Showing 1 - 20 results of 73 for search 'Generation Kill', query time: 0.09s Refine Results
  1. 1
  2. 2
  3. 3

    Third-Generation Anti-CD47-Specific CAR-T Cells Effectively Kill Cancer Cells and Reduce the Genes Expression in Lung Cancer Cell Metastasis by Huyen Thi La, Dao Bich Thi Tran, Hai Manh Tran, Linh Trong Nguyen

    Published 2021-01-01
    “…We used the complementarity-determining regions (CDRs) of the B6H12 mouse antibody grafted onto the IgG1 framework to create the humanized single-chain variable fragment (scFv) with linker (G4S)x3. scFv was used to design the chimeric antigen receptor with the structure CD8signal-CD47scFv-CD8a hinge-CD4TM-CD28-41BB-CD3ζ, which was then transformed into T lymphocytes by the lentivirus to create third generation of CAR-T. Results revealed that the new CAR-T cells efficiently killed A549 cancer cells. …”
    Get full text
    Article
  4. 4

    Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

    Published 2006-01-01
    “…This review summarizes the generation, mechanism, and development of these agents. …”
    Get full text
    Article
  5. 5
  6. 6

    Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment by Yi Ouyang, Yan Chen, Ting Xu, Yihao Sun, Sheng Zhao, Chunmei Chen, Yixin Tan, Liang He, Hui Liu

    Published 2023-02-01
    “…Conclusions: The developed MPDA-CPT-MnO2 nanocomposites can kill tumor cells through collaborative chemo/photothermal/chemodynamic therapy (CDT).…”
    Get full text
    Article
  7. 7

    Hydrogen‐Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine‐125 Brachytherapy by Pan Hu, Letao Lin, Guanyu Chen, Dengyao Liu, Huanqing Guo, Meigui Xiao, Zhihui Zhong, Guang Yang, Bingchen Xu, Dongcun Huang, Sheng Peng, Yong Li, Yanling Zhang, Tao Huang, Fujun Zhang

    Published 2025-02-01
    “…Abstract Radioactive iodine‐125 (125I) seed implantation, a brachytherapy technique, effectively kills tumor cells via X‐rays and gamma rays, serving as an alternative therapeutic option following the failure of frontline treatments for various solid tumors. …”
    Get full text
    Article
  8. 8

    Electric Discharge-Generating Devices Developed for Pathogen, Insect Pest, and Weed Management: Current Status and Future Directions by Shin-ichi Kusakari, Hideyoshi Toyoda

    Published 2025-01-01
    “…The electric discharge-generating devices can be assembled using commonplace conductor materials, such as ordinary metal nets linked to a voltage booster and a grounded electric wire. …”
    Get full text
    Article
  9. 9

    Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment by Yichao Tao, Wenbin Zhuang, Wensi Fan, Longxiang Zhou, Lihong Fan, Huanlong Qin, Yefei Zhu

    Published 2025-02-01
    “…In vitro studies demonstrated excellent biocompatibility and enhanced cell-killing effects of ZnO@Ag NRs on CT-26 cells, while in vivo results confirmed its superior anti-tumor efficacy and biosafety. …”
    Get full text
    Article
  10. 10
  11. 11

    Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor by Linlin Huo, Shiqi Zhu, Muyao Li, Mingya Tan, Mengke Fan, Jiayi Zhao, Jie Zeng, Meiling Liu, Kunyan Liu, Chao Tong, Zhenghuan Zhao

    Published 2025-01-01
    “…This switchable activity ensures this inducer to precisely kill the tumor cells with augmented immunogenicity while causing minimal damage to normal cells. …”
    Get full text
    Article
  12. 12

    Applications and enhancement strategies of ROS-based non-invasive therapies in cancer treatment by Qiuyan Guo, Yingnan Tang, Shengmei Wang, Xinhua Xia

    Published 2025-03-01
    “…These therapies directly kill tumor cells by generating ROS, and although they show great promise in tumor treatment, many challenges remain to be addressed in practical applications. …”
    Get full text
    Article
  13. 13

    Potential of Black Phosphorus in Immune-Based Therapeutic Strategies by Wenjuan Dong, Hu Wang, Hailin Liu, Chunqiao Zhou, Xuelin Zhang, Song Wang, Lin He

    Published 2022-01-01
    “…Based on the prospective phototherapy, BP with irradiation can cause a “double-kill” to tumor cells, involving tumor-structure damage induced by heat, ROS, and shockwaves and a subsequent anticancer immune response induced by in situ vaccines construction in tumor site, which is referred to as photoimmunotherapy (PIT). …”
    Get full text
    Article
  14. 14

    Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update by Arif Malik, Misbah Sultana, Aamer Qazi, Mahmood Husain Qazi, Gulshan Parveen, Sulayman Waquar, Abdul Basit Ashraf, Mahmood Rasool

    Published 2016-01-01
    “…Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. …”
    Get full text
    Article
  15. 15

    Study on the Mechanism of Black Phosphorus Nanosheets Loading Sr2+ Used in Photothermal Antibacterial Treatment by Ma G, Li B, Diao J, Zhang Y, Zhang B, Wu D, Gui H, Zhong J, Zhu H, Zhang D

    Published 2025-01-01
    “…Photothermal therapy has shown promising prospects in the treatment of bacterial infections as it can effectively kill bacteria and reduce inflammation. Black phosphorus (BP) is an emerging nanoparticle that can generate heat under the action of near-infrared light, it can safely and effectively kill bacteria through photothermal therapy. …”
    Get full text
    Article
  16. 16

    Six events that shaped antibody approvals in oncology by Suman Paul, Suman Paul, Shibin Zhou, Shibin Zhou

    Published 2025-02-01
    “…Finally, we explore the development of ipilimumab, the first immune checkpoint-inhibiting antibody that activates the immune system to kill cancer cells, and the discovery that allowed the use of checkpoint inhibitors across all cancer types based on the presence of genetic markers. …”
    Get full text
    Article
  17. 17

    Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system by Sarah Hollingshead, Gareth McVicker, Maria R. Nielsen, YuGeng Zhang, Giulia Pilla, Rebekah A. Jones, Jonathan C. Thomas, Sarah E. H. Johansen, Rachel M. Exley, Ditlev E. Brodersen, Christoph M. Tang

    Published 2025-02-01
    “…ABSTRACT Toxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division. …”
    Get full text
    Article
  18. 18
  19. 19

    Synergistic Antifungal Activity of Terbinafine in Combination with Light-Activated Gelatin–Silver Nanoparticles Against <i>Candida albicans</i> Strains by Atif Ullah, Fawad Ali, Farman Ullah, Sajid Khan Sadozai, Saeed Ahmed Khan, Sajid Hussain, Abdulwahed Fahad Alrefaei, Sajid Ali

    Published 2025-01-01
    “…These results were complemented by the findings of the time-to-kill assay, where the same strain showed a 3.2 log₁₀ CFU/mL decrease in viable cell count. …”
    Get full text
    Article
  20. 20

    Priestia megaterium cells are primed for surviving lethal doses of antibiotics and chemical stress by Manisha Guha, Abhyudai Singh, Nicholas C. Butzin

    Published 2025-02-01
    “…Abstract Antibiotic resistant infections kill millions worldwide yearly. However, a key factor in recurrent infections is antibiotic persisters. …”
    Get full text
    Article