Investigating the Reliability of Shore Hardness in the Design of Procedural Task Trainers by Kyleigh Kriener, Kate Sinclair, Grant Robison, Raushan Lala, Hayley Finley, William Jase Richardson, Mark J. Midwinter

“…Testing revealed that although Shore A demonstrated better inter-rater reliability compared to Shore OO, both scales exhibited poor-to-moderate reliability. …”
Get full text

Liposomal Formulation of Hydroxychloroquine Can Inhibit Autophagy In Vivo by Wieslawa H. Dragowska, Jagbir Singh, Mohamed Wehbe, Malathi Anantha, Katarina Edwards, Sharon M. Gorski, Marcel B. Bally, Ada W. Y. Leung

“…<b>Results:</b> The liposomal formulations engendered ~850-fold increases in total drug exposure over time relative to the free drug. Both liposomal and free HCQ in combination with gefitinib provided comparable therapeutic benefits (<i>p</i> > 0.05). …”
Get full text

Toll-Like Receptors and Diabetic Nephropathy: A Review of Recent Advances by Mohammad Sadra Gholami Chahkand, Yasaman Tavakoli, Ava Aghakhani, Monireh Askarzadeh, Hosein Azimi, Nogol Ghalamkarpour, Alaleh Alizadeh, Iman Archin, Sajad Kermani, Akram Ansari, Mohadeseh Poudineh, Zahra Mali, Elaheh Foroughi, Gisou Erabi, Seyed Amirhossein Mazhari, Mohammad Sadegh Fallahi, Niloofar Deravi, Parisa Alsadat Dadkhah

“…TLR4, TLR2, TLR5, TLR7, TLR8, TLR9, and TLR11 are essential in the pathogenesis of DN, according to recent evidence collected from both in vivo and in vitro studies. Studies have shown that TLR2 and TLR4 expression is higher in patients with renal failure and nephrotic diabetes. …”
Get full text

Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma by Qiangan Jing, Yunyi Wu, Yanchun Li, Chaoting Zhou, Junyu Zhang, Jun Xia, Keyi Li, Yuhuan Shen, Hongfeng Yao, Xiangmin Tong, Jing Du, Lushan Yu, Ying Wang

“…Abstract Thioredoxin1 (TRX1) and telomerase are both attractive oncology targets that are tightly implicated in tumor initiation and development. …”
Get full text

Side effects of psychotropic drugs on eye by A.A. Petukhova, A.A. Panov, Ya.V. Malygin, M.A. Kazanfarova

“…However, the intake of both typical and atypical neuroleptics, lithium salts, some anticonvulsants (e.g., topiramate) is associated with high risks of vision loss. …”
Get full text

Cross-Sectional Relationship between Carotid-Femoral Pulse Wave Velocity and Biomarkers in Vascular-Related Diseases by Jinbo Liu, Kuanting Wang, Huan Liu, Hongwei Zhao, Wei Huang, Na Zhao, Lihong Li, Hongyu Wang

“…Levels of Log NT-proBNP and Log UAE were significantly higher in group 3 than in group 1 (2.27 ± 0.4 vs 2.10 ± 0.4, 1.00 ± 0.65 vs 0.68 ± 0.56, both p<0.05). Positive correlation between CFWV and Hcy, Log UAE, and Log NT-proBNP was found in the entire study group (r = 0.109, 0.196, and 0.119, all p<0.05). …”
Get full text

Advanced microgrid optimization using price-elastic demand response and greedy rat swarm optimization for economic and environmental efficiency by Arvind R. Singh, Bishwajit Dey, Mohit Bajaj, Sahil Kadiwala, Rangu Seshu Kumar, Soham Dutta, Ievgen Zaitsev

“…The GRSO algorithm outperformed traditional metaheuristics in terms of both execution time and convergence, making it a viable solution for real-time microgrid optimization. …”
Get full text

Characterization of meat quality, storage stability, flavor-related compounds, and their relationship in Korean Woorimatdag No. 2 chicken breast meat during cold storage by Yousung Jung, Soomin Oh, Sangrok Lee, Hee-Jeong Lee, Hyo-Jun Choo, Cheorun Jo, Ki-Chang Nam, Jun-Heon Lee, Aera Jang

“…We found that pH and drip loss increased gradually during storage and WRMD2 exhibited a significantly lower pH and higher drip loss than CB. In both groups, aerobic plate counts, volatile basic nitrogen, and lipid oxidation levels increased, whereas creatine and dipeptide levels gradually decreased during storage. …”
Get full text

Lower trapezius tendon transfer for massive irreparable rotator cuff tears improves outcomes in patients with high grade fatty infiltration of teres minor by Eva Gusnowski, MD, FRCSC, Eric Wagner, MD, Sheila McRae, PhD, Hayden Cooke, MD, Anthony Karzon, MD, Michael Gottschalk, MD, Peter MacDonald, MD, FRCSC, Jarret Woodmass, MD, FRCSC

“…No group differences were found in preoperative SANE score, forward elevation or active external rotation (ER). Both groups showed significant postoperative improvements in SANE score with no differences between the groups. …”
Get full text

Induced mesenchymal stem cells generated from periodontal ligament fibroblast for regenerative therapy by Hemanathan Vembuli, Sheeja Rajasingh, Patrick Nabholz, Jefferson Guenther, Brian R. Morrow, Margaret M. Taylor, Marziyeh Aghazadeh, Vinoth Sigamani, Johnson Rajasingh, Johnson Rajasingh, Johnson Rajasingh

“…Stem cells derived from oral tissues and umbilical cord mesenchymal stem cells (MSCs) have shown potential in both preclinical and clinical studies for bone tissue regeneration. …”
Get full text

Standardised activities in wheelchair rugby, comparison between athletes with coordination impairment and athletes with other impairments by Viola C. Altmann, Viola C. Altmann, Viola C. Altmann, Mariska Janssen, Mariska Janssen, Johanna L. J. de Wit, Rienk M. A. van der Slikke, Rienk M. A. van der Slikke, Rienk M. A. van der Slikke

“…Differences between athletes with CI and OI were assessed using a Mann-Whitney U test.ResultsMost activities showed a high correlation with the athlete class in both athletes with CI and athletes with OI. Furthermore, outcome measures of athletes with CI overlapped with athletes with OI in the same sports class for all activities. …”
Get full text

Assessment of root resorption on lateral incisors after primary canine extraction treating mesioangular displaced permanent canines: a randomised controlled trial by Narmin Helal, Reem Naaman, Najlaa Alamoudi, Azza El-Housseiny, Fatima Jadu

“…Severe resorption was observed more frequently in cases involving palatally displaced canines within both groups, but it did not reach statistical significance.ConclusionsLateral incisor root resorption (RR) progressed significantly within a 12-month period irrespective of treatment modality. …”
Get full text

Screening for retinopathy of prematurity in China: a five-year cohort study in seven screening centers by Yusheng Zhong, Xiacheng Lin, Yating Yang, Liying He, Na Li, Jun Lu, Yu Zhou, Rong Zhang, Yacong Wang, Zhongyu Zhang, Mochi Yang, Hong Yin, Mingwei Zhao, Xiaoxin Li, Jianhong Liang, Yong Cheng

“…Conclusion Considering the decrease in both GA and BW among the population requiring ROP treatment in China, it is imperative to contemplate updating the ROP screening guideline.…”
Get full text

A DFT Analysis on Antioxidant and Antiradical Activities from Anthraquinones Isolated from the Cameroonian Flora by Judith Caroline Ngo Nyobe, Laurent Gael Eyia Andiga, Désiré Bikele Mama, Baruch Ateba Amana, Joseph Zobo Mfomo, Toze Flavien Aristide Alfred, Jean Claude Ndom

“…The single electron transfer mechanism has been adopted to examine both biological activities. The classification of the antiradical profile to integrate the electrodonating power (ω−), electroaccepting power (ω+), donor index (Rd) and acceptor index (Ra) has been performed using the donor-acceptor map (DAM). …”
Get full text

Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and metabolic dysfunction-associated steatotic liver disease among Chinese children with obesity by Meijuan Liu, Bingyan Cao, Qipeng Luo, Yanning Song, Kai Liu, Di Wu

“…UHR levels were higher in obese children with MASLD than those with non-MASLD for both genders. After dividing all individuals into three groups according to the tertiles of UHR, the prevalence rate of MASLD increased progressively from the tertile 1 to tertile 3 of UHR (34.11% vs. 70.56% vs. 80.61%). …”
Get full text

Integrating CT-based radiomics and clinical features to better predict the prognosis of acute pancreatitis by Hang Chen, Yao Wen, Xinya Li, Xia Li, Liping Su, Xinglan Wang, Fang Wang, Dan Liu

“…The patients were dichotomized into good and poor prognosis subgroups based on follow-up CT and clinical data. …”
Get full text

Hormonal Contraceptives and Athletic Outcomes - analysis of potential effects of oral contraceptives on strength, endurance, mood, and overall competitive results by Dominika Lewandowska, Dominika Rosińska-Lewandoska, Dominika Strep, Anna Podraza, Julia Grabowska, Maciej Kwiatkowski, Patryk Romańczyk, Julia Białczak, Weronika Kanownik, Jakub Rosiński

“…Further, well-controlled research is needed to clarify these effects, enabling more targeted guidance for both athletes and healthcare professionals. …”
Get full text

Psychological responses to acute exercise in patients with stress-induced exhaustion disorder: a cross-over randomized trial by Jenny Kling, Robert Persson Asplund, Örjan Ekblom, Victoria Blom

“…Trial registration The study was retrospectively registered on 05/30/2024 at Clinical Trials.gov, with trial registration number 2022–04943-01.…”
Get full text

Lifestyle Interventions Targeting Body Weight Changes during the Menopause Transition: A Systematic Review by Janet Jull, Dawn Stacey, Sarah Beach, Alex Dumas, Irene Strychar, Lee-Anne Ufholz, Stephanie Prince, Joseph Abdulnour, Denis Prud’homme

Get full text

Increased birth rank of homosexual males: disentangling the older brother effect and sexual antagonism hypothesis by Raymond, Michel, Turek, Daniel, Durand, Valérie, Nila, Sarah, Suryobroto, Bambang, Vadez, Julien, Barthes, Julien, Apostolou, Menelaos, Crochet, Pierre-André

“…However, there is no consensus on whether both FBOE and AE are present in human populations, or if only one of these mechanisms is at play with its effect mimicking the signature of the other mechanism. …”
Get full text