Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade by Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

“…We evaluated the concentration of 37 cytokines and used cytometry by time of flight to characterize immune cell clusters and cell-surface expression markers at baseline and on-treatment.Results We enrolled 94 patients, of whom 30 (32%) were obese and 64 (68%) were non-obese. …”
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Inconsistencia del equilibrio parcial en la teoría del valor y su consistencia macroeconómica* by José Guillermo Peláez Gramajo

“…El pleno desarrollo de la incorporación del dinero dentro de la teoría del valor es mérito de Marx, quien introdujo el oro como moneda mercancía que tiene valor intrínseco. …”
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Prevalence and Intensity of Soil-Transmitted Helminths and Associated Factors among Adolescents and Adults in Bibugn Woreda, Northwest Ethiopia: A Community-Based Cross-Sectional S... by Abrham Goshu, Getaneh Alemu, Animen Ayehu

“…Using multistage proportionate sampling technique, 641 adolescents and adults were enrolled in this study. Data on sociodemographic characteristics and factors associated with helminthic infections was collected using structured questionnaire prepared in Amharic and administered through face-to-face interview. …”
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Rationale and design of a multicentre randomised controlled trial on circulating tumour DNA-guided neoadjuvant treatment strategy for locally advanced rectal cancer (CINTS-R) by Bin Wu, Yi Xiao, Xiao Zhang, Tao Xu, Qian Liu, Wei Fu, Yang An, Yongheng Li, Guole Lin, Huadan Xue, Guoju Wu, Jiaolin Zhou, Hongwei Yao, Zhenjun Wang, Weijie Chen, Junyang Lu, Guannan Zhang, Xiaoyuan Qiu

“…The trial will enrol 470 patients diagnosed with LARC (staged cT3-4N0 or cTanyN1-2) with tumours located ≤12 cm from the anal verge across seven centres in China. …”
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Caracterización clínico epidemiológica de UNA cohorte de pacientes con Artritis Reumatoide: Datos preliminares by Sonia Cabrera Villalba, Claudia Coronel, Lourdes Román, Vannia Valinotti, Angélica Amarilla, Mariela Zarza, Evelyn Leiva, Paola Pusineri, Raquel Aranda, Alexis Pineda, Gabriela Avila Pedretti, Paloma de Abreu

“…Más del 60% tenían al menos una comorbilidad, siendo la HTA y la obesidad las más frecuentes.…”
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Sistema de costos basado en actividades para establecimientos de alojamiento turístico by Marysela Morillo

“…El crecimiento vertiginoso de los servicios, especialmente de los turísticos, desde inicios del siglo XX, no puede pasar desapercibido por la contabilidad de costos; por el contrario ésta debe aplicar sus principios y características a dicho sector, dada su importancia en la economía mundial. Dentro de la actividad turística, aunque los servicios de recreación y transporte son considerados relevantes, el alojamiento constituye un gran soporte estratégico, por lo que el estudio de su gestión es vital para determinar y abordar problemas de dicha actividad. …”
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Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized control... by Chenhui Wang, Mengwei Yan, Yuru Li, Lei Han, Hongqian Wang, Shufeng Jia, Xingchen Liu, Yang Liu, Fan Wu, Baoguo Wang

“…Secondary outcomes included inflammation levels (hs-CRP, NLR, PLR, LMR), Chair Stand Test (CST), Timed Up and Go (TUG), 36-item short-form health survey (SF-36), Exercise Adherence Rating Scale (EARS), and adverse events.ResultsA total of 121 subjects were enrolled, with an average age of 81.2 years, and 80.2% were female. …”
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The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population by Neda K. Dezfuli, Ian M. Adcock, Shamila D. Alipoor, Sharareh Seyfi, Babak Salimi, Maryam Mafi Golchin, Neda Dalil Roofchayee, Mohammad Varhram, Esmaeil Mortaz

“…MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and may act as both tumor suppressors and as oncogenes. …”
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Effect of Dalmavital and Ovulik Plus on conception rate in Ovsynch synchronized Nili-Ravi buf- faloes by Muhammad Tayyab Khan, Muhammad Muzammal Niaz, Ghulam Shabbir Khan

“…For the Ovsynch protocol, buffaloes were administered with 2ml (IM) injection of GnRH (Lecirelin acetate 25μg/ml) at day 0, followed by 2ml (IM) injection of PGF2α (D-cloprostenol 75μg/ml) at day 7. …”
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Crystalloid resuscitation is associated with decreased treatment delays and improved systolic blood pressures in a blood-constrained setting by Melissa Carvalho, Alain Chichom-Mefire, Catherine Juillard, S Ariane Christie, Rasheedat Oke, Thompson Kinge, Jean-Gustave Tsiagadigui, Mbiarikai A Mbianyor, Mark T Yost, Matt Driban, Fanny Nadia Dissak Delon, Richard Njock, Daniel Nkusu

“…We hypothesized that more patients would receive crystalloid-based (CB) resuscitation with a faster time to administration than blood product (BL) resuscitation.Methods We included patients enrolled between 2017 and 2019 in the Cameroon Trauma Registry (CTR). …”
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Development and Validation of a Risk Prediction Model for Ventricular Arrhythmia in Elderly Patients with Coronary Heart Disease by Ying Dong, Yajun Shi, Jinli Wang, Qing Dan, Ling Gao, Chenghui Zhao, Yang Mu, Miao Liu, Chengliang Yin, Rilige Wu, Yuqi Liu, Yang Li, Xueping Wang

“…In the retrospective study, a total of 2231 consecutive elderly patients (≥60 years old) with CHD hospitalized were investigated, and finally 1983 patients were enrolled as the model group. The occurrence of VA within 12 months was mainly collected. …”
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Predictive value of bile acids as metabolite biomarkers for gallstone disease: A systematic review and meta-analysis. by Xu Han, Juan Wang, Yingnan Wu, Hao Gu, Ning Zhao, Xing Liao, Miao Jiang

“…<h4>Results</h4>A total of 30 studies were enrolled which included 2313 participants and reported the 39 BAs or their ratios. …”
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Sex-related functional outcome after periacetabular osteotomy in mild to severe hip dysplasia by Maximilian Fischer, Lars Nonnenmacher, Andre Hofer, Alexander Zimmerer, Andreas Nitsch, Rico Großjohann, Sabrina Erdmann, Georgi I. Wassilew

“…Methods: A single-centre study was conducted, enrolling patients undergoing PAO and completing a preoperative and postoperative radiological and clinical outcome assessment. …”
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Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia by Renata M. N. Eleutério, Francisco O. Nascimento, Tamara G. Araújo, Marilena F. Castro, Tarcísio P. Almeida Filho, Pedro A. Maia Filho, José Eleutério, Darcielle B. D. Elias, Romélia P. G. Lemes

“…This was a randomized double-blind clinical study of adults with SCA with continuous use of HU at the State Blood Centre of Ceará. The clinical study enrolled 25 patients receiving HU + L-arginine (500 mg) and 25 patients receiving HU + placebo. …”
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Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations by Muhammad Asif, Abrar Hussain, Abdul Wali, Nazeer Ahmed, Irfan Ali, Zafar Iqbal, Muhammad Amir, Muhammad Shafiq, Mahmood Rasool

“…In this study, 131 CML patients were enrolled. Complete blood cell count was performed at the time of diagnosis for all the patients. …”
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Del mito a la viralidad by Isabel Palomo-Domínguez

“…Desarrollo lógico del tema: En enero de 2021, la marca cervecera Cruzcampo lanzó una campaña publicitaria protagonizada por Lola Flores, artista española de fama internacional fallecida en 1995. …”
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Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis by Eun Hye Lee, Mi Hwa Shin, Se Hyun Kwak, Ji Soo Choi, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Young Sam Kim, Sang-Guk Lee, Moo Suk Park

“…Hence, we examined their potential as biomarkers of sepsis.MethodsIn total, 117 participants, including 20 healthy controls, 21 patients with systemic inflammatory response syndrome (SIRS), and 76 patients with sepsis, were enrolled in this study. Sepsis severity was assessed using the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA) scores.ResultsThe Median plasma EphA2 levels increased progressively from healthy controls to SIRS and sepsis cases (154.29, 293.52, and 554.24 pg/mL; all p &lt; 0.05). …”
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Clinical Characteristics of Metastatic Colorectal Cancer Combined with Gastrointestinal Perforation and Prognostic Value of Circulating Tumor DNA by Hong Yang, Dongwen Rong, Wenhui Yang

“…A total of 97 patients with metastatic colorectal cancer and gastrointestinal perforation were enrolled as the research objects between February 2016 and January 2019. …”
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Prediction of Inadequate Bowel Preparation Using Total and Segmental Colon Transit Time in Patients with Chronic Constipation: Some Different Outcomes by Chunying Zhai, Qiyang Huang, Ningli Chai, Wengang Zhang, Enqiang Linghu

“…A total of fifty-six patients with constipation and fifty-two healthy controls (HC) were enrolled in this study. All subjects underwent the colonic transit study using radio-opaque markers and were given a follow-up colonoscopy examination on day 3 to 7 to determine BBPS. …”
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Effect of HBeAg/anti-HBe coexistence on HBeAg seroconversion in treatment-naïve chronic hepatitis B patients with peginterferon-α by Kaimin Song, Huitong Wang, Dawu Zeng, Yunyun Qian, Zhixiang Guo, Huatang Zhang, Yijuan Zheng, Yongjun Zhou, Xueping Yu, Zhijun Su

“…Results: A total of 140 HBeAg-positive CHB patients were enrolled. Patients with HBeAg/anti-HBe coexistence accounted for 11.4% of HBeAg-positive patients, and their hepatitis B surface antigen (HBsAg) and HBeAg levels were significantly lower than those of anti-HBe negative patients, but the HBeAg seroconversion rate was higher after Peg-IFN-α treatment. …”
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