Efficacy of sacubitril/valsartan among patients with chronic heart failure with reduced ejection fraction by Madiha Butt, Ayesha Niazi, Zahra Rafique, Nadia Shams, Lubna Meraj, Asma Rauf

“…Adult patients (≥ 25 years of age; both genders) presenting with chronic heart failure (CHF) with LVEF ≤ 40% for ≥ 3 months duration; NYHA-II/III/ambulatory-IV, ischemic/non-ischemic cardiomyopathy cases were included by consecutive non-probability sampling. …”
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A systematic review and meta-analysis of the impact of transcranial direct current stimulation on cognitive function in older adults with cognitive impairments: the influence of do... by Thatchaya Prathum, Thanwarat Chantanachai, Oranich Vimolratana, Chotica Laksanaphuk, Irin Apiworajirawit, Benchaporn Aneksan, Kanthika Latthirun, Cheng-Ta Yang, Wanalee Klomjai

“…Results A total of 19 RCTs were included. tDCS significantly improved the Mini-Mental State Examination score both immediately post-intervention (SMD = 0.51, p = 0.005) and at follow-up (SMD = 2.29, p = 0.0003). …”
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Microbes on the Mobile Phones of Healthcare Workers in Palestine: Identification, Characterization, and Comparison by Mohammad Qadi, Rasha Khayyat, Mohammed A. AlHajhamad, Yazan I. Naji, Beesan Maraqa, Kais Abuzaitoun, Ahmed Mousa, Maysa Daqqa

“…Data collection was done using a self-administrated questionnaire, and a swab sample from both HCW and non-HCW MPs was obtained and transferred to An-Najah National University (NNU) microbiology lab for bacterial identification and antibiotic susceptibility. …”
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Anticonvulsant Effects of Synthetic <i>N</i>-(3-Methoxybenzyl)oleamide and <i>N</i>-(3-Methoxybenzyl)linoleamide Macamides: An In Silico and In Vivo Study by Karin Jannet Vera-López, Jorge Alberto Aguilar-Pineda, Rodrigo Martín Moscoso-Palacios, Gonzalo Davila-Del-Carpio, José Luis Manrique-Murillo, Badhin Gómez, Minerva González-Melchor, Rita Nieto-Montesinos

“…On the other hand, the in vivo results showed an anticonvulsant effect of both macamides, with 3-MBL being the most active, resulting in a higher survival probability in the rats. …”
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Longitudinal DNA methylation profiles in saliva of offspring from mothers with gestational diabetes: associations with early childhood growth patterns by Teresa M. Linares-Pineda, Alfonso Lendínez-Jurado, Alberto Piserra-López, María Suárez-Arana, María Pozo, María Molina-Vega, María José Picón-César, Sonsoles Morcillo

“…Functional analysis linked several of these DMPs to genes involved in inflammation and metabolic processes, including CYTH3 and FARP2, both implicated in growth and metabolic pathways. …”
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Influence of Rapid Urbanization on Thyroid Autoimmune Disease in China by Yingchao Chen, Bing Han, Jie Yu, Yi Chen, Jing Cheng, Chunfang Zhu, Fangzhen Xia, Ningjian Wang, Yingli Lu

“…Genotype TT in rs11675434 was associated with an increased risk of TPOAb positivity both in SY (OR = 2.955) and in NJ (OR = 1.819). GMDR analysis showed a two-locus model (SNP2 × urbanization) and a three-locus model (SNP2 × SNP3 × urbanization), which had testing accuracies of 56.88% and 57.25%, respectively (P values were 0.001 and 0.001). …”
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Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japane... by Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh

“…Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, declines in multiple organs and tissues with aging and obesity. …”
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Drying kinetic for moisture content prediction of peels Tahiti lemon (Citrus latifolia): Approach by machine learning and optimization - genetic algorithms and nonlinear programmin... by Maressa O. Camilo, Romero F. Carvalho, Ariany B.S. Costa, Esly F.C. Junior, Andréa O.S. Costa, Robson C. Sousa

“…The application of a versatile approach for modeling and prediction the moisture content of dried peels was evaluated using both empirical and semi-empirical equations (Lewis, Page, Henderson and Pabis, Modified Page, Logarithmic, and Modified Logistic) as well as machine learning models (K-nearest neighbor | KNN, Decision Tree | DT, Artificial Neural Network | ANN and Support Vector Regression | SVR). …”
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Cytogenetically Unrelated Clones in Acute Myeloid Leukemia Showing Different Responses to Chemotherapy by Kohei Kasahara, Masahiro Onozawa, Naohiro Miyashita, Emi Yokohata, Miho Yoshida, Minoru Kanaya, Mizuha Kosugi-Kanaya, Ryo Takemura, Shojiro Takahashi, Junichi Sugita, Akio Shigematsu, Mutsumi Takahata, Shinichi Fujisawa, Daigo Hashimoto, Katsuya Fujimoto, Tomoyuki Endo, Takeshi Kondo, Takanori Teshima

“…The clone with multiple trisomies was eliminated after induction therapy and never recurred, but a clone with monosomy 7 was still detected in myelodysplastic marrow with a normal blast percentage. Both clones were successfully eliminated after related peripheral blood stem cell transplantation, but the patient died of relapsed AML with monosomy 7. …”
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Investigating the effect of using a home safety training application by caregivers on accident risk management in the elderly by Mahdie Dehnavi, Najmeh Valizadeh zare, Seyd Reza Mazlom, Samira Mohajer, Tahereh Sadeghi, Mohammad Namazinia, Danial Baghie

“…The majority of participants in both groups had a high school education. Before the training, there was no significant difference in the mean accident risk management scores between the two groups (p = 0.713). …”
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The Upregulation of IL-1&beta; Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

“…IL-1β promoted MMP9 secretion from pericytes via the PI3K/AKT pathway, leading to disruption of tight junctions. Both MMP9 and PI3K-AKT inhibitors abrogated IL-1β-induced changes.Conclusion: Our findings suggest that CDDP initiates a cascade of events starting with IL-1β release from endothelial cells. …”
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Use of an observer tool to enhance learning of anaesthesia resident’s non-technical skills during high-fidelity simulation: a randomised controlled trial by Caroline Havard, Viridiana Jouffroy, Agnès Le Gouez, Marie Bruyère, Samy Figueiredo, Philippe Roulleau, Dan Benhamou, Aurore Margat, Antonia Blanié

“…Both groups observed a high-fidelity simulation of crisis management (with or without OT), then were asked to perform actively another simulation. …”
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ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1 by Živa Frangež, Deborah Gérard, Zhaoyue He, Marios Gavriil, Yuniel Fernández-Marrero, Yuniel Fernández-Marrero, S. Morteza Seyed Jafari, Robert E. Hunger, Philippe Lucarelli, Shida Yousefi, Thomas Sauter, Lasse Sinkkonen, Hans-Uwe Simon, Hans-Uwe Simon, Hans-Uwe Simon, Hans-Uwe Simon

“…Our results support the concept that reduced autophagic activity contributes to melanoma development and progression, and identifies NRF1 as a novel TF involved in the regulation of both ATG5 and ATG7 genes.…”
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Microbial dynamics of acute pancreatitis: integrating culture, sequencing, and bile impact on bacterial populations and gaseous metabolites by Agnieszka Chmielarczyk, Edyta Golińska, Anna Tomusiak-Plebanek, Natalia Żeber-Lubecka, Natalia Żeber-Lubecka, Maria Kulecka, Maria Kulecka, Antoni Szczepanik, Katarzyna Jedlińska, Krzysztof Mech, Konrad Szaciłowski, Agata Kuziak, Agata Pietrzyk, Magdalena Strus

“…Furthermore, the effect of bile on the shift in the population of selected bacterial species was examined.ResultsThe NGS technique confirmed greater consistency in bacteria percentage (phyla/family) between stoma content and peripancreatic fluid. In both samples, a clear dominance of the Proteobacteria phyla (over 75%) and the Enterobacteriaceae family was demonstrated. …”
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Age and sex differences in the relationship of body weight changes with colon cancer risks: A nationwide cohort study by Jae Hyun Kim, Young Ko, Hyun Jung Kim, Seun Ja Park

“…In males with a body mass index (BMI) range of 18–30 kg/m2, both a weight gain of 5–20% (HR 1.07, P > z 0.01 [95% CI 1.02–1.13]) and weight gain > 20% (HR 1.27, P > z 0.03 [95% CI 1.03–1.56]) were associated with an increased risk for colon cancer. …”
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The impact of war on ACS admissions and triage – a single center experience by Sharon Bruoha, Tatiana Stolichny, Vladimir Chitoroga, Michael Shilo, Michael Friger, Jamal Jafari, Evgeny Chernogoz, Maggie Cohen Grisaru, Amos Katz, Chaim Yosefy, Gili Givaty

“…Compared to the control period, a significant reduction in ACS admissions per month was noted (38.91 vs. 28.79, p < 0.001) driven by fewer cases of both STEMI and NSTEMI (15.65 vs. 13.29, p = 0.011 and 23.26 vs. 15.5, p < 0.001, respectively). …”
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Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II) by Jaeseong Jo, Chung Mo Nam, Jae Woong Sull, Ji Eun Yun, Sang Yeun Kim, Sun Ju Lee, Yoon Nam Kim, Eun Jung Park, Heejin Kimm, Sun Ha Jee

“…The area under the curve (AUC) increased by 0.5% to 5.2% when either counted or weighted GRS was added to a prediction model consisting of age alone (AUC 0.687 for men, 0.598 for women) or age and family history of CRC (AUC 0.692 for men, 0.603 for women) for both men and women. Furthermore, the risk of CRC significantly increased for individuals with a family history of CRC in the highest quartile of GRS when compared to subjects without a family history of CRC in the lowest quartile of GRS (counted GRS odds ratio [OR], 47.9; 95% confidence interval [CI], 4.9 to 471.8 for men; OR, 22.3; 95% CI, 1.4 to 344.2 for women) (weighted GRS OR, 35.9; 95% CI, 5.9 to 218.2 for men; OR, 18.1, 95% CI, 3.7 to 88.1 for women). …”
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Taung and beyond: The mining history, geology and taphonomy of Australopithecus in South Africa by Rieneke Weij, Stephanie E. Baker, Tara R. Edwards, Job Kibii, Georgina Luti, Robyn Pickering

“…The South African Fossil Hominid sites provide a unique opportunity to expand our understanding of the intersection between human evolution and changing environmental conditions, as the karstic landscape and remnant cave systems preserve both fossils and sedimentary archives of past environmental change. …”
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Imaging and Clinical Characteristics of 8 Cases of COVID-19 Complicated with Pneumomediastinum in Children by FU Qiang, REN Zuolei, LIN Zhiqiang, GONG Jianfeng, WANG Changzheng, WANG Ting, HU Yalan, TAN Jufang

“…In addition, pulmonary lesions could involve the stroma or parenchyma, and both lungs were affected, with various manifestations. …”
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Assessing Physician and Patient Agreement on Whether Patient Outcomes Captured in Clinical Progress Notes Reflect Treatment Success: Cross-Sectional Study by Sarah B Floyd, Jordyn C Sutton, Marvin Okon, Mary McCarthy, Liza Fisher, Benjamin Judkins, Zachary Cole Reynolds, Ann Blair Kennedy

“…A group of 2 patients then reviewed the sample of 100 clinical notes and labeled each note as reflecting treatment success or failure. …”
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