Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with... by Jianrong Zhang, Yu Huang, Hengrui Liang, Wenhua Liang, Jianxing He, Yiyin Zhang, Jiaxi He, Jieyu Wu, Long Jiang, Shiyan Tang, Qihua He, Lindsey Tristine Hamblin, Zhiheng Xu, Yaoqi Chen, Difei Chen, Xinyu Wang, Kexin Deng, Shuhan Jiang, Jiaqing Zhou, Jiaxuan Xu, Xuanzuo Chen

“…Pooling analysis presented no systematic bias when comparing treatment effects of both assessments (ORR: OR=1.02 (95% CI 0.97 to 1.07), p=0.42, I2=0%; DCR: OR=0.97 (95% CI 0.92 to 1.03), p=0.32, I2=0%); PFS: HR=1.01 (95% CI 0.99 to 1.02), p=0.32, I2=0%; TTP: HR=1.04 (95% CI 0.95 to 1.14), p=0.37, I2=0%), regardless of funding source, mask, region, tumour type, study design, number of enrolled patients, response assessment criteria, primary endpoint and trials with statistically consistent/inconsistent inferences. …”
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Symptoms of anxiety, depression, and post-traumatic stress disorder 6 weeks and 6 months after ICU: Six out of 10 survivors affected by E van der Merwe, L Stroud, G Sharp, N van Vuuren, M Mosola, T Fodo, F Paruk

“…Critically ill patients in a multidisciplinary tertiary ICU were prospectively enrolled upon ICU discharge. Survivors were screened for anxiety, depression and post-traumatic stress syndrome at 6 weeks and 6 months after hospital discharge. …”
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Inflammatory burden index as a prognostic marker in patients with advanced gastric cancer treated with neoadjuvant chemotherapy and immunotherapy by Jiao-Bao Huang, Zhi-Yong Zhou, Jun Lu, Ji-Yun Zhu, Bin Lai, Sheng-Xun Mao, Jia-Qing Cao

“…Finally, Inflammatory burden index(IBI) was grouped by X-tile software, and Kaplan-Meier method was used to compare the survival difference between groups.ResultsA total of 163 patients were enrolled in this study. The median age was 63 years(56-68). …”
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Association of workforce participation with depression among US older adults: results from NHANES 2005–2018 by Zhenyu Sun, Yi Wang, Xi Chen, Dongfu Qian

“…Results A total of 10,312 participants aged 60 or above were enrolled with a prevalence of depression of 6.4%. There was a significantly negative association of PHQ-9 score with working (Exp [β] = 0.68; 95%CI: 0.53–0.87), working as private employee (Exp [β] = 0.67; 95%CI: 0.50–0.89), or working on regular daytime (Exp [β] = 0.65; 95%CI: 0.52–0.82). …”
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The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection by Qingqing Chen, Haohao Wu, Xinwei Guo, Ke Gu, Wenjie Wang, Xiaochen Chen, Shengjun Ji, Hui Yang, Jiahao Zhu

“…A total 206 patients were enrolled in this study. Clinicopathologic characteristics and survival were assessed. …”
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Cost-effectiveness of decentralising acute malnutrition treatment with a standard or simplified treatment protocol: an economic evaluation in the region of Gao, Mali by Bernardette Cichon, Noemí López-Ejeda, Salimata Samake, Cornelia Aton, Abdias Ogobara Dougnon, Mahamadou N’tji Samake, Aliou Bagayoko, Magloire Bunkembo, Alexandra Rutishauser-Perera, Pilar Charle-Cuellar

“…Methods This economic evaluation was part of a three-arm cluster randomized controlled trial which enrolled 2038 children with moderate and severe acute malnutrition. …”
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The impact of radiation-related lymphocyte recovery on the prognosis of locally advanced esophageal squamous cell carcinoma patients: a retrospective analysis by Hongshan Ji, Ping Zhang, Chanjun Zhen, Liyuan Fu, Dongjie Lv, Wenwen Bai, Rui Zhang, Jing Li, Hang Gao, Yajing Wang, Qiuying An, Yuhao Su, Hanyu Si, Xueying Qiao, Zhiguo Zhou

“…Results 116 patients were enrolled. During RT, ALCs reached the bottom 5 weeks after RT started and 70.7% of patients experienced G3 lymphopenia. …”
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Sex-specific differences in the efficacy of renal denervation in patients with resistant hypertension depending on visceral obesity and kidney function by Irina Zyubanova, Nadezhda Ryumshina, Victor Mordovin, Musheg Manukyan, Valeriya Lichikaki, Ekaterina Solonskaya, Anna Gusakova, Tatjana Suslova, Stanislav Pekarskiy, Simzhit Khunkhinova, Anastasia Popova, Veronika Rudenko, Alla Falkovskaya

“…ObjectiveTo investigate the sex differences in the efficacy of renal denervation (RDN) in patients with resistant hypertension (RHT) concerning the size of abdominal fat depots, changes in biomarkers of sympathetic activity, and renal function.Materials and methods24 men (56.5 ± 7.8 years) and 33 women (59.5 ± 8.4 years) with RHT were enrolled in the study and underwent RDN. 24-h ambulatory blood pressure (BP) [systolic/diastolic (SBP/DBP)], serum creatinine (with eGFR calculation), serum adipocytokines (leptin, adiponectin, resistin), serum metanephrines and normetanephrines were measured baseline and 12 months after RDN. …”
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The Efficacy of Parenteral Nutrition and Enteral Nutrition Supports in Traumatic Brain Injury: A Systemic Review and Network Meta-Analysis by Yan Qin, Maoxia Liu, Fengbao Guo, Du Chen, Peng Yang, Xionghui Chen, Feng Xu

“…The network meta-analysis was performed to adjust for indirect comparison and mixed treatment analysis. Results. 7 studies enroll a total of 456 patients who received different nutritional supports including parenteral nutrition (PN), enteral nutrition (EN), and PN + EN. …”
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YEARS clinical decision rule for diagnosing pulmonary embolism: a prospective diagnostic cohort follow-up study in primary care by Frans H Rutten, Menno V Huisman, Jeanet Blom, Rosanne van Maanen, Frederikus A Klok, Geert-Jan Geersing, Karel Moons, Hannah M la Roi-Teeuw, Melchior Nierman, Tuur Egbers

“…Of these patients, three patients had a diagnosis of non-fatal PE during 3 months follow-up, all three with zero YEARS items and D-dimer between 500 and 1000 ng/mL, resulting in an overall diagnostic failure rate of 0.50% (3/603 patients, 95% CI 0.13% to 1.57%). …”
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Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of Chi... by Zhongzhong Liu, Zhongzhong Liu, Zhongzhong Liu, Dandan Zhang, Dandan Zhang, Lingxia Zeng, Weiyan Guo, Qingli Lu, Qingli Lu, Zhen Lei, Yunlong Hao, Pei Liu, Pei Liu, Tong Liu, Tong Liu, Linna Peng, Linna Peng, Qiaoqiao Chang, Qiaoqiao Chang, Mi Zhang, Mi Zhang, Xuemei Lin, Xuemei Lin, Fang Wang, Fang Wang, Songdi Wu, Songdi Wu, Songdi Wu, Songdi Wu

“…Multivariable Cox regression, curve fitting, and stratified analyses were employed to assess the relationship between SUA/SCr and 1-year stroke recurrence in patients with AIS and abnormal renal function, considering SUA/SCr as both a continuous variable and in quartiles (Q1–Q4).ResultsOf 1,932 enrolled patients (65.3% male; mean age 66.7 ± 11.3 years), each unit of increase in SUA/SCr was associated with a 17% decrease in 1-year stroke recurrence (HR = 0.83, 95% CI 0.73 to 0.96, P = 0.009). …”
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Risk of Dysglycemia in Pregnancy amongst Kenyan Women with HIV Infection: A Nested Case-Control Analysis from the STRiDE Study by Sonak D. Pastakia, Wycliffe K. Kosgei, Astrid Christoffersen-Deb, Benson Kiragu, John N. Hector, Gertrude Anusu, Ponnusamy Saravanan

“…The STRiDE study is one of the largest ever conducted studies of GDM in Kenya. This study enrolled pregnant women aged between 16 and 50 who were receiving care from public and private sector facilities in Eldoret, Kenya. …”
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Impacto en los flujos hídricos por la presencia de horizontes petrocálcicos en parcelas forestadas en ambientes de llanura by C.R. MUJICA, G.M. MILIONE, S.A. BEA, J.E. GYENGE

“…Sin embargo, el impacto de esta práctica sobre suelos con presencia de horizontes petrocálcicos no ha sido suficientemente estudiado. Dentro de esta región se han monitoreado variables hidrológicas de un conjunto parcelas de pastizal y forestación apareadas, con niveles de horizontes petrocálcicos. …”
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Cryoballoon ablation for atrial fibrillation in South Africa: One-year outcome from the Cryo Global Registry by A Stanley, K A van Bragt, V Obidigbo, B Vezi

“…In this sub-analysis of the Cryo Global Registry, 81 participants with paroxysmal AF (PAF) and persistent AF (PsAF) were enrolled between 2017 and 2021 across two private SA hospitals. …”
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Survival Status and Predictors of Mortality among Multidrug-Resistant Tuberculosis Patients in Saint Peter’s Specialized Hospital, Addis Ababa, Ethiopia by Mikyas Arega Muluneh, Abayneh Birlie Zeru, Behailu Tariku Derseh, Abebaw Molla Kebede

“…An institutional retrospective cohort study was conducted using all MDR-TB patients who were enrolled in Saint. Peter’s Specialized Hospital from January 01, 2015, to December 31, 2017. …”
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The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C∗07 Expression in Patients with Endometriosis by Wenrong Zhao, Lei Lei, Rui Chen, Yanmin Zhang, Linlin Chang, Jingxin Cheng

“…Then, an additional 22 patients and 26 healthy controls were enrolled to further verify the difference in the selected genes between endometriosis patients and healthy women. …”
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Epidemiology, clinical spectrum, and outcomes of severe malaria in Eastern Uganda: a prospective study by Cate Namayanja, George Paasi, Jimmy Patrick Alunyo, Denis Amorut, Charles Benard Okalebo, William Okiror, Paul Ongodia, Grace Abongo, Rita Muhindo, Yovani A. M. Lubaale, Peter Olupot-Olupot

“…Children aged 60 days to 12 years who at admission tested positive for malaria and fulfilled the clinical World Health Organization criteria for surveillance of severe malaria were enrolled into the study following appropriate informed consent. …”
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The Effect of Intravenous Metoclopramide on Pain, Nausea, Discomfort, and Ease of Insertion of Nasogastric Tube in Emergency Department: A Double-blind Randomized Clinical Trial by Seyed Mohammad Hosseininejad, Farzad Bozorgi, Asieh Khodami, Hamed Aminiahidashti, Mohammad Hajizade Juybari

“…Methods: In this randomized, double-blind, placebo-controlled trial, 80 patients referred to Imam Khomeini Hospital, Mazandaran Province, Iran were enrolled. Data were collected from December 2015 to March 2016. …”
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The serum level of sclerostin decreases in radiographic axial spondyloarthritis patients with fatty lesions by Xuegang Li, Haijian Jiang, Xu Wang, Shuping Zhong

“…Methods 73 r-axSpA patients were enrolled in this study. 48 and 25 patients were divided into r-axSpA group with and without fatty lesions. …”
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Incidence and Risk Factors of Ventilator-Associated Pneumonia among Patients with Delirium in the Intensive Care Unit: A Prospective Observational Study by Morteza Shamsizadeh, Ali Fathi Jouzdani, Farshid Rahimi-Bashar

“…A total of 108 patients with delirium were identified using the Confusion Assessment Method (CAM) for the ICU and Intensive Care Delirium Screening Checklist (ICDSC) and enrolled in this study. The association between VAP and delirium, risk factors, and outcomes (ICU length of stay and ICU mortality) for VAP were investigated using the Cox proportional hazards model and logistic and simple linear regression analyses with a 95% confidence interval. …”
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