgroundArtificial intelligence (AI) has the potential to revolutionize health care by enhancing both clinical outcomes and operational efficiency. …”
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Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-κB Pathway by Weijuan Li, Zhi Li, Yaoqi Chen, Songhai Li, Yuanyuan Lv, Wenping Zhou, Mengyang Liao, Feng Zhu, Zihua Zhou, Xiang Cheng, Qiutang Zeng, Yuhua Liao, Yumiao Wei

“…Interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), and monocyte chemotactic protein-1 (MCP-1) expression were improved at both mRNA and protein levels in HEC, while NF-κB in the DNA level was improved detected by electrophoretic mobility shift assays (EMSA). …”
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