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Quadratic Killing tensors on symmetric spaces which are not generated by Killing vector fields
Published 2024-11-01Get full text
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Kojic Acid Derivative as an Antimitotic Agent That Selectively Kills Tumour Cells
Published 2024-12-01Get full text
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Third-Generation Anti-CD47-Specific CAR-T Cells Effectively Kill Cancer Cells and Reduce the Genes Expression in Lung Cancer Cell Metastasis
Published 2021-01-01“…We used the complementarity-determining regions (CDRs) of the B6H12 mouse antibody grafted onto the IgG1 framework to create the humanized single-chain variable fragment (scFv) with linker (G4S)x3. scFv was used to design the chimeric antigen receptor with the structure CD8signal-CD47scFv-CD8a hinge-CD4TM-CD28-41BB-CD3ζ, which was then transformed into T lymphocytes by the lentivirus to create third generation of CAR-T. Results revealed that the new CAR-T cells efficiently killed A549 cancer cells. …”
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Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties
Published 2006-01-01“…This review summarizes the generation, mechanism, and development of these agents. …”
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Description of Methodology for Testing the Synergistic and Additive Effects of Antibiotics in Vitro
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Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment
Published 2023-02-01“…Conclusions: The developed MPDA-CPT-MnO2 nanocomposites can kill tumor cells through collaborative chemo/photothermal/chemodynamic therapy (CDT).…”
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Hydrogen‐Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine‐125 Brachytherapy
Published 2025-02-01“…Abstract Radioactive iodine‐125 (125I) seed implantation, a brachytherapy technique, effectively kills tumor cells via X‐rays and gamma rays, serving as an alternative therapeutic option following the failure of frontline treatments for various solid tumors. …”
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Electric Discharge-Generating Devices Developed for Pathogen, Insect Pest, and Weed Management: Current Status and Future Directions
Published 2025-01-01“…The electric discharge-generating devices can be assembled using commonplace conductor materials, such as ordinary metal nets linked to a voltage booster and a grounded electric wire. …”
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Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment
Published 2025-02-01“…In vitro studies demonstrated excellent biocompatibility and enhanced cell-killing effects of ZnO@Ag NRs on CT-26 cells, while in vivo results confirmed its superior anti-tumor efficacy and biosafety. …”
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Concentration-dependent effects of immunomodulatory cocktails on the generation of leukemia-derived dendritic cells, DCleu mediated T-cell activation and on-target/off-tumor toxici...
Published 2025-01-01“…For Kit-I, we observed DC/DCleu generation and enhanced T- and immune cell activation across a broader range of OK-432 concentrations (5-40 µg/mL), which also facilitated improved leukemic blast killing. …”
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Intelligent Pyroptosis Inducer for Precise and Augmented Tumor Therapy Through Specific Activation Pyroptosis in Tumor
Published 2025-01-01“…This switchable activity ensures this inducer to precisely kill the tumor cells with augmented immunogenicity while causing minimal damage to normal cells. …”
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Applications and enhancement strategies of ROS-based non-invasive therapies in cancer treatment
Published 2025-03-01“…These therapies directly kill tumor cells by generating ROS, and although they show great promise in tumor treatment, many challenges remain to be addressed in practical applications. …”
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Potential of Black Phosphorus in Immune-Based Therapeutic Strategies
Published 2022-01-01“…Based on the prospective phototherapy, BP with irradiation can cause a “double-kill” to tumor cells, involving tumor-structure damage induced by heat, ROS, and shockwaves and a subsequent anticancer immune response induced by in situ vaccines construction in tumor site, which is referred to as photoimmunotherapy (PIT). …”
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Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update
Published 2016-01-01“…Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. …”
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Study on the Mechanism of Black Phosphorus Nanosheets Loading Sr2+ Used in Photothermal Antibacterial Treatment
Published 2025-01-01“…Photothermal therapy has shown promising prospects in the treatment of bacterial infections as it can effectively kill bacteria and reduce inflammation. Black phosphorus (BP) is an emerging nanoparticle that can generate heat under the action of near-infrared light, it can safely and effectively kill bacteria through photothermal therapy. …”
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Six events that shaped antibody approvals in oncology
Published 2025-02-01“…Finally, we explore the development of ipilimumab, the first immune checkpoint-inhibiting antibody that activates the immune system to kill cancer cells, and the discovery that allowed the use of checkpoint inhibitors across all cancer types based on the presence of genetic markers. …”
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Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system
Published 2025-02-01“…ABSTRACT Toxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division. …”
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Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection
Published 2025-01-01“…Time-kill experiments revealed strong bactericidal activity of ceftobiprole alone at concentrations four times higher than the MIC for some enterococcal strains. …”
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Synergistic Antifungal Activity of Terbinafine in Combination with Light-Activated Gelatin–Silver Nanoparticles Against <i>Candida albicans</i> Strains
Published 2025-01-01“…These results were complemented by the findings of the time-to-kill assay, where the same strain showed a 3.2 log₁₀ CFU/mL decrease in viable cell count. …”
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Priestia megaterium cells are primed for surviving lethal doses of antibiotics and chemical stress
Published 2025-02-01“…Abstract Antibiotic resistant infections kill millions worldwide yearly. However, a key factor in recurrent infections is antibiotic persisters. …”
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