A contribuição do Programa ALI Produtividade para as micro e pequenas empresas da Região Central do estado do Rio Grande do Sul by Camila de Freitas Santos, Rafael Mozart da Silva

“…Como resultado, observou-se que mais de 94% dessas empresas apresentaram variação positiva em pelo menos uma dimensão analisada e que mais de 82% tiveram aumento do indicador de Produtividade após a conclusão da Jornada de Inovação, com destaque para o ganho de maturidade, ou seja, houve mudanças voltadas a processos e estratégias e com clareza de objetivos, permitindo assim resultados ainda mais consistentes. …”
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A prospective model of the potential clinical and economic impact of cervical cancer screening supported by a mobile phone app. by Fredrick Chite Asirwa, Brian W Bresnahan, Faith Yego, Dana Duncan, James K Karichu, Louis P Garrison

“…<h4>Results</h4>In a simulated cohort of women using the app-based intervention compared to conventional care, with 10,000 women in each arm, use of the app is projected to increase healthcare costs by $12.53 per enrolled woman during the trial period and to detect and treat an additional 247 women-229 with precancerous cervical lesions and 18 with cervical cancer. …”
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Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

“…Objective Assess long-term safety, tolerability and efficacy of bimekizumab in ankylosing spondylitis (radiographic axial spondyloarthritis (r-axSpA)).Methods Patients with active r-axSpA completing the dose-ranging 48-week randomised controlled trial could enrol in the open-label extension, where patients received bimekizumab 160 mg every 4 weeks. …”
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A Prospective Study of Lumbar Facet Arthroplasty in the Treatment of Degenerative Spondylolisthesis and Stenosis: Early Cost-effective Assessment from the Total Posterior Spine Sys... by Jared D. Ament, Amir Vokshoor, Yaser Badr, Todd Lanman, Kee D. Kim, J. Patrick Johnson

“…**Methods:** The study patient population was extracted from a multicenter RCT with current enrollment at n=121 with complete 1-year follow-up. …”
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The Prevalence of Intestinal Parasites and Their Associated Factors among Diabetes Mellitus Patients at the University of Gondar Referral Hospital, Northwest Ethiopia by Sintayehu Ambachew, Muluneh Assefa, Yalewayker Tegegne, Ayalew Jejaw Zeleke

“…A total of 234 diabetes mellitus patients were enrolled. A systematic random sampling technique was used to select study participants. …”
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Neural structural alterations correlates of quadriceps muscle strength deficits in patients after anterior cruciate ligament reconstruction by Le Yu, Shanshan Zheng, Yushi Chen, Xiao'ao Xue, Zikun Wang, JiaYan Cheng, Yang Sun, He Wang, Yinghui Hua

“…Methods: Twenty-nine participants who had undergone unilateral ACLR (29 males; age = 32.61 ± 6.72 years) were enrolled in a cross-sectional investigation. We chose CST as a region of interest and performed diffusion tensor imaging (DTI) that measured the microstructure of white matter tracts. …”
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Physical and Sensory Long-Term Disabilities from <i>Bothrops</i> Snakebite Envenomings in Manaus, Western Brazilian Amazon by Eduardo M. G. Fernández, Débora N. Oliveira, Alexandre V. Silva-Neto, Rafaela N. Dávila, Ligia Lengler, Marco A. Sartim, Altair S. Farias, Luiz C. L. Ferreira, Érica da Silva Carvalho, Fan H. Wen, Felipe Murta, Fernando Almeida-Val, Manuela B. Pucca, Jacqueline A. G. Sachett, Wuelton M. Monteiro

“…Fifty participants were enrolled. A frequency of 20% of the participants reported difficulty in moving the affected limb (20%), and 23.7% reported difficulty in walking. …”
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Function and Morphology of the Meibomian Glands Using a LipiView Interferometer in Rotating Shift Medical Staff by Jing Zhang, Zhengzheng Wu, Liangnan Sun, Xin-hua Liu

“…Sixty-two eyes of 31 patients in the MS group and 59 eyes of 31 patients in the control group were consecutively enrolled. All participants completed Ocular Surface Disease Index (OSDI) and Standard Patient Dry Eye Evaluation (SPEED) questionnaires for dry eye severity, as well as Schirmer I and tear break-up time (TBUT) tests. …”
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The Role of Omega-3 Polyunsaturated Fatty Acids in Patients with Metabolic Syndrome and Endothelial Dysfunction by Andrej Dzupina, Dominik Pella, Pavol Zenuch, Zuzana Zenuchova, Jaipaul Singh, Monika Jankajova, Jan Fedacko

“…<i>Materials and Methods:</i> A total of 80 patients with MS were enrolled in two groups. The study evaluated endothelial function (EF) in subjects before and after a three-month treatment with n-3 PUFAs in a dose of 2.4 g daily (800 mg, three times a day) vs. placebo, using an Endo-PAT2000 device (Itamar Medical Ltd., Caesarea, Israel) measuring the reactive hyperemia index (a parameter of EF) and augmentation index (a parameter of arterial stiffness). …”
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Elastosonographic Evaluation of Endometrium in Postmenopausal Bleeding by İsmail Burak Gültekin, Orhan Altınboğa, Serap Gültekin, Elif Akkaş Yılmaz, Gökşen İnanç İmamoğlu, Afra Alkan, Tuncay Küçüközkan

“…STUDY DESIGN: A total of 80 women in their postmenopausal period were enrolled for the study; 19 with postmenopausal bleeding and 61 normal healthy controls. …”
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Semen Parameters Can be Used as a Credible Marker with Doppler Ultrasonography in the Diagnosis of Subclinical Varicocele Cases by Tulay Irez, Bahar Sarikaya, Mine Erguven, Emre Salabas

“…STUDY DESIGN: The current prospective cohort study included infertile male patients (n=44) enrolled in the Urology Clinic of Biruni University Hospital from January 2017 to January 2018. …”
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Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

“…This led to a phase 1b clinical trial to determine the safety, tolerability, and immunologic effects of ibrutinib treatment in patients with advanced PDAC.Methods Previously untreated patients with PDAC were enrolled in a phase 1b clinical trial (ClinicalTrials.gov) to determine the safety, toxicity, and maximal tolerated dose of ibrutinib when administered with the standard regimen of gemcitabine and nab-paclitaxel. …”
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Sex Disparity in Characteristics, Management, and In-Hospital Outcomes of Patients with ST-Segment Elevated Myocardial Infarction: Insights from Henan STEMI Registry by Shan Wang, You Zhang, Qianqian Cheng, Datun Qi, Xianpei Wang, Zhongyu Zhu, Muwei Li, Junhui Zhang, Dayi Hu, Chuanyu Gao, On behalf of Henan STEMI registry study group

“…We analyzed 5063 STEMI patients prospectively enrolled from 66 hospitals during 2016–2018 and compared sex differences in mortality, death, or treatment withdrawal and main adverse cardiovascular and cerebrovascular events (MACCE) using the generalized linear mixed model, following sequential adjustment for covariates. …”
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Twelve-Week Quadriceps Strength as A Predictor of Quadriceps Strength At Time Of Return To Sport Testing Following Bone-Patellar Tendon-Bone Autograft Anterior Cruciate Ligament Re... by Joseph P Hannon, Sharon Wang-Price, Shiho Goto, Steven Singleton, Lindsey Dietrich, James Bothwell, Curtis Bush, Craig Garrison

“… # Study Design Cohort Study # Methods A total of 120 participants (males = 55; females =65) were enrolled in the study (age = 16.1±1.4 yrs; height = 1.72±10.5 m; mass = 70.7±16.3 kg). …”
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Cross-Sectional Relationship between Carotid-Femoral Pulse Wave Velocity and Biomarkers in Vascular-Related Diseases by Jinbo Liu, Kuanting Wang, Huan Liu, Hongwei Zhao, Wei Huang, Na Zhao, Lihong Li, Hongyu Wang

“…Methods. 656 subjects were enrolled into our study. There were 377 patients with hypertension, 231 with coronary heart disease, 154 with diabetes mellitus, and 186 healthy subjects. …”
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El poder biopolítico oculto de la arquitectura. La descajanegrización del túnel entre dos edificios brutalistas en un campus de Berlín by Jorge Caminero Gabernet, Atxu Amann Alcocer

“…Descajanegrizar esta escenografía construida del dominio y el uso de los animales por los humanos y de su apropiación bajo el pretexto de ser el objeto de estudio por la ciencia, permite explorar desde un enfoque más-que-humano las relaciones que se establecen entre naturaleza, cultura y arquitectura. Dentro de una relación biotecnológica entre estos tres ámbitos, se puede desarrollar una aproximación crítica a la arquitectura, no desde las variables formales, lingüísticas o urbanísticas, sino desde su consideración como dispositivo de control biopolítico sobre las entidades de naturaleza no humana. …”
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Biomasa acumulada e indicadores de calidad nutritiva en cebadilla chaqueña (Bromus auleticus Trinius ex Nees) by E.G.R. BUSTAMANTE, M.A. RUIZ, E. MORICI, F.J. BABINEC, A.B. PORDOMINGO

“…Los clones U presentaron mayor PB, menor FDN y mayor DMS. Dentro de cada origen, los argentinos presentaron menos diferencias que los uruguayos, tanto en biomasa acumulada como en calidad. …”
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A maChine and deep Learning Approach to predict pulmoNary hyperteNsIon in newbornS with congenital diaphragmatic Hernia (CLANNISH): Protocol for a retrospective study. by Ilaria Amodeo, Giorgio De Nunzio, Genny Raffaeli, Irene Borzani, Alice Griggio, Luana Conte, Francesco Macchini, Valentina Condò, Nicola Persico, Isabella Fabietti, Stefano Ghirardello, Maria Pierro, Benedetta Tafuri, Giuseppe Como, Donato Cascio, Mariarosa Colnaghi, Fabio Mosca, Giacomo Cavallaro

“…<h4>Methods and analytics</h4>Patients with isolated CDH from singleton pregnancies will be enrolled, whose prenatal checks were performed at the Fetal Surgery Unit of the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milan, Italy) from the 30th week of gestation. …”
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Novel Models for the Prediction of Left Atrial Appendage Thrombus in Patients with Chronic Nonvalvular Atrial Fibrillation by Do Van Chien, Pham Thai Giang, Pham Truong Son, Le Van Truong, Pham Nguyen Son

“…In this study, we sought to develop new and simpler models for LAAT prediction in chronic nonvalvular atrial fibrillation. The study enrolled 144 patients with chronic nonvalvular atrial fibrillation who underwent transesophageal echocardiography for LAAT detection. …”
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Heatwave warnings mitigate long-term cardiovascular diseases risk from heat-related illness: a real-world prospective cohort studyResearch in context by Qi Huang, Limei Ke, Linfeng Liu, Yuyang Liu, Yanjun Li, Guoqing Feng, Bo Yin, Wenxin Xiang, Jiarun Li, Keyi Lyu, Miao Wang, Qiannan Tian, Liqun Wu, Xiaofeng He, Wannian Liang, Huatang Zeng, Jiming Zhu, Kuiying Gu, Qian Di

“…Methods: Our cohort study enrolled 9,658,745 participants free of cardiovascular disease (CVD) at baseline from 1332 hospitals and 922 primary care centres in Shenzhen, China. …”
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