Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism by Susan Lin, Aravind R Gade, Hong-Gang Wang, James E Niemeyer, Allison Galante, Isabella DiStefano, Patrick Towers, Jorge Nunez, Maiko Matsui, Theodore H Schwartz, Anjali Rajadhyaksha, Geoffrey S Pitt

“…While best studied as a voltage-gated sodium channel (Nav) regulator, we observed no effect of Fgf13 ablation in interneurons on Navs but rather a marked reduction in K+ channel currents. …”
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An approach to boost adherence to self-data reporting in mHealth applications for users without specific health conditions by Maria Aguiar, Ander Cejudo, Gorka Epelde, Deisy Chaves, Maria Trujillo, Garazi Artola, Unai Ayala, Roberto Bilbao, Itziar Tueros

“…With a first group of users, we perform a comparative analysis in terms of adherence and system usability scale of two versions of the app, both including the most common categories of behavior change techniques but the second version having added gamification features. …”
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Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone by Jianping Jiang, Astrid V. Cienfuegos-Galletd, Tengfei Long, Gisele Peirano, Tingyu Chu, Johann D. D. Pitout, Barry N. Kreiswirth, Liang Chen

“…Surprisingly, almost all CG147 strains (99.7%, 1009/1,012) harbor a chromosomal type I-E CRISPR-Cas system, with 41.8% (423/1012) containing an additional plasmid-borne type IV-A3 CRISPR-Cas system, and both target IncF plasmids, e.g., the most prevalent KPC-encoding pKpQIL-like plasmids. …”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…This pocket was exploited in a virtual screening of a large small-molecule library, identifying two promising candidates, C599 and C998. Both compounds exhibited dose-dependent antiproliferative effects in glioblastoma cell lines and induced apoptosis, as evidenced by caspase 3/7 activation. …”
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Early Myocardial Strain Reduction and miR-122-5p Elevation Associated with Interstitial Fibrosis in Anthracycline-Induced Cardiotoxicity by María de Regla Caballero-Valderrama, Elisa Bevilacqua, Miriam Echevarría, Francisco Javier Salvador-Bofill, Antonio Ordóñez, José Eduardo López-Haldón, Tarik Smani, Eva M. Calderón-Sánchez

“…Among them, hsa-miR-122-5p is increased in both patient and rat serum post-treatment. Conclusions: A notable percentage of low-risk patients exhibited cardiac strain reduction due to cardiotoxicity. …”
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Different cortex activation between young and middle-aged people during different type problem-solving: An EEG&fNIRS study by Mevhibe Saricaoglu, Meryem Ayşe Yücel, Miray Budak, Ahmet Omurtag, Lutfu Hanoglu

“…The alpha power varied across different electrodes for various question types in both young and middle-aged groups. The highest alpha frequency band power for different electrodes was recorded while solving general knowledge questions in the young group and insight questions in the middle-aged group. …”
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Phenylalanine-derived β-lactam TRPM8 antagonists: revisiting configuration and new benzoyl derivatives by Cristina Martín-Escura, Maria Angeles Bonache, Alicia Medina-Peris, Thomas Voets, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz

“…Methods: Diastereoisomeric compounds derived from H-Phe-OtBu, and analogues incorporating differently substituted benzoyl groups, were synthesized by stereoselective solution pathways. …”
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In Vivo Functional Assessment of Sodium-Glucose Cotransporters (SGLTs) Using [18F]Me4FDG PET in Rats by Yohji Matsusaka, Xinyu Chen, Paula Arias-Loza, Rudolf A. Werner, Naoko Nose, Takanori Sasaki, Steven P. Rowe, Martin G. Pomper, Constantin Lapa, Takahiro Higuchi

“…As a noninvasive read-out of the concurrent SGLT expression in both the digestive tract and the renal cortex, [18F]Me4FDG PET may serve as a surrogate marker for treatment response to SGLT inhibition. …”
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Nurses intention to stay in the nursing profession and associated factors in Ethiopia: a systematic review and meta-analysis by Kirubel Eshetu Haile, Yordanos Sisay Asgedom, Atitegeb Alebachew Amsalu, Gizachew Ambaw Kassie, Tsion Zebdiwos Chema, Amanuel Yosef Gebrekidan, Gedion Asnake Azeze

“…Abstract Introduction The persistent attrition of nurses from the profession is a significant challenge for both healthcare policymakers and administrative bodies within numerous low-income countries. …”
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Systematic review of amyloid-beta clearance proteins from the brain to the periphery: implications for Alzheimer’s disease diagnosis and therapeutic targets by Letian Huang, Mingyue Liu, Ze Li, Bing Li, Jiahe Wang, Ke Zhang

“…Notably, TREM2 and cathepsin D showed changes in both brain (SMD = 0.31, 95% CI: 0.16–0.47, P < 0.001, I2 = 78.4%; SMD = 1.24, 95% CI: 0.01–2.48, P = 0.048, I2 = 90.1%) and peripheral blood (SMD = 1.01, 95% CI: 0.35–1.66, P = 0.003, I2 = 96.5%; SMD = 7.55, 95% CI: 3.92–11.18, P < 0.001, I2 = 98.2%) samples. …”
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Morphological properties of two-dimensional and three-dimensional bedforms in open channel flow: A flume experiments study by Wenhong Cao, Xu Geng, Chunjing Liu, Lingfeng Zhang

“…A streamwise ridge is an important form located in the upstream area of the dunes stoss side, and they are symmetrically distributed on both sides. Multiple streamwise ridges divide the stoss side of the dunes into relatively independent movement areas, restricting the movement of sediment particles to specific regions. …”
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Air Quality Index, Indicatory Air Pollutants and Impact of COVID-19 Event on the Air Quality near Central China by Kaijie Xu, Kangping Cui, Li-Hao Young, Ya-Fen Wang, Yen-Kung Hsieh, Shun Wan, Jiajia Zhang

“…Abstract Both the air quality index (AQI) and indicatory air pollutants of Anqing, Hefei, and Suzhou near central China from 2017 to 2019, and the impact of COVID-19 epidemic prevention and control actions on air quality were investigated. …”
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Healthcare trajectories of aging individuals during their last year of life: application of process mining methods to administrative health databases by Delphine Bosson-Rieutort, Alexandra Langford-Avelar, Juliette Duc, Benjamin Dalmas

“…Conclusion Despite some limitations related to data and visual limitations, process mining seems to be a method that is both relevant and simple to implement. It provides a visual representation of the processes recorded in various health system databases and allows for the visualization of the different trajectories of healthcare utilization.…”
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Novel functional eQTL-SNPs associated with susceptibility to occupational pulmonary fibrosis: A multi-stage study by Rui Zhao, Xiaobo Tao, Wendi Zhang, Siqi Li, Shenxuan Zhou, Anhui Ning, Zhenyu Li, Minjie Chu, Wei Wang, Junhong Jiang

“…Aim: Identifying the common functional single-nucleotide polymorphisms (SNPs) that can both affect the susceptibility to idiopathic pulmonary fibrosis (IPF) and silicosis. …”
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The Electroanatomic Volume of the Left Atrium as a Determinant of Recurrences in Patients with Atrial Fibrillation After Pulmonary Vein Isolation: A Prospective Study by Amaia Martínez León, David Testa Alonso, María Salgado, Ruth Álvarez Velasco, Minel Soroa, Daniel Gracia Iglesias, David Calvo

“…Cox regression analyses (univariate and multivariate), Kaplan–Meier curves and log-rank tests were used to illustrate freedom from atrial arrhythmia during follow-up. Both EAV by EAM and TTE volumes were significant predictors of AF recurrence in the univariate analysis (HR 1.002 [1.001–1.003], <i>p</i> = 0.033 and HR 1.001 [1.006–1.012], <i>p</i> < 0.01, respectively). …”
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Evaluation of the effectiveness of GASMAN anesthesia simulation software combined with case-based learning versus traditional lecture-based learning in inhalation anesthesia educat... by Chao Chen, Chao Chen, Shengfeng Yang, Xinglong Xiong, Xinglong Xiong, Yewei Shi, Yewei Shi, Zhenyan Zhu, Zhenyan Zhu, Jing Shi, Jing Shi

“…Post-course test scores were also higher in the IGC group for both total post-course test and subjective questions scores (adjusted P &lt; 0.001), though no difference was found for objective question scores. …”
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The impact of endolymphatic hydrops on wideband acoustic immittance and otoacoustic emissions in guinea pigs by Huan Lin, Xuanyi Li, Huiying Zhang, Yi Mu, Xi Wang, Naveena Konduru, Renlong Ji, Wen Liu, Wen Liu, Wen Liu, Zhao Fei, Wen Jiang, Wen Jiang, Wen Jiang, Yuehua Qiao, Yuehua Qiao, Yuehua Qiao

“…After 14 days of EH induction, absorbance at 1 kHz significantly increased, whereas it significantly decreased at 4 kHz and 6 kHz (p &lt; 0.05). DPOAE measures, both magnitude and phase, showed no significant changes (p &gt; 0.05).ConclusionWAI demonstrates greater sensitivity than DPOAE in the early detection of acoustic transmission alterations in EH models, suggesting its utility as a diagnostic tool in early-stage inner ear disorders.…”
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Meta-synthesizing of Practices of Corporate Social Responsibility: External Stake-holders Approach by Maryam Khalatbari Moazam, Hamidreza Yazdani, Naser Asgari

“…The distinctive nature of the research methodology, incorporating both qualitative approaches and meta-synthesis strategies, enabled the researchers to tackle this issue from a holistic perspective. …”
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Diagnosis of hepatocellular carcinoma using liquid biopsy-based biomarkers: a systematic review and network meta-analysis by Yutong Jiang, Yutong Jiang, Shangwen Qi, Shangwen Qi, Rongrong Zhang, Rongrong Zhang, Ruixia Zhao, Yu Fu, Yuxuan Fang, Yuxuan Fang, Mingyi Shao

“…Further subgroup analysis of the top-ranking liquid biopsy-based diagnostic biomarkers revealed that hsa_circ_000224 (superiority index: 3.091 (95% CI[0.143-9]) ranked remarkably higher in distinguishing HCC from both healthy populations and liver disease patients. …”
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New Insights on <i>Gordonia alkanivorans</i> Strain 1B Surface-Active Biomolecules: Gordofactin Properties by João Tavares, Susana M. Paixão, Tiago P. Silva, Luís Alves

“…Furthermore, gordofactin exhibited growth inhibition against both Gram-positive and Gram-negative bacteria, and it demonstrated concentration-dependent free radical scavenging activity for 2,2-diphenyl-1-picrylhydrazyl (IC₅₀ ≈ 1471 mg/L). …”
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