Wartime activities of the Vavilov Institute by I. G. Loskutov

“…In the harsh reality of the winter in 1941–1942, the daily bread rationing was cut down, and hunger raged in the city, killing tens of thousands of city residents, including VIR employees who kept the stored seeds and tubers untouched. …”
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Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study by Kaylie I. Kirkwood-Donelson, Alan K. Jarmusch, Carl D. Bortner, Bruce Alex Merrick, Birandra K. Sinha

“…Erastin (ER), a ferroptosis inducer, kills tumor cells by generating and accumulating reactive oxygen species (ROS) within the cell, resulting in an iron-dependent oxidative damage-mediated ferroptotic cell death.MethodsWe have utilized human ovarian cancer cell lines, OVCAR-8 and its adriamycin-selected, multi-drug resistance protein (MDR1)-expressing NCI/ADR-RES, both equally sensitive to ER, to identify metabolic biomarkers of ferroptosis.ResultsOur studies showed that ER treatment rapidly depleted cellular glutathione and cysteine and enhanced formation of ophthalamate (OPH) in both cells. …”
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Dysregulated Circulating Dendritic Cell Function in Ulcerative Colitis Is Partially Restored by Probiotic Strain Lactobacillus casei Shirota by Elizabeth R. Mann, Jialu You, Verena Horneffer-van der Sluis, David Bernardo, Hafid Omar Al-Hassi, Jon Landy, Simon T. Peake, Linda V. Thomas, Cheng T. Tee, Gui Han Lee, Ailsa L. Hart, Parveen Yaqoob, Stella C. Knight

“…Human blood DC from healthy controls (control-DC) and UC patients (UC-DC) were conditioned with heat-killed LcS and used to stimulate allogeneic T cells in a 5-day mixed leucocyte reaction. …”
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Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice by Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng

“…Env–gag virus-like particles (VLPs) were generated through co-transfection with env and gag mRNA vaccines. …”
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Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency by Tim Heemskerk, Gerarda van de Kamp, Marta Rovituso, Roland Kanaar, Jeroen Essers

“…Background and purpose: Radiotherapy induces tumor cell killing by generating DNA double strand breaks (DSBs). …”
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Genetically Engineered Bacterial Ghosts as Vaccine Candidates Against <i>Klebsiella pneumoniae</i> Infection by Svetlana V. Dentovskaya, Anastasia S. Vagaiskaya, Alexandra S. Trunyakova, Alena S. Kartseva, Tatiana A. Ivashchenko, Vladimir N. Gerasimov, Mikhail E. Platonov, Victoria V. Firstova, Andrey P. Anisimov

“…Previously, this kit made it possible to generate bacterial cells of <i>Yersinia pestis</i> with varying degrees of hydrolysis and variable protective activity. …”
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Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans by Mariano A. Aufiero, Li-Yin Hung, De'Broski R. Herbert, Tobias M. Hohl

“…We found that Mpeg1−/− mice generated on a mixed C57BL/6J-DBA/2 background exhibited enhanced survival, reduced lung fungal burden, and greater neutrophil fungal killing activity compared to wild-type C57BL/6J (B6) mice, suggesting that Perforin-2 may impair antifungal immune responses. …”
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Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia by Haotian Ma, Zhifeng Yan, Runxia Gu, Yingxi Xu, Shaowei Qiu, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Min Wang, Jianxiang Wang

“…All CAR-T cells were generated by lentivirus transduction of T cells from healthy donors. …”
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TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…To generate an ‘off-the-shelf’ multitargeting Ag-scaffold product of relevance to patients with metastatic melanoma, we identified the 30 most frequently recognized shared HLA-A0201-restricted melanoma epitopes in a cohort of 87 patients. …”
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La transformation de l’ancien centre de détention secrète de Derb Moulay Cherif en musée des « années de plomb » (Casablanca, Maroc) by Anissa Habane

“…For several decades, this secret site, the centerpiece of the repressive system, held, tortured and killed political activists, union members and student activists, as well as random individuals. …”
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Assessing the Future ODYSEA Satellite Mission for the Estimation of Ocean Surface Currents, Wind Stress, Energy Fluxes, and the Mechanical Coupling Between the Ocean and the Atmosp... by Marco Larrañaga, Lionel Renault, Alexander Wineteer, Marcela Contreras, Brian K. Arbic, Mark A. Bourassa, Ernesto Rodriguez

“…Over the past decade, several studies based on coupled ocean–atmosphere simulations have shown that the oceanic surface current feedback to the atmosphere (CFB) leads to a slow-down of the mean oceanic circulation and, overall, to the so-called eddy killing effect, i.e., a sink of kinetic energy from oceanic eddies to the atmosphere that damps the oceanic mesoscale activity by about 30%, with upscaling effects on large-scale currents. …”
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Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity by Congcong Zhang, Anja Waldmann, Winfried S Wels, Jasmin Röder, Anne Scherer, Malena Bodden, Jordi Pfeifer Serrahima, Anita Bhatti, Nina Müller, Pranav Oberoi

“…Furthermore, NKAB-ErbB2 synergized with NK-92 cells or primary T cells engineered to express an NKG2D-CD3ζ chimeric antigen receptor (NKAR), leading to targeted cell killing and greatly enhanced antitumor activity, which remained unaffected by soluble MICA known as an inhibitor of NKG2D-mediated natural cytotoxicity. …”
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Educide amid conflict: the struggle of the Palestinian education system by Dalal Iriqat, Rula Alousi, Tahani Z. Aldahdouh, Alaa AlDahdouh, Iman Dankar, Dima Alburai, Mohamed Buheji, Abdo Hassoun

“…The study documents the systematic destruction of educational infrastructure, including schools and universities, as well as the targeted killing of students and educators, which impedes current and future access to education. …”
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