Sex differences in intracranial plaque burden in patients with type 2 diabetes mellitus with acute ischemic cerebrovascular disease: a pilot study based on high-resolution MRI by Xuejiao Yan, Ling Li, Jie Gao, Lihui Wang, Kai Ai, Xiaoyan Lei, Min Tang, Xiaoling Zhang, Dongsheng Zhang

“…The intracranial culprit plaque was located proximal to the artery in both male (85.3%) and female (88.9%) patients. The adjusted total and proximal intracranial plaque burdens were 1.261 times (95% confidence interval [CI], 1.050–1.515, P=0.013) and 1.322 times (95%CI, 1.055–1.682, P=0.016) higher in male than in female patients. …”
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Diagnostics and treatment of exocrine pancreatic insufficiency: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…The starting dose of pancreatic enzymes for adults is 25 000 units of lipase per meal, which should be subsequently increased up to achievement of complete response confirmed by both clinical and laboratory scores. Digestive enzymes should be taken at the beginning of food intake, to increase treatment efficacy PERT should be accompanied by prescription of proton pump inhibitors. …”
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Development and validation of machine learning models for MASLD: based on multiple potential screening indicators by Hao Chen, Jingjing Zhang, Xueqin Chen, Ling Luo, Wenjiao Dong, Yongjie Wang, Jiyu Zhou, Canjin Chen, Wenhao Wang, Wenbin Zhang, Zhiyi Zhang, Yongguang Cai, Danli Kong, Yuanlin Ding

“…Subsequently, the partial dependence plot(PDP) method and SHapley Additive exPlanations (SHAP) were utilized to explain the roles of important variables in the model to filter out the optimal indicators for constructing the MASLD risk model.ResultsRanking the feature importance of the Random Forest (RF) model and eXtreme Gradient Boosting (XGBoost) model constructed using all variables found that both homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride glucose-waist circumference (TyG-WC) were the first and second most important variables. …”
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Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios by Hu Liu, Peiqi Li, Tan Zhou, Ziqi Yu, Weigao Zhang, Yunfeng Zhu, Jiayi Xu, Xiaoxiao Wu, Jing Li, Chi Zhang, Lei Chen, Dan Weng

“…This study investigated the impact of leachates from heat-treated polypropylene (PP) plastic food containers on glucose and lipid metabolism using both in vitro and in vivo models. AML12 hepatocytes exposed to leachates from three different PP plastic containers exhibited significant disruptions in the homeostasis of lipid and glucose metabolism, evidenced by increased intracellular lipid content and altered gene expression related to lipogenesis, lipid uptake, lipolysis, and fatty acid β-oxidation. …”
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Hypothermia regulates mitophagy and apoptosis via PINK1/Parkin-VDAC 3 signaling pathway during oxygen-glucose deprivation/recovery injury by Luying Zhang, Song Yang, Hao Cui, Chenchen Hang, Xingsheng Wang, Le An, Zhenyu Shan, Zhen Liang, Rui Shao, Ziren Tang

“…However, whether hypothermia can regulate both apoptosis and mitophagy through the PINK1/Parkin-VDAC3 signaling pathway or not. …”
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Business’ Attitudes Towards Corruption in Selected Central European Countries by Nenad Vretenar, Ana Marija Filipas, Martina Briš Alić

“…., Model 1 and Model 2, with a total number of observations of 901 and 902, respectively. Both models displayed adequate fit indices and enabled predictions that allowed us to draw conclusions. …”
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Response surface method-driven design of experiments for the synthesis of fly ash-based geopolymers in the gallic acid optimized removal from wastewater by Ana Paula Ferreira, Ana Paula S. Natal, Arthur P. Baldo, Adriano S. Silva, Jose L. Diaz de Tuesta, Pricila Marin, José A. Peres, Helder T. Gomes

“…At the same time, equilibrium data fitted well with both Langmuir and Freundlich isotherms, with GP_2.0_10_2.5 showing the best fit for the Langmuir model. …”
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C-reactive protein testing in primary care and antibiotic use in children with acute respiratory tract infections in Kyrgyzstan: an open-label, individually randomised, controlled... by Elvira Isaeva, Joakim Bloch, Azamat Akylbekov, Robert L. Skov, Anja Poulsen, Jørgen A.L. Kurtzhals, Susanne Reventlow, Nandini Sreenivasan, Maamed Mademilov, Volkert D. Siersma, Talant Sooronbaev, Jesper Kjærgaard, Rune M. Aabenhus

“…Hospital admissions were similar in both groups (CRP: 31 (5%), control: 26 (4%); odds ratio (OR) 1.20, 95% CI 0.69–2.10), but the CRP group re-consulted more often (OR 1.31, 95% CI 1.01–1.71) during the 14 days of follow-up. …”
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Unique thermal architecture integrating heliostat solar fields with a dual-loop power generation cycle employing thermoelectric; thermal/financial study and GA optimization by Amr S. Abouzied, Xiaoming Guo, Azher M. Abed, Mohammed A. Alghassab, Fahad M. Alhomayani, Baseem Khan, Yasser Elmasry, Ahmad Almadhor, Salem Alkhalaf, Albara Ibrahim Alrawashdeh

“…This study delineates the development of a solar energy system that leverages concentrated solar power (CSP) technology to supply both electricity and potable water for residential applications. …”
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Adalimumab Treatment in Biologically Naïve Crohn’s Disease: Relationship with Ectopic MUC5AC Expression and Endoscopic Improvement by Tsutomu Mizoshita, Satoshi Tanida, Hironobu Tsukamoto, Keiji Ozeki, Takahito Katano, Hirotaka Nishiwaki, Masahide Ebi, Yoshinori Mori, Eiji Kubota, Hiromi Kataoka, Takeshi Kamiya, Takashi Joh

“…We examined them clinically and pathologically with ectopic MUC5AC expression in the lesions before and after 12 and 52 weeks of ADA therapy, retrospectively. Results. Both mean CD activity index scores and serum C-reactive protein values were significantly lower after ADA therapy (P<0.001). …”
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Novel N-quaternary coumarin-3-yl-imidazo[1,2-a]pyridines as fluorescent hybrids: Their synthesis and biological evaluation in cancer cells by Karla Armendariz-Barrientos, Luis A. Pérez, Selene Lagunas-Rivera, Yolanda Alcaraz-Contreras, Marco A. García-Revilla, Heriberto Prado-Garcia, Rocío García-Becerra, Miguel A. Vazquez

“…To assess the effect of the quaternary hybrid coumarin-3-yl-imidazo[1,2-a]pyridines on proliferation, both breast (MDA-MB-231) and prostate (PC3) cancer cell lines were utilized. …”
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Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes by Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen

“…Moreover, activating transcription factor 2 (ATF-2), a substrate of both JNK and P38, was suppressed by iguratimod. Conclusions. …”
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Effect of miR-144-3p-Targeted Regulation of PTEN on Proliferation, Apoptosis, and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells under Stretch by Shiyong Ling, Xi Luo, Bo Lv, Hua Wang, Mengzhi Xie, Kai Huang, Jingchuan Sun

“…The BMSCs of rats were randomly divided into the tension MSC group with detrusor stimulation and the MSC group without detrusor stimulation, after which osteogenic differentiation of BMSCs was induced in both groups. Alkaline phosphatase (ALP) staining and alizarin red staining were used to detect the osteogenic differentiation ability of the two groups of cells. …”
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Exploring the effects of dietary methionine supplementation on European seabass mucosal immune responses against Tenacibaculum maritimum by Inês Carvalho, Inês Carvalho, Diogo Peixoto, Diogo Peixoto, Inês Ferreira, Inês Ferreira, Diego Robledo, Diego Robledo, Lourenço Ramos-Pinto, Rodolfo Miguel Silva, José Fernando Gonçalves, Marina Machado, Carolina Tafalla, Benjamin Costas, Benjamin Costas

“…`DiscussionOverall, these findings indicate that dietary methionine supplementation may significantly influence both systemic and local immune responses in European seabass, highlighting the need for careful consideration when supplementing diets with methionine.…”
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The CNDP1 (CTG)5 Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration by Thomas Albrecht, Shiqi Zhang, Jana D. Braun, Li Xia, Angelica Rodriquez, Jiedong Qiu, Verena Peters, Claus P. Schmitt, Jacob van den Born, Stephan J. L. Bakker, Alexander Lammert, Hannes Köppel, Peter Schnuelle, Bernhard K. Krämer, Benito A. Yard, Sibylle J. Hauske

“…This was also observed for diabetes duration but only reached significance when both (CTG)5 homo- and heterozygous patients were included. …”
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The influence of scapular orientation on the medial scapula corpus angle in snapping scapula syndrome by Brittany Percin, BS, MS4, Joseph Featherall, MD, Robert Z. Tashjian, MD, Peter N. Chalmers, MD, Christopher D. Joyce, MD, Alexander J. Mortensen, MD, Heath B. Henninger, PhD

“…Numerous statistical differences were detected in MSCA between the reference plane and those translated and rotated below that plane in both non-SSS and SSS groups. Planes translated above the reference plane showed consistent statistical differences in MSCA to the reference plane, but only in the SSS group. …”
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Assessing the visibility and public engagement of bone marrow and stem cell transplantation research: An altmetric analysis by Mohammad Ahmadian, Shaban Alizadeh, Azadeh Omidkhoda, Fatemeh Sheikhshoaei, Brenda Van Wyk

“…Furthermore, highly cited articles on social media have attracted more attention. Both traditional and web-based metrics offer different perspectives on scholarly impact. …”
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Effects of deoxynivalenol contaminated corn distiller's dried grains with solubles on growth performance, body composition, immunological response, and gastrointestinal health in y... by Deependra Paneru, Milan K. Sharma, Hanyi Shi, Doyun Goo, Venkata S.R. Choppa, Ishwari Gyawali, Revathi Shanmugasundaram, Woo K. Kim

“…Additionally, interleukin 1β (IL-1β) expression significantly increased in the cecal tonsil by day 28 with 15 and 20% DDGS inclusions (P = 0.002). Gut health was compromised as gut permeability increased linearly with increasing DDGS inclusion (linear, P = 0.043), aligning with significant alterations in the expression of the tight junction protein occludin (OCLN; P = 0.007). …”
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Ultraviolet-C-based sanitization is a cost-effective option for hospitals to manage health care-associated infection risks from high touch mobile phones by David C. Cook, David C. Cook, Matthew Olsen, Oystein Tronstad, Oystein Tronstad, Oystein Tronstad, John F. Fraser, John F. Fraser, John F. Fraser, John F. Fraser, John F. Fraser, Adrian Goldsworthy, Adrian Goldsworthy, Rashed Alghafri, Rashed Alghafri, Simon J. McKirdy, Lotti Tajouri, Lotti Tajouri, Lotti Tajouri

“…We assessed each intervention on material and opportunity costs assuming both achieved an equivalent reduction in microbe transmission within the hospital. …”
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A More Efficient and Safer Improved Percutaneous Pedicle Screw Insertion Technique—Trajectory Dynamic Adjustment Technique, Technical Note, and Clinical Efficacy by Hao Li, Zhiguo Ding, Bin Wei, Zhihao Ma, Jing Xie, Yonghao Tian, Lianlei Wang, Xinyu Liu, Suomao Yuan

“…Moreover, FJV rate was significantly lower than that in PPSF group (p < 0.05). In both TDA group and PPSF group, postoperative back and leg pain and the JOA score were significantly improved (p < 0.05). …”
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