Modeling and simulation for toxicity assessment by Cristina Anton, Jian Deng, Yau Shu Wong, Yile Zhang, Weiping Zhang, Stephan Gabos, Dorothy Yu Huang, Can Jin

“…Using stability analysis and numerical simulations, we determine the lowest concentration of toxin that can kill the cells. This information can be used to better design experimental studies for cytotoxicity profiling assessment.…”
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Novel Antibiotic Combinations of Diverse Subclasses for Effective Suppression of Extensively Drug-Resistant Methicillin-Resistant Staphylococcus aureus (MRSA) by Shumyila Nasir, Muhammad Sufyan Vohra, Danish Gul, Umm E Swaiba, Maira Aleem, Khalid Mehmood, Saadia Andleeb

“…First-line β-lactams of lower generations can be used effectively against MRSA infection when used in combination. …”
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<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells by V. G. Subrakova, S. V. Kulemzin, T. N. Belovezhets, A. N. Chikaev, N. A. Chikaev, O. A. Koval, A. A. Gorchakov, A. V. Taranin

“…NK lymphocytes are known to kill cancer cells expressing a number of stress ligands; and the balance of signals from inhibitory and activating receptors on the surface of the NK cell determines whether a cytotoxic reaction is triggered. …”
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Inhibition and evasion of neutrophil microbicidal responses by Legionella longbeachae by Hannah E. Hanford, Christopher T. D. Price, Silvia Uriarte, Yousef Abu Kwaik

“…Consequently, infected neutrophils fail to generate robust ROS in response to L. longbeachae. …”
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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…It can selectively release Ca2+ and generate H2O2 in the tumor microenvironment (TME) by acid-triggered degradation of the two-layer protective shell (ie, unlocking the “double-lock”). …”
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Defective production of interferon-γ and tumour necrosis factor-α by AIDS mononuclear cells after in vitro exposure to Rhodococcus equi by S. Delia, C. M. Mastroianni, M. Lichtner, F. Mengoni, S. Moretti, V. Vullo

“…PBMCs from healthy donors secreted elevated levels of IFN-γ and TNF-α when challenged in vitro with killed R. equi, whereas the release of both cytokines was impaired in supernatant cultures from AIDS patients. …”
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Synthesis and Characterization of Nickel Nanoparticles: Biological and Photocatalytic Properties by Fadliah Fadliah, Indah Raya, Ahyar Ahmad, Paulina Taba, Muhammad Burhanuddinnur, Maming Gaffar, Tri Widayati Putri, Arfiani Nur, Andi Nur Fitriani Abubakar, Rachmin Munadi, Ahmad Fudhail Majid, Irham Pratama, M. Yasser, Sulistiani Jarre, Harningsih Karim

“…We also investigate the possibility of using the generated nickel nanoparticles as a cytotoxic, photocatalytic, antioxidant, and antibacterial agents. …”
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Mechanism(s) of Toxic Action of Zn2+ and Selenite: A Study on AS-30D Hepatoma Cells and Isolated Mitochondria by Elena A. Belyaeva, Nils-Erik L. Saris

“…High [mu]M concentrations of Zn2+ or selenite were strongly cytotoxic, killing the AS-30D cells by both apoptotic and necrotic ways. …”
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Editorial by Jörg Tremmel, Markus Rutsche

“…We should protect future generations from foreseeable damage if we have the power to do so. …”
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Bouwen aan morgen met het bouwmateriaal van gisteren: Tobit 7-8 over de rol van geliefden als hoenders en verzorgers van elkanders psychische kwetsuren by S. Veulemans

“…In this way, “to love” becomes synonymous with the generation of a future in which the ideal of Paradise is brought ever closer. …”
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iPSC Technology Revolutionizes CAR-T Cell Therapy for Cancer Treatment by Jiepu Zong, Yan-Ruide Li

“…Experimental evidence has demonstrated the successful generation of various human CAR-T cells using iPSC technology, showcasing high yield, purity, robustness, and promising tumor-killing efficacy. …”
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Blockade Effects of Anti-Interferon- (IFN-) γ Autoantibodies on IFN-γ-Regulated Antimicrobial Immunity by Dyah Ika Krisnawati, Yung-Ching Liu, Yuarn-Jang Lee, Yun-Ting Wang, Chia-Ling Chen, Po-Chun Tseng, Ting-Jing Shen, Chiou-Feng Lin

“…The interferon- (IFN-) γ expression is elicited in response to microbial infections and activates immune surveillance by antimicrobial immune elements to induce microbial killing. Patients with adult-onset immunodeficiency who suffer from recurrent infections with microbes, particularly nontuberculous mycobacteria (NTM), commonly display genetic defects in IFN-γ signaling as well as the generation of anti-IFN-γ autoantibodies (autoAbs). …”
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Synergistic Effects of Cabozantinib and EGFR-Specific CAR-NK-92 Cells in Renal Cell Carcinoma by Qing Zhang, Kang Tian, Jinjing Xu, Haixu Zhang, Liantao Li, Qiang Fu, Dafei Chai, Huizhong Li, Junnian Zheng

“…The specific killing ability of the CAR-modified NK-92 cells (CAR-NK-92) against renal cell carcinoma (RCC) cell lines was confirmed in vitro. …”
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Mathematical Modelling of Cholera Transmission incorporating Media Coverage. by Muhereza, Obed

“…Since cholera spreads and kills very fast, the effectiveness of control strategies such as vaccination, water chlorination and therapeutic treatment may be enhanced by the use of media alert and awareness campaigns. …”
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Evaluation of Telenomus remus (Hymenoptera: Platygastridae) as a biocontrol agent of Spodoptera litura (Lepidoptera: Noctuidae) based on two-sex life table and functional response... by Zhen Shen, Li-Hui Liu, Lian-Sheng Zang, Tie-Jun Deng, Zhen-Bao Luo, Jun-Yi Gao, Liang-De Tang

“…The net killing rate of T. remus on S. litura was 101.49 eggs/female, indicating the high capacity of T. remus to parasitize S. litura eggs. …”
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Cancer stem cell populations are resistant to 5-aminolevulinic acid-photodynamic therapy (5-ALA-PDT) by Chantel P. J. Rice, Vipin Shankar Chelakkot, Noah T. Conohan, Kensuke Hirasawa

“…Although 5-ALA-PDT is effective at killing cancer cells, in prior studies conducted by our group we normally observed in in vitro experiments that approximately 5–10% of cells survive 5-ALA-PDT, which served as an impetus for further investigation. …”
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Exploring Glypican-3 targeted CAR-NK treatment and potential therapy resistance in hepatocellular carcinoma. by Lei Yang, Kien Pham, Yibo Xi, Qunfeng Wu, Dongfang Liu, Keith D Robertson, Chen Liu

“…These cell lines were engineered with third generation GPC3-specific CARs, and their activities were subsequently evaluated in the treatment of HCC. …”
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Hate Music by Claude Chastagner

“…On August 5, 2012, Wade Michael Page killed six Sikhs outside their temple in Wisconsin. …”
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