Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide by Audrey Le Bas, Bradley R. Clarke, Tanisha Teelucksingh, Micah Lee, Kamel El Omari, Andrew M. Giltrap, Stephen A. McMahon, Hui Liu, John H. Beale, Vitaliy Mykhaylyk, Ramona Duman, Neil G. Paterson, Philip N. Ward, Peter J. Harrison, Miriam Weckener, Els Pardon, Jan Steyaert, Huanting Liu, Andrew Quigley, Benjamin G. Davis, Armin Wagner, Chris Whitfield, James H. Naismith

“…Here, we present the first X-ray structures of WzxE from Escherichia coli in complex with nanobodies. Both inward- and outward-facing conformations highlight two pairs of arginine residues that move in a reciprocal fashion, enabling flipping. …”
Get full text

Enabling participation in community-dwelling children and young people with acquired brain injuries and their families: a theory-based, evidence-based and person-based approach to... by Jane Williams, Rachel Keetley, Emily Bennett, Joseph C Manning, Victoria Lyon, Jade Kettlewell, Kate Radford

“…The findings demonstrate the significant long-term impact of an ABI on CYP participation and both CYP and parent well-being with significant unmet family needs. …”
Get full text

Study of a Deep Learning Reconstruction Algorithm for Displaying Small- and Medium-sized Blood Vessels in Upper Abdominal Energy Spectrum CT by Qin WANG, Weijie YAN, Yuan YUAN, Hehan TANG, Liping DENG

“…The kappa test was used to compare differences in the consistency of the subjective evaluations. Results: In both objective and subjective evaluations, the SNR, CNR, overall image quality score, and noise of the DL-H images were superior to those of the DL-M images, where the latter in turn were superior to those of the AV images. …”
Get full text

Diagnostic accuracy in coronary CT angiography analysis: artificial intelligence versus human assessment by James K Min, Paul Knaapen, Nick S Nurmohamed, Erik S G Stroes, Andrew D Choi, Ibrahim Danad, James Earls, Michiel J Bom, Ruben W de Winter, Rachel Bernardo, Ruurt Jukema, Ralf Sprengers

“…At the per-vessel level, AI-QCT achieved an AUC of 0.86, similar to level 3 (AUC 0.82; p=0.098) stenosis, but superior to level 2 readers (both AUC 0.69; p<0.001).Conclusions AI-QCT demonstrated superior agreement with invasive QCA compared to clinical CCTA assessments, particularly compared to level 2 readers in those with extensive CAD. …”
Get full text

Reseeding promotes plant biomass by improving microbial community stability and soil fertility in a degraded subalpine grassland by Debao Li, Sicheng Li, Hao Chen, Jianping Wu

“…Here, we conducted a 3-year field reseeding experiment with eight treatments in a degraded grassland in southern China to test how the link between plant biomass and soil microbial community stability are influenced by plant community structure. Assessments of both above- and below-ground characteristics revealed that reseeding significantly improved plant biomass, soil fertility, and community stability by 53.96 %-126.32 %, 40.74 %-106.91 %, and 13.97 %–33.17 % (P < 0.05) on average, respectively. …”
Get full text

Dengue dynamics, predictions, and future increase under changing monsoon climate in India by Yacob Sophia, Mathew Koll Roxy, Raghu Murtugudde, Anand Karipot, Amir Sapkota, Panini Dasgupta, Kalpana Baliwant, Sujata Saunik, Abhiyant Tiwari, Rajib Chattopadhyay, Revati K. Phalkey

“…The current study investigates these non-linear climate-dengue links in Pune, a dengue hotspot region in India with a monsoonal climate and presents a model framework for predicting both the near-term and future dengue mortalities. …”
Get full text

A family with normal sperm motility carrying a sY86 deletion in AZFa region and partial deletion in AZFc region by Yuhong Zhao, Weiwei Zhi, Weiwei Zhi, Dongsheng Xiong, Dongsheng Xiong, Ningjing Li, Xinrong Du, Jiuzhi Zeng, Jiuzhi Zeng, Guohui Zhang, Guohui Zhang, Weixin Liu, Weixin Liu

“…Here, we reported a rare case of AZF deletion in a family, where both father and son exhibited a deletion at the sY86 site in the AZFa region and a partial deletion in the AZFc region.Methods and ResultsDetection was performed using classical multiplex polymerase chain reaction and the “Male AZF Full-region Detection” Panel, revealing specific deletions in AZFa: Yq11.21 (14,607,372–14,637,973), 30.6 kb; AZFc: Yq11.223–11.23 (25,848,831–27,120,665), 1.3 M for the father; and Yq11.223–11.23 (25,505,378–27,120,665), 1.6 M for the son. …”
Get full text

Quantifying the Suitability of Biosignals Acquired During Surgery for Multimodal Analysis by Ennio Idrobo-Avila, Gergo Bognar, Dagmar Krefting, Thomas Penzel, Peter Kovacs, Nicolai Spicher

“…<italic>Goal:</italic> Recently, large datasets of biosignals acquired during surgery became available. …”
Get full text

Testicular Nitric Oxide and Thiobarbituric Acid Reactive Substances Levels in Obstructive Azoospermia: A Possible Role in Pathophysiology of Infertility

“…Testicular tissue nitrate/nitrite and TBARS levels were <mml:math alttext="$35.7pm 3.1$"><mml:mrow><mml:mn>35.7</mml:mn><mml:mo>&#x00B1;</mml:mo><mml:mn>3.1</mml:mn></mml:mrow></mml:math><mml:math alttext="$mu$"><mml:mi>&#x03BC;</mml:mi> </mml:math>mol/g protein and <mml:math alttext="$3.7pm 0.1$"><mml:mrow> <mml:mn>3.7</mml:mn><mml:mo>&#x00B1;</mml:mo><mml:mn>0.1</mml:mn> </mml:mrow></mml:math> nmol/g protein in Group-1, and <mml:math alttext="$19.3pm 0.7$"> <mml:mrow><mml:mn>19.3</mml:mn><mml:mo>&#x00B1;</mml:mo><mml:mn>0.7</mml:mn> </mml:mrow></mml:math><mml:math alttext="$mu$"><mml:mi>&#x03BC;</mml:mi> </mml:math>mol/g protein and <mml:math alttext="$3.1pm 0.1$"><mml:mrow><mml:mn>3.1</mml:mn><mml:mo>&#x00B1;</mml:mo><mml:mn>0.1</mml:mn></mml:mrow></mml:math> nmol/g protein in Group-2, respectively. Both parameters showed statistical differences between the two groups. …”
Get full text

Influence of elevated temperature exposure on the residual compressive strength and radiation shielding efficiency of ordinary concrete incorporating granodiorite and ceramic powde... by Alaa A. Mahmoud, Alaa A. El-Sayed, Ayman M. Aboraya, Islam N. Fathy, Mohamed A. Abouelnour, Maged E. Elfakharany, Mohy S. Fattouh, Abdelmoniem E. Alahmer, Islam M. Nabil

“…The impact of these waste materials on the compressive strength and radiation shielding effectiveness of traditional concrete was evaluated under both ambient and elevated temperature conditions. …”
Get full text

Evaluation of Body Composition in Hemodialysis Thai Patients: Comparison between Two Models of Bioelectrical Impedance Analyzer and Dual-Energy X-Ray Absorptiometry by Kulapong Jayanama, Supanee Putadechakun, Praopilad Srisuwarn, Sakda Arj-Ong Vallibhakara, Prapimporn Chattranukulchai Shantavasinkul, Chanika Sritara, Surasak Kantachuvesiri, Surat Komindr

“…Dual-energy X-ray absorptiometry (DXA) is a gold standard test, but clinically limited. Bioelectrical impedance analysis (BIA) with multifrequency technique is a practical and reliable tool. …”
Get full text

Chromium "(VI)" phytoremediation using Azolla pinnata: effects on Vicia faba growth, physiology, cytogenetics, and gene expression profiling by Elham R. S. Soliman, Kareem Moustafa, Mohamed Khamis, Zeinab A. Shedeed

“…Upon continuous irrigation with Cr-polluted water (0.05 to 50 ppm), the in vivo pot experiment on Vicia faba plants revealed high Cr accumulation in the roots reached 52.5 mg Kg-1 dry weight (Dwt) at the 50 ppm Cr treatment. …”
Get full text

Exploring the correlations between six serological inflammatory markers and different stages of type 2 diabetic retinopathy by Rongjin Deng, Suhui Zhu, Bin Fan, Xiaohu Chen, Hongbin Lv, Yan Dai

“…Similarly, the AISI values were significantly elevated in the PDR group compared to both the NPDR and NDR groups (P < 0.05). The SIRI and MLR values were significantly higher in the PDR group than in the NDR group (P < 0.05). …”
Get full text

BSG 2024 IBD guidelines protocol (standard operating procedures) by Philip Smith, Rachel Cooney, Jimmy Limdi, Sreedhar Subramanian, Polychronis Pavlidis, Ajay Verma, Said Din, Gordon W Moran, Naila Arebi, Shahida Din, Morris Gordon, Kamal V Patel, Klaartje Bel Kok, Dennis McGonagle, Matthew Shale, Ana-Maria Darie, Vasiliki Sinopoulou, Newton A C S Wong

“…The guideline development group is formed by a variety of disciplines, across both primary and secondary care that took part in an online Delphi process and split into key areas. …”
Get full text

Multi-Objective Optimal Trajectory Planning for Woodworking Manipulator and Worktable Based on the INSGA-II Algorithm by Jiaping Yi, Changqing Zhang, Sihan Chen, Qinglong Dai, Hang Yu, Guang Yang, Leyuan Yu

“…The improved NSGA-II algorithm markedly enhanced both the uniformity of the population distribution and convergence speed. …”
Get full text

Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients by Si-Jie Chen, Qing-Yang Li, Jiang Zhou, Qian Wu, Yu Zhang, Qian-Qian Zhang, Hao Hu, Xiao-Quan Xu, Fei-Yun Wu, Qi Niu

“…Results: Compared with ALS-L, ALS-B showed increased ALFF values in the right gyrus rectus/ orbital part of right middle frontal gyrus, orbital part of left middle frontal gyrus and left dorsolateral superior frontal gyrus/ left medial superior frontal gyrus and decreased ALFF values in the left superior occipital gyrus (FDR-corrected, P < 0.05). Both ALS subtypes demonstrated distinct ALFF alterations compared to HC. …”
Get full text

On the tracks of an uninvited guest, the Asian tiger mosquito, Aedes albopictus in Cyprus by Riccardo Piccinno, Giulia Fiorenza, Marlen Ines Vasquez, Jeremy Bouyer, Gregoris Notarides, Ludvik Marcus Gomulski, Soteris Meletiou, Mustafa Akiner, Antonios Michaelakis, Federico Forneris, Giovanni Maga, Giuliano Gasperi, Anna Rodolfa Malacrida

“…Bayesian clustering analyses using STRUCTURE and BayesAss version 3 were employed to derive information on the degree of ancestry among Cypriot and Mediterranean mosquitoes and on recent mosquito movements both within Cyprus and between Cyprus and the Central Mediterranean areas. …”
Get full text

Incidence and estimated risk of residual transmission of hepatitis a virus and parvovirus B19 by blood transfusion in the state of Rio De Janeiro – Brazil: a retrospective study by Arthur Daniel Rocha Alves, Mariana Magaldi, Ana Carolina Sathler de Menezes, Josiane Iole França Lopes, Carlos Alexandre da Costa Silva, Jaqueline Mendes de Oliveira, Camila Mattos, Leonardo Bastos, Luiz de Melo Amorim Filho, Marcelo Alves Pinto, Luciane Almeida Amado

“…Conclusion This study originally assessed the incidence of both Hepatitis A Virus (HAV) and B19 Virus (B19V) among Brazilian blood donors, as well as the potential risk of residual transmission of these infections through blood transfusions. …”
Get full text

Exploration of pulse wave analysis under reactive hyperemia and close to an arteriovenous fistula: a comparative analysis by Veit Busch, Sandra Müller, Joachim Streis, Timm H. Westhoff, Thomas Felderhoff, Felix S. Seibert, Stefan Reuter, Niklas Mueller

“…Consistent with their different vascular status and endothelial function, changes in pulse wave parameters during reactive hyperemia were significantly different in patients and healthy subjects. Both high flow conditions induced similar changes in the pulse waveform and a delay of the systolic peak in all three collectives. …”
Get full text

CCR7 and CD48 as Predicted Targets in Acute Rejection Related to M1 Macrophage after Pediatric Kidney Transplantation by Jie Zhang, Jun Pei, Chengjun Yu, Jin Luo, Yifan Hong, Yi Hua, Guanghui Wei

“…They have been verified in external validation sets, originated from both pediatric patients and adult patients, and animal experiments. …”
Get full text