Oxaliplatin-Loaded Chitosan Nanoparticles Decorated with Cetuximab Single-Chain Variable Fragment for Human Colorectal Cancer Treatment by Khadijeh Falahzadeh, Fariba Esmaeili, Leila Nematollahi, Elham Bayat, Mehdi Khoobi, Mohammadali Mazloomi, Masumeh Jalalvand, Reza Faridi Majidi, Babak Negahdari

“…We aimed to prepare non-targeted oxaliplatin-loaded chitosan nanoparticles (OXPT-CS NPs) and targetedOXPT-CS NPs decorated with cetuximab single-chain variable fragment (scFv) to send both NPs to epidermal growth factorreceptor (EGFR) overexpressing HCT 116 cells, a human colorectal carcinoma cell line, for comparing their cytotoxicity.Materials and Methods: In this experimental study, OXPT-CS NPs were synthesized using a fluid system. …”
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Are neurasthenia and depression the same disease entity? An electroencephalography study by Ge Dang, Lin Zhu, Chongyuan Lian, Silin Zeng, Xue Shi, Zian Pei, Xiaoyong Lan, Jian Qing Shi, Nan Yan, Yi Guo, Xiaolin Su

“…Our aim was to identify objective electroencephalography (EEG) measures that can differentiate neurasthenia from major depressive disorder (MDD). Methods Both electronic medical information records and EEG records from patients with neurasthenia and MDD were gathered. …”
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Impact of religious fasting on ocular dryness: objective and subjective assessment by Amal F. Alomari, Sara Issa, Asma Musleh, Mohammad Abusamak, Mohammad Abusamak, Omar Bdair, Omar Bdair, Saif Aldeen AlRyalat, Saif Aldeen AlRyalat, Alanoud Al-Wakfi, Mohammed Jaber, Ahmad Alloubani, Haitham Sahawneh, Haitham Sahawneh, Muhannd El-Faouri, Ayman Abdul Aziz, Muawyah Al Bdour

“…In this prospective study, we evaluated the effect of prolonged fasting on dry eye disease using both objective and subjective measures.MethodsWe included patients who fasted for at least 12 h a day for at least 2 weeks, including the testing day, and retested them at least 1 week after the fasting period had ended with no fasting on the testing day. …”
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Cardioattentionnet: advancing ECG beat characterization with a high-accuracy and portable deep learning model by Youfu He, Youfu He, Youfu He, Yu Zhou, Yu Zhou, Yu Qian, Jingjie Liu, Jinyan Zhang, Debin Liu, Qiang Wu, Qiang Wu

“…The model demonstrated exceptional capabilities in detecting cardiac arrhythmias, surpassing existing models in both cross-validation and external testing scenarios. …”
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Emergence and polyclonal dissemination of NDM-5/OXA-181 carbapenemase-producing Escherichia coli in the French Indian Ocean territories by Thibaut Vedani, Matthieu Pot, Thomas Garrigos, Loïk Sababadichetty, Marion Daniel, David Wilkinson, Thierry Benoit-Cattin, Olivier Belmonte, Patrick Mavingui, Laurent Dortet, Guillaume Miltgen

“…Abstract Aim Located in the Southwest Indian Ocean area (SIOA), the two French overseas territories (FOTs) of Reunion and Mayotte islands are heavily impacted by antimicrobial resistance. …”
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Six-Gene Signature Associated with Immune Cells in the Progression of Atherosclerosis Discovered by Comprehensive Bioinformatics Analyses by Bin Zhao, Dan Wang, Yanling Liu, Xiaohong Zhang, Zheng Wan, Jinling Wang, Ting Su, Linshan Duan, Yan Wang, Yuehua Zhang, Yilin Zhao

“…However, fewer studies focused on both genes and immune cells, and the correlation of genes and immune cells was evaluated via comprehensive bioinformatics analyses. …”
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Farmer perception of impacts of fall armyworm (Spodoptera frugiperda J.E. Smith) and transferability of its management practices in Uganda by Andrew Kalyebi, Michael H. Otim, Tom Walsh, Wee Tek Tay

“…A small number of farmers (ca. 4%) in both districts reportedly took no intentional action against FAW. …”
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A novel nomogram to predict all‐cause readmission or death risk in Chinese elderly patients with heart failure by Mengxi Yang, Liyuan Tao, Hui An, Gang Liu, Qiang Tu, Hu Zhang, Li Qin, Zhu Xiao, Yu Wang, Jiaxai Fan, Dongping Feng, Yan Liang, Jingyi Ren

“…The independent risk factors associated with both 30 day and 1 year readmission or death were older age, stroke, diastolic blood pressure < 60 mmHg, body mass index ≤ 18.5 kg/m2, lower estimated glomerular filtration rate, and BNP > 400 pg/mL (all P < 0.05). …”
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Does Sex Matter in Obesity-Induced Periodontal Inflammation in the SS^LepR Mutant Rats? by Abdulmohsin Alhashim, Kim Capehart, Jocelyn Tang, Karim M. Saad, Rafik Abdelsayed, Marion A. Cooley, Jan M. Williams, Ahmed A. Elmarakby

“…<b>Aim:</b> In the current study, it was hypothesized that obesity drives periodontal inflammation and bone loss in both sexes. <b>Methodology:</b> Utilizing leptin receptor mutant (SS^LepR mutant) rats as a genetic model of obesity, 11–12-week-old male and female lean Dahl salt-sensitive (SS) rats and obese SS^LepR mutant rats were used to investigate sex differences in obesity-induced periodontal inflammation. …”
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Beverage consumption modifies the risk of type 2 diabetes associated with ambient air pollution exposure by Chaonan Fan, Wenjuan Wang, Wenxue Xiong, Zhiyao Li, Li Ling

“…Conversely, those with > 1 cup of SSB had a higher T2D risk associated with both NO2 and NOX (Pheter <0.05). Conclusions: This study highlights the significant role of beverage consumption in mitigating or exacerbating the T2D risk associated with long-term NO2 and NOX exposure.…”
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Phylogenetic analysis, metabolic profiling, and environmental adaptation of strain LCG007: a novel Rhodobacteraceae isolated from the East China Sea intertidal zone by Cuizhu Liang, Jiahua Wang, Jie Liu, Zekai Wang, Junwei Cao, Xi Yu, Li Zhang, Jiasong Fang, Jiasong Fang

“…Metabolically, it possesses a wide array of amino acid metabolic genes that enable it to thrive on both amino acids or peptides. Also, it could hydrolyze peptides containing D-amino acids, highlighting its potential role in the cycling of refractory organic matter. …”
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Natural and Migration Balance of the Population in Sibiu County Between 1992 and 2021 by Raularian RUSU, Ciprian MOLDOVAN, Titus MAN, Elena-Manuela BÎRSĂNUC, Cosmina-Daniela URSU

“…However, the steep decline of the natural balance rate during the pandemic also affected the total balance rate, which became negative in both 2020 and 2021. Nevertheless, the total balance rate is expected to reverse back to positive values after the end of the pandemic. …”
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Long-term Prospective Comparative Analysis of Ototoxic and Survival Outcomes of Sequential Boost and Simultaneous Integrated Boost of Volumetric Modulated Arc Therapy for Head-Neck... by Nidhin Das, Sri Harsha Kombathula, Vidhu Sharma, Puneet Pareek, Kapil Soni, Amit Goyal

“…No significant differences were found between SEQ and SIB plans in sensorineural hearing loss, late toxicity, or survival, making both suitable for head and neck carcinoma treatment.…”
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Blowing Out the Candle: How to Quench Galaxies at High Redshift—An Ensemble of Rapid Starbursts, AGN Feedback, and Environment by Lucas C. Kimmig, Rhea-Silvia Remus, Benjamin Seidel, Lucas M. Valenzuela, Klaus Dolag, Andreas Burkert

“…Recent observations with JWST and the Atacama Large Millimeter/submillimeter Array have revealed extremely massive quiescent galaxies at redshifts of z = 3 and higher, indicating both rapid onset and quenching of star formation. …”
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Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon by Menglu Chen, Lei Gao, Pan Chen, Dandan Feng, Yalin Jiang, Yongchao Chang, Jianjun Jin, Fong-Fong Chu, Qiang Gao

“…Results. 5-HT exacerbated DSS-induced colitis, low-dose 5-HT induces both MMP-3 and MMP-9, and high-dose 5-HT only increased MMP-3 mRNA expression in mouse colon. …”
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Correlation Between the Ratio of Uric Acid to High-Density Lipoprotein Cholesterol (UHR) and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus:A Cross-Sectional Study by Wang L, Liu L, Luo H, Wu Y, Zhu L

“…Furthermore, the receiver operating characteristic (ROC) curve analysis indicated that the UHR ratio was the most precise predictor for diagnosing DR, with an area under the ROC curve (AUC) of 78.4%, a sensitivity of 87%, and a specificity of 60.6%.Conclusion: Our research has found that the UHR ratio is an independent risk factor for diabetic retinopathy (DR) in patients with type 2 diabetes and can serve as a readily available indicator that takes into account both metabolic status and inflammatory status for the early detection of DR.Keywords: uric acid to high-density lipoprotein cholesterol ratio, UHR, Type 2 diabetes mellitus, diabetic retinopathy…”
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The use and subjective experience of sleep apps and their relationship with personality characteristics among young adults by Ståle Pallesen, Ståle Pallesen, Øystein Vedaa, Øystein Vedaa, Erlend Sunde, Erlend Sunde, Anette Harris, Siri Waage, Siri Waage, Ingvild West Saxvig, Jiewen Zhang, Bjørn Bjorvatn, Bjørn Bjorvatn

“…Still, understanding of characteristics of users and the impact of sleep app usage remains limited.MethodsA sample of 940 young adults (18–30 years) living in the UK were recruited from Prolific (online research platform offering researchers access to survey panels) and invited to participate in a survey on the use and experience with sleep apps. Both sleep app users and non-users were invited. …”
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Effect of different diets on the fatty acid composition of buffalo bulk milk by Sebastiana Failla, Giuliano Palocci, Michela Contò, Gianluca Renzi, Chiara Evangelista, Loredana Basiricò, Umberto Bernabucci

“…The second diet was  supplemented with linseed (L), brewer’s spent grain (T), alfalfa and mixed hay (H), corn grain (M), and grass (G) as additional constituents. Other farms included both grass and cottonseed (CG), grass and linseed (GL), or grass and brewer’s spent grain (TG) and grass, linseed and brewer’s spent grain (LTG). …”
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Bradykinin B1 receptor signaling triggers complement activation on endothelial cells by Ingrid Lopatko Fagerström, Alexandra Gerogianni, Markus Wendler, Ida Arvidsson, Ashmita Tontanahal, Ann-Charlotte Kristoffersson, Fatimunnisa Qadri, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Diana Karpman

“…IntroductionThe complement and kallikrein-kinin systems (KKS) are both activated during vascular inflammation, and there are many known interactions between the two systems. …”
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HDL Particle Size and Functionality Comparison between Patients with and without Confirmed Acute Myocardial Infarction by Raissa de Miranda Teixeira, Nicole Cruz de Sá, Ana Paula Caires dos Santos, Vanessa Rocha Anjos e Silva, Elaine Christine de Magalhães Cabral Albuquerque, Luiz Claudio Lemos Correia, Ricardo David Couto

“…The study groups consisted of patients from both sexes, older than 35 years, presented to the Hospital São Rafael (HSR) initially with AMI clinical symptoms. …”
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