Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma by Wei Gao, Tong Ding, Beicheng Sun, Nan Li, Fang Gao, Meng Jia, Mitchell Ho, Na Li, Luan Sun, Zhanhui Gao, Lei Ao, Sujuan Ma, Peihua Lu, Shaochang Jia

“…Therefore, sGPC3 acted as dominant negative regulators when competed with cell surface GPC3 to bind anti-GPC3 CAR-T cells, leading to an inhibitory effect on CAR-T cells in HCC.Conclusions We provide a proof-of-concept study demonstrating that GPC3 shedding might cause worse response to CAR-T cell treatment by competing with cell surface GPC3 for CAR-T cell binding, which revealed a new mechanism of tumor immune escape in HCC, providing a novel biomarker for patient enrolment in future clinical trials and/or treatments with GPC3-targeted CAR-T cells.…”
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PET/CT-derived coronary calcium score may predict cardiac complications in anthracycline-treated patients with lymphoma by Genevieve Douglas, Zoe Loh, Evonne S.Y. Shum, Sze-Ting Lee, Niamh Waters, Garry Hamilton, Geoffrey Chong, Alexandra C. Murphy, Eliza A. Hawkes

“…Our study aimed to evaluate whether CACS obtained from pretreatment positron emission tomography (PET)/computed tomography (CT) scans could stratify cardiac event risk in patients with lymphoma receiving anthracycline-based chemotherapy. We enrolled 358 consecutive patients with lymphoma treated between 2012 and 2022, calculating the CACS from their pretreatment PET/CT. …”
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Femtosecond Laser Implantation of a 355-Degree Intrastromal Corneal Ring Segment in Keratoconus: A Three-Year Follow-Up by Marwa Mahmoud Abdellah, Hatem Gamal Ammar

“…Results. 38 eyes of 26 patients with mean age 25.92 ± 5.44 years were enrolled in the study, 11 were males (42.3%). The mean UCVA improved from 0.93 ± 0.21 to 0.63 ± 0.21 logMAR (P≤0.001) and the mean BCVA from 0.67 ± 0.22 to 0.43 ± 0.26 logMAR (P<0.001). …”
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Clinical implication of NT-proBNP to predict mortality in patients with acute type A aortic dissection: a retrospective cohort study by Rui Zhang, Hao Wang, Chenxi Song, Rui Fu, Kefei Dou, Shuai Liu, Qianqian Liu, Xiaohui Bian, Weida Liu, Chengang Zhu, Jingjing Gao, Sheng Yuan, Xinming Cui, Sijia Qin, Yumeng Li

“…We aimed to investigate the prognostic value of N-terminal pro-B type natriuretic peptide (NT-proBNP) among this critically ill population.Design The design of this study was a retrospective cohort study.Setting The study population was recruited in the Emergency Department of Fuwai hospital in China from 2018 to 2020.Participants We consecutively enrolled 829 patients with acute type A aortic dissection and measurable baseline NT-proBNP.Primary outcome The primary endpoint was 1-year all-cause death.Results Based on tertiles of NT-proBNP (pg/mL), patients were stratified into low (≤150.3, n=276), intermediate (150.3–667.6, n=277) and high (&gt;667.6, n=276) NT-proBNP groups. …”
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Strategic foresight of staffing needs of innovative development of socio-economic systems by Elena Okunkova

“…A number of methodological problems of the existing systems of providing innovative economy in a personnel has been revealed, described and systematized: the forecast of balance of a labor resources does not consider changes of working conditions, modernization of production assets and new technologies; planning of target figures of enrollment of students for master programs is performed in a separation from real personnel requirements; lack of criteria system of detection of competence-based requirements of innovative economy; the imminent need of transition from scenario approach of forecasting of needs of economy for professional staff to approach “a threefold spiral”. …”
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Alcances del derecho a la salud en colombia: una revisión constitucional, legal y jurisprudencial by Elena Cárdenas Ramírez

“…Sin embargo, para su protección se ha hecho necesario la utilización de la acción de tutela, que durante estos últimos veinte años ha ido aumentando hasta llegar a más de tres millones de tutelas ante las constantes negaciones de los servicios de salud, ya sea que estén contemplados o no dentro del plan obligatorio de salud. Este trabajo pretende revisar la evolución del derecho a la salud desde tres puntos de vista: constitucional, legal y jurisprudencial, durante estos últimos 20 años.…”
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Impact of mild hypothermic circulatory arrest on surgical outcomes in acute type a aortic dissection patients: a single-centre study by Zhenxiong Li, Hao Tang, Chao Deng, Kangjun Shen, Jingyu Li, Song Tian, WenYao Zhan, Ling Tan

“…Methods Acute type A aortic dissection (ATAAD) patients who underwent total arch replacement (TAR) and frozen elephant trunk (FET) surgery between January 2014 and December 2023 were enrolled in this study. The patients were divided into two groups according to the minimum nasopharyngeal temperature: the moderate hypothermic circulatory arrest (MHCA) group (20–28 °C) and the MI-HCA group (> 28 °C). …”
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Efficacy and Safety of Allisartan Isoproxil/Amlodipine in Patients With Essential Hypertension Uncontrolled by Amlodipine: A Phase III, Multicenter, Double‐Blind, Parallel‐Group, R... by Hongjie Chi, Xin Zhang, Shumei Ma, Gang Pan, Xiaojuan Lian, Yan Chen, Haotian Pei, Zichen Liu, Xiangmin Lin

“…A total of 300 patients were enrolled, with 149 and 151 patients randomly assigned to ALI/AML and AML groups, respectively. …”
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A Preliminary Screening Tool for High-Risk Frailty in Older Adults Patients with Pulmonary Tuberculosis by Li HJ, Zhou YY, Yu HH, Jiang J, Cai YW

“…Hui-Juan Li, Yue-Ying Zhou, He-He Yu, Jian Jiang, Yu-Wei Cai Department of Infectious Diseases, Wenzhou Central Hospital, Wenzhou, People’s Republic of ChinaCorrespondence: Yue-Ying Zhou, Department of Infectious Diseases, Wenzhou Central Hospital, No. 252 Baili East Road, Lucheng District, Wenzhou City, 325000, People’s Republic of China, Tel +86-0577-88882121, Email zhouyueying25@163.comObjective: To understand the current status and analyse the factors influencing frailty in older adults patients with pulmonary tuberculosis.Methods: This retrospective case-control study included 204 older adults patients with pulmonary tuberculosis. The enrolled patients were divided into a frailty group (n = 101) and a non-frailty group (n = 103). …”
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Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects by Ada Alice Dona, Theophilus Tandoh, Lokesh Nigam, Mahmoud Singer, Enrico Caserta, Mariam Murtadha, Yinghui Zhu, Milad Moloudizargari, Preeti Sharma, Ottavio Napolitano, Janet Winchester, Arnab Chowdhury, Alex Pozhitkov, James F. Sanchez, Hawa Vahed, Guido Marcucci, Matt Coffey, Gerard Nuovo, Douglas W. Sborov, Flavia Pichiorri, Craig C Hofmeister

“…T-cell receptor (TCR) sequencing was also conducted both in immune competent MM mice and in patients enrolled in a phase 1b trial per a standard 3 + 3 dose escalation schedule. …”
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NEODUALISMO VERSUS HETEROGEIDAD: el caso de la pequena producción agraria em la Argentina by Pedro Tsakoumagkos

“…C) Los sujetos de la pequeña producción agraria em la Argentina pueden ser produtores agropecuários exclusivos o desarrollar estratégias caracterizadas por uma pluralidad de posiciones em le proceso de reproducción social a escala familiar. Dentro de la coherencia de la unidad familiar, las fuentes de ingresso pueden ser laborales o no, prediales o no, agrarias o no, etc. …”
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Epidemiology of community-acquired pneumonia among hospitalised children in Indonesia: a multicentre, prospective study by Rina Triasih, Yan Mardian, Dewi Lokida, Helmia Farida, Herman Kosasih, Adhella Menur Naysilla, Arif Budiman, Chakrawati Hayuningsih, Moh Syarofil Anam, Dwi Wastoro, Mujahidah Mujahidah, Setya Dipayana, Amalia Setyati, Abu Tholib Aman, Nurhayati Lukman, Muhammad Karyana, Ahnika Kline, Aaron Neal, Chuen-Yen Lau, Clifford Lane

“…We applied a previously published algorithm (PEER-PePPeS rules) to determine the causative pathogen(s).Results 188 subjects were enrolled. Based on our algorithm, 48 (25.5%) had a bacterial infection, 31 (16.5%) had a viral infection, 76 (40.4%) had mixed bacterial and viral infections, and 33 (17.6%) were unable to be classified. …”
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DNA copy number variations and craniofacial abnormalities in 1,457 children with neurodevelopmental disorders by Dandan Wu, Ran Chen, Jerry Zhang, Wu Yan, Mengyin Chen, Dongqing Xia, Xiaonan Li, Yanyan Dai, Yinhua Chen, Rong Li

“…Regarding the pathogenicity of CNVs, 91 (57.96%, 91/157) were identified as pathogenic, 28 (17.83%, 28/157) as variants of uncertain clinical significance (VOUS), and 38 (24.20%, 38/157) as benign according to the American College of Medical Genetics and Genomics (ACMG).Using a specific sign-scoring scale, the proportion of pathogenic CNVs in children graded 1 point or higher (64%, 58/91) was significantly higher than that of non-pathogenic CNVs (43%, 29/66) (P < 0.05). …”
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Appropriate Timing of Gestational Diabetes Mellitus Diagnosis in Medium- and Low-Risk Women: Effectiveness of the Italian NHS Recommendations in Preventing Fetal Macrosomia by Paola Quaresima, Federica Visconti, Eusebio Chiefari, Maria Mirabelli, Massimo Borelli, Patrizia Caroleo, Daniela Foti, Luigi Puccio, Roberta Venturella, Costantino Di Carlo, Antonio Brunetti

“…Patients and Methods. We retrospectively enrolled 769 consecutive singleton pregnant women who underwent both anomaly scan at 19-21 weeks of gestation and screening for GDM at 16-18 and/or 24-28 weeks of gestation, in agreement with the NHS recommendations and risk stratification criteria. …”
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Héctor y el Norte by Diego Bravo Fuenzalida

“…Esta historia se desarrolla en el contexto de significativos cambios organizativos dentro de Codelco, el mayor productor de cobre del mundo. …”
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The relationship between self-perception of smile aesthetics and personality traits of university students: A cross-sectional study by Claudia Denisse Piscoche-Rodríguez, Livia Sonia Zambrano de la Peña, Maria Eugenia Guerrero, Dian Agustin Wahjuningrum, Novaldy Wahjudianto, Karissa Navita Saragih

“…This study used an observational design, and an electronic research form distributed via the institutional email addresses of the first-year undergraduate students enrolled at Universidad Nacional Mayor de San Marcos in 2021. …”
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Early COVID-19 and protection from Omicron in a highly vaccinated population in Ontario, Canada: a matched prospective cohort study by Altynay Shigayeva, Christopher Kandel, Lubna Farooqi, Zoe Zhong, Anne-Claude Gingras, Brenda L. Coleman, Lois Gilbert, Wayne L. Gold, Maria Major, Tony Mazzulli, Samira Mubareka, Jelena Vojicic, Jingyan Yang, Pingping Zhang, Catherine Martin, Moe H. Kyaw, John M. McLaughlin, Allison McGeer

“…We assessed whether early COVID-19 provided protection against Omicron infection. Methods We enrolled a cohort of adults in Ontario, Canada, with COVID-19 prior to October 2020 (early infection, EI), and a matched cohort with COVID-19 testing and a negative PCR (non-EI). …”
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Right ventricular mechanical pattern in patients undergoing mitral valve surgery: a predictor of post‐operative dysfunction? by Márton Tokodi, Endre Németh, Bálint K. Lakatos, Erika Kispál, Zoltán Tősér, Levente Staub, Kristóf Rácz, Ádám Soltész, Szabolcs Szigeti, Tamás Varga, János Gál, Béla Merkely, Attila Kovács

“…Methods and results We prospectively enrolled 42 patients (63 ± 11 years, 69% men) undergoing open‐heart MVR. …”
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Joint fluid multi-omics improves diagnostic confidence during evaluation of children with presumed septic arthritis by Yolanda Peña-López, Naureen G. Tareen, Bo Zhang, Indu Raman, Carlos A. Arana, Chengsong Zhu, Yang Liu, Pratibha Selvakumar, Nicolai S. C. van Oers, Simrat Morris, Lora V. Hooper, Lawson A. B. Copley, Prithvi Raj

“…Methods Twelve children with suspected septic arthritis were prospectively enrolled to compare standard of care tests with a rapid multi-omics approach. …”
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Efficacy Of Vocal Cord Medialization by Injection Thyroplasty Using Liquid Paraffin In Relieving Hoarseness Of Voice In Idiopathic And Traumatic Unilateral Vocal Cord Paralysis by Muhammad Saleem, Muhammad Sarim Khan, Ashar Alamgir, Muhammad Hamza Rana, Hafiz Sajjad Hyder, Syeda Jamila Ali

“…Methodology: A total of 37 patients were enrolled in the study after obtaining approval from the ethical review board. …”
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