Intrinsic PD‐L1 Degradation Induced by a Novel Self‐Assembling Hexapeptide for Enhanced Cancer Immunotherapy by Hongxia Zhang, Ming Ji, Yamei Wang, Mengmeng Jiang, Zongyu Lv, Gongyu Li, Lulu Wang, Zhen Zheng

“…This work addresses these challenges by developing a hexapeptide, KFM (Lys‐Phe‐Met‐Phe‐Met‐Lys), capable of both directly downregulating PD‐L1 and self‐assembling into a ROS‐responsive supramolecular hydrogel. …”
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Isolation, Identification, and Antimicrobial Susceptibilities of Bacteria from the Conjunctival Sacs of Dogs with Bacterial Conjunctivitis in Different Regions of Wuhan, China by Yuxin Li, Yinan Wang, Xin Gao, Lihong Luo, Bohan Zhang, Xiao Wang, Jing Li, Ruijia Wu, Lixin He, Wenxuan Li, Changwei Qiu

“…Among them, 14 <i>Escherichia coli</i> strains were not resistant to tobramycin and gentamicin, but they showed high resistance rates to neomycin and kanamycin (both at 50%). The detection rate of the <i>aacA-aphD</i> gene in <i>Staphylococcus pseudointermedius</i> strains was 100%. …”
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Nonhomogeneous Markov chains for degeneration behaviour of RC members’ durability and its Bayesian updating by Ruiqi Guo, Dengguo Li, Guoxin Chen, Yu Jin, Hui Li, Yuanpeng Zhang

“…The results indicate that the updated model predictions envelop both the predictions from the prior model and the actual state assessment results, effectively integrating common understanding with individualized information.…”
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Transformers for Neuroimage Segmentation: Scoping Review by Maya Iratni, Amira Abdullah, Mariam Aldhaheri, Omar Elharrouss, Alaa Abd-alrazaq, Zahiriddin Rustamov, Nazar Zaki, Rafat Damseh

“…Studies generally reported increased segmentation accuracy and the ability to model both local and global features in brain images. …”
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Study on the multidrug resistance and transmission factors of Staphylococcus aureus at the ‘animal–environment–human’ interface in the broiler feeding cycle by Fangyuan Hu, Fangyuan Hu, Yaopeng Liu, Yaopeng Liu, Lin Wang, Juan Wang, Na Liu, Yan Li, Xiaoxiao Duan, Junwei Wang, Mingzhe Lu, Junhui Liu, Zhina Qu, Keguang Han

“…The resistance rates to eight drugs including erythromycin, clindamycin, enrofloxacin, ofloxacin, doxycycline, florfenicol, tylosin, and tilmicosin were elevated, but the differences were not significant (p &gt; 0.05). ST398 (79.13%) was the dominant strain in both stages, which was prevalent in 11 types of samples from 3 sources and clustered in the same sub-branch of the single-nucleotide polymorphism (SNP) evolutionary tree. …”
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The Closer, The Harder? Investigating the use of peripheral vision in 3vs3 counter-attack VR situations in football by Božo Vukojević, Svitlana Pinchuk, Christian Vater

“…In half of the trials, both wing strikers out-ran their defenders, so the correct decision was to move after the direct opponent played the pass. …”
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Nanoscale polarization transient gratings by Laura Foglia, Björn Wehinger, Giovanni Perosa, Riccardo Mincigrucci, Enrico Allaria, Francesco Armillotta, Alexander Brynes, Matthew Copus, Riccardo Cucini, Dario De Angelis, Giovanni De Ninno, W. Dieter Engel, Danny Fainozzi, Luca Giannessi, Ezio Iacocca, Nupur N. Khatu, Simone Laterza, Ettore Paltanin, Jacopo Stefano Pelli-Cresi, Giuseppe Penco, Denny Puntel, Primož Rebernik Ribič, Filippo Sottocorona, Mauro Trovò, Clemens von Korff Schmising, Kelvin Yao, Claudio Masciovecchio, Stefano Bonetti, Filippo Bencivenga

“…Abstract Light manipulation at the nanoscale is essential both for fundamental science and modern technology. …”
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The association between tobacco and alcohol use and health outcomes in individuals living with diabetes and prediabetes in South Africa: A cross-sectional study by S J Mulder, T Chivese, C O Egbe

“…Smoking and alcohol misuse are lifestyle factors that can be controlled and have significant health effects. Both these factors increase the risk of developing conditions such as diabetes mellitus because they affect glucose metabolism and can interfere with blood glucose control in individuals with diabetes. …”
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Doctor, what is my risk of bleeding after cardiac surgery while on combined anticoagulant with antiplatelet therapy? A validated nomogram for risk assessment by Haolong Han, Haolong Han, Hang Xu, Hang Xu, Jifan Zhang, Weihui Zhang, Yi Yang, Xia Wang, Li Wang, Dongjin Wang, Weihong Ge

“…NRI and IDI analyses further confirmed the superior predictive ability of Mod2 (NRI &lt; 0.05, IDI &lt; 0.05). Both DCA and CIC indicated that Mod2 exhibited good clinical applicability.ConclusionThis research established and validated a nomogram model incorporating eight predictive factors to evaluate the bleeding risk in patients who receive anticoagulation combined with antiplatelet therapy following cardiac surgery. …”
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Assessment of Vitamin D3 Level Among a Sample of Type 2 Diabetic Patients Attending Diabetes and Endocrinology Center in Al-Hilla City by Ahmed Mahdi Habeeb, Atta Ah Mousa Al-Sarray, Ali Hussein Al Hafidh, Rafah Sabah Barrak, Afraa Brahim

“…that is necessary for calcium homeostasis and the maintenance of proper function in a variety of tissues. Humans get vitamin D from their diets or from being exposed to ultraviolet B radiation from the sun. …”
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Biochemical composition of tomato fruits of various colors by A. B. Kurina, A. E. Solovieva, I. A. Khrapalova, A. M. Artemyeva

“…Tomato (Lycopersicon esculentum Mill.) is an economically important and widely cultivated vegetable crop that is consumed both fresh and processed. The nutritional value of tomato fruits is related to the content of carotenoids, polyphenols, sugars, organic acids, minerals and vitamins. …”
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Assimilating ESA CCI land surface temperature into the ORCHIDEE land surface model: insights from a multi-site study across Europe by L.-E. Olivera-Guerra, C. Ottlé, N. Raoult, P. Peylin

“…Notably, the performance for both LST and fluxes exhibits consistent stability over the years, comparable to using site-specific parameters, and indicates a significant improvement in the modelled fluxes. …”
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Feasibility of fetal cardiac function and anatomy assessment by real-time spiral balanced steady-state free precession magnetic resonance imaging at 0.55T by Ye Tian, Jon Detterich, Jay D. Pruetz, Ecrin Yagiz, John C. Wood, Krishna S. Nayak

“…Conclusion: A spiral real-time bSSFP pulse sequence at 0.55T can provide both low-framerate and high-framerate fetal heart images without relying on maternal breath-hold, specialized gating devices, or cardiac gating. …”
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Prevalence and clinicopathological features of driver gene mutations profile in BCR:ABL1 negative classical myeloproliferative neoplasm—A single-center study from North India by Khaliqur Rahman, Seema Biswas, Akhilesh Sharma, Kusum Gupta, Dinesh Chandra, Manish K. Singh, Ruchi Gupta, Ashish Mishra, Sanjeev Kumar, Anshul Gupta, Faheema Hasan, Soniya Nityanand, Rajesh Kahsyap

“…JAK2V617F mutation was noted in 90.3%, 61.1%, and 69.2% of cases of PV, ET, and PMF, respectively. …”
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Assessment of Soil Organic and Inorganic Carbon Under Afforestation and Natural Vegetation Restoration Using Stable Carbon Isotope (δ¹³C) Measurements by Mengyao Wu, Yaru Zhao, Hui Li, Wenchang Ma, Yang Gao

“…The δ¹³C-SOC in topsoil was significantly (<i>p</i> < 0.05) lower than the subsoil in both lands. The δ¹³C-SIC in forestland was significantly (<i>p</i> < 0.05) lower than in abandoned farmland. …”
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Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3 by Jian Zhou, Jia Fan, Zhiqiang Hu, Jia Li, Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Haoyang Xin, Chubin Luo, Shaolai Zhou

“…TANs and TAMs produced higher levels of oncostatin M and interleukin-11, respectively, in co-culture than in monoculture. Both of those cytokines activated STAT3 signaling in ICC cells. …”
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Wound-healing activity of solvent fractions and antiinflammatory activity of crude extract and solvent fractions of Acokanthera schimperi Schweinf (Apocynaceae) leaves in mice mode... by Workineh Woldeselassie Hammeso, Tesfaye Yimer, Getnet Tadege, Wakuma Wakene Jifar, Dejen Nureye

“…Background: In Ethiopia, Acokanthera schimperi is frequently used to treat wounds and other conditions. Nothing has been published to date on the anti-inflammatory properties of A. schimperi leaves or the wound-healing effects of solvent fractions, despite a report on the crude extract's ability to heal wounds being available in the literature. …”
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Association between vitamin D deficiency and major depression in patients with chronic kidney disease: a cohort study by I-Wen Chen, I-Wen Chen, Wei-Ting Wang, Yi-Chen Lai, Yi-Chen Lai, Ying-Jen Chang, Yao-Tsung Lin, Kuo-Chuan Hung, Kuo-Chuan Hung

“…BackgroundPatients with chronic kidney disease (CKD) have an elevated risk of both vitamin D deficiency (VDD) and depression. However, the relationship between VDD and the risk of depression in this population remains unclear.MethodsUsing the TriNetX network database (2010–2019), we conducted a propensity score-matched cohort study of CKD patients aged ≥50 years. …”
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Effects of Immune System-Related Medications on COVID-19 Outcome in a Cohort of Iranian Patients: Preliminary Report of a Data Mining Study by Ehsan Bitaraf, Seyyed Amir Yasin Ahmadi, Alireza Gandomi-Mohammadabadi, Zahra Noorani Mejareh, Bahare Abdollahi, Javad Balasi, Farzan Moodi, Nima Hemmati, Ali Kabir

“…Regulation of the immune system is critical for fighting against viral infections. Both suppression and hyperactivity of the immune system result in failure of treatment. …”
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Anti-inflammatory treatment using alpha melanocyte stimulating hormone (α-MSH) does not alter osteoblasts differentiation and fracture healing by Johanna Graue, Melanie Timmen, Katharina Schmitz, Daniel Kronenberg, Markus Böhm, Kishor K. Sivaraj, M. Gabriele Bixel, Richard Stange

“…All four melanocortin receptor-molecules were expressed in murine osteoblastic cells but in very limited amounts and this did not change upon treatment with inflammatory cytokines or α-MSH or both at the same time. Callus formation in fractured femurs of α-MSH-treated mice was slightly delayed at day 14 post fracture with regard to less cartilage formation (NaCl: 19.9%; α-MSH: 13.5%) and soft tissue remodeling (NaCl: 15.2%; α-MSH: 19.5%) but these results were not significantly different and fracture healing overall occurred in a regular way. …”
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