NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled... by Deborah D Stocken, Maureen Twiddy, Hisham Mehanna, Jonathan Wadsley, Neil Corrigan, Katie Gordon, Julie Croft, Neil Sharma, Anna Perry, Mark Strachan, Gemma Ainsworth, Elizabeth Glenister, Sabapathy Prakash P Balasubramanian

“…The trial incorporates a process evaluation (IDEAL (Idea, Development, Exploration, Assessment and Long-term follow-up framework) 2a) to inform the trial protocol, a phase II (IDEAL 2b) analysis using a surrogate primary outcome of 1 day transient hypocalcaemia to determine early futility and phase III (IDEAL 3) assessment of the primary outcome of PoSH at 6 months after surgery. 454 participants will be randomised on a 1:1 basis to evaluate thyroid surgery with NIRF and indocyanine green against standard thyroid surgery in reducing PoSH at 6 months after surgery, with the phase II analysis occurring once data are available for 200 participants. Analysis in both phases will be using multilevel logistic regression incorporating random effects with respect to surgeon and adjusting for minimisation factors. …”
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Individualized diagnosis of Parkinson’s disease based on multivariate magnetic resonance imaging radiomics and clinical indexes by Qianqian Ye, Chenhui Lin, Fangyi Xiao, Tao Jiang, Jialong Hou, Yi Zheng, Jiaxue Xu, Jiani Huang, Keke Chen, Jinlai Cai, Jingjing Qian, Weiwei Quan, Yanyan Chen

“…Support Vector Machine (SVM) classifiers were developed using MRI radiomics data from both monomodal and multimodal radiomics models. The clinical-radiomics model was constructed by integrating clinical variables, including UPDRS, Hoehn-Yahr stage, age, sex, and MMSE scores. …”
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Immune Mediator Profile in Aqueous Humor Differs in Patients with Primary Acquired Ocular Toxoplasmosis and Recurrent Acute Ocular Toxoplasmosis by Claudia Thieme, Stephan Schlickeiser, Sylvia Metzner, Claudia Dames, Uwe Pleyer

“…Cytokine ratios showed no difference between pOT and rOT, indicating a dominant Th1-type response in both infectious groups. …”
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Chemotherapy in synergy with innate immune agonists enhances T cell priming for checkpoint inhibitor treatment in pancreatic cancer by Nan Niu, Keyu Li, Junke Wang, Vanessa Funes, Birginia Espinoza, Pan Li, Jianxin Wang, Melissa Lyman, Mengni He, Brian Herbst, Michael Wichroski, Ruslan Novosiadly, Sami Shoucair, Yiping Mou, Lei Zheng

“…Conclusion This study supports the clinical testing of both STING and NLRP3 agonists, respectively, in combination with chemotherapy to sensitize PDAC patients for ICI treatments.…”
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A novel sensitizer reduces EGFR-TKI resistance by regulating the PI3K/Akt/mTOR pathway and autophagy by Jue Zhang, Zhipeng Qu, Xi Xiao, David L. Adelson, Funeng Wang, Aisheng Wei, Yuka Harata-Lee, Jian Cui, Dongying He, Le Xie, Lingling Sun, Jing Li, Zijing Huang, Thazin Aung, Hong Yao, Lizhu Lin

“…PI3K, Akt and mTOR were downregulated, while after 24 and 48 h of treatment with YFSJ alone and in combination with gefitinib, LC3A and LC3B were up-regulated in both cell lines. Conclusion: YFSJ reduced the viability of EGFR-TKI-resistant cell lines, reducing resistance to gefitinib. …”
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Waning neutralizing antibodies through 180 days after homologous and heterologous boosters of inactivated COVID-19 vaccine by Zhifei Chen, Fangqin Xie, Hairong Zhang, Dong Li, Suhan Zhang, Mengping Zhang, Junrong Li, Jianfeng Xie, Lina Zhang, Xiuhui Yang, Dongjuan Zhang

“…Notably, heterologous boosting with the Convidecia vaccine maintained higher GMTs of neutralizing antibodies against both Delta and Omicron variants compared to the other boosters. …”
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P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion by Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Vanessa Figliuolo, Claudia Lucia Martins Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva

“…Our in vivo experiments also showed that intralesional UTP treatment reduced both parasite load (in the footpads and popliteal lymph nodes) and lesion size in wild-type (WT) and CASP-11−/− but not in CASP-1,11−/− mice. …”
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A Hospital-Based, Single-Center, Cross-Sectional Study to Investigate the Status Quo of Hyperuricaemia in a Booming Seaside City with Young Population from 2020 to 2021 in China by Li C, Sun J, Wei Q, Yue J, Wang X, Zhang Q, Peng S, Liao X, Zeng H, Asakawa T

“…In addition, during analyses of the data, we found that both the prevalence of HUA and age of the population need to be seriously considered. …”
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Nutritional strategies for laying hens to address environmental challenges by reducing the nitrogen excretion by Vlaicu Petru Alexandru, Untea Arabela Elena, Panaite Tatiana Dumitra, Cornescu Gabriela Maria, Saracila Mihaela, Varzaru Iulia, Oancea Alexandra Gabriela

“…The lowest CP absorption was determined in the RPL group, while the RPC group (88.24%), had the highest coefficient of apparent absorption, compared with both CON (86.18%) and RPL (86.22%) groups. No significant effect on mineral excretion content was observed.…”
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Polymorphisms in Adipokines in Mexican Children with Obesity by Angélica Saraí Jiménez-Osorio, Alma Olivia Aguilar-Lucio, Helios Cárdenas-Hernández, Claudette Musalem-Younes, Jacqueline Solares-Tlapechco, Paula Costa-Urrutia, Oscar Medina-Contreras, Julio Granados, Martha Eunice Rodríguez-Arellano

“…No significant contribution was found with adipokines and cytokines polymorphisms in this study. Only both TMEM18 (rs6548238; rs7561317) polymorphisms were found associated with obesity (OR=0.5, P=0.008) and were in linkage disequilibrium (r2=0.87). …”
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Dual disease co-expression analysis reveals potential roles of estrogen-related genes in postmenopausal osteoporosis and Parkinson’s disease by Dongdong Yu, Dongdong Yu, Jian Kang, Chengguo Ju, Qingyan Wang, Ye Qiao, Ye Qiao, Long Qiao, Long Qiao, Dongxiang Yang

“…Differentially expressed genes (DEGs) among PMO, PD, and ERGs were subjected to an array of bioinformatics analyses, including Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses, in addition to protein-protein interaction (PPI) network analysis. …”
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Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication by Fuencisla Pilar-Cuéllar, Rebeca Vidal, Alvaro Díaz, Elena Castro, Severiano dos Anjos, Jesús Pascual-Brazo, Raquel Linge, Veronica Vargas, Helena Blanco, Beatriz Martínez-Villayandre, Ángel Pazos, Elsa M. Valdizán

“…Herein, we review the state-of-the-art of the changes in these signalling pathways which appear to underlie both depressive disorders and antidepressant actions. …”
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The COVID‐19 pandemic‐induced behavioral restrictions and their impact on child and adolescent psychiatric units—Infection control or freedom by Masahide Usami, Yoshinori Sasaki, Mayuna Ichikawa, Miki Matsudo, Mutsumi Ohashi, Yui Higashino, Yusuke Kono, Haruna Matsudo, Yuki Nomura, Minjae Ma, Yuuki Sakoh, Maiko Odaka, Kotoe Itagaki, Keita Yamamoto, Momoka Takahashi, Yuta Yoshimura, Saori Inoue, Masahiro Ishida, Kumi Inazaki, Yuki Hakoshima, Yuki Mizumoto

“…Results During the COVID‐19 pandemic, the decrease in both outings and overnight stays among child psychiatric inpatients in Japan was statistically significant. …”
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Comparison of the Influence of Vegetarian and Mediterranean Diets on the Formation of Kidney Stones by Sebastian Samuła, Michał Mazur, Dorota Waz, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski

“…Diet plays a critical role in both the prevention and development of this condition. …”
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Inhibition of the invasive plant Ambrosia trifida by Sigesbeckia glabrescens extracts by Lijuan Yin, Guangzhong Zhang, Haoyu Zhao, Yuxin Zhang, Jiaozi Wangchen, Fanghao Wan, Bo Liu, Wanqiang Qian

“…Here, we found that extracts from both the roots and leaves of the medicinal plant Sigesbeckia glabrescens suppressed the growth of A. trifida by reducing the plant height and biomass. …”
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A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease by Rossana Scutari, Giulia Linardos, Stefania Ranno, Mara Pisani, Anna Chiara Vittucci, Luana Coltella, Luna Colagrossi, Velia Chiara Di Maio, Annamaria Sisto, Livia Mancinelli, Simona Landi, Sebastian Cristaldi, Massimiliano Raponi, Paola Bernaschi, Alberto Villani, Cristina Russo, Carlo Federico Perno

“…Methods From January to May 2024, a total of 1,151 children and adolescents (both inpatients and outpatients) were screened for the presence of respiratory pathogens, including B.pertussis, with clinically relevant respiratory symptoms. …”
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Tofacitinib downregulates JAK1 and JAK3 on human intestinal monocytes and macrophages without affecting dendritic cells phenotype or function by Elisa Arribas-Rodríguez, Ángel De Prado, Beatriz de Andrés, Benito Velayos, Jesús Barrio, Alejandro Romero, Francisco Javier García-Alonso, Álvaro Martín-Muñoz, José A. Garrote, Eduardo Arranz, Luis Fernández-Salazar, David Bernardo

“…Given the central role that conventional dendritic cells (cDC) elicit in gut homeostasis, we hypothesised that Tofacitinib acts modulating cDC function in UC. …”
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Maternal and paternal depressive symptoms and parental vocalisation behaviours in infancy: findings from UK-based birth cohort by Amy Campbell, Amy Campbell, Amy Campbell, Amy Campbell, Gemma Lewis, Ilaria Costantini, Miguel Cordero, Andy Skinner, Esther Dermott, Tina Miller, Mari-Rose Kennedy, Iryna Culpin, Iryna Culpin

“…BackgroundBoth maternal and paternal postnatal depression (PND) are associated with increased risk of less optimal offspring developmental outcomes. …”
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Hydra Radio Access Network (H-RAN): Multi-Functional Communications and Sensing Networks, Initial Access Implementation, and Task-2 Approach by Rafid I. Abd, Daniel J. Findley, Kwang Soon Kim

“…Our solution contains several novelties that enhance both overhead and model accuracy. To this end, we have developed a novel adaptive environment-aware blockage beamforming codebook structure. …”
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Audit Sistem Informasi pada Sistem Manajemen Layanan Satu Atap (SIMANTAP) Menggunakan Kerangka COBIT 5.0 (Studi Kasus: Bank Indonesia Provinsi Bengkulu) by Arie Vatresia, Pieters N.P Tambunan, Aan Erlanshari

“…The role of information technology has supported banking business processes, both in the ownership of human resources as well as data and information. …”
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