Comparison of IMO vifa24plus(1-2) and Humphrey Field Analyzer 24-2 by Takagi Y, Asano R, Yamashita K, Sakai Y, Yokoyama S, Ichikawa K, Ichikawa K

“…A Wilcoxon signed-rank test was used to compare fixation, false positives, false negatives, and total test time for both eyes between the HFA and IMO vifa tests. Only eyes with reliable test results were selected, and the visual field index (VFI), mean deviation (MD), and pattern standard deviation (PSD) were examined using Spearman’s rank correlation coefficient and the Wilcoxon signed-rank test.Results: The test times for the HFA 24– 2 and IMO vifa 24plus(1– 2) were 716.83± 118.80 and 628.75± 142.70 s, respectively, with the IMO vifa being significantly shorter (P< 0.001). …”
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Sex differences in the association between metabolic disorder and inflammatory cytokines in Han Chinese patients with chronic schizophrenia by Yinghan Tian, Yinghan Tian, Zhenkuo Li, Yun Zhang, Pei Tang, Yu Zhuang, Lewei Liu, Lewei Liu, Haojie Fan, Haojie Fan, Haojie Fan, Xianhu Yao, Wenzheng Li, Lei Xia, Lei Xia, Lei Xia, Huanzhong Liu, Huanzhong Liu, Huanzhong Liu

“…BackgroundPrevious evidence suggests that immune-inflammatory dysfunction plays an important role in metabolic disorder (MD) of patients with schizophrenia, yet studies on sex differences in the association between both are limited. The current study aimed to investigate sex differences in the association between MD and inflammatory cytokines in Han Chinese patients with chronic schizophrenia (CS).MethodsThis multicentre cross-sectional study was conducted in one general hospital and two psychiatric hospitals in Anhui Province, China. …”
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Temperature-dependent toxicity and mechanisms of florfenicol on the embryonic development of marine medaka (Oryzias melastigma) by Xingying Guo, Xu Gong, Jinhui Wang, Tan-Duc Nguyen, Syed Shabi Ul Hassan Kazmi, Jiezhang Mo, Feng Hua, Wenhua Liu, Zhen Wang

“…For genes related to DNA damage and apoptosis (pi3k, akt, foxo1, tp53, bcl-2, bax, apaf-1, caspase 9, and 3), alterations in gene expression were evident for all florfenicol treatments at both 20 °C and 30 °C. Therefore, this study suggests that the combined effects of florfenicol and temperature may disrupt the normal function of mitochondria, impacting ATP production, thereby inducing oxidative stress, inflammatory response, DNA damage, and apoptosis, ultimately resulting in decreased hatching rates and increased mortality. …”
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Study of Soluble HLA-G in Congenital Human Cytomegalovirus Infection by Roberta Rizzo, Liliana Gabrielli, Daria Bortolotti, Valentina Gentili, Giulia Piccirilli, Angela Chiereghin, Claudia Pavia, Silvia Bolzani, Brunella Guerra, Giuliana Simonazzi, Francesca Cervi, Maria Grazia Capretti, Enrico Fainardi, Dario Di Luca, Maria Paola Landini, Tiziana Lazzarotto

“…Our results suggest the determination of sHLA-G molecules in both maternal blood and amniotic fluid as a promising biomarker of diagnosis of maternal HCMV primary infection and fetal HCMV disease.…”
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PD-1 cis-targeted IL-2v in combination with radiotherapy inhibits lung cancer growth and remodels the immune microenvironment by Pedro J Romero, Sara Labiano, Gregory Verdeil, Christian Klein, Pablo Umana, Tania Wyss, Christine Trumpfheller, Marie-Catherine Vozenin, Céline Godfroid, Jackeline Romero, Vincent Roh, Genrich V Tolstonog, Chia-Hsien Chuang, Andrea Kelemen, Laura Codarri Deak

“…The addition of muFAP-CD40 to the combination treatment further increased infiltrating CD8+ T cells, expressing high levels of effector molecules, both in the periphery and core tumor regions. An accumulation of CD8+ PD-1+ TOX+ (exhausted) T cells, already at the ‘early’ timepoint, is consistent with the limited clinical benefits provided by the various combination treatments in this model. …”
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Impact of Helicobacter pylori infection on neoadjuvant chemotherapy in locally advanced gastric cancer: a retrospective analysis by Bin Zhong, Zhizhong Xiong, Jiabo Zheng, Saddam Ahmed Mohamed, Jiachen Sun, Dayin Huang, Zijian Deng, Jianping Guo, Junsheng Peng, Huashe Wang, Lei Lian

“…Multivariate analysis showed that factors related to major pathological response included; age ≤ 50 (OR: 0.423, 95% CI: 0.194–0.925), H. pylori infection (OR: 0.396, 95% CI: 0.183–0.854), pathological stage T 3/4 (OR: 0.524, 95% CI: 0.288–0.954), and CA12-5 > 35 U/mL (OR: 0.345, 95% CI: 0.132–0.904). Both overall survival (OS) and disease-free survival (DFS) rates were poorer in the H. pylori-positive group than in the H. pylori-negative group (OS: Log-Rank P = 0.035; DFS: Log-Rank P = 0.029). …”
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Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats by Faisal A. Alzahrani, Mohammed A. El-Magd, Ahmed Abdelfattah-Hassan, Ayman A. Saleh, Islam M. Saadeldin, Eman S. El-Shetry, Abdelnaser A. Badawy, Saleh Alkarim

“…CSCs-exosomes induced a significant increase in liver relative weight and serum levels of cancer markers (AFP and GGT) and liver enzymes (ALT, AST, and ALP), intensive immunostaining for the HCC marker GST-P, and an increased number and area of tumor nodules as compared to HCC rats injected by PBS. …”
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Sodium Butyrate: A Multifaceted Modulator in Colorectal Cancer Therapy by Alexandra Laura Mederle, Alexandra Semenescu, George Andrei Drăghici, Cristina Adriana Dehelean, Nicolae-Valentin Vlăduț, Dragoş Vasile Nica

“…<i>Conclusions</i>: NaB can modulate critical apoptotic and cell cycle genes, disrupt tumor cell proliferation, and overcome resistance mechanisms associated with anti-apoptotic regulators such as <i>MCL-1</i>. By targeting both short-term and long-term anti-apoptotic defenses, NaB shows promise as a preventive and therapeutic agent in CRC, particularly in high-risk phenotypes with compromised p53 functionality. …”
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Multiple Gene Deletion Mutants of Equine Herpesvirus 1 Exhibit Strong Protective Efficacy Against Wild Virus Challenge in a Murine Model by Stephanie S. Pradhan, Vekataramireddy Balena, Bidhan Chandra Bera, Taruna Anand, Rhushikesh Khetmalis, Aashwina Madhwal, Supriya Kandasamy, Selvaraj Pavulraj, Manju Bernela, Priya Mor, Bhupendra Nath Tripathi, Nitin Virmani

“…Furthermore, vToH-QMV provided good protection in mice against the virulent challenge. …”
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Multimodal Deep Learning for Differentiating Bacterial and Fungal Keratitis Using Prospective Representative Data by N.V. Prajna, MD, Jad Assaf, MD, Nisha R. Acharya, MD, MS, Jennifer Rose-Nussbaumer, MD, Thomas M. Lietman, MD, J. Peter Campbell, MD, MPH, Jeremy D. Keenan, MD, MPH, Xubo Song, PhD, Travis K. Redd, MD, MPH

“…These models included a clinical data model, a computer vision model using the EfficientNet architecture, and a multimodal model combining both imaging and clinical data. We partitioned the MADURAI dataset into 70% train/validation and 30% test sets. …”
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Longitudinal changes in factors affecting postoperative patient satisfaction after robot-assisted radical prostatectomy: an assessment using a patient-reported questionnaire by Soichiro Ogawa, Kei Yaginuma, Yuki Harigane, Shunta Makabe, Hitomi Imai, Satoru Meguro, Ryo Tanji, Akifumi Onagi, Ruriko Honda-Takinami, Kanako Matsuoka, Seiji Hoshi, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Motohide Uemura, Yoshiyuki Kojima

“…Our results suggest that giving sufficient information before treatment choice is both important and useful for patients’ decision-making, leading to improved patient QOL.…”
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Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regenera... by Zhaoyang Gong, Zhenhao Chen, Dachuan Li, Xiao Lu, Jianwei Wu, Hanqiu Sun, Ximeng Wang, Siyang Liu, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Chi Sun, Hongli Wang, Feng Zeng, Xiaosheng Ma

“…The Lightgel/NGF/CeMn NP-PEG composite was synthesized and characterized via electron microscopy, compression testing, rheological analysis, NGF release kinetics, and 30-day degradation studies. Both in vitro and in vivo experiments were conducted to evaluate the therapeutic effects of the composite on SCI. …”
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The Rapid Formation of the Metal-poor Milky Way by Turner Woody, Charlie Conroy, Phillip Cargile, Ana Bonaca, Vedant Chandra, Jiwon Jesse Han, Benjamin D. Johnson, Rohan P. Naidu, Yuan-Sen Ting

“…These results reinforce the emerging picture that both the disk and halo of the Milky Way experienced a rapid assembly.…”
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Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender by Nicoletta Luciano, Elisa Barone, Enrico Brunetta, Alessio D’Isanto, Maria De Santis, Angela Ceribelli, Marta Caprioli, Giacomo M. Guidelli, Daniela Renna, Carlo Selmi

“…Results Seventy-one/458 (16%) patients fulfilled the 2021 EULAR criteria for D2T-RA with no significant differences for age (median 62 years interquartile range -IQR- 58- 65 vs. 62 IQR 60 – 63 in non-D2T), gender prevalence (23% in both groups) and positivity rates for rheumatoid factors (62% vs. 62% in non-D2T) and Anti-Citrullinated Protein Antibodies (ACPA) (69% vs. 61% in non-D2T). …”
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Molecular Detection of Carbapenemase-Encoding Genes in Multidrug-Resistant Acinetobacter baumannii Clinical Isolates in South Africa by Yaw Adjei Anane, Teke Apalata, Sandeep Vasaikar, Grace Emily Okuthe, Sandile Songca

“…The detection of blaOXA-23-like, ISAba1/blaOXA-51-like, ISAba1/blaOXA-23-like, and blaOXA-23-like, blaOXA-58-like, and blaIMP-1 carbapenemases in strains had a significant effect on both imipenem and meropenem MICs. Conclusions. Results showed a high level of oxacillinases producing A. baumannii circulating in our study setting, highlighting the need for local molecular surveillance to inform appropriate management and prevention strategies.…”
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Schwann Cell‐Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in Mice by Lisa Gambarotto, Loris Russo, Silvia Bresolin, Luca Persano, Rachele D'Amore, Giulia Ronchi, Federica Zen, Luisa Muratori, Alice Cani, Samuele Negro, Aram Megighian, Sonia Calabrò, Paola Braghetta, Dario Bizzotto, Matilde Cescon

“…Transcriptomic and histological analysis from sciatic nerves of 10‐day and 2‐month‐old mice revealed pro‐mitotic gene deregulation and increased SCs proliferation at both stages with axonal loss and increased immune infiltration in adults, well reflecting the progressive motor and sensory functional impairment that characterizes Becn1 cKO mice, compared to controls. …”
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Description and Analysis of Horse Swimming Strategies in a U-Shaped Pool by Pauline Gaulmin, Frédéric Marin, Claire Moiroud, Audrey Beaumont, Sandrine Jacquet, Emeline De Azevedo, Pauline Martin, Fabrice Audigié, Henry Chateau, Chloé Giraudet

“…One of the primary findings is the variability in swimming strategies both within and between individual horses. While five horses consistently maintained the same strategy throughout their swimming sessions, six others exhibited variations in their strategy between laps. …”
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Effect of the Flavor and Quality of Wolfberry Tea Processed with Buds and Leaves under Different Degree of Spreading by Guanjun PAN, Linyuan DUAN, Jiake ZHAO, Ping SHUAI, Guoli DAI, Weisu TIAN, Jinyuan WANG, Jiapeng HUANG, Xiaotong BI, Enzhao LIN, Ken QIN, Zhilong HAO, Bo ZHANG

“…Meanwhile, the levels of flavonoids, water-soluble dicarboxylic acid, and hydroxyl polycarboxylic acids in the tea were decreased, while the accumulation of pleasant aroma compounds such as dihydroactinolactone was enhanced. In conclusion, both D and G plants are suitable for processing tea with a 55% water content spreading degree, providing valuable insights for the quality improvement of wolfberry tea.…”
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IL-17A, IL-22, IL-6, and IL-21 Serum Levels in Plaque-Type Psoriasis in Brazilian Patients by Priscilla Stela Santana de Oliveira, Pablo Ramon Gualberto Cardoso, Emerson Vasconcelos de Andrade Lima, Michelly Cristiny Pereira, Angela Luzia Branco Pinto Duarte, Ivan da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Maira Galdino da Rocha Pitta

“…Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. …”
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In Vitro Antibacterial and Antioxidant Activities and Molecular Docking Analysis of Phytochemicals from Cadia purpurea Roots by Tsegu Kiros, Rajalakshmanan Eswaramoorthy, Yadessa Melaku, Aman Dekebo

“…Compound 2 produced a comparable inhibition value (9.6 ± 0.0 mm to 18.5 ± 0.0 mm) to that of chloramphenicol (21.5 ± 0.3 mm) against E. coli at doses up to 1.0 mg/mL; whereas, compound 1 showed a slight activity (7.1 ± 0.1 mm–10.3 ± 0.0 mm). Both compounds were found generally inactive against S. aureus, while they provided an activity better than chloramphenicol (7.2 ± 0.6 mm) against P. aeruginosa with inhibition zones ranging from 7.1 ± 0.0 mm to 9.0 ± 0.1 mm for compound 1 and 7.2 ± 0.0 mm to 10.6 ± 0.0 mm for compound 2. …”
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