Identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plus by Subhankar Saren, Animesh Mandal, Amit Kumar Das, Ranjit Kumar Haldar, Sudipta Pandit

“…Background: Early detection of malignant pleural effusions (MPE) through routine biochemical tests will go a long way in improving morbidity and mortality of these patients. …”
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Integrated analysis of cell cycle and p53 signaling pathways related genes in breast, colorectal, lung, and pancreatic cancers: implications for prognosis and drug sensitivity for... by Jiyauddin Khan, Priyanjana Ghosh, Urmi Bajpai, Kountay Dwivedi, Daman Saluja

“…The top 10 hub genes were validated both for mRNA and protein expression, revealing they are significantly overexpressed in all studied cancers. …”
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Role and sensitivity of Positron Emission Tomography with [18F]Fluorodeoxyglucose in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA) by Gianfranco Schiraldi, Cristina Elena Popescu, Michele Chiericozzi, Salvatore Lo Cicero, Flavio Allegri, Franco Mosca, Claudio Rossetti

“…Results: At the time of first diagnosis, agreement between 18F-FDG PET/CT and serologic tests was ‘almost perfect’ (88%, Kappa = 0.846, P < 0.05), whereas it was ‘good’ at 12 months follow-up (81%, Kappa = 0.684, P < 0.05). …”
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Patterns and trends of heat and wildfire smoke indicators across rural–urban and social vulnerability gradients in Idaho by Seyd Teymoor Seydi, Jennifer Pierce, John T Abatzoglou, Anna Radin, Ethan Sims, Hilary Flint, Stephanie Wicks, Eric Henderson, Bhaskar Chittoori, Mojtaba Sadegh

“…We show that in rural regions in Idaho, low vulnerability populations had both the highest long-term average and the highest increase rate of exposure to heatwaves from 2002–2020, coincident with a higher population density in low—as compared to high—vulnerability rural census tracts. …”
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Lesbian, gay, bisexual, and transgender clinical competence of health professionals in Poland and Spain: results of the health exclusion research in Europe (HERE) study by Piotr Karniej, Anthony Dissen, Łukasz Pietrzykowski, Raúl Juárez-Vela, Antonio Martinez Sabater, Janina Kulińska, Jakub Zieliński, Michał Czapla

“…Participation in LGBT-related training was associated with higher clinical preparedness in both countries, with those attending training 3 or more times scoring higher than those who never attended (B = 1.659, p < 0.001). …”
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APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence by Jingyi Xie, Daniel G. Chen, William Chour, Rachel H. Ng, Rongyu Zhang, Dan Yuan, Jongchan Choi, Michaela McKasson, Pamela Troisch, Brett Smith, Lesley Jones, Andrew Webster, Yusuf Rasheed, Sarah Li, Rick Edmark, Sunga Hong, Kim M. Murray, Jennifer K. Logue, Nicholas M. Franko, Christopher G. Lausted, Brian Piening, Heather Algren, Julie Wallick, Andrew T. Magis, Kino Watanabe, Phil Mease, Philip D. Greenberg, Helen Chu, Jason D. Goldman, Yapeng Su, James R. Heath

“…We leverage this comprehensive dataset to integrate with peptide antigen properties, TCR CDR3 sequences, and T cell phenotypes to show that distinct physicochemical features of the antigen-TCR pairs strongly associate with both T cell phenotype and T cell persistence. This analysis suggests that CD8 T cell phenotype following antigen stimulation is at least partially deterministic, rather than the result of stochastic biological properties.…”
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Prescription pattern, glycemic control status, and predictors of poor glycemic control among diabetic patients with comorbid chronic kidney disease in Ethiopia: a facility-based cr... by Oumer Sada Muhammed, Minimize Hassen, Samuel Mamusha

“…Results This study found that 98.2% of patients had type 2 diabetes, with a mean diabetes duration of 16.36 years. Only 4.4% achieved good glycemic control (glycated hemoglobin [HbA1c] < 7%), while 95.6% had poor glycemic control (HbA1c ≥ 7%). …”
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Effect of High Pressure and Sub-Zero Temperature on Total Antioxidant Capacity and the Content of Vitamin C, Fatty Acids and Secondary Products of Lipid Oxidation in Human Milk by Martysiak-Żurowska Dorota, Puta Małgorzata, Barczak Natalia, Dąbrowska Joanna, Malinowska-Pańczyk Edyta, Kiełbratowska Bogumiła, Kołodziejska Ilona

“…It was shown that no significant changes in the content and composition of FAs and TBARS levels were noted in both pressurized and LTLT pasteurized milk samples. …”
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GPIHBP1 increase accounts for rheumatic arthritis-related hypotriglyceridemia by facilitating lipids uptake of white adipose tissues by Meng-Ke Song, Meng-Fan Gu, Ling Liu, Lian-Jun He, Peng Ye, Kui Yang, Dan-Dan Wang, Opeyemi Joshua Olatunji, Qin Yin, Jian Zuo

“…RA serum slightly inhibited LPL secretion in pre-adipocytes. Both HUVEC cells co-culture and GPIHBP1 supplement reduced LPL distribution on pre-adipocytes, and eliminated LPL activity difference between normal and RA serum-treated cells. …”
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Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report by Carolin Seeling, Sonja Dahlum, Ralf Marienfeld, Vera Jan, Brigitte Rack, Uwe Gerstenmaier, Ambros J. Beer, Regine Mayer-Steinacker, Wolfgang Thaiss, Thomas F. E. Barth, Thomas Seufferlein, Nadine T. Gaisa, Stephan Stilgenbauer, Wolfgang Janni, Reiner Siebert, Hartmut Döhner, Verena I. Gaidzik

“…Case presentation We present the case of a woman with breast cancer and subsequent osteosarcoma, both treated with surgery and chemotherapy. Constitutional genetic germline testing identified a pathogenic TP53 variant in line with the clinical features of Li-Fraumeni syndrome. …”
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Lactoferrin Induces Osteoblast Growth through IGF-1R by Jian-Ming Hou, En-Yu Chen, Fan Lin, Qing-Ming Lin, Ying Xue, Xu-Hua Lan, Man Wu

“…MMT staining and flow cytometry both indicated that there was no significant difference between the shIGF-1R group and the shIGF-1R + 100 μg/mL lactoferrin group. (3) Lactoferrin (100 μg/mL) induced PI3K and RAS phosphorylation and silence of IGF-1R resulted in decreased p-PI3K and p-RAS expression. …”
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The effect of exercise intervention on inhibitory function in obese and overweight children and adolescents: a systematic review and meta-analysis by Aona Chen, Chenggen Guo, Shuhua Qu

“…Additionally, Stroop, Flanker, and Go/No-go tasks (SMD = -0.88, -0.62, 0.73, 95% CI = -1.43 to -0.32, -1.09 to -0.15, 0.20 to 1.25, p < 0.01) effectively assessed inhibitory function in obese and overweight children and adolescents. …”
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Transdifferentiation of rat keratinocyte progenitors to corneal epithelial cells by limbal niche via the STAT3/PI3K/AKT signaling pathway by Bei Wang, Jiang-Lan Zhao, Gong-Yue Wang, Wan-Ying Cai, Yu-Ting Xiao, Jia-Song Wang, Chao Wang, Yu-Zhi Li, Xi Peng, Tian-Yu Yao, Ming-Chang Zhang, Hua-Tao Xie

“…Key transcription factors and signaling pathways involved in the transdifferentiation process were identified through single-cell and RNA sequencing, and were validated by western blot and quantitative real-time PCR. Results Both LN-KS and LN-SH protocols successfully induced corneal epithelial cell transdifferentiation from KPCs, with LN-KS demonstrating higher efficiency in generating CK12 + and p63 + cells (p < 0.001). …”
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Radiological and Clinical Features and Outcomes of Patients with Primary Pulmonary Salivary Gland-Type Tumors by Xiaoyu Han, Jianchu Zhang, Jun Fan, Yukun Cao, Jin Gu, Heshui Shi

“…MEC was equally distributed between both sexes, whereas ACC was more frequent in females (66.7%). …”
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Immune-related gene SOX10 affects ferroptosis in pancreatic cancer and facilitates tumor progression by targeting CMTM7-mediated Wnt/β-catenin signaling pathway by Guixing Jiang, Bicheng Wu, Kaikai Wang, Xiaofan Pu, Senhao Zhou, Xin Zhong, Xiaolong Liu, Suihan Wang, Tianyu Lin

“…Mechanically, SOX10 level was increased and CMTM7 was down-regulated in both PANC-1 cells and PC tissues. When SOX10 was downregulated or CMTM7 was overexpressed, it notably hindered the cells' activity, while also promoting cell apoptosis in vitro. …”
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Constructing benzothiadiazole‐based donor‒acceptor covalent organic frameworks for efficient photocatalytic H2 evolution by Yanchang Huang, Bin Gao, Qihang Huang, De‐Li Ma, Hongwei Wu, Cheng Qian

“…Density functional theory (DFT) calculations revealed that both triphenylamine and benzothiadiazole units are the main active sites for HER over the DHU‐COF‐BB. …”
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Assessment of Green Extraction Techniques in the Utilization of Oak Tree (<i>Quercus robur</i>) and Mugwort (<i>Artemisia vulgaris</i>) Biomass for the Production of Bioactive Extr... by David Villanueva-Bermejo, Diego Martín Hernández, Elvis Judith Hernández, Susana Santoyo, Tiziana Fornari

“…The anti-inflammatory activity of <i>Q. robur</i> extracts, the antibacterial activity of <i>A. vulgaris</i> extracts and the antioxidant activity of the extracts from both materials were determined. The highest phenolic compound content and antioxidant activity of <i>Q. robur</i> extracts were achieved with water at 100 °C (487.97 mg GAE/g and 3741 µg trolox/g). …”
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Individualized resting-state functional connectivity abnormalities unveil two major depressive disorder subtypes with contrasting abnormal patterns of abnormality by Keke Fang, Lianjie Niu, Baohong Wen, Liang Liu, Ya Tian, Huiting Yang, Ying Hou, Shaoqiang Han, Xianfu Sun, Wenzhou Zhang

“…Our findings provide new insights into the taxonomy and have potential implications for both diagnosis and treatment of MDD.…”
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A Large-Scale Agricultural Land Classification Method Based on Synergistic Integration of Time Series Red-Edge Vegetation Index and Phenological Features by Huansan Zhao, Chunyan Chang, Zhuoran Wang, Gengxing Zhao

“…The study yielded three significant findings: (1) The synergistic application of NDRE₇₀₅ and PSRI significantly outperformed single-index approaches, demonstrating the effectiveness of our dual-index strategy; (2) The integration of SFPs and PFPs with time series REVI markedly enhanced feature discrimination at crucial growth stages, with PFPs showing superior capability in distinguishing agricultural land types through amplified phenological signatures; (3) Our optimal classification scheme (FC6), leveraging both enhanced spatial and phenological features, achieved remarkable accuracy (93.21%) with a Kappa coefficient of 0.9159, representing improvements of 4.83% and 0.0538, respectively, over the baseline approach. …”
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Candidate SNP markers of social dominance, which may affect the affinity of the TATAbinding protein for human gene promoters by I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko

“…Within the framework of the proposed heuristic hypotheses and database dbSNP v.147, we found statistically significant (α &lt; 10-5) evidence of the effects of natural selection against the deficient expression of genes, which can affect the predisposition to dominate, as well as in favor of both subordination and domination behavior as a norm of reaction of aggressiveness (difference not significant: α &gt; 0.35). …”
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