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21281
Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD
Published 2025-01-01“…This study investigates the relationship between Sirtuin 1 levels, BMD, and bone metabolism in newly diagnosed T2DM patients, specifically examining alterations in Sirtuin 1 levels in those with concomitant osteoporosis or osteopenia.MethodsA total of 69 newly diagnosed T2DM patients and 82 control subjects with normal glucose tolerance (NGT) were enrolled. Serum Sirtuin 1 levels and bone turnover markers, including osteocalcin (OC), procollagen type 1 N-terminal propeptide (P1NP), and β-C-terminal telopeptide of type I collagen (β-CTX), were measured using enzyme-linked immunosorbent assay (ELISA). …”
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21282
Goitre Prevalence and Urinary Iodine Concentration in School-Aged Children in the Ashanti Region of Ghana
Published 2020-01-01“…A total of 852 children were enrolled in the study. Thyroid volume and urinary iodine concentrations of the children were determined using the standardized methods recommended by WHO/ICCIDD. …”
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21283
Dysgeusia in MASLD-related advanced chronic liver disease (ACLD): a silent driver towards the “Bermuda” triangle of malnutrition-sarcopenia-frailty severely affecting prognosis
Published 2025-01-01“…Methods 200 MASLD patients [60 ≤ F3 fibrosis, 70 compensated ACLD (cACLD), and 70 decompensated (dACLD)] were enrolled. At baseline, the Child–Pugh (CP) score was determined. …”
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21284
Social determinants and follow-up care after emergency department discharge for traumatic intracranial hemorrhage
Published 2025-02-01“…Results: The average age of enrolled patients was 53 ± 20 years with 39 % female, 26 % Black, 69 % White, and 6 % Hispanic. …”
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21285
Integration of simulation-based medical education: Student satisfaction and self-confidence at Faculty of Medicine, Jazan University, Saudi Arabia
Published 2024-12-01“…These instruments were translated into Arabic and circulated among 532 medical students enrolled in the internal medicine clerkship courses. …”
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21286
Effect of Medication Management at Home via Pharmacist-Led Home Televisits: Protocol for a Cluster Randomized Controlled Trial
Published 2025-02-01“…The pilot phase of the study was completed December 2021 with 20 veterans and was primarily informed by the Steinman model of the prescribing process adapted to include system- and provider-level factors. The last date of enrollment was August 6, 2021. We anticipate the completion of the ongoing trial in spring 2025. …”
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21287
A comparative study on the efficacy of over-the-counter wax solvents versus distilled water for managing ear cerumen
Published 2024-04-01“…Materials and Methods: This double-masked, randomized prospective cohort study enrolled 236 patients seeking treatment for ear wax-related concerns at the Ear, Nose, Throat outpatient department. …”
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21288
Triatoma venosa and Panstrongylus geniculatus challenge the certification of interruption of vectorial Trypanosoma cruzi transmission by Rhodnius prolixus in eastern Colombia.
Published 2025-01-01“…For this, we designed a comprehensive, multi-faceted study in 6 rural villages and performed: (i) A cross-sectional serological and molecular study enrolling 155 people and 58 domestic dogs living within 80 households, (ii) a domestic entomological survey, (iii) a determination of the natural infection and blood meal source in collected triatomine bugs, and (iv) an evaluation of synanthropic mammal infection by parasitological and molecular tools. …”
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21289
The anti-circumsporozoite antibody response to repeated, seasonal booster doses of the malaria vaccine RTS,S/AS01E
Published 2025-02-01“…Anti-CSP antibody titres were measured in sera obtained from a randomly selected subset of children enrolled in this trial collected before and one month after three priming and four annual booster doses of vaccine using the GSK ELISA developed at the University of Ghent and, in a subset of these samples, by a multiplex assay developed at the University of Oxford. …”
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21290
Evaluation of Lyso-Gb1 as a biomarker for Gaucher disease treatment outcomes using data from the Gaucher Outcome Survey
Published 2025-01-01“…Results Of 2007 patients enrolled in the Gaucher Outcome Survey as of February 25, 2022, 435 met the inclusion criteria and were included in the study: 318 treated (‘all treated’; 277 receiving treatment at baseline, 41 treatment naive at baseline), 38 receiving treatment at baseline who stopped treatment before the last lyso-Gb1 assessment, and 79 untreated. …”
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21291
Primary repair vs arthroscopic reconstruction for proximal anterior cruciate ligament tears: a comparative study
Published 2024-12-01“…In the period from 2020 to 2023, we conducted randomized prospective multicenter control comparative study, which enrolled 170 patients with the ACL tear types A, B, E according to the Gächter classification. …”
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21292
The value of metagenomic next-generation sequencing in the diagnosis of fever of unknown origin
Published 2025-01-01“…In a single-centre retrospective cohort study, 263 FUO patients who underwent both mNGS and culture at the First Affiliated Hospital of Nanchang University were enrolled from December 2020 to February 2023. The sensitivity and specificity of culture and mNGS were analyzed based on the final clinical diagnosis as the gold standard to assess the diagnostic value of mNGS in FUO cases. …”
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21293
Relationship Between Short‐Term Outcomes and PD‐L1 Expression Based on Combined Positive Score and Tumor Proportion Score in Recurrent or Metastatic Head and Neck Cancers Treated W...
Published 2025-01-01“…Methods R/M‐HNSCC patients receiving APA monotherapy from 2018 to 2021 with available samples were enrolled. An experienced pathologist evaluated CPS and TPS utilizing the PD‐L1 IHC 22C3 pharmDx assay. …”
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21294
Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain
Published 2023-12-01“…**Methods:** Children were enrolled in this 24-month observational, multicentric, cross-sectional, retrospective study (N = 107) if they had been treated with biologic disease-modifying anti-rheumatic drugs (bDMARDs), had participated in a previous study (ITACA), and continued to be followed up at pediatric rheumatology units at 3 tertiary Spanish hospitals. …”
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21295
Efficacy and Safety of Risankizumab in Patients with Psoriasis Showing Suboptimal Response to Secukinumab or Ixekizumab: Results from a Phase 3b, Open-Label, Single-Arm (aIMM) Stud...
Published 2024-11-01“…Methods This 52-week, phase 3b study enrolled patients (≥ 18 years) with moderate-to-severe plaque psoriasis who had previously been treated with the recommended dose of secukinumab or ixekizumab for ≥ 6 months but did not achieve an optimal response (static Physician's Global Assessment [sPGA] 2/3; body surface are [BSA] 3– < 10%). …”
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21296
Perioperative Treatment with Rivaroxaban and Dabigatran on Changes of Coagulation and Platelet Activation Biomarkers following Left Atrial Appendage Closure
Published 2024-01-01“…A total of 120 nonvalvular atrial fibrillation patients intolerant of long-term anticoagulants, who underwent successful WATCHMAN closure implantation, were enrolled (rivaroxaban, n=82; dabigatran, n=38). Blood samples were obtained from left atrium (LA) and left atrial appendage (LAA) during the operation and fasting blood samples on the same day of LAAC and 45 days after discharge. …”
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21297
Unlocking the power of population health management to strengthen primary health care
Published 2025-07-01“…Resumen: La gestión poblacional de la salud (GPS) es un enfoque proactivo, centrado en las personas y basado en los datos para mejorar la salud y el bienestar de una población determinada, teniendo en cuenta las diferencias dentro de esa población y sus determinantes sociales de la salud. …”
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21298
Factors Associated With Adolescents' Human Papillomavirus Vaccination Intention: A Cross‐Sectional Survey
Published 2024-12-01“…Methods 119 adolescents ages 11–17 years who had not received any HPV vaccine were enrolled. Purposive sampling was used to recruit participants from community and clinical settings, with the majority of households located in economically disadvantaged neighbourhoods in a southwest state. …”
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21299
Relationship between stress hyperglycemia ratio and progression of non target coronary lesions: a retrospective cohort study
Published 2025-01-01“…Methods This study retrospectively enrolled patients diagnosed with acute coronary syndrome who underwent stent implantation and follow-up evaluations by coronary angiography at Zhongda Hospital between January 2019 and January 2024. …”
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21300
Bacterial Profile and Antibiotic Susceptibility Pattern of Urinary Tract Infection among Pregnant Women Attending Antenatal Care at a Tertiary Care Hospital in Southern Ethiopia
Published 2020-01-01“…A cross-sectional study was conducted in which consecutive pregnant women enrolled in the study from March to June 2019. The structured questionnaire used to collect sociodemographic and clinical data in a face-to-face interview. …”
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